KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ULK4
Full Name:
Serine/threonine-protein kinase ULK4
Alias:
EC 2.7.11.1
Type:
Protein-serine kinase, Other group, ULK family
Mass (Da):
64973
Number AA:
580
UniProt ID:
Q96C45
International Prot ID:
IPI00807602
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Unc-51-like kinase 4 / Serine-threonine-protein kinase ULK4 (E1-K20, human) peptide - Powder PE-01BFL99T#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFL99T
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
E
N
F
I
L
Y
E
E
I
G
R
G
S
Site 2
S14
Y
E
E
I
G
R
G
S
K
T
V
V
Y
K
G
Site 3
T16
E
I
G
R
G
S
K
T
V
V
Y
K
G
R
R
Site 4
Y19
R
G
S
K
T
V
V
Y
K
G
R
R
K
G
T
Site 5
T26
Y
K
G
R
R
K
G
T
I
N
F
V
A
I
L
Site 6
T50
I
T
N
W
V
R
L
T
R
E
I
K
H
K
N
Site 7
T60
I
K
H
K
N
I
V
T
F
H
E
W
Y
E
T
Site 8
T85
C
T
G
G
S
L
K
T
V
I
A
Q
D
E
N
Site 9
S107
E
F
G
I
D
L
I
S
G
L
H
H
L
H
K
Site 10
S174
G
E
N
V
L
K
K
S
M
K
S
R
V
K
G
Site 11
S177
V
L
K
K
S
M
K
S
R
V
K
G
S
P
V
Site 12
S182
M
K
S
R
V
K
G
S
P
V
Y
T
A
P
E
Site 13
Y185
R
V
K
G
S
P
V
Y
T
A
P
E
V
V
R
Site 14
T186
V
K
G
S
P
V
Y
T
A
P
E
V
V
R
G
Site 15
S199
R
G
A
D
F
S
I
S
S
D
L
W
S
L
G
Site 16
S221
S
G
K
P
P
F
F
S
E
S
I
S
E
L
T
Site 17
S223
K
P
P
F
F
S
E
S
I
S
E
L
T
E
K
Site 18
S244
L
P
P
I
P
K
D
S
S
R
P
K
A
S
S
Site 19
S245
P
P
I
P
K
D
S
S
R
P
K
A
S
S
D
Site 20
S251
S
S
R
P
K
A
S
S
D
F
I
N
L
L
D
Site 21
T270
R
D
P
Q
K
R
L
T
W
T
R
L
L
Q
H
Site 22
S292
A
G
A
D
Q
E
S
S
V
E
D
L
S
L
S
Site 23
S297
E
S
S
V
E
D
L
S
L
S
R
N
T
M
E
Site 24
S299
S
V
E
D
L
S
L
S
R
N
T
M
E
C
S
Site 25
T302
D
L
S
L
S
R
N
T
M
E
C
S
G
P
Q
Site 26
S311
E
C
S
G
P
Q
D
S
K
E
L
L
Q
N
S
Site 27
S318
S
K
E
L
L
Q
N
S
Q
S
R
Q
A
K
G
Site 28
S320
E
L
L
Q
N
S
Q
S
R
Q
A
K
G
H
K
Site 29
S328
R
Q
A
K
G
H
K
S
G
Q
P
L
G
H
S
Site 30
S335
S
G
Q
P
L
G
H
S
F
R
L
E
N
P
T
Site 31
T342
S
F
R
L
E
N
P
T
E
F
R
P
K
S
T
Site 32
S348
P
T
E
F
R
P
K
S
T
L
E
G
Q
L
N
Site 33
S357
L
E
G
Q
L
N
E
S
M
F
L
L
S
S
R
Site 34
S362
N
E
S
M
F
L
L
S
S
R
P
T
P
R
T
Site 35
S363
E
S
M
F
L
L
S
S
R
P
T
P
R
T
S
Site 36
T366
F
L
L
S
S
R
P
T
P
R
T
S
T
A
V
Site 37
T369
S
S
R
P
T
P
R
T
S
T
A
V
E
V
S
Site 38
S370
S
R
P
T
P
R
T
S
T
A
V
E
V
S
P
Site 39
T371
R
P
T
P
R
T
S
T
A
V
E
V
S
P
G
Site 40
S376
T
S
T
A
V
E
V
S
P
G
E
D
M
T
H
Site 41
T382
V
S
P
G
E
D
M
T
H
C
S
P
Q
K
T
Site 42
S385
G
E
D
M
T
H
C
S
P
Q
K
T
S
P
L
Site 43
T389
T
H
C
S
P
Q
K
T
S
P
L
T
K
I
T
Site 44
S390
H
C
S
P
Q
K
T
S
P
L
T
K
I
T
S
Site 45
T393
P
Q
K
T
S
P
L
T
K
I
T
S
G
H
L
Site 46
S397
S
P
L
T
K
I
T
S
G
H
L
S
Q
Q
D
Site 47
S401
K
I
T
S
G
H
L
S
Q
Q
D
L
E
S
Q
Site 48
S407
L
S
Q
Q
D
L
E
S
Q
M
R
E
L
I
Y
Site 49
Y414
S
Q
M
R
E
L
I
Y
T
D
S
D
L
V
V
Site 50
T415
Q
M
R
E
L
I
Y
T
D
S
D
L
V
V
T
Site 51
T422
T
D
S
D
L
V
V
T
P
I
I
D
N
P
K
Site 52
Y448
K
I
L
H
L
P
T
Y
S
V
D
K
L
L
F
Site 53
S470
D
F
L
Q
Q
V
C
S
Q
I
D
S
T
E
K
Site 54
S474
Q
V
C
S
Q
I
D
S
T
E
K
S
M
G
A
Site 55
T475
V
C
S
Q
I
D
S
T
E
K
S
M
G
A
S
Site 56
S478
Q
I
D
S
T
E
K
S
M
G
A
S
R
A
K
Site 57
S482
T
E
K
S
M
G
A
S
R
A
K
L
N
L
L
Site 58
S568
I
R
E
N
F
R
N
S
K
L
K
Q
C
L
L
Site 59
T577
L
K
Q
C
L
L
P
T
L
G
E
L
I
Y
L
Site 60
Y583
P
T
L
G
E
L
I
Y
L
V
A
T
Q
E
E
Site 61
T587
E
L
I
Y
L
V
A
T
Q
E
E
K
K
K
N
Site 62
T634
K
I
I
E
N
V
C
T
T
F
S
A
Q
S
Q
Site 63
S659
L
W
Y
L
F
R
H
S
T
A
D
S
L
R
I
Site 64
T660
W
Y
L
F
R
H
S
T
A
D
S
L
R
I
T
Site 65
S663
F
R
H
S
T
A
D
S
L
R
I
T
A
V
S
Site 66
S679
L
C
R
I
T
R
H
S
P
T
A
F
Q
N
V
Site 67
T746
R
L
L
D
S
P
S
T
C
I
R
A
K
A
F
Site 68
Y778
C
Q
A
R
L
V
M
Y
I
E
R
D
S
R
K
Site 69
S783
V
M
Y
I
E
R
D
S
R
K
T
T
P
G
K
Site 70
T786
I
E
R
D
S
R
K
T
T
P
G
K
E
Q
Q
Site 71
T787
E
R
D
S
R
K
T
T
P
G
K
E
Q
Q
S
Site 72
Y798
E
Q
Q
S
G
N
E
Y
L
S
K
C
L
D
L
Site 73
S800
Q
S
G
N
E
Y
L
S
K
C
L
D
L
L
I
Site 74
S829
L
N
S
L
A
N
V
S
G
R
K
H
P
S
T
Site 75
T836
S
G
R
K
H
P
S
T
V
Q
V
K
Q
L
K
Site 76
S879
F
S
Y
G
T
I
L
S
H
I
K
S
V
D
S
Site 77
S883
T
I
L
S
H
I
K
S
V
D
S
G
E
T
N
Site 78
S886
S
H
I
K
S
V
D
S
G
E
T
N
I
D
G
Site 79
Y924
Y
P
I
L
L
K
D
Y
R
S
T
V
V
D
Y
Site 80
S942
P
L
V
S
L
V
Q
S
Q
N
V
E
W
R
L
Site 81
S951
N
V
E
W
R
L
F
S
L
R
L
L
S
E
T
Site 82
S960
R
L
L
S
E
T
T
S
L
L
V
N
Q
E
F
Site 83
S975
G
D
G
K
E
K
A
S
V
D
S
D
S
N
L
Site 84
S978
K
E
K
A
S
V
D
S
D
S
N
L
L
A
L
Site 85
S980
K
A
S
V
D
S
D
S
N
L
L
A
L
I
R
Site 86
Y994
R
D
V
L
L
P
Q
Y
E
H
I
L
L
E
P
Site 87
T1021
A
M
T
E
H
N
P
T
F
T
R
L
V
E
E
Site 88
S1045
V
T
L
E
H
Q
E
S
I
L
G
N
T
M
Q
Site 89
S1067
N
L
V
A
C
K
D
S
N
M
E
L
L
Y
E
Site 90
Y1073
D
S
N
M
E
L
L
Y
E
Q
G
L
V
S
H
Site 91
S1135
L
A
L
Q
A
Q
K
S
G
S
G
E
D
P
Q
Site 92
Y1187
L
S
I
L
V
Q
L
Y
G
G
E
N
P
D
S
Site 93
S1194
Y
G
G
E
N
P
D
S
L
S
P
E
N
V
E
Site 94
S1196
G
E
N
P
D
S
L
S
P
E
N
V
E
I
F
Site 95
T1228
R
I
L
R
R
M
I
T
S
N
E
K
H
L
E
Site 96
S1229
I
L
R
R
M
I
T
S
N
E
K
H
L
E
S
Site 97
S1236
S
N
E
K
H
L
E
S
L
K
N
A
G
S
L
Site 98
S1242
E
S
L
K
N
A
G
S
L
L
R
A
L
E
R
Site 99
S1254
L
E
R
L
A
P
G
S
G
S
F
A
D
S
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation