PhosphoNET

           
Protein Info 
   
Short Name:  SIRT1
Full Name:  NAD-dependent deacetylase sirtuin-1
Alias:  HSIR2; HSIRT1; NAD-dependent deacetylase sirtuin 1; SIR1; SIR2L1; SIR2-like protein 1; Sirtuin (silent mating type information regulation 2) 1; Sirtuin 1
Type:  Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator; Apoptosis
Mass (Da):  81681
Number AA:  747
UniProt ID:  Q96EB6
International Prot ID:  IPI00016802
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016605  GO:0005737  GO:0005635 Uniprot OncoNet
Molecular Function:  GO:0070403  GO:0017136  GO:0042393 PhosphoSite+ KinaseNET
Biological Process:  GO:0006281  GO:0006260  GO:0006915 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S14LALQPGGSPSAAGAD
Site 2S16LQPGGSPSAAGADRE
Site 3S26GADREAASSPAGEPL
Site 4S27 ADREAASSPAGEPLR
Site 5S47DGPGLERSPGEPGGA
Site 6T95GEQEAQATAAAGEGD
Site 7S111GPGLQGPSREPPLAD
Site 8Y121PPLADNLYDEDDDDE
Site 9S159IITNGFHSCESDEED
Site 10S162NGFHSCESDEEDRAS
Site 11S169SDEEDRASHASSSDW
Site 12S172EDRASHASSSDWTPR
Site 13S173DRASHASSSDWTPRP
Site 14S174RASHASSSDWTPRPR
Site 15T177HASSSDWTPRPRIGP
Site 16Y185PRPRIGPYTFVQQHL
Site 17T186RPRIGPYTFVQQHLM
Site 18T209LKDLLPETIPPPELD
Site 19S229QIVINILSEPPKRKK
Site 20T242KKRKDINTIEDAVKL
Site 21S275CGIPDFRSRDGIYAR
Site 22Y280FRSRDGIYARLAVDF
Site 23Y301QAMFDIEYFRKDPRP
Site 24Y317FKFAKEIYPGQFQPS
Site 25S333CHKFIALSDKEGKLL
Site 26Y343EGKLLRNYTQNIDTL
Site 27T344GKLLRNYTQNIDTLE
Site 28T349NYTQNIDTLEQVAGI
Site 29Y428QFHRAMKYDKDEVDL
Site 30S441DLLIVIGSSLKVRPV
Site 31S442LLIVIGSSLKVRPVA
Site 32Y497CHRLGGEYAKLCCNP
Site 33Y523RTQKELAYLSELPPT
Site 34S525QKELAYLSELPPTPL
Site 35T530YLSELPPTPLHVSED
Site 36S535PPTPLHVSEDSSSPE
Site 37S538PLHVSEDSSSPERTS
Site 38S539LHVSEDSSSPERTSP
Site 39S540HVSEDSSSPERTSPP
Site 40T544DSSSPERTSPPDSSV
Site 41S545SSSPERTSPPDSSVI
Site 42S549ERTSPPDSSVIVTLL
Site 43S550RTSPPDSSVIVTLLD
Site 44T554PDSSVIVTLLDQAAK
Site 45S562LLDQAAKSNDDLDVS
Site 46S569SNDDLDVSESKGCME
Site 47S571DDLDVSESKGCMEEK
Site 48S585KPQEVQTSRNVESIA
Site 49S605PDLKNVGSSTGEKNE
Site 50S615GEKNERTSVAGTVRK
Site 51T619ERTSVAGTVRKCWPN
Site 52S634RVAKEQISRRLDGNQ
Site 53Y642RRLDGNQYLFLPPNR
Site 54S659FHGAEVYSDSEDDVL
Site 55S661GAEVYSDSEDDVLSS
Site 56S667DSEDDVLSSSSCGSN
Site 57S668SEDDVLSSSSCGSNS
Site 58S669EDDVLSSSSCGSNSD
Site 59S670DDVLSSSSCGSNSDS
Site 60S673LSSSSCGSNSDSGTC
Site 61S675SSSCGSNSDSGTCQS
Site 62S677SCGSNSDSGTCQSPS
Site 63T679GSNSDSGTCQSPSLE
Site 64S682SDSGTCQSPSLEEPM
Site 65S684SGTCQSPSLEEPMED
Site 66S693EEPMEDESEIEEFYN
Site 67T719AGGAGFGTDGDDQEA
Site 68Y742QEVTDMNYPSNKS__
Site 69S747MNYPSNKS_______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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