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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MASTL
Full Name:
Microtubule-associated serine/threonine-protein kinase-like
Alias:
EC 2.7.11.1; THC2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
AGC
group; MAST family
Mass (Da):
97319
Number AA:
879
UniProt ID:
Q96GX5
International Prot ID:
IPI00074258
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006468
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
I
A
V
P
K
P
P
S
I
E
E
F
S
I
V
Site 2
S36
P
P
S
I
E
E
F
S
I
V
K
P
I
S
R
Site 3
Y50
R
G
A
F
G
K
V
Y
L
G
Q
K
G
G
K
Site 4
Y59
G
Q
K
G
G
K
L
Y
A
V
K
V
V
K
K
Site 5
S88
E
R
D
A
L
A
L
S
K
S
P
F
I
V
H
Site 6
Y98
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
Site 7
S165
K
P
D
N
M
L
I
S
N
E
G
H
I
K
L
Site 8
T173
N
E
G
H
I
K
L
T
D
F
G
L
S
K
V
Site 9
T194
N
M
M
D
I
L
T
T
P
S
M
A
K
P
R
Site 10
Y204
M
A
K
P
R
Q
D
Y
S
R
T
P
G
Q
V
Site 11
S205
A
K
P
R
Q
D
Y
S
R
T
P
G
Q
V
L
Site 12
T207
P
R
Q
D
Y
S
R
T
P
G
Q
V
L
S
L
Site 13
S213
R
T
P
G
Q
V
L
S
L
I
S
S
L
G
F
Site 14
S216
G
Q
V
L
S
L
I
S
S
L
G
F
N
T
P
Site 15
S217
Q
V
L
S
L
I
S
S
L
G
F
N
T
P
I
Site 16
T222
I
S
S
L
G
F
N
T
P
I
A
E
K
N
Q
Site 17
S236
Q
D
P
A
N
I
L
S
A
C
L
S
E
T
S
Site 18
S240
N
I
L
S
A
C
L
S
E
T
S
Q
L
S
Q
Site 19
S254
Q
G
L
V
C
P
M
S
V
D
Q
K
D
T
T
Site 20
T260
M
S
V
D
Q
K
D
T
T
P
Y
S
S
K
L
Site 21
T261
S
V
D
Q
K
D
T
T
P
Y
S
S
K
L
L
Site 22
S264
Q
K
D
T
T
P
Y
S
S
K
L
L
K
S
C
Site 23
S265
K
D
T
T
P
Y
S
S
K
L
L
K
S
C
L
Site 24
S270
Y
S
S
K
L
L
K
S
C
L
E
T
V
A
S
Site 25
S277
S
C
L
E
T
V
A
S
N
P
G
M
P
V
K
Site 26
T287
G
M
P
V
K
C
L
T
S
N
L
L
Q
S
R
Site 27
S288
M
P
V
K
C
L
T
S
N
L
L
Q
S
R
K
Site 28
S293
L
T
S
N
L
L
Q
S
R
K
R
L
A
T
S
Site 29
T299
Q
S
R
K
R
L
A
T
S
S
A
S
S
Q
S
Site 30
S300
S
R
K
R
L
A
T
S
S
A
S
S
Q
S
H
Site 31
S301
R
K
R
L
A
T
S
S
A
S
S
Q
S
H
T
Site 32
S304
L
A
T
S
S
A
S
S
Q
S
H
T
F
I
S
Site 33
S306
T
S
S
A
S
S
Q
S
H
T
F
I
S
S
V
Site 34
T308
S
A
S
S
Q
S
H
T
F
I
S
S
V
E
S
Site 35
S311
S
Q
S
H
T
F
I
S
S
V
E
S
E
C
H
Site 36
S312
Q
S
H
T
F
I
S
S
V
E
S
E
C
H
S
Site 37
S315
T
F
I
S
S
V
E
S
E
C
H
S
S
P
K
Site 38
S319
S
V
E
S
E
C
H
S
S
P
K
W
E
K
D
Site 39
S320
V
E
S
E
C
H
S
S
P
K
W
E
K
D
C
Site 40
S370
K
D
L
E
L
A
L
S
P
I
H
N
S
S
A
Site 41
S375
A
L
S
P
I
H
N
S
S
A
L
P
T
T
G
Site 42
S376
L
S
P
I
H
N
S
S
A
L
P
T
T
G
R
Site 43
T380
H
N
S
S
A
L
P
T
T
G
R
S
C
V
N
Site 44
T381
N
S
S
A
L
P
T
T
G
R
S
C
V
N
L
Site 45
S394
N
L
A
K
K
C
F
S
G
E
V
S
W
E
A
Site 46
S398
K
C
F
S
G
E
V
S
W
E
A
V
E
L
D
Site 47
T413
V
N
N
I
N
M
D
T
D
T
S
Q
L
G
F
Site 48
S416
I
N
M
D
T
D
T
S
Q
L
G
F
H
Q
S
Site 49
S430
S
N
Q
W
A
V
D
S
G
G
I
S
E
E
H
Site 50
S434
A
V
D
S
G
G
I
S
E
E
H
L
G
K
R
Site 51
S442
E
E
H
L
G
K
R
S
L
K
R
N
F
E
L
Site 52
S452
R
N
F
E
L
V
D
S
S
P
C
K
K
I
I
Site 53
S453
N
F
E
L
V
D
S
S
P
C
K
K
I
I
Q
Site 54
Y477
H
N
E
M
T
N
C
Y
T
N
Q
N
T
G
L
Site 55
T485
T
N
Q
N
T
G
L
T
V
E
V
Q
D
L
K
Site 56
S494
E
V
Q
D
L
K
L
S
V
H
K
S
Q
Q
N
Site 57
S498
L
K
L
S
V
H
K
S
Q
Q
N
D
C
A
N
Site 58
S512
N
K
E
N
I
V
N
S
F
T
D
K
Q
Q
T
Site 59
T514
E
N
I
V
N
S
F
T
D
K
Q
Q
T
P
E
Site 60
T519
S
F
T
D
K
Q
Q
T
P
E
K
L
P
I
P
Site 61
S544
D
E
D
C
E
K
N
S
K
R
D
Y
L
S
S
Site 62
Y548
E
K
N
S
K
R
D
Y
L
S
S
S
F
L
C
Site 63
S550
N
S
K
R
D
Y
L
S
S
S
F
L
C
S
D
Site 64
S551
S
K
R
D
Y
L
S
S
S
F
L
C
S
D
D
Site 65
S552
K
R
D
Y
L
S
S
S
F
L
C
S
D
D
D
Site 66
S556
L
S
S
S
F
L
C
S
D
D
D
R
A
S
K
Site 67
S562
C
S
D
D
D
R
A
S
K
N
I
S
M
N
S
Site 68
S566
D
R
A
S
K
N
I
S
M
N
S
D
S
S
F
Site 69
S569
S
K
N
I
S
M
N
S
D
S
S
F
P
G
I
Site 70
S571
N
I
S
M
N
S
D
S
S
F
P
G
I
S
I
Site 71
S577
D
S
S
F
P
G
I
S
I
M
E
S
P
L
E
Site 72
S581
P
G
I
S
I
M
E
S
P
L
E
S
Q
P
L
Site 73
S585
I
M
E
S
P
L
E
S
Q
P
L
D
S
D
R
Site 74
S590
L
E
S
Q
P
L
D
S
D
R
S
I
K
E
S
Site 75
S593
Q
P
L
D
S
D
R
S
I
K
E
S
S
F
E
Site 76
S597
S
D
R
S
I
K
E
S
S
F
E
E
S
N
I
Site 77
S598
D
R
S
I
K
E
S
S
F
E
E
S
N
I
E
Site 78
S602
K
E
S
S
F
E
E
S
N
I
E
D
P
L
I
Site 79
T611
I
E
D
P
L
I
V
T
P
D
C
Q
E
K
T
Site 80
T618
T
P
D
C
Q
E
K
T
S
P
K
G
V
E
N
Site 81
S619
P
D
C
Q
E
K
T
S
P
K
G
V
E
N
P
Site 82
S631
E
N
P
A
V
Q
E
S
N
Q
K
M
L
G
P
Site 83
T645
P
P
L
E
V
L
K
T
L
A
S
K
R
N
A
Site 84
S657
R
N
A
V
A
F
R
S
F
N
S
H
I
N
A
Site 85
S665
F
N
S
H
I
N
A
S
N
N
S
E
P
S
R
Site 86
S668
H
I
N
A
S
N
N
S
E
P
S
R
M
N
M
Site 87
S671
A
S
N
N
S
E
P
S
R
M
N
M
T
S
L
Site 88
S677
P
S
R
M
N
M
T
S
L
D
A
M
D
I
S
Site 89
S684
S
L
D
A
M
D
I
S
C
A
Y
S
G
S
Y
Site 90
Y691
S
C
A
Y
S
G
S
Y
P
M
A
I
T
P
T
Site 91
T696
G
S
Y
P
M
A
I
T
P
T
Q
K
R
R
S
Site 92
T698
Y
P
M
A
I
T
P
T
Q
K
R
R
S
C
M
Site 93
S703
T
P
T
Q
K
R
R
S
C
M
P
H
Q
Q
T
Site 94
T710
S
C
M
P
H
Q
Q
T
P
N
Q
I
K
S
G
Site 95
S716
Q
T
P
N
Q
I
K
S
G
T
P
Y
R
T
P
Site 96
T718
P
N
Q
I
K
S
G
T
P
Y
R
T
P
K
S
Site 97
Y720
Q
I
K
S
G
T
P
Y
R
T
P
K
S
V
R
Site 98
T722
K
S
G
T
P
Y
R
T
P
K
S
V
R
R
G
Site 99
S725
T
P
Y
R
T
P
K
S
V
R
R
G
V
A
P
Site 100
T741
D
D
G
R
I
L
G
T
P
D
Y
L
A
P
E
Site 101
T782
I
P
P
F
N
D
E
T
P
Q
Q
V
F
Q
N
Site 102
S805
P
E
G
E
E
K
L
S
D
N
A
Q
S
A
V
Site 103
T821
I
L
L
T
I
D
D
T
K
R
A
G
M
K
E
Site 104
S836
L
K
R
H
P
L
F
S
D
V
D
W
E
N
L
Site 105
T858
I
P
Q
P
D
D
E
T
D
T
S
Y
F
E
A
Site 106
S861
P
D
D
E
T
D
T
S
Y
F
E
A
R
N
T
Site 107
Y862
D
D
E
T
D
T
S
Y
F
E
A
R
N
T
A
Site 108
T868
S
Y
F
E
A
R
N
T
A
Q
H
L
T
V
S
Site 109
T873
R
N
T
A
Q
H
L
T
V
S
G
F
S
L
_
Site 110
S875
T
A
Q
H
L
T
V
S
G
F
S
L
_
_
_
Site 111
S878
H
L
T
V
S
G
F
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation