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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPAG5
Full Name:
Sperm-associated antigen 5
Alias:
Astrin; DEEPEST; HMAP126; MAP126; Mitotic spindle associated protein p126; Mitotic spindle coiled-coil related protein; Sperm associated antigen 5
Type:
Cell cycle regulation
Mass (Da):
134422
Number AA:
1193
UniProt ID:
Q96R06
International Prot ID:
IPI00328118
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
W
R
V
K
K
L
S
L
S
L
S
P
S
P
Site 2
S10
R
V
K
K
L
S
L
S
L
S
P
S
P
Q
T
Site 3
S12
K
K
L
S
L
S
L
S
P
S
P
Q
T
G
K
Site 4
S14
L
S
L
S
L
S
P
S
P
Q
T
G
K
P
S
Site 5
T17
S
L
S
P
S
P
Q
T
G
K
P
S
M
R
T
Site 6
S21
S
P
Q
T
G
K
P
S
M
R
T
P
L
R
E
Site 7
T24
T
G
K
P
S
M
R
T
P
L
R
E
L
T
L
Site 8
T30
R
T
P
L
R
E
L
T
L
Q
P
G
A
L
T
Site 9
T37
T
L
Q
P
G
A
L
T
N
S
G
K
R
S
P
Site 10
S39
Q
P
G
A
L
T
N
S
G
K
R
S
P
A
C
Site 11
S43
L
T
N
S
G
K
R
S
P
A
C
S
S
L
T
Site 12
S47
G
K
R
S
P
A
C
S
S
L
T
P
S
L
C
Site 13
S48
K
R
S
P
A
C
S
S
L
T
P
S
L
C
K
Site 14
T50
S
P
A
C
S
S
L
T
P
S
L
C
K
L
G
Site 15
S62
K
L
G
L
Q
E
G
S
N
N
S
S
P
V
D
Site 16
S65
L
Q
E
G
S
N
N
S
S
P
V
D
F
V
N
Site 17
S66
Q
E
G
S
N
N
S
S
P
V
D
F
V
N
N
Site 18
T76
D
F
V
N
N
K
R
T
D
L
S
S
E
H
F
Site 19
S79
N
N
K
R
T
D
L
S
S
E
H
F
S
H
S
Site 20
S80
N
K
R
T
D
L
S
S
E
H
F
S
H
S
S
Site 21
S84
D
L
S
S
E
H
F
S
H
S
S
K
W
L
E
Site 22
S86
S
S
E
H
F
S
H
S
S
K
W
L
E
T
C
Site 23
T92
H
S
S
K
W
L
E
T
C
Q
H
E
S
D
E
Site 24
S109
L
D
P
I
P
Q
I
S
S
T
P
K
T
S
E
Site 25
S110
D
P
I
P
Q
I
S
S
T
P
K
T
S
E
E
Site 26
T111
P
I
P
Q
I
S
S
T
P
K
T
S
E
E
A
Site 27
T114
Q
I
S
S
T
P
K
T
S
E
E
A
V
D
P
Site 28
Y125
A
V
D
P
L
G
N
Y
M
V
K
T
I
V
L
Site 29
S135
K
T
I
V
L
V
P
S
P
L
G
Q
Q
Q
D
Site 30
T151
I
F
E
A
R
L
D
T
M
A
E
T
N
S
I
Site 31
T155
R
L
D
T
M
A
E
T
N
S
I
S
L
N
G
Site 32
S157
D
T
M
A
E
T
N
S
I
S
L
N
G
P
L
Site 33
S159
M
A
E
T
N
S
I
S
L
N
G
P
L
R
T
Site 34
S183
P
C
M
G
D
R
F
S
E
V
A
A
V
S
E
Site 35
S197
E
K
P
I
F
Q
E
S
P
S
H
L
L
E
E
Site 36
S205
P
S
H
L
L
E
E
S
P
P
N
P
C
S
E
Site 37
S211
E
S
P
P
N
P
C
S
E
Q
L
H
C
S
K
Site 38
S217
C
S
E
Q
L
H
C
S
K
E
S
L
S
S
R
Site 39
S220
Q
L
H
C
S
K
E
S
L
S
S
R
T
E
A
Site 40
S222
H
C
S
K
E
S
L
S
S
R
T
E
A
V
R
Site 41
S237
E
D
L
V
P
S
E
S
N
A
F
L
P
S
S
Site 42
S249
P
S
S
V
L
W
L
S
P
S
T
A
L
A
A
Site 43
T284
E
R
E
M
R
F
P
T
H
P
K
E
S
E
T
Site 44
S299
E
D
Q
A
L
V
S
S
V
E
D
I
L
S
T
Site 45
S317
P
N
L
V
E
M
E
S
Q
E
A
P
G
P
A
Site 46
S334
D
V
G
R
I
L
G
S
D
T
E
S
W
M
S
Site 47
T336
G
R
I
L
G
S
D
T
E
S
W
M
S
P
L
Site 48
S338
I
L
G
S
D
T
E
S
W
M
S
P
L
A
W
Site 49
S341
S
D
T
E
S
W
M
S
P
L
A
W
L
E
K
Site 50
T352
W
L
E
K
G
V
N
T
S
V
M
L
E
N
L
Site 51
S353
L
E
K
G
V
N
T
S
V
M
L
E
N
L
R
Site 52
S362
M
L
E
N
L
R
Q
S
L
S
L
P
S
M
L
Site 53
S364
E
N
L
R
Q
S
L
S
L
P
S
M
L
R
D
Site 54
T376
L
R
D
A
A
I
G
T
T
P
F
S
T
C
S
Site 55
T377
R
D
A
A
I
G
T
T
P
F
S
T
C
S
V
Site 56
T389
C
S
V
G
T
W
F
T
P
S
A
P
Q
E
K
Site 57
S391
V
G
T
W
F
T
P
S
A
P
Q
E
K
S
T
Site 58
S397
P
S
A
P
Q
E
K
S
T
N
T
S
Q
T
G
Site 59
T400
P
Q
E
K
S
T
N
T
S
Q
T
G
L
V
G
Site 60
S401
Q
E
K
S
T
N
T
S
Q
T
G
L
V
G
T
Site 61
T403
K
S
T
N
T
S
Q
T
G
L
V
G
T
K
H
Site 62
S411
G
L
V
G
T
K
H
S
T
S
E
T
E
Q
L
Site 63
S413
V
G
T
K
H
S
T
S
E
T
E
Q
L
L
C
Site 64
T415
T
K
H
S
T
S
E
T
E
Q
L
L
C
G
R
Site 65
T427
C
G
R
P
P
D
L
T
A
L
S
R
H
D
L
Site 66
S430
P
P
D
L
T
A
L
S
R
H
D
L
E
D
N
Site 67
S457
R
Q
L
R
D
W
K
S
Q
L
A
V
P
H
P
Site 68
T466
L
A
V
P
H
P
E
T
Q
D
S
S
T
Q
T
Site 69
S469
P
H
P
E
T
Q
D
S
S
T
Q
T
D
T
S
Site 70
T471
P
E
T
Q
D
S
S
T
Q
T
D
T
S
H
S
Site 71
T473
T
Q
D
S
S
T
Q
T
D
T
S
H
S
G
I
Site 72
S476
S
S
T
Q
T
D
T
S
H
S
G
I
T
N
K
Site 73
S506
Q
A
R
N
V
M
Q
S
W
V
L
I
S
K
E
Site 74
T530
L
H
L
E
E
D
K
T
T
V
S
Q
E
S
R
Site 75
T531
H
L
E
E
D
K
T
T
V
S
Q
E
S
R
R
Site 76
S533
E
E
D
K
T
T
V
S
Q
E
S
R
R
A
E
Site 77
T541
Q
E
S
R
R
A
E
T
L
V
C
C
C
F
D
Site 78
S559
K
L
R
A
K
L
Q
S
L
K
A
E
R
E
E
Site 79
S593
E
A
F
C
A
H
A
S
Q
R
I
S
Q
L
E
Site 80
S597
A
H
A
S
Q
R
I
S
Q
L
E
Q
D
L
A
Site 81
S605
Q
L
E
Q
D
L
A
S
M
R
E
F
R
G
L
Site 82
T634
Q
E
E
L
V
Q
Q
T
V
S
L
T
S
T
L
Site 83
S636
E
L
V
Q
Q
T
V
S
L
T
S
T
L
Q
Q
Site 84
T640
Q
T
V
S
L
T
S
T
L
Q
Q
D
W
R
S
Site 85
Y652
W
R
S
M
Q
L
D
Y
T
T
W
T
A
L
L
Site 86
T653
R
S
M
Q
L
D
Y
T
T
W
T
A
L
L
S
Site 87
T654
S
M
Q
L
D
Y
T
T
W
T
A
L
L
S
R
Site 88
T656
Q
L
D
Y
T
T
W
T
A
L
L
S
R
S
R
Site 89
S660
T
T
W
T
A
L
L
S
R
S
R
Q
L
T
E
Site 90
T666
L
S
R
S
R
Q
L
T
E
K
L
T
V
K
S
Site 91
T670
R
Q
L
T
E
K
L
T
V
K
S
Q
Q
A
L
Site 92
S673
T
E
K
L
T
V
K
S
Q
Q
A
L
Q
E
R
Site 93
S716
E
Q
L
E
L
E
N
S
R
L
A
T
D
L
R
Site 94
T720
L
E
N
S
R
L
A
T
D
L
R
A
Q
L
Q
Site 95
S734
Q
I
L
A
N
M
D
S
Q
L
K
E
L
Q
S
Site 96
S741
S
Q
L
K
E
L
Q
S
Q
H
T
H
C
A
Q
Site 97
T761
D
E
L
L
C
Q
L
T
Q
S
N
E
E
Q
A
Site 98
S763
L
L
C
Q
L
T
Q
S
N
E
E
Q
A
A
Q
Site 99
T802
E
V
R
D
L
K
E
T
L
E
F
A
D
Q
E
Site 100
S835
L
E
V
L
R
E
R
S
L
Q
C
E
N
L
K
Site 101
T844
Q
C
E
N
L
K
D
T
V
E
N
L
T
A
K
Site 102
Y870
D
L
E
K
T
R
Q
Y
S
Q
K
L
G
L
L
Site 103
S871
L
E
K
T
R
Q
Y
S
Q
K
L
G
L
L
T
Site 104
T878
S
Q
K
L
G
L
L
T
E
Q
L
Q
S
L
T
Site 105
S904
E
Q
E
T
L
L
L
S
T
A
C
P
P
T
Q
Site 106
T910
L
S
T
A
C
P
P
T
Q
E
H
P
L
P
N
Site 107
T920
H
P
L
P
N
D
R
T
F
L
G
S
I
L
T
Site 108
S936
V
A
D
E
E
P
E
S
T
P
V
P
L
L
G
Site 109
T937
A
D
E
E
P
E
S
T
P
V
P
L
L
G
S
Site 110
S947
P
L
L
G
S
D
K
S
A
F
T
R
V
A
S
Site 111
T950
G
S
D
K
S
A
F
T
R
V
A
S
M
V
S
Site 112
S954
S
A
F
T
R
V
A
S
M
V
S
L
Q
P
A
Site 113
S957
T
R
V
A
S
M
V
S
L
Q
P
A
E
T
P
Site 114
T963
V
S
L
Q
P
A
E
T
P
G
M
E
E
S
L
Site 115
S969
E
T
P
G
M
E
E
S
L
A
E
M
S
I
M
Site 116
S974
E
E
S
L
A
E
M
S
I
M
T
T
E
L
Q
Site 117
T978
A
E
M
S
I
M
T
T
E
L
Q
S
L
C
S
Site 118
S985
T
E
L
Q
S
L
C
S
L
L
Q
E
S
K
E
Site 119
T997
S
K
E
E
A
I
R
T
L
Q
R
K
I
C
E
Site 120
S1062
I
L
E
Q
I
D
K
S
G
E
L
I
S
L
R
Site 121
S1067
D
K
S
G
E
L
I
S
L
R
E
E
V
T
H
Site 122
S1078
E
V
T
H
L
T
R
S
L
R
R
A
E
T
E
Site 123
T1084
R
S
L
R
R
A
E
T
E
T
K
V
L
Q
E
Site 124
S1099
A
L
A
G
Q
L
D
S
N
C
Q
P
M
A
T
Site 125
S1116
I
Q
E
K
V
W
L
S
Q
E
V
D
K
L
R
Site 126
S1142
K
L
M
I
K
F
Q
S
H
R
N
I
L
E
E
Site 127
S1154
L
E
E
N
L
R
R
S
D
K
E
L
E
K
L
Site 128
T1171
I
V
Q
H
I
Y
K
T
L
L
S
I
P
E
V
Site 129
S1174
H
I
Y
K
T
L
L
S
I
P
E
V
V
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation