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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP28
Full Name:
Ubiquitin carboxyl-terminal hydrolase 28
Alias:
Ubiquitin thioesterase 28
Type:
Mass (Da):
122491
Number AA:
1077
UniProt ID:
Q96RU2
International Prot ID:
IPI00045496
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0006511
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
A
A
D
G
H
G
S
S
C
Q
M
L
L
N
Q
Site 2
T32
L
N
Q
L
R
E
I
T
G
I
Q
D
P
S
F
Site 3
S38
I
T
G
I
Q
D
P
S
F
L
H
E
A
L
K
Site 4
T52
K
A
S
N
G
D
I
T
Q
A
V
S
L
L
T
Site 5
S67
D
E
R
V
K
E
P
S
Q
D
T
V
A
T
E
Site 6
T70
V
K
E
P
S
Q
D
T
V
A
T
E
P
S
E
Site 7
S76
D
T
V
A
T
E
P
S
E
V
E
G
S
A
A
Site 8
S81
E
P
S
E
V
E
G
S
A
A
N
K
E
V
L
Site 9
T95
L
A
K
V
I
D
L
T
H
D
N
K
D
D
L
Site 10
T130
L
N
R
M
H
E
A
T
S
A
E
T
K
R
S
Site 11
S131
N
R
M
H
E
A
T
S
A
E
T
K
R
S
K
Site 12
T134
H
E
A
T
S
A
E
T
K
R
S
K
R
K
R
Site 13
S137
T
S
A
E
T
K
R
S
K
R
K
R
C
E
V
Site 14
S192
E
F
R
R
L
V
L
S
Y
S
L
P
Q
N
V
Site 15
S194
R
R
L
V
L
S
Y
S
L
P
Q
N
V
L
E
Site 16
S205
N
V
L
E
N
C
R
S
H
T
E
K
R
N
I
Site 17
T207
L
E
N
C
R
S
H
T
E
K
R
N
I
M
F
Site 18
S249
L
K
G
A
F
R
S
S
E
E
Q
Q
Q
D
V
Site 19
S257
E
E
Q
Q
Q
D
V
S
E
F
T
H
K
L
L
Site 20
S279
Q
L
A
V
N
V
N
S
P
R
N
K
S
E
N
Site 21
S284
V
N
S
P
R
N
K
S
E
N
P
M
V
Q
L
Site 22
T298
L
F
Y
G
T
F
L
T
E
G
V
R
E
G
K
Site 23
Y316
N
N
E
T
F
G
Q
Y
P
L
Q
V
N
G
Y
Site 24
S344
G
D
V
E
L
L
P
S
D
H
S
V
K
Y
G
Site 25
S347
E
L
L
P
S
D
H
S
V
K
Y
G
Q
E
R
Site 26
Y350
P
S
D
H
S
V
K
Y
G
Q
E
R
W
F
T
Site 27
T357
Y
G
Q
E
R
W
F
T
K
L
P
P
V
L
T
Site 28
T364
T
K
L
P
P
V
L
T
F
E
L
S
R
F
E
Site 29
S368
P
V
L
T
F
E
L
S
R
F
E
F
N
Q
S
Site 30
S375
S
R
F
E
F
N
Q
S
L
G
Q
P
E
K
I
Site 31
Y393
L
E
F
P
Q
I
I
Y
M
D
R
Y
M
Y
R
Site 32
Y397
Q
I
I
Y
M
D
R
Y
M
Y
R
S
K
E
L
Site 33
Y399
I
Y
M
D
R
Y
M
Y
R
S
K
E
L
I
R
Site 34
Y429
L
Q
Q
K
L
E
R
Y
V
K
Y
G
S
G
P
Site 35
Y432
K
L
E
R
Y
V
K
Y
G
S
G
P
A
R
F
Site 36
Y447
P
L
P
D
M
L
K
Y
V
I
E
F
A
S
T
Site 37
T454
Y
V
I
E
F
A
S
T
K
P
A
S
E
S
C
Site 38
S458
F
A
S
T
K
P
A
S
E
S
C
P
P
E
S
Site 39
S460
S
T
K
P
A
S
E
S
C
P
P
E
S
D
T
Site 40
S465
S
E
S
C
P
P
E
S
D
T
H
M
T
L
P
Site 41
T467
S
C
P
P
E
S
D
T
H
M
T
L
P
L
S
Site 42
T470
P
E
S
D
T
H
M
T
L
P
L
S
S
V
H
Site 43
S479
P
L
S
S
V
H
C
S
V
S
D
Q
T
S
K
Site 44
S481
S
S
V
H
C
S
V
S
D
Q
T
S
K
E
S
Site 45
T484
H
C
S
V
S
D
Q
T
S
K
E
S
T
S
T
Site 46
S485
C
S
V
S
D
Q
T
S
K
E
S
T
S
T
E
Site 47
S488
S
D
Q
T
S
K
E
S
T
S
T
E
S
S
S
Site 48
T489
D
Q
T
S
K
E
S
T
S
T
E
S
S
S
Q
Site 49
S490
Q
T
S
K
E
S
T
S
T
E
S
S
S
Q
D
Site 50
T491
T
S
K
E
S
T
S
T
E
S
S
S
Q
D
V
Site 51
S494
E
S
T
S
T
E
S
S
S
Q
D
V
E
S
T
Site 52
S495
S
T
S
T
E
S
S
S
Q
D
V
E
S
T
F
Site 53
S500
S
S
S
Q
D
V
E
S
T
F
S
S
P
E
D
Site 54
T501
S
S
Q
D
V
E
S
T
F
S
S
P
E
D
S
Site 55
S503
Q
D
V
E
S
T
F
S
S
P
E
D
S
L
P
Site 56
S504
D
V
E
S
T
F
S
S
P
E
D
S
L
P
K
Site 57
S508
T
F
S
S
P
E
D
S
L
P
K
S
K
P
L
Site 58
S512
P
E
D
S
L
P
K
S
K
P
L
T
S
S
R
Site 59
T516
L
P
K
S
K
P
L
T
S
S
R
S
S
M
E
Site 60
S517
P
K
S
K
P
L
T
S
S
R
S
S
M
E
M
Site 61
S518
K
S
K
P
L
T
S
S
R
S
S
M
E
M
P
Site 62
S520
K
P
L
T
S
S
R
S
S
M
E
M
P
S
Q
Site 63
S521
P
L
T
S
S
R
S
S
M
E
M
P
S
Q
P
Site 64
S526
R
S
S
M
E
M
P
S
Q
P
A
P
R
T
V
Site 65
T532
P
S
Q
P
A
P
R
T
V
T
D
E
E
I
N
Site 66
T534
Q
P
A
P
R
T
V
T
D
E
E
I
N
F
V
Site 67
S550
T
C
L
Q
R
W
R
S
E
I
E
Q
D
I
Q
Site 68
T561
Q
D
I
Q
D
L
K
T
C
I
A
S
T
T
Q
Site 69
Y574
T
Q
T
I
E
Q
M
Y
C
D
P
L
L
R
Q
Site 70
Y616
P
R
Q
S
W
L
K
Y
N
D
I
S
V
T
E
Site 71
S620
W
L
K
Y
N
D
I
S
V
T
E
S
S
W
E
Site 72
S624
N
D
I
S
V
T
E
S
S
W
E
E
V
E
R
Site 73
S625
D
I
S
V
T
E
S
S
W
E
E
V
E
R
D
Site 74
S633
W
E
E
V
E
R
D
S
Y
G
G
L
R
N
V
Site 75
Y634
E
E
V
E
R
D
S
Y
G
G
L
R
N
V
S
Site 76
Y654
Y
I
N
D
K
L
P
Y
F
N
A
E
A
A
P
Site 77
T662
F
N
A
E
A
A
P
T
E
S
D
Q
M
S
E
Site 78
S664
A
E
A
A
P
T
E
S
D
Q
M
S
E
V
E
Site 79
S668
P
T
E
S
D
Q
M
S
E
V
E
A
L
S
V
Site 80
Y680
L
S
V
E
L
K
H
Y
I
Q
E
D
N
W
R
Site 81
S708
C
K
I
P
Q
M
E
S
S
T
N
S
S
S
Q
Site 82
S709
K
I
P
Q
M
E
S
S
T
N
S
S
S
Q
D
Site 83
T710
I
P
Q
M
E
S
S
T
N
S
S
S
Q
D
Y
Site 84
S712
Q
M
E
S
S
T
N
S
S
S
Q
D
Y
S
T
Site 85
S713
M
E
S
S
T
N
S
S
S
Q
D
Y
S
T
S
Site 86
S714
E
S
S
T
N
S
S
S
Q
D
Y
S
T
S
Q
Site 87
Y717
T
N
S
S
S
Q
D
Y
S
T
S
Q
E
P
S
Site 88
S718
N
S
S
S
Q
D
Y
S
T
S
Q
E
P
S
V
Site 89
T719
S
S
S
Q
D
Y
S
T
S
Q
E
P
S
V
A
Site 90
S720
S
S
Q
D
Y
S
T
S
Q
E
P
S
V
A
S
Site 91
S724
Y
S
T
S
Q
E
P
S
V
A
S
S
H
G
V
Site 92
S728
Q
E
P
S
V
A
S
S
H
G
V
R
C
L
S
Site 93
Y757
I
A
N
T
A
R
A
Y
E
K
S
G
V
E
A
Site 94
S760
T
A
R
A
Y
E
K
S
G
V
E
A
A
L
S
Site 95
T788
A
I
A
K
A
R
Q
T
F
D
R
D
G
S
E
Site 96
S794
Q
T
F
D
R
D
G
S
E
A
G
L
I
K
A
Site 97
Y810
H
E
E
Y
S
R
L
Y
Q
L
A
K
E
T
P
Site 98
T816
L
Y
Q
L
A
K
E
T
P
T
S
H
S
D
P
Site 99
S819
L
A
K
E
T
P
T
S
H
S
D
P
R
L
Q
Site 100
S821
K
E
T
P
T
S
H
S
D
P
R
L
Q
H
V
Site 101
Y831
R
L
Q
H
V
L
V
Y
F
F
Q
N
E
A
P
Site 102
T845
P
K
R
V
V
E
R
T
L
L
E
Q
F
A
D
Site 103
S856
Q
F
A
D
K
N
L
S
Y
D
E
R
S
I
S
Site 104
Y857
F
A
D
K
N
L
S
Y
D
E
R
S
I
S
I
Site 105
S863
S
Y
D
E
R
S
I
S
I
M
K
V
A
Q
A
Site 106
Y892
Y
K
K
W
H
E
D
Y
S
L
F
R
K
V
S
Site 107
S893
K
K
W
H
E
D
Y
S
L
F
R
K
V
S
V
Site 108
Y901
L
F
R
K
V
S
V
Y
L
L
T
G
L
E
L
Site 109
Y909
L
L
T
G
L
E
L
Y
Q
K
G
K
Y
Q
E
Site 110
Y914
E
L
Y
Q
K
G
K
Y
Q
E
A
L
S
Y
L
Site 111
S919
G
K
Y
Q
E
A
L
S
Y
L
V
Y
A
Y
Q
Site 112
Y920
K
Y
Q
E
A
L
S
Y
L
V
Y
A
Y
Q
S
Site 113
S943
P
R
R
G
V
K
E
S
V
I
A
L
Y
R
R
Site 114
Y948
K
E
S
V
I
A
L
Y
R
R
K
C
L
L
E
Site 115
S962
E
L
N
A
K
A
A
S
L
F
E
T
N
D
D
Site 116
T966
K
A
A
S
L
F
E
T
N
D
D
H
S
V
T
Site 117
S971
F
E
T
N
D
D
H
S
V
T
E
G
I
N
V
Site 118
T1048
I
V
L
K
E
P
P
T
I
R
P
N
S
P
Y
Site 119
S1053
P
P
T
I
R
P
N
S
P
Y
D
L
C
S
R
Site 120
Y1055
T
I
R
P
N
S
P
Y
D
L
C
S
R
F
A
Site 121
S1059
N
S
P
Y
D
L
C
S
R
F
A
A
V
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation