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Updated November 2019
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Protein Info
Short Name:
RSKL1
Full Name:
Ribosomal protein S6 kinase delta-1
Alias:
EC 2.7.11.1; HumS6PKh1; KS6C1; Ribosomal protein S6 kinase, 52kDa, polypeptide 1; RPK118; RPS6KC1
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
AGC
group; RSKL family
Mass (Da):
118682
Number AA:
1066
UniProt ID:
Q96S38
International Prot ID:
IPI00291351
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005769
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0035091
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
S
Y
R
E
R
S
A
D
L
A
R
F
Y
Site 2
Y15
S
A
D
L
A
R
F
Y
T
V
T
E
P
Q
R
Site 3
T16
A
D
L
A
R
F
Y
T
V
T
E
P
Q
R
H
Site 4
T18
L
A
R
F
Y
T
V
T
E
P
Q
R
H
P
R
Site 5
Y27
P
Q
R
H
P
R
G
Y
T
V
Y
K
V
T
A
Site 6
T28
Q
R
H
P
R
G
Y
T
V
Y
K
V
T
A
R
Site 7
Y30
H
P
R
G
Y
T
V
Y
K
V
T
A
R
V
V
Site 8
T33
G
Y
T
V
Y
K
V
T
A
R
V
V
S
R
R
Site 9
S38
K
V
T
A
R
V
V
S
R
R
N
P
E
D
V
Site 10
S75
H
K
N
L
F
R
H
S
E
L
F
P
P
F
A
Site 11
T93
V
F
G
R
F
D
E
T
V
I
E
E
R
R
Q
Site 12
S109
A
E
D
L
L
Q
F
S
A
N
I
P
A
L
Y
Site 13
Y116
S
A
N
I
P
A
L
Y
N
S
K
Q
L
E
D
Site 14
S118
N
I
P
A
L
Y
N
S
K
Q
L
E
D
F
F
Site 15
S133
K
G
G
I
I
N
D
S
S
E
L
I
G
P
A
Site 16
S134
G
G
I
I
N
D
S
S
E
L
I
G
P
A
E
Site 17
S144
I
G
P
A
E
A
H
S
D
S
L
I
D
T
F
Site 18
S146
P
A
E
A
H
S
D
S
L
I
D
T
F
P
E
Site 19
T150
H
S
D
S
L
I
D
T
F
P
E
C
S
T
E
Site 20
S155
I
D
T
F
P
E
C
S
T
E
G
F
S
S
D
Site 21
T156
D
T
F
P
E
C
S
T
E
G
F
S
S
D
S
Site 22
S161
C
S
T
E
G
F
S
S
D
S
D
L
V
S
L
Site 23
S163
T
E
G
F
S
S
D
S
D
L
V
S
L
T
V
Site 24
S167
S
S
D
S
D
L
V
S
L
T
V
D
V
D
S
Site 25
S174
S
L
T
V
D
V
D
S
L
A
E
L
D
D
G
Site 26
S184
E
L
D
D
G
M
A
S
N
Q
N
S
P
I
R
Site 27
S188
G
M
A
S
N
Q
N
S
P
I
R
T
F
G
L
Site 28
T192
N
Q
N
S
P
I
R
T
F
G
L
N
L
S
S
Site 29
S198
R
T
F
G
L
N
L
S
S
D
S
S
A
L
G
Site 30
S209
S
A
L
G
A
V
A
S
D
S
E
Q
S
K
T
Site 31
S211
L
G
A
V
A
S
D
S
E
Q
S
K
T
E
E
Site 32
T216
S
D
S
E
Q
S
K
T
E
E
E
R
E
S
R
Site 33
S222
K
T
E
E
E
R
E
S
R
S
L
F
P
G
S
Site 34
S224
E
E
E
R
E
S
R
S
L
F
P
G
S
L
K
Site 35
S229
S
R
S
L
F
P
G
S
L
K
P
K
L
G
K
Site 36
Y239
P
K
L
G
K
R
D
Y
L
E
K
A
G
E
L
Site 37
Y259
K
K
E
E
E
D
D
Y
E
A
A
S
D
F
Y
Site 38
S263
E
D
D
Y
E
A
A
S
D
F
Y
R
K
G
V
Site 39
Y266
Y
E
A
A
S
D
F
Y
R
K
G
V
D
L
L
Site 40
S281
L
E
G
V
Q
G
E
S
S
P
T
R
R
E
A
Site 41
S282
E
G
V
Q
G
E
S
S
P
T
R
R
E
A
V
Site 42
T284
V
Q
G
E
S
S
P
T
R
R
E
A
V
K
R
Site 43
T293
R
E
A
V
K
R
R
T
A
E
Y
L
M
R
A
Site 44
Y296
V
K
R
R
T
A
E
Y
L
M
R
A
E
S
I
Site 45
S302
E
Y
L
M
R
A
E
S
I
S
S
L
Y
G
K
Site 46
S304
L
M
R
A
E
S
I
S
S
L
Y
G
K
P
Q
Site 47
S305
M
R
A
E
S
I
S
S
L
Y
G
K
P
Q
L
Site 48
Y307
A
E
S
I
S
S
L
Y
G
K
P
Q
L
D
D
Site 49
S316
K
P
Q
L
D
D
V
S
Q
P
P
G
S
L
S
Site 50
S321
D
V
S
Q
P
P
G
S
L
S
S
R
P
L
W
Site 51
S323
S
Q
P
P
G
S
L
S
S
R
P
L
W
N
L
Site 52
S332
R
P
L
W
N
L
R
S
P
A
E
E
L
K
A
Site 53
T360
M
D
T
R
T
E
Q
T
F
I
L
K
G
L
R
Site 54
S369
I
L
K
G
L
R
K
S
S
E
Y
S
R
N
R
Site 55
S370
L
K
G
L
R
K
S
S
E
Y
S
R
N
R
K
Site 56
Y372
G
L
R
K
S
S
E
Y
S
R
N
R
K
T
I
Site 57
S373
L
R
K
S
S
E
Y
S
R
N
R
K
T
I
I
Site 58
T378
E
Y
S
R
N
R
K
T
I
I
P
R
C
V
P
Site 59
S414
A
E
G
G
K
L
W
S
Y
I
S
K
F
L
N
Site 60
Y415
E
G
G
K
L
W
S
Y
I
S
K
F
L
N
R
Site 61
S417
G
K
L
W
S
Y
I
S
K
F
L
N
R
S
P
Site 62
S423
I
S
K
F
L
N
R
S
P
E
E
S
F
D
I
Site 63
S427
L
N
R
S
P
E
E
S
F
D
I
K
E
V
K
Site 64
T447
K
V
H
L
Q
Q
P
T
S
S
P
Q
D
S
S
Site 65
S448
V
H
L
Q
Q
P
T
S
S
P
Q
D
S
S
S
Site 66
S449
H
L
Q
Q
P
T
S
S
P
Q
D
S
S
S
F
Site 67
S453
P
T
S
S
P
Q
D
S
S
S
F
E
S
R
G
Site 68
S454
T
S
S
P
Q
D
S
S
S
F
E
S
R
G
S
Site 69
S455
S
S
P
Q
D
S
S
S
F
E
S
R
G
S
D
Site 70
S458
Q
D
S
S
S
F
E
S
R
G
S
D
G
G
S
Site 71
S461
S
S
F
E
S
R
G
S
D
G
G
S
M
L
K
Site 72
S465
S
R
G
S
D
G
G
S
M
L
K
A
L
P
L
Site 73
S474
L
K
A
L
P
L
K
S
S
L
T
P
S
S
Q
Site 74
S475
K
A
L
P
L
K
S
S
L
T
P
S
S
Q
D
Site 75
T477
L
P
L
K
S
S
L
T
P
S
S
Q
D
D
S
Site 76
S479
L
K
S
S
L
T
P
S
S
Q
D
D
S
N
Q
Site 77
S480
K
S
S
L
T
P
S
S
Q
D
D
S
N
Q
E
Site 78
S484
T
P
S
S
Q
D
D
S
N
Q
E
D
D
G
Q
Site 79
S493
Q
E
D
D
G
Q
D
S
S
P
K
W
P
D
S
Site 80
S494
E
D
D
G
Q
D
S
S
P
K
W
P
D
S
G
Site 81
S500
S
S
P
K
W
P
D
S
G
S
S
S
E
E
E
Site 82
S502
P
K
W
P
D
S
G
S
S
S
E
E
E
C
T
Site 83
S504
W
P
D
S
G
S
S
S
E
E
E
C
T
T
S
Site 84
T509
S
S
S
E
E
E
C
T
T
S
Y
L
T
L
C
Site 85
T510
S
S
E
E
E
C
T
T
S
Y
L
T
L
C
N
Site 86
S511
S
E
E
E
C
T
T
S
Y
L
T
L
C
N
E
Site 87
Y512
E
E
E
C
T
T
S
Y
L
T
L
C
N
E
Y
Site 88
T514
E
C
T
T
S
Y
L
T
L
C
N
E
Y
G
Q
Site 89
S528
Q
E
K
I
E
P
G
S
L
N
E
E
P
F
M
Site 90
T544
T
E
G
N
G
V
D
T
K
A
I
K
S
F
P
Site 91
S558
P
A
H
L
A
A
D
S
D
S
P
S
T
Q
L
Site 92
S560
H
L
A
A
D
S
D
S
P
S
T
Q
L
R
A
Site 93
S562
A
A
D
S
D
S
P
S
T
Q
L
R
A
H
E
Site 94
S582
N
D
D
P
E
A
V
S
S
P
R
T
S
D
S
Site 95
S583
D
D
P
E
A
V
S
S
P
R
T
S
D
S
L
Site 96
T586
E
A
V
S
S
P
R
T
S
D
S
L
S
R
S
Site 97
S587
A
V
S
S
P
R
T
S
D
S
L
S
R
S
K
Site 98
S589
S
S
P
R
T
S
D
S
L
S
R
S
K
N
S
Site 99
S591
P
R
T
S
D
S
L
S
R
S
K
N
S
P
M
Site 100
S593
T
S
D
S
L
S
R
S
K
N
S
P
M
E
F
Site 101
S596
S
L
S
R
S
K
N
S
P
M
E
F
F
R
I
Site 102
S605
M
E
F
F
R
I
D
S
K
D
S
A
S
E
L
Site 103
S608
F
R
I
D
S
K
D
S
A
S
E
L
L
G
L
Site 104
S610
I
D
S
K
D
S
A
S
E
L
L
G
L
D
F
Site 105
Y622
L
D
F
G
E
K
L
Y
S
L
K
S
E
P
L
Site 106
S623
D
F
G
E
K
L
Y
S
L
K
S
E
P
L
K
Site 107
S626
E
K
L
Y
S
L
K
S
E
P
L
K
P
F
F
Site 108
T634
E
P
L
K
P
F
F
T
L
P
D
G
D
S
A
Site 109
S640
F
T
L
P
D
G
D
S
A
S
R
S
F
N
T
Site 110
S642
L
P
D
G
D
S
A
S
R
S
F
N
T
S
E
Site 111
S644
D
G
D
S
A
S
R
S
F
N
T
S
E
S
K
Site 112
S648
A
S
R
S
F
N
T
S
E
S
K
V
E
F
K
Site 113
T659
V
E
F
K
A
Q
D
T
I
S
R
G
S
D
D
Site 114
S661
F
K
A
Q
D
T
I
S
R
G
S
D
D
S
V
Site 115
S664
Q
D
T
I
S
R
G
S
D
D
S
V
P
V
I
Site 116
S667
I
S
R
G
S
D
D
S
V
P
V
I
S
F
K
Site 117
S672
D
D
S
V
P
V
I
S
F
K
D
A
A
F
D
Site 118
S682
D
A
A
F
D
D
V
S
G
T
D
E
G
R
P
Site 119
S701
N
L
P
G
E
L
E
S
T
R
E
A
A
A
M
Site 120
T702
L
P
G
E
L
E
S
T
R
E
A
A
A
M
G
Site 121
S737
D
V
L
C
L
R
L
S
T
E
Q
C
Q
A
H
Site 122
T738
V
L
C
L
R
L
S
T
E
Q
C
Q
A
H
E
Site 123
S753
E
K
G
I
E
E
L
S
D
P
S
G
P
K
S
Site 124
S756
I
E
E
L
S
D
P
S
G
P
K
S
Y
S
I
Site 125
S760
S
D
P
S
G
P
K
S
Y
S
I
T
E
K
H
Site 126
S762
P
S
G
P
K
S
Y
S
I
T
E
K
H
Y
A
Site 127
T764
G
P
K
S
Y
S
I
T
E
K
H
Y
A
Q
E
Site 128
S785
V
A
A
V
D
H
S
S
S
G
D
M
S
L
L
Site 129
S786
A
A
V
D
H
S
S
S
G
D
M
S
L
L
P
Site 130
S790
H
S
S
S
G
D
M
S
L
L
P
S
S
D
P
Site 131
S794
G
D
M
S
L
L
P
S
S
D
P
K
F
Q
G
Site 132
S795
D
M
S
L
L
P
S
S
D
P
K
F
Q
G
L
Site 133
T810
G
V
V
E
S
A
V
T
A
N
N
T
E
E
S
Site 134
S817
T
A
N
N
T
E
E
S
L
F
R
I
C
S
P
Site 135
S823
E
S
L
F
R
I
C
S
P
L
S
G
A
N
E
Site 136
S834
G
A
N
E
Y
I
A
S
T
D
T
L
K
T
E
Site 137
T850
V
L
L
F
T
D
Q
T
D
D
L
A
K
E
E
Site 138
S860
L
A
K
E
E
P
T
S
L
F
Q
R
D
S
E
Site 139
S866
T
S
L
F
Q
R
D
S
E
T
K
G
E
S
G
Site 140
T868
L
F
Q
R
D
S
E
T
K
G
E
S
G
L
V
Site 141
S872
D
S
E
T
K
G
E
S
G
L
V
L
E
G
D
Site 142
T946
D
R
G
H
I
Q
L
T
Y
F
S
R
W
S
E
Site 143
Y947
R
G
H
I
Q
L
T
Y
F
S
R
W
S
E
V
Site 144
S952
L
T
Y
F
S
R
W
S
E
V
E
D
S
C
D
Site 145
S957
R
W
S
E
V
E
D
S
C
D
S
D
A
I
E
Site 146
S960
E
V
E
D
S
C
D
S
D
A
I
E
R
M
Y
Site 147
Y967
S
D
A
I
E
R
M
Y
C
A
P
E
V
G
A
Site 148
S1026
C
V
S
E
E
A
R
S
L
I
Q
Q
L
L
Q
Site 149
S1052
A
G
V
E
D
I
K
S
H
P
F
F
T
P
V
Site 150
T1057
I
K
S
H
P
F
F
T
P
V
D
W
A
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation