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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RUFY1
Full Name:
RUN and FYVE domain-containing protein 1
Alias:
FLJ22251; FYVE-finger protein EIP1; RABIP4; RUF1; RUN and FYVE domain containing 1; ZFYVE12; Zinc finger FYVE domain containing protein 12
Type:
Ubiquitin conjugating system
Mass (Da):
79818
Number AA:
708
UniProt ID:
Q96T51
International Prot ID:
IPI00465429
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008289
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
E
P
G
P
G
P
G
S
A
L
E
P
G
E
E
Site 2
S42
E
F
E
I
V
D
R
S
Q
L
P
G
P
G
D
Site 3
S52
P
G
P
G
D
L
R
S
A
T
R
P
R
A
A
Site 4
T54
P
G
D
L
R
S
A
T
R
P
R
A
A
E
G
Site 5
T74
L
T
L
A
R
R
A
T
G
N
L
S
A
S
C
Site 6
S78
R
R
A
T
G
N
L
S
A
S
C
G
S
A
L
Site 7
S80
A
T
G
N
L
S
A
S
C
G
S
A
L
R
A
Site 8
S83
N
L
S
A
S
C
G
S
A
L
R
A
A
A
G
Site 9
S96
A
G
L
G
G
G
D
S
G
D
G
T
A
R
A
Site 10
T100
G
G
D
S
G
D
G
T
A
R
A
A
S
K
C
Site 11
S105
D
G
T
A
R
A
A
S
K
C
Q
M
M
E
E
Site 12
S123
L
M
H
M
M
K
L
S
I
K
V
L
L
Q
S
Site 13
S137
S
A
L
S
L
G
R
S
L
D
A
D
H
A
P
Site 14
S165
H
G
L
K
V
K
K
S
F
I
G
Q
N
K
S
Site 15
S172
S
F
I
G
Q
N
K
S
F
F
G
P
L
E
L
Site 16
S188
E
K
L
C
P
E
A
S
D
I
A
T
S
V
R
Site 17
T192
P
E
A
S
D
I
A
T
S
V
R
N
L
P
E
Site 18
S193
E
A
S
D
I
A
T
S
V
R
N
L
P
E
L
Site 19
T202
R
N
L
P
E
L
K
T
A
V
G
R
G
R
A
Site 20
Y212
G
R
G
R
A
W
L
Y
L
A
L
M
Q
K
K
Site 21
Y223
M
Q
K
K
L
A
D
Y
L
K
V
L
I
D
N
Site 22
S275
L
K
G
E
D
L
D
S
Q
V
G
V
I
D
F
Site 23
T302
G
K
E
H
E
R
I
T
D
V
L
D
Q
K
N
Site 24
Y310
D
V
L
D
Q
K
N
Y
V
E
E
L
N
R
H
Site 25
S319
E
E
L
N
R
H
L
S
C
T
V
G
D
L
Q
Site 26
T321
L
N
R
H
L
S
C
T
V
G
D
L
Q
T
K
Site 27
T335
K
I
D
G
L
E
K
T
N
S
K
L
Q
E
E
Site 28
S337
D
G
L
E
K
T
N
S
K
L
Q
E
E
L
S
Site 29
S344
S
K
L
Q
E
E
L
S
A
A
T
D
R
I
C
Site 30
T347
Q
E
E
L
S
A
A
T
D
R
I
C
S
L
Q
Site 31
S352
A
A
T
D
R
I
C
S
L
Q
E
E
Q
Q
Q
Site 32
S371
N
E
L
I
R
E
R
S
E
K
S
V
E
I
T
Site 33
S374
I
R
E
R
S
E
K
S
V
E
I
T
K
Q
D
Site 34
Y389
T
K
V
E
L
E
T
Y
K
Q
T
R
Q
G
L
Site 35
Y400
R
Q
G
L
D
E
M
Y
S
D
V
W
K
Q
L
Site 36
S401
Q
G
L
D
E
M
Y
S
D
V
W
K
Q
L
K
Site 37
T448
D
T
H
E
K
Q
D
T
L
V
A
L
R
Q
Q
Site 38
S486
Q
K
N
E
A
I
T
S
F
E
G
K
T
N
Q
Site 39
T491
I
T
S
F
E
G
K
T
N
Q
V
M
S
S
M
Site 40
S496
G
K
T
N
Q
V
M
S
S
M
K
Q
M
E
E
Site 41
S508
M
E
E
R
L
Q
H
S
E
R
A
R
Q
G
A
Site 42
S538
G
A
L
Q
L
Q
L
S
Q
L
H
E
Q
C
S
Site 43
S545
S
Q
L
H
E
Q
C
S
S
L
E
K
E
L
K
Site 44
S546
Q
L
H
E
Q
C
S
S
L
E
K
E
L
K
S
Site 45
S553
S
L
E
K
E
L
K
S
E
K
E
Q
R
Q
A
Site 46
S572
L
Q
H
E
K
D
T
S
S
L
L
R
M
E
L
Site 47
S573
Q
H
E
K
D
T
S
S
L
L
R
M
E
L
Q
Site 48
S618
Q
E
M
G
L
H
L
S
Q
S
K
L
K
M
E
Site 49
S620
M
G
L
H
L
S
Q
S
K
L
K
M
E
D
I
Site 50
S656
R
Q
C
E
K
E
F
S
I
S
R
R
K
H
H
Site 51
S684
S
N
E
L
A
L
P
S
Y
P
K
P
V
R
V
Site 52
Y685
N
E
L
A
L
P
S
Y
P
K
P
V
R
V
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation