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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UHRF1
Full Name:
E3 ubiquitin-protein ligase UHRF1
Alias:
FLJ21925; HuNp95; ICBP90; Inverted CCAAT box-binding protein of 90 kDa; Np95; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; RNF106; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like with PHD and ring finger domains 1; Ubiquitin-like-containing PHD and RING finger domains protein 1
Type:
Transcription factor; Ligase; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
89814
Number AA:
793
UniProt ID:
Q96T88
International Prot ID:
IPI00797945
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0016874
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0007049
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
R
T
M
D
G
R
Q
T
H
T
V
D
S
L
S
Site 2
T15
M
D
G
R
Q
T
H
T
V
D
S
L
S
R
L
Site 3
S18
R
Q
T
H
T
V
D
S
L
S
R
L
T
K
V
Site 4
S20
T
H
T
V
D
S
L
S
R
L
T
K
V
E
E
Site 5
T23
V
D
S
L
S
R
L
T
K
V
E
E
L
R
R
Site 6
Y47
P
G
L
Q
R
L
F
Y
R
G
K
Q
M
E
D
Site 7
T57
K
Q
M
E
D
G
H
T
L
F
D
Y
E
V
R
Site 8
Y61
D
G
H
T
L
F
D
Y
E
V
R
L
N
D
T
Site 9
S76
I
Q
L
L
V
R
Q
S
L
V
L
P
H
S
T
Site 10
S82
Q
S
L
V
L
P
H
S
T
K
E
R
D
S
E
Site 11
S88
H
S
T
K
E
R
D
S
E
L
S
D
T
D
S
Site 12
S91
K
E
R
D
S
E
L
S
D
T
D
S
G
C
C
Site 13
T93
R
D
S
E
L
S
D
T
D
S
G
C
C
L
G
Site 14
S95
S
E
L
S
D
T
D
S
G
C
C
L
G
Q
S
Site 15
S102
S
G
C
C
L
G
Q
S
E
S
D
K
S
S
T
Site 16
S104
C
C
L
G
Q
S
E
S
D
K
S
S
T
H
G
Site 17
S107
G
Q
S
E
S
D
K
S
S
T
H
G
E
A
A
Site 18
S108
Q
S
E
S
D
K
S
S
T
H
G
E
A
A
A
Site 19
T109
S
E
S
D
K
S
S
T
H
G
E
A
A
A
E
Site 20
S119
E
A
A
A
E
T
D
S
R
P
A
D
E
D
M
Site 21
T130
D
E
D
M
W
D
E
T
E
L
G
L
Y
K
V
Site 22
Y135
D
E
T
E
L
G
L
Y
K
V
N
E
Y
V
D
Site 23
Y140
G
L
Y
K
V
N
E
Y
V
D
A
R
D
T
N
Site 24
T160
E
A
Q
V
V
R
V
T
R
K
A
P
S
R
D
Site 25
S165
R
V
T
R
K
A
P
S
R
D
E
P
C
S
S
Site 26
S171
P
S
R
D
E
P
C
S
S
T
S
R
P
A
L
Site 27
S172
S
R
D
E
P
C
S
S
T
S
R
P
A
L
E
Site 28
T173
R
D
E
P
C
S
S
T
S
R
P
A
L
E
E
Site 29
Y184
A
L
E
E
D
V
I
Y
H
V
K
Y
D
D
Y
Site 30
Y188
D
V
I
Y
H
V
K
Y
D
D
Y
P
E
N
G
Site 31
Y191
Y
H
V
K
Y
D
D
Y
P
E
N
G
V
V
Q
Site 32
T210
D
V
R
A
R
A
R
T
I
I
K
W
Q
D
L
Site 33
Y227
G
Q
V
V
M
L
N
Y
N
P
D
N
P
K
E
Site 34
Y239
P
K
E
R
G
F
W
Y
D
A
E
I
S
R
K
Site 35
T249
E
I
S
R
K
R
E
T
R
T
A
R
E
L
Y
Site 36
T251
S
R
K
R
E
T
R
T
A
R
E
L
Y
A
N
Site 37
Y256
T
R
T
A
R
E
L
Y
A
N
V
V
L
G
D
Site 38
S287
I
E
R
P
G
E
G
S
P
M
V
D
N
P
M
Site 39
S298
D
N
P
M
R
R
K
S
G
P
S
C
K
H
C
Site 40
S301
M
R
R
K
S
G
P
S
C
K
H
C
K
D
D
Site 41
S350
Y
C
L
D
P
P
L
S
S
V
P
S
E
D
E
Site 42
S351
C
L
D
P
P
L
S
S
V
P
S
E
D
E
W
Site 43
S354
P
P
L
S
S
V
P
S
E
D
E
W
Y
C
P
Site 44
Y359
V
P
S
E
D
E
W
Y
C
P
E
C
R
N
D
Site 45
S368
P
E
C
R
N
D
A
S
E
V
V
L
A
G
E
Site 46
S380
A
G
E
R
L
R
E
S
K
K
K
A
K
M
A
Site 47
S388
K
K
K
A
K
M
A
S
A
T
S
S
S
Q
R
Site 48
S392
K
M
A
S
A
T
S
S
S
Q
R
D
W
G
K
Site 49
S393
M
A
S
A
T
S
S
S
Q
R
D
W
G
K
G
Site 50
T411
V
G
R
T
K
E
C
T
I
V
P
S
N
H
Y
Site 51
Y418
T
I
V
P
S
N
H
Y
G
P
I
P
G
I
P
Site 52
S439
F
R
V
Q
V
S
E
S
G
V
H
R
P
H
V
Site 53
Y458
G
R
S
N
D
G
A
Y
S
L
V
L
A
G
G
Site 54
S459
R
S
N
D
G
A
Y
S
L
V
L
A
G
G
Y
Site 55
T477
V
D
H
G
N
F
F
T
Y
T
G
S
G
G
R
Site 56
Y478
D
H
G
N
F
F
T
Y
T
G
S
G
G
R
D
Site 57
T479
H
G
N
F
F
T
Y
T
G
S
G
G
R
D
L
Site 58
S481
N
F
F
T
Y
T
G
S
G
G
R
D
L
S
G
Site 59
S487
G
S
G
G
R
D
L
S
G
N
K
R
T
A
E
Site 60
T492
D
L
S
G
N
K
R
T
A
E
Q
S
C
D
Q
Site 61
S496
N
K
R
T
A
E
Q
S
C
D
Q
K
L
T
N
Site 62
Y547
K
G
G
K
N
S
K
Y
A
P
A
E
G
N
R
Site 63
Y555
A
P
A
E
G
N
R
Y
D
G
I
Y
K
V
V
Site 64
Y559
G
N
R
Y
D
G
I
Y
K
V
V
K
Y
W
P
Site 65
Y564
G
I
Y
K
V
V
K
Y
W
P
E
K
G
K
S
Site 66
Y578
S
G
F
L
V
W
R
Y
L
L
R
R
D
D
D
Site 67
T604
R
I
K
K
L
G
L
T
M
Q
Y
P
E
G
Y
Site 68
Y607
K
L
G
L
T
M
Q
Y
P
E
G
Y
L
E
A
Site 69
S625
R
E
R
E
K
E
N
S
K
R
E
E
E
E
Q
Site 70
S639
Q
Q
E
G
G
F
A
S
P
R
T
G
K
G
K
Site 71
T642
G
G
F
A
S
P
R
T
G
K
G
K
W
K
R
Site 72
S651
K
G
K
W
K
R
K
S
A
G
G
G
P
S
R
Site 73
S657
K
S
A
G
G
G
P
S
R
A
G
S
P
R
R
Site 74
S661
G
G
P
S
R
A
G
S
P
R
R
T
S
K
K
Site 75
T665
R
A
G
S
P
R
R
T
S
K
K
T
K
V
E
Site 76
S666
A
G
S
P
R
R
T
S
K
K
T
K
V
E
P
Site 77
T669
P
R
R
T
S
K
K
T
K
V
E
P
Y
S
L
Site 78
S675
K
T
K
V
E
P
Y
S
L
T
A
Q
Q
S
S
Site 79
T677
K
V
E
P
Y
S
L
T
A
Q
Q
S
S
L
I
Site 80
S682
S
L
T
A
Q
Q
S
S
L
I
R
E
D
K
S
Site 81
S689
S
L
I
R
E
D
K
S
N
A
K
L
W
N
E
Site 82
S700
L
W
N
E
V
L
A
S
L
K
D
R
P
A
S
Site 83
S707
S
L
K
D
R
P
A
S
G
S
P
F
Q
L
F
Site 84
S709
K
D
R
P
A
S
G
S
P
F
Q
L
F
L
S
Site 85
S716
S
P
F
Q
L
F
L
S
K
V
E
E
T
F
Q
Site 86
S751
C
K
D
C
L
D
R
S
F
R
A
Q
V
F
S
Site 87
Y770
R
Y
D
L
G
R
S
Y
A
M
Q
V
N
Q
P
Site 88
Y789
L
N
Q
L
F
P
G
Y
G
N
G
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation