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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAP3K14
Full Name:
Mitogen-activated protein kinase kinase kinase 14
Alias:
EC 2.7.11.25; M3K14
Type:
Protein-serine kinase, STE group, STE-Unique family
Mass (Da):
104042
Number AA:
947
UniProt ID:
Q99558
International Prot ID:
IPI00016099
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004709
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
C
P
G
A
P
G
S
A
V
G
Q
Q
K
E
Site 2
T29
L
P
K
A
K
E
K
T
P
P
L
G
K
K
Q
Site 3
S37
P
P
L
G
K
K
Q
S
S
V
Y
K
L
E
A
Site 4
S38
P
L
G
K
K
Q
S
S
V
Y
K
L
E
A
V
Site 5
S48
K
L
E
A
V
E
K
S
P
V
F
C
G
K
W
Site 6
S71
K
G
T
A
K
E
G
S
E
A
G
P
A
A
I
Site 7
S89
A
Q
A
E
C
E
N
S
Q
E
F
S
P
T
F
Site 8
S93
C
E
N
S
Q
E
F
S
P
T
F
S
E
R
I
Site 9
T95
N
S
Q
E
F
S
P
T
F
S
E
R
I
F
I
Site 10
S97
Q
E
F
S
P
T
F
S
E
R
I
F
I
A
G
Site 11
S105
E
R
I
F
I
A
G
S
K
Q
Y
S
Q
S
E
Site 12
S109
I
A
G
S
K
Q
Y
S
Q
S
E
S
L
D
Q
Site 13
S111
G
S
K
Q
Y
S
Q
S
E
S
L
D
Q
I
P
Site 14
S113
K
Q
Y
S
Q
S
E
S
L
D
Q
I
P
N
N
Site 15
T125
P
N
N
V
A
H
A
T
E
G
K
M
A
R
V
Site 16
S140
C
W
K
G
K
R
R
S
K
A
R
K
K
R
K
Site 17
S150
R
K
K
R
K
K
K
S
S
K
S
L
A
H
A
Site 18
S151
K
K
R
K
K
K
S
S
K
S
L
A
H
A
G
Site 19
S153
R
K
K
K
S
S
K
S
L
A
H
A
G
V
A
Site 20
T168
L
A
K
P
L
P
R
T
P
E
Q
E
S
C
T
Site 21
S183
I
P
V
Q
E
D
E
S
P
L
G
A
P
Y
V
Site 22
Y189
E
S
P
L
G
A
P
Y
V
R
N
T
P
Q
F
Site 23
T193
G
A
P
Y
V
R
N
T
P
Q
F
T
K
P
L
Site 24
S224
L
R
P
A
L
P
R
S
E
L
H
K
L
I
S
Site 25
S231
S
E
L
H
K
L
I
S
P
L
Q
C
L
N
H
Site 26
T255
G
G
P
L
P
L
P
T
H
P
F
P
Y
S
R
Site 27
S261
P
T
H
P
F
P
Y
S
R
L
P
H
P
F
P
Site 28
S282
W
K
P
H
P
L
E
S
F
L
G
K
L
A
C
Site 29
S292
G
K
L
A
C
V
D
S
Q
K
P
L
P
D
P
Site 30
S302
P
L
P
D
P
H
L
S
K
L
A
C
V
D
S
Site 31
S309
S
K
L
A
C
V
D
S
P
K
P
L
P
G
P
Site 32
S321
P
G
P
H
L
E
P
S
C
L
S
R
G
A
H
Site 33
S332
R
G
A
H
E
K
F
S
V
E
E
Y
L
V
H
Site 34
Y336
E
K
F
S
V
E
E
Y
L
V
H
A
L
Q
G
Site 35
S346
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
Site 36
S352
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
Site 37
T354
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
Site 38
S355
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
Site 39
T359
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
Site 40
S365
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
Site 41
S367
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
Site 42
S371
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
Site 43
T374
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
Site 44
Y391
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
Site 45
Y393
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
Site 46
S410
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
Site 47
Y456
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
Site 48
Y494
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
Site 49
Y495
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
Site 50
Y505
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
Site 51
S508
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
Site 52
S524
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
Site 53
S549
Q
P
D
G
L
G
K
S
L
L
T
G
D
Y
I
Site 54
Y555
K
S
L
L
T
G
D
Y
I
P
G
T
E
T
H
Site 55
T559
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
Site 56
S610
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
Site 57
S621
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
Site 58
T626
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
Site 59
S643
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
Site 60
S663
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
Site 61
Y669
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
P
Site 62
Y682
P
P
P
N
Q
A
N
Y
H
Q
T
L
H
A
Q
Site 63
S694
H
A
Q
P
R
E
L
S
P
R
A
P
G
P
R
Site 64
T706
G
P
R
P
A
E
E
T
T
G
R
A
P
K
L
Site 65
S727
E
P
P
E
P
N
K
S
P
P
L
T
L
S
K
Site 66
T731
P
N
K
S
P
P
L
T
L
S
K
E
E
S
G
Site 67
S733
K
S
P
P
L
T
L
S
K
E
E
S
G
M
W
Site 68
S737
L
T
L
S
K
E
E
S
G
M
W
E
P
L
P
Site 69
S746
M
W
E
P
L
P
L
S
S
L
E
P
A
P
A
Site 70
S747
W
E
P
L
P
L
S
S
L
E
P
A
P
A
R
Site 71
S757
P
A
P
A
R
N
P
S
S
P
E
R
K
A
T
Site 72
S758
A
P
A
R
N
P
S
S
P
E
R
K
A
T
V
Site 73
T764
S
S
P
E
R
K
A
T
V
P
E
Q
E
L
Q
Site 74
S783
E
L
F
L
N
S
L
S
Q
P
F
S
L
E
E
Site 75
S787
N
S
L
S
Q
P
F
S
L
E
E
Q
E
Q
I
Site 76
S796
E
E
Q
E
Q
I
L
S
C
L
S
I
D
S
L
Site 77
S804
C
L
S
I
D
S
L
S
L
S
D
D
S
E
K
Site 78
S806
S
I
D
S
L
S
L
S
D
D
S
E
K
N
P
Site 79
S809
S
L
S
L
S
D
D
S
E
K
N
P
S
K
A
Site 80
S814
D
D
S
E
K
N
P
S
K
A
S
Q
S
S
R
Site 81
S817
E
K
N
P
S
K
A
S
Q
S
S
R
D
T
L
Site 82
S819
N
P
S
K
A
S
Q
S
S
R
D
T
L
S
S
Site 83
S820
P
S
K
A
S
Q
S
S
R
D
T
L
S
S
G
Site 84
T823
A
S
Q
S
S
R
D
T
L
S
S
G
V
H
S
Site 85
S825
Q
S
S
R
D
T
L
S
S
G
V
H
S
W
S
Site 86
S826
S
S
R
D
T
L
S
S
G
V
H
S
W
S
S
Site 87
S830
T
L
S
S
G
V
H
S
W
S
S
Q
A
E
A
Site 88
S833
S
G
V
H
S
W
S
S
Q
A
E
A
R
S
S
Site 89
S840
S
Q
A
E
A
R
S
S
S
W
N
M
V
L
A
Site 90
S841
Q
A
E
A
R
S
S
S
W
N
M
V
L
A
R
Site 91
T852
V
L
A
R
G
R
P
T
D
T
P
S
Y
F
N
Site 92
T854
A
R
G
R
P
T
D
T
P
S
Y
F
N
G
V
Site 93
S856
G
R
P
T
D
T
P
S
Y
F
N
G
V
K
V
Site 94
Y857
R
P
T
D
T
P
S
Y
F
N
G
V
K
V
Q
Site 95
S867
G
V
K
V
Q
I
Q
S
L
N
G
E
H
L
H
Site 96
S918
Y
D
M
E
V
P
D
S
G
I
D
L
Q
C
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation