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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIF2C
Full Name:
Kinesin-like protein KIF2C
Alias:
KF2C; Kinesin family member 2C; Kinesin-like protein 6; KNSL6; MCAK; Mitotic centromere-associated kinesin
Type:
Motor protein; Microtubule binding protein
Mass (Da):
81313
Number AA:
725
UniProt ID:
Q99661
International Prot ID:
IPI00290435
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
GO:0005737
GO:0005871
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0019237
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0030951
GO:0007019
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
A
I
K
I
Q
R
S
N
G
L
I
H
S
A
Site 2
S28
R
S
N
G
L
I
H
S
A
N
V
R
T
V
N
Site 3
S39
R
T
V
N
L
E
K
S
C
V
S
V
E
W
A
Site 4
S42
N
L
E
K
S
C
V
S
V
E
W
A
E
G
G
Site 5
T51
E
W
A
E
G
G
A
T
K
G
K
E
I
D
F
Site 6
S95
I
Q
K
Q
K
R
R
S
V
N
S
K
I
P
A
Site 7
S98
Q
K
R
R
S
V
N
S
K
I
P
A
P
K
E
Site 8
S106
K
I
P
A
P
K
E
S
L
R
S
R
S
T
R
Site 9
S109
A
P
K
E
S
L
R
S
R
S
T
R
M
S
T
Site 10
S111
K
E
S
L
R
S
R
S
T
R
M
S
T
V
S
Site 11
T112
E
S
L
R
S
R
S
T
R
M
S
T
V
S
E
Site 12
S115
R
S
R
S
T
R
M
S
T
V
S
E
L
R
I
Site 13
T116
S
R
S
T
R
M
S
T
V
S
E
L
R
I
T
Site 14
S118
S
T
R
M
S
T
V
S
E
L
R
I
T
A
Q
Site 15
T123
T
V
S
E
L
R
I
T
A
Q
E
N
D
M
E
Site 16
S144
A
N
S
R
K
Q
F
S
V
P
P
A
P
T
R
Site 17
S153
P
P
A
P
T
R
P
S
C
P
A
V
A
E
I
Site 18
S166
E
I
P
L
R
M
V
S
E
E
M
E
E
Q
V
Site 19
S175
E
M
E
E
Q
V
H
S
I
R
G
S
S
S
A
Site 20
S179
Q
V
H
S
I
R
G
S
S
S
A
N
P
V
N
Site 21
S180
V
H
S
I
R
G
S
S
S
A
N
P
V
N
S
Site 22
S181
H
S
I
R
G
S
S
S
A
N
P
V
N
S
V
Site 23
S187
S
S
A
N
P
V
N
S
V
R
R
K
S
C
L
Site 24
S192
V
N
S
V
R
R
K
S
C
L
V
K
E
V
E
Site 25
Y223
R
M
K
R
A
Q
E
Y
D
S
S
F
P
N
W
Site 26
S225
K
R
A
Q
E
Y
D
S
S
F
P
N
W
E
F
Site 27
S226
R
A
Q
E
Y
D
S
S
F
P
N
W
E
F
A
Site 28
T242
M
I
K
E
F
R
A
T
L
E
C
H
P
L
T
Site 29
T249
T
L
E
C
H
P
L
T
M
T
D
P
I
E
E
Site 30
T251
E
C
H
P
L
T
M
T
D
P
I
E
E
H
R
Site 31
T301
P
K
L
K
V
D
L
T
K
Y
L
E
N
Q
A
Site 32
Y303
L
K
V
D
L
T
K
Y
L
E
N
Q
A
F
C
Site 33
T318
F
D
F
A
F
D
E
T
A
S
N
E
V
V
Y
Site 34
T328
N
E
V
V
Y
R
F
T
A
R
P
L
V
Q
T
Site 35
T335
T
A
R
P
L
V
Q
T
I
F
E
G
G
K
A
Site 36
Y347
G
K
A
T
C
F
A
Y
G
Q
T
G
S
G
K
Site 37
T357
T
G
S
G
K
T
H
T
M
G
G
D
L
S
G
Site 38
S363
H
T
M
G
G
D
L
S
G
K
A
Q
N
A
S
Site 39
Y374
Q
N
A
S
K
G
I
Y
A
M
A
S
R
D
V
Site 40
Y390
L
L
K
N
Q
P
C
Y
R
K
L
G
L
E
V
Site 41
Y398
R
K
L
G
L
E
V
Y
V
T
F
F
E
I
Y
Site 42
Y405
Y
V
T
F
F
E
I
Y
N
G
K
L
F
D
L
Site 43
S453
I
K
M
I
D
M
G
S
A
C
R
T
S
G
Q
Site 44
T457
D
M
G
S
A
C
R
T
S
G
Q
T
F
A
N
Site 45
S458
M
G
S
A
C
R
T
S
G
Q
T
F
A
N
S
Site 46
T461
A
C
R
T
S
G
Q
T
F
A
N
S
N
S
S
Site 47
S465
S
G
Q
T
F
A
N
S
N
S
S
R
S
H
A
Site 48
S467
Q
T
F
A
N
S
N
S
S
R
S
H
A
C
F
Site 49
S470
A
N
S
N
S
S
R
S
H
A
C
F
Q
I
I
Site 50
S489
G
R
M
H
G
K
F
S
L
V
D
L
A
G
N
Site 51
S503
N
E
R
G
A
D
T
S
S
A
D
R
Q
T
R
Site 52
S504
E
R
G
A
D
T
S
S
A
D
R
Q
T
R
M
Site 53
T509
T
S
S
A
D
R
Q
T
R
M
E
G
A
E
I
Site 54
S519
E
G
A
E
I
N
K
S
L
L
A
L
K
E
C
Site 55
T537
L
G
Q
N
K
A
H
T
P
F
R
E
S
K
L
Site 56
S542
A
H
T
P
F
R
E
S
K
L
T
Q
V
L
R
Site 57
T545
P
F
R
E
S
K
L
T
Q
V
L
R
D
S
F
Site 58
S551
L
T
Q
V
L
R
D
S
F
I
G
E
N
S
R
Site 59
S571
T
I
S
P
G
I
S
S
C
E
Y
T
L
N
T
Site 60
Y574
P
G
I
S
S
C
E
Y
T
L
N
T
L
R
Y
Site 61
T575
G
I
S
S
C
E
Y
T
L
N
T
L
R
Y
A
Site 62
S589
A
D
R
V
K
E
L
S
P
H
S
G
P
S
G
Site 63
S592
V
K
E
L
S
P
H
S
G
P
S
G
E
Q
L
Site 64
T604
E
Q
L
I
Q
M
E
T
E
E
M
E
A
C
S
Site 65
S611
T
E
E
M
E
A
C
S
N
G
A
L
I
P
G
Site 66
S621
A
L
I
P
G
N
L
S
K
E
E
E
E
L
S
Site 67
S628
S
K
E
E
E
E
L
S
S
Q
M
S
S
F
N
Site 68
S629
K
E
E
E
E
L
S
S
Q
M
S
S
F
N
E
Site 69
S632
E
E
L
S
S
Q
M
S
S
F
N
E
A
M
T
Site 70
S633
E
L
S
S
Q
M
S
S
F
N
E
A
M
T
Q
Site 71
T639
S
S
F
N
E
A
M
T
Q
I
R
E
L
E
E
Site 72
S666
G
P
D
W
L
E
L
S
E
M
T
E
Q
P
D
Site 73
Y674
E
M
T
E
Q
P
D
Y
D
L
E
T
F
V
N
Site 74
T678
Q
P
D
Y
D
L
E
T
F
V
N
K
A
E
S
Site 75
S695
A
Q
Q
A
K
H
F
S
A
L
R
D
V
I
K
Site 76
S715
M
Q
L
E
E
Q
A
S
R
Q
I
S
S
K
K
Site 77
S719
E
Q
A
S
R
Q
I
S
S
K
K
R
P
Q
_
Site 78
S720
Q
A
S
R
Q
I
S
S
K
K
R
P
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation