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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIOK1
Full Name:
Serine/threonine-protein kinase RIO1
Alias:
AD034; BA288G3.1; EC 2.7.11.1; FLJ30006; Kinase RIOK1; RIO kinase 1
Type:
EC 2.7.11.1; Protein kinase, atypical;
ATYPICAL
group; RIO family; RIO1 subfamily
Mass (Da):
65583
Number AA:
568
UniProt ID:
Q9BRS2
International Prot ID:
IPI00171336
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase RIO1 Y466 phosphosite-specific antibody AB-PK794#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK794
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
Y
R
R
L
L
M
S
R
V
V
P
G
Q
F
Site 2
S21
G
Q
F
D
D
A
D
S
S
D
S
E
N
R
D
Site 3
S22
Q
F
D
D
A
D
S
S
D
S
E
N
R
D
L
Site 4
S24
D
D
A
D
S
S
D
S
E
N
R
D
L
K
T
Site 5
T31
S
E
N
R
D
L
K
T
V
K
E
K
D
D
I
Site 6
Y63
E
D
E
E
E
E
G
Y
D
D
D
D
D
D
W
Site 7
Y83
V
G
K
L
A
K
G
Y
V
W
N
G
G
S
N
Site 8
T97
N
P
Q
A
N
R
Q
T
S
D
S
S
S
A
K
Site 9
S98
P
Q
A
N
R
Q
T
S
D
S
S
S
A
K
M
Site 10
S100
A
N
R
Q
T
S
D
S
S
S
A
K
M
S
T
Site 11
S101
N
R
Q
T
S
D
S
S
S
A
K
M
S
T
P
Site 12
S102
R
Q
T
S
D
S
S
S
A
K
M
S
T
P
A
Site 13
S106
D
S
S
S
A
K
M
S
T
P
A
D
K
V
L
Site 14
T107
S
S
S
A
K
M
S
T
P
A
D
K
V
L
R
Site 15
S130
D
K
L
N
V
T
D
S
V
I
N
K
V
T
E
Site 16
S139
I
N
K
V
T
E
K
S
R
Q
K
E
A
D
M
Site 17
Y147
R
Q
K
E
A
D
M
Y
R
I
K
D
K
A
D
Site 18
T157
K
D
K
A
D
R
A
T
V
E
Q
V
L
D
P
Site 19
T166
E
Q
V
L
D
P
R
T
R
M
I
L
F
K
M
Site 20
T175
M
I
L
F
K
M
L
T
R
G
I
I
T
E
I
Site 21
Y195
T
G
K
E
A
N
V
Y
H
A
S
T
A
N
G
Site 22
Y223
V
F
K
D
R
D
K
Y
V
S
G
E
F
R
F
Site 23
S225
K
D
R
D
K
Y
V
S
G
E
F
R
F
R
H
Site 24
Y234
E
F
R
F
R
H
G
Y
C
K
G
N
P
R
K
Site 25
T245
N
P
R
K
M
V
K
T
W
A
E
K
E
M
R
Site 26
T259
R
N
L
I
R
L
N
T
A
E
I
P
C
P
E
Site 27
S296
L
L
K
N
V
Q
L
S
E
S
K
A
R
E
L
Site 28
S298
K
N
V
Q
L
S
E
S
K
A
R
E
L
Y
L
Site 29
Y304
E
S
K
A
R
E
L
Y
L
Q
V
I
Q
Y
M
Site 30
Y310
L
Y
L
Q
V
I
Q
Y
M
R
R
M
Y
Q
D
Site 31
Y315
I
Q
Y
M
R
R
M
Y
Q
D
A
R
L
V
H
Site 32
S343
G
V
Y
I
I
D
V
S
Q
S
V
E
H
D
H
Site 33
T386
R
E
L
F
E
F
V
T
D
P
S
I
T
H
E
Site 34
Y398
T
H
E
N
M
D
A
Y
L
S
K
A
M
E
I
Site 35
S400
E
N
M
D
A
Y
L
S
K
A
M
E
I
A
S
Site 36
S407
S
K
A
M
E
I
A
S
Q
R
T
K
E
E
R
Site 37
S416
R
T
K
E
E
R
S
S
Q
D
H
V
D
E
E
Site 38
Y429
E
E
V
F
K
R
A
Y
I
P
R
T
L
N
E
Site 39
T433
K
R
A
Y
I
P
R
T
L
N
E
V
K
N
Y
Site 40
Y440
T
L
N
E
V
K
N
Y
E
R
D
M
D
I
I
Site 41
Y466
A
Q
Q
D
N
I
L
Y
Q
T
V
T
G
L
K
Serine/threonine-protein kinase RIO1 Y466 phosphosite-specific antibody AB-PK794#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK794
Site 42
T468
Q
D
N
I
L
Y
Q
T
V
T
G
L
K
K
D
Site 43
T470
N
I
L
Y
Q
T
V
T
G
L
K
K
D
L
S
Site 44
S477
T
G
L
K
K
D
L
S
G
V
Q
K
V
P
A
Site 45
T494
E
N
Q
V
E
E
R
T
C
S
D
S
E
D
I
Site 46
S496
Q
V
E
E
R
T
C
S
D
S
E
D
I
G
S
Site 47
S498
E
E
R
T
C
S
D
S
E
D
I
G
S
S
E
Site 48
S503
S
D
S
E
D
I
G
S
S
E
C
S
D
T
D
Site 49
S504
D
S
E
D
I
G
S
S
E
C
S
D
T
D
S
Site 50
S507
D
I
G
S
S
E
C
S
D
T
D
S
E
E
Q
Site 51
T509
G
S
S
E
C
S
D
T
D
S
E
E
Q
G
D
Site 52
S511
S
E
C
S
D
T
D
S
E
E
Q
G
D
H
A
Site 53
T524
H
A
R
P
K
K
H
T
T
D
P
D
I
D
K
Site 54
T564
R
K
E
K
T
A
K
T
K
K
G
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation