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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
mucolipin 1
Full Name:
Mucolipin-1
Alias:
MCLN1; MCOLN1; MG-2; ML4; MLIV; MST080; MSTP080; Mucolipidin; Mucolipin 1; TRPML1; TRPM-L1
Type:
Channel, cation; Membrane protein, integral
Mass (Da):
65022
Number AA:
580
UniProt ID:
Q9GZU1
International Prot ID:
IPI00003750
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005768
GO:0005887
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005261
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
P
A
G
P
R
G
S
E
T
E
R
L
L
T
Site 2
T12
A
G
P
R
G
S
E
T
E
R
L
L
T
P
N
Site 3
T17
S
E
T
E
R
L
L
T
P
N
P
G
Y
G
T
Site 4
Y22
L
L
T
P
N
P
G
Y
G
T
Q
A
G
P
S
Site 5
S29
Y
G
T
Q
A
G
P
S
P
A
P
P
T
P
P
Site 6
T34
G
P
S
P
A
P
P
T
P
P
E
E
E
D
L
Site 7
Y47
D
L
R
R
R
L
K
Y
F
F
M
S
P
C
D
Site 8
S51
R
L
K
Y
F
F
M
S
P
C
D
K
F
R
A
Site 9
T92
L
S
N
Q
L
A
V
T
F
R
E
E
N
T
I
Site 10
Y109
R
H
L
F
L
L
G
Y
S
D
G
A
D
D
T
Site 11
T116
Y
S
D
G
A
D
D
T
F
A
A
Y
T
R
E
Site 12
Y120
A
D
D
T
F
A
A
Y
T
R
E
Q
L
Y
Q
Site 13
Y126
A
Y
T
R
E
Q
L
Y
Q
A
I
F
H
A
V
Site 14
Y147
P
D
V
S
L
G
R
Y
A
Y
V
R
G
G
G
Site 15
Y149
V
S
L
G
R
Y
A
Y
V
R
G
G
G
D
P
Site 16
T158
R
G
G
G
D
P
W
T
N
G
S
G
L
A
L
Site 17
Y169
G
L
A
L
C
Q
R
Y
Y
H
R
G
H
V
D
Site 18
Y170
L
A
L
C
Q
R
Y
Y
H
R
G
H
V
D
P
Site 19
S206
E
R
P
P
P
P
P
S
D
D
L
T
L
L
E
Site 20
T210
P
P
P
S
D
D
L
T
L
L
E
S
S
S
S
Site 21
S214
D
D
L
T
L
L
E
S
S
S
S
Y
K
N
L
Site 22
S216
L
T
L
L
E
S
S
S
S
Y
K
N
L
T
L
Site 23
S217
T
L
L
E
S
S
S
S
Y
K
N
L
T
L
K
Site 24
Y218
L
L
E
S
S
S
S
Y
K
N
L
T
L
K
F
Site 25
T222
S
S
S
Y
K
N
L
T
L
K
F
H
K
L
V
Site 26
S244
L
K
T
I
N
L
Q
S
L
I
N
N
E
I
P
Site 27
T261
Y
T
F
S
V
L
I
T
F
D
N
K
A
H
S
Site 28
S268
T
F
D
N
K
A
H
S
G
R
I
P
I
S
L
Site 29
S274
H
S
G
R
I
P
I
S
L
E
T
Q
A
H
I
Site 30
S343
R
Q
R
G
R
V
I
S
L
W
E
R
L
E
F
Site 31
S456
P
Y
H
V
K
F
R
S
L
S
M
V
S
E
C
Site 32
S488
Q
A
Q
Q
G
R
S
S
L
V
W
L
F
S
Q
Site 33
T523
L
I
T
G
A
Y
D
T
I
K
H
P
G
G
A
Site 34
S535
G
G
A
G
A
E
E
S
E
L
Q
A
Y
I
A
Site 35
Y540
E
E
S
E
L
Q
A
Y
I
A
Q
C
Q
D
S
Site 36
S547
Y
I
A
Q
C
Q
D
S
P
T
S
G
K
F
R
Site 37
T549
A
Q
C
Q
D
S
P
T
S
G
K
F
R
R
G
Site 38
S550
Q
C
Q
D
S
P
T
S
G
K
F
R
R
G
S
Site 39
S557
S
G
K
F
R
R
G
S
G
S
A
C
S
L
L
Site 40
S559
K
F
R
R
G
S
G
S
A
C
S
L
L
C
C
Site 41
S572
C
C
C
G
R
D
P
S
E
E
H
S
L
L
V
Site 42
S576
R
D
P
S
E
E
H
S
L
L
V
N
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation