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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RACGAP1
Full Name:
Rac GTPase-activating protein 1
Alias:
GTPase activating protein ID-GAP; Male germ cell RacGap; MgcRacGAP; MGCRACGAP variant alpha; MGCRACGAP variant beta; Rac GTPase activating protein 1; RAC GTPase-activating protein; RAC GTPase-activating protein 1; RGAP1
Type:
GTPase-activating protein for G protein
Mass (Da):
71027
Number AA:
632
UniProt ID:
Q9H0H5
International Prot ID:
IPI00152946
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001669
GO:0005874
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0043014
GO:0048487
PhosphoSite+
KinaseNET
Biological Process:
GO:0000915
GO:0007108
GO:0009790
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
V
R
R
V
E
I
L
S
E
G
N
E
V
Q
F
Site 2
Y54
T
D
H
E
L
G
K
Y
K
D
L
L
M
K
A
Site 3
T63
D
L
L
M
K
A
E
T
E
R
S
A
L
D
V
Site 4
S66
M
K
A
E
T
E
R
S
A
L
D
V
K
L
K
Site 5
S112
E
M
L
M
C
D
T
S
G
S
I
Q
L
S
E
Site 6
S114
L
M
C
D
T
S
G
S
I
Q
L
S
E
E
Q
Site 7
S118
T
S
G
S
I
Q
L
S
E
E
Q
K
S
A
L
Site 8
S123
Q
L
S
E
E
Q
K
S
A
L
A
F
L
N
R
Site 9
S134
F
L
N
R
G
Q
P
S
S
S
N
A
G
N
K
Site 10
S135
L
N
R
G
Q
P
S
S
S
N
A
G
N
K
R
Site 11
S136
N
R
G
Q
P
S
S
S
N
A
G
N
K
R
L
Site 12
S144
N
A
G
N
K
R
L
S
T
I
D
E
S
G
S
Site 13
T145
A
G
N
K
R
L
S
T
I
D
E
S
G
S
I
Site 14
S149
R
L
S
T
I
D
E
S
G
S
I
L
S
D
I
Site 15
S151
S
T
I
D
E
S
G
S
I
L
S
D
I
S
F
Site 16
S154
D
E
S
G
S
I
L
S
D
I
S
F
D
K
T
Site 17
S157
G
S
I
L
S
D
I
S
F
D
K
T
D
E
S
Site 18
T161
S
D
I
S
F
D
K
T
D
E
S
L
D
W
D
Site 19
S164
S
F
D
K
T
D
E
S
L
D
W
D
S
S
L
Site 20
S169
D
E
S
L
D
W
D
S
S
L
V
K
T
F
K
Site 21
S170
E
S
L
D
W
D
S
S
L
V
K
T
F
K
L
Site 22
T174
W
D
S
S
L
V
K
T
F
K
L
K
K
R
E
Site 23
S185
K
K
R
E
K
R
R
S
T
S
R
Q
F
V
D
Site 24
T186
K
R
E
K
R
R
S
T
S
R
Q
F
V
D
G
Site 25
S187
R
E
K
R
R
S
T
S
R
Q
F
V
D
G
P
Site 26
T201
P
P
G
P
V
K
K
T
R
S
I
G
S
A
V
Site 27
S203
G
P
V
K
K
T
R
S
I
G
S
A
V
D
Q
Site 28
S206
K
K
T
R
S
I
G
S
A
V
D
Q
G
N
E
Site 29
S214
A
V
D
Q
G
N
E
S
I
V
A
K
T
T
V
Site 30
T220
E
S
I
V
A
K
T
T
V
T
V
P
N
D
G
Site 31
S234
G
G
P
I
E
A
V
S
T
I
E
T
V
P
Y
Site 32
T235
G
P
I
E
A
V
S
T
I
E
T
V
P
Y
W
Site 33
T238
E
A
V
S
T
I
E
T
V
P
Y
W
T
R
S
Site 34
Y241
S
T
I
E
T
V
P
Y
W
T
R
S
R
R
K
Site 35
S245
T
V
P
Y
W
T
R
S
R
R
K
T
G
T
L
Site 36
T249
W
T
R
S
R
R
K
T
G
T
L
Q
P
W
N
Site 37
T251
R
S
R
R
K
T
G
T
L
Q
P
W
N
S
D
Site 38
S257
G
T
L
Q
P
W
N
S
D
S
T
L
N
S
R
Site 39
S259
L
Q
P
W
N
S
D
S
T
L
N
S
R
Q
L
Site 40
T260
Q
P
W
N
S
D
S
T
L
N
S
R
Q
L
E
Site 41
S263
N
S
D
S
T
L
N
S
R
Q
L
E
P
R
T
Site 42
T270
S
R
Q
L
E
P
R
T
E
T
D
S
V
G
T
Site 43
T272
Q
L
E
P
R
T
E
T
D
S
V
G
T
P
Q
Site 44
S274
E
P
R
T
E
T
D
S
V
G
T
P
Q
S
N
Site 45
T277
T
E
T
D
S
V
G
T
P
Q
S
N
G
G
M
Site 46
S280
D
S
V
G
T
P
Q
S
N
G
G
M
R
L
H
Site 47
S291
M
R
L
H
D
F
V
S
K
T
V
I
K
P
E
Site 48
T293
L
H
D
F
V
S
K
T
V
I
K
P
E
S
C
Site 49
S299
K
T
V
I
K
P
E
S
C
V
P
C
G
K
R
Site 50
S313
R
I
K
F
G
K
L
S
L
K
C
R
D
C
R
Site 51
T342
C
I
P
T
L
I
G
T
P
V
K
I
G
E
G
Site 52
T379
E
I
E
Q
R
G
L
T
E
T
G
L
Y
R
I
Site 53
T381
E
Q
R
G
L
T
E
T
G
L
Y
R
I
S
G
Site 54
Y384
G
L
T
E
T
G
L
Y
R
I
S
G
C
D
R
Site 55
S387
E
T
G
L
Y
R
I
S
G
C
D
R
T
V
K
Site 56
T392
R
I
S
G
C
D
R
T
V
K
E
L
K
E
K
Site 57
T405
E
K
F
L
R
V
K
T
V
P
L
L
S
K
V
Site 58
S410
V
K
T
V
P
L
L
S
K
V
D
D
I
H
A
Site 59
T435
N
L
K
E
P
L
L
T
F
R
L
N
R
A
F
Site 60
S486
H
L
Q
R
V
A
Q
S
P
H
T
K
M
D
V
Site 61
T516
V
P
N
P
D
P
V
T
M
L
Q
D
I
K
R
Site 62
S533
K
V
V
E
R
L
L
S
L
P
L
E
Y
W
S
Site 63
S559
P
L
H
V
I
E
N
S
N
A
F
S
T
P
Q
Site 64
S563
I
E
N
S
N
A
F
S
T
P
Q
T
P
D
I
Site 65
T564
E
N
S
N
A
F
S
T
P
Q
T
P
D
I
K
Site 66
T567
N
A
F
S
T
P
Q
T
P
D
I
K
V
S
L
Site 67
S573
Q
T
P
D
I
K
V
S
L
L
G
P
V
T
T
Site 68
T579
V
S
L
L
G
P
V
T
T
P
E
H
Q
L
L
Site 69
T580
S
L
L
G
P
V
T
T
P
E
H
Q
L
L
K
Site 70
T588
P
E
H
Q
L
L
K
T
P
S
S
S
S
L
S
Site 71
S590
H
Q
L
L
K
T
P
S
S
S
S
L
S
Q
R
Site 72
S591
Q
L
L
K
T
P
S
S
S
S
L
S
Q
R
V
Site 73
S592
L
L
K
T
P
S
S
S
S
L
S
Q
R
V
R
Site 74
S593
L
K
T
P
S
S
S
S
L
S
Q
R
V
R
S
Site 75
S595
T
P
S
S
S
S
L
S
Q
R
V
R
S
T
L
Site 76
S600
S
L
S
Q
R
V
R
S
T
L
T
K
N
T
P
Site 77
T601
L
S
Q
R
V
R
S
T
L
T
K
N
T
P
R
Site 78
T603
Q
R
V
R
S
T
L
T
K
N
T
P
R
F
G
Site 79
T606
R
S
T
L
T
K
N
T
P
R
F
G
S
K
S
Site 80
S611
K
N
T
P
R
F
G
S
K
S
K
S
A
T
N
Site 81
S613
T
P
R
F
G
S
K
S
K
S
A
T
N
L
G
Site 82
S615
R
F
G
S
K
S
K
S
A
T
N
L
G
R
Q
Site 83
T617
G
S
K
S
K
S
A
T
N
L
G
R
Q
G
N
Site 84
S628
R
Q
G
N
F
F
A
S
P
M
L
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation