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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANAPC1
Full Name:
Anaphase-promoting complex subunit 1
Alias:
Anaphase promoting complex subunit 1; ANC1; APC1; Cyclosome subunit 1; MCPR; Mitotic checkpoint regulator; Protein Tsg24; TSG24
Type:
Ubiquitin conjugating protein, cell cycle regulation
Mass (Da):
216500
Number AA:
1944
UniProt ID:
Q9H1A4
International Prot ID:
IPI00033907
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
N
F
Y
E
E
R
T
T
M
I
A
A
R
D
L
Site 2
S46
L
R
Q
L
Q
P
A
S
E
L
W
S
S
D
G
Site 3
S50
Q
P
A
S
E
L
W
S
S
D
G
A
A
G
L
Site 4
S51
P
A
S
E
L
W
S
S
D
G
A
A
G
L
V
Site 5
S60
G
A
A
G
L
V
G
S
L
Q
E
V
T
I
H
Site 6
T65
V
G
S
L
Q
E
V
T
I
H
E
K
Q
K
E
Site 7
Y89
E
I
G
E
D
V
D
Y
D
E
E
L
Y
V
A
Site 8
S103
A
G
N
M
V
I
W
S
K
G
S
K
S
Q
A
Site 9
S108
I
W
S
K
G
S
K
S
Q
A
L
A
V
Y
K
Site 10
T118
L
A
V
Y
K
A
F
T
V
D
S
P
V
Q
Q
Site 11
S121
Y
K
A
F
T
V
D
S
P
V
Q
Q
A
L
W
Site 12
S138
F
I
I
S
Q
D
K
S
E
K
A
Y
S
S
N
Site 13
Y142
Q
D
K
S
E
K
A
Y
S
S
N
E
V
E
K
Site 14
S143
D
K
S
E
K
A
Y
S
S
N
E
V
E
K
C
Site 15
S144
K
S
E
K
A
Y
S
S
N
E
V
E
K
C
I
Site 16
Y169
H
S
I
E
G
K
D
Y
I
A
S
L
P
F
Q
Site 17
S172
E
G
K
D
Y
I
A
S
L
P
F
Q
V
A
N
Site 18
Y185
A
N
V
W
P
T
K
Y
G
L
L
F
E
R
S
Site 19
S192
Y
G
L
L
F
E
R
S
A
S
S
H
E
V
P
Site 20
S194
L
L
F
E
R
S
A
S
S
H
E
V
P
P
G
Site 21
S195
L
F
E
R
S
A
S
S
H
E
V
P
P
G
S
Site 22
S202
S
H
E
V
P
P
G
S
P
R
E
P
L
P
T
Site 23
T209
S
P
R
E
P
L
P
T
M
F
S
M
L
H
P
Site 24
S212
E
P
L
P
T
M
F
S
M
L
H
P
L
D
E
Site 25
S233
K
S
G
S
L
F
G
S
S
R
V
Q
Y
V
V
Site 26
Y238
F
G
S
S
R
V
Q
Y
V
V
D
H
A
M
K
Site 27
Y259
D
P
S
I
V
M
T
Y
D
A
V
Q
N
V
H
Site 28
T270
Q
N
V
H
S
V
W
T
L
R
R
V
K
S
E
Site 29
S276
W
T
L
R
R
V
K
S
E
E
E
N
V
V
L
Site 30
S286
E
N
V
V
L
K
F
S
E
Q
G
G
T
P
Q
Site 31
T291
K
F
S
E
Q
G
G
T
P
Q
N
V
A
T
S
Site 32
S299
P
Q
N
V
A
T
S
S
S
L
T
A
H
L
R
Site 33
S300
Q
N
V
A
T
S
S
S
L
T
A
H
L
R
S
Site 34
S307
S
L
T
A
H
L
R
S
L
S
K
G
D
S
P
Site 35
S309
T
A
H
L
R
S
L
S
K
G
D
S
P
V
T
Site 36
S313
R
S
L
S
K
G
D
S
P
V
T
S
P
F
Q
Site 37
T316
S
K
G
D
S
P
V
T
S
P
F
Q
N
Y
S
Site 38
S317
K
G
D
S
P
V
T
S
P
F
Q
N
Y
S
S
Site 39
S323
T
S
P
F
Q
N
Y
S
S
I
H
S
Q
S
R
Site 40
S324
S
P
F
Q
N
Y
S
S
I
H
S
Q
S
R
S
Site 41
S327
Q
N
Y
S
S
I
H
S
Q
S
R
S
T
S
S
Site 42
S329
Y
S
S
I
H
S
Q
S
R
S
T
S
S
P
S
Site 43
S331
S
I
H
S
Q
S
R
S
T
S
S
P
S
L
H
Site 44
T332
I
H
S
Q
S
R
S
T
S
S
P
S
L
H
S
Site 45
S333
H
S
Q
S
R
S
T
S
S
P
S
L
H
S
R
Site 46
S334
S
Q
S
R
S
T
S
S
P
S
L
H
S
R
S
Site 47
S336
S
R
S
T
S
S
P
S
L
H
S
R
S
P
S
Site 48
S339
T
S
S
P
S
L
H
S
R
S
P
S
I
S
N
Site 49
S341
S
P
S
L
H
S
R
S
P
S
I
S
N
M
A
Site 50
S343
S
L
H
S
R
S
P
S
I
S
N
M
A
A
L
Site 51
S345
H
S
R
S
P
S
I
S
N
M
A
A
L
S
R
Site 52
S351
I
S
N
M
A
A
L
S
R
A
H
S
P
A
L
Site 53
S355
A
A
L
S
R
A
H
S
P
A
L
G
V
H
S
Site 54
S362
S
P
A
L
G
V
H
S
F
S
G
V
Q
R
F
Site 55
S364
A
L
G
V
H
S
F
S
G
V
Q
R
F
N
I
Site 56
S372
G
V
Q
R
F
N
I
S
S
H
N
Q
S
P
K
Site 57
S373
V
Q
R
F
N
I
S
S
H
N
Q
S
P
K
R
Site 58
S377
N
I
S
S
H
N
Q
S
P
K
R
H
S
I
S
Site 59
S382
N
Q
S
P
K
R
H
S
I
S
H
S
P
N
S
Site 60
S384
S
P
K
R
H
S
I
S
H
S
P
N
S
N
S
Site 61
S386
K
R
H
S
I
S
H
S
P
N
S
N
S
N
G
Site 62
S389
S
I
S
H
S
P
N
S
N
S
N
G
S
F
L
Site 63
S391
S
H
S
P
N
S
N
S
N
G
S
F
L
A
P
Site 64
S394
P
N
S
N
S
N
G
S
F
L
A
P
E
T
E
Site 65
S425
T
N
I
R
E
K
N
S
Q
A
S
K
V
F
I
Site 66
T464
F
Q
E
S
N
D
K
T
Q
L
I
F
G
S
V
Site 67
S518
I
P
G
L
P
A
P
S
L
T
M
S
N
T
M
Site 68
T520
G
L
P
A
P
S
L
T
M
S
N
T
M
P
R
Site 69
S522
P
A
P
S
L
T
M
S
N
T
M
P
R
P
S
Site 70
T524
P
S
L
T
M
S
N
T
M
P
R
P
S
T
P
Site 71
S529
S
N
T
M
P
R
P
S
T
P
L
D
G
V
S
Site 72
T530
N
T
M
P
R
P
S
T
P
L
D
G
V
S
T
Site 73
S536
S
T
P
L
D
G
V
S
T
P
K
P
L
S
K
Site 74
T537
T
P
L
D
G
V
S
T
P
K
P
L
S
K
L
Site 75
S542
V
S
T
P
K
P
L
S
K
L
L
G
S
L
D
Site 76
S547
P
L
S
K
L
L
G
S
L
D
E
V
V
L
L
Site 77
S555
L
D
E
V
V
L
L
S
P
V
P
E
L
R
D
Site 78
S563
P
V
P
E
L
R
D
S
S
K
L
H
D
S
L
Site 79
S564
V
P
E
L
R
D
S
S
K
L
H
D
S
L
Y
Site 80
S569
D
S
S
K
L
H
D
S
L
Y
N
E
D
C
T
Site 81
Y571
S
K
L
H
D
S
L
Y
N
E
D
C
T
F
Q
Site 82
T596
D
P
V
H
N
R
V
T
L
E
L
S
N
G
S
Site 83
S600
N
R
V
T
L
E
L
S
N
G
S
M
V
R
I
Site 84
Y642
V
Q
M
L
V
K
W
Y
N
V
H
S
A
P
G
Site 85
S652
H
S
A
P
G
G
P
S
Y
H
S
E
W
N
L
Site 86
Y653
S
A
P
G
G
P
S
Y
H
S
E
W
N
L
F
Site 87
S686
R
N
F
D
F
E
G
S
L
S
P
V
I
A
P
Site 88
S688
F
D
F
E
G
S
L
S
P
V
I
A
P
K
K
Site 89
S699
A
P
K
K
A
R
P
S
E
T
G
S
D
D
D
Site 90
T701
K
K
A
R
P
S
E
T
G
S
D
D
D
W
E
Site 91
S703
A
R
P
S
E
T
G
S
D
D
D
W
E
Y
L
Site 92
Y709
G
S
D
D
D
W
E
Y
L
L
N
S
D
Y
H
Site 93
S713
D
W
E
Y
L
L
N
S
D
Y
H
Q
N
V
E
Site 94
Y715
E
Y
L
L
N
S
D
Y
H
Q
N
V
E
S
H
Site 95
S727
E
S
H
L
L
N
R
S
L
C
L
S
P
S
E
Site 96
S731
L
N
R
S
L
C
L
S
P
S
E
A
S
Q
M
Site 97
S733
R
S
L
C
L
S
P
S
E
A
S
Q
M
K
D
Site 98
S744
Q
M
K
D
E
D
F
S
Q
N
L
S
L
D
S
Site 99
S748
E
D
F
S
Q
N
L
S
L
D
S
S
T
L
L
Site 100
Y802
R
D
L
K
L
G
P
Y
V
D
H
Y
Y
R
D
Site 101
Y806
L
G
P
Y
V
D
H
Y
Y
R
D
Y
P
T
L
Site 102
Y807
G
P
Y
V
D
H
Y
Y
R
D
Y
P
T
L
V
Site 103
Y810
V
D
H
Y
Y
R
D
Y
P
T
L
V
R
T
T
Site 104
T812
H
Y
Y
R
D
Y
P
T
L
V
R
T
T
G
Q
Site 105
T822
R
T
T
G
Q
V
C
T
I
D
P
G
Q
T
G
Site 106
S835
T
G
F
M
H
H
P
S
F
F
T
S
E
P
P
Site 107
T838
M
H
H
P
S
F
F
T
S
E
P
P
S
I
Y
Site 108
S839
H
H
P
S
F
F
T
S
E
P
P
S
I
Y
Q
Site 109
S843
F
F
T
S
E
P
P
S
I
Y
Q
W
V
S
S
Site 110
Y845
T
S
E
P
P
S
I
Y
Q
W
V
S
S
C
L
Site 111
S849
P
S
I
Y
Q
W
V
S
S
C
L
K
G
E
G
Site 112
Y860
K
G
E
G
M
P
P
Y
P
Y
L
P
G
I
C
Site 113
Y862
E
G
M
P
P
Y
P
Y
L
P
G
I
C
E
R
Site 114
S876
R
S
R
L
V
V
L
S
I
A
L
Y
I
L
G
Site 115
S886
L
Y
I
L
G
D
E
S
L
V
S
D
E
S
S
Site 116
S889
L
G
D
E
S
L
V
S
D
E
S
S
Q
Y
L
Site 117
S892
E
S
L
V
S
D
E
S
S
Q
Y
L
T
R
I
Site 118
S893
S
L
V
S
D
E
S
S
Q
Y
L
T
R
I
T
Site 119
Y895
V
S
D
E
S
S
Q
Y
L
T
R
I
T
I
A
Site 120
T897
D
E
S
S
Q
Y
L
T
R
I
T
I
A
P
Q
Site 121
T900
S
Q
Y
L
T
R
I
T
I
A
P
Q
K
L
Q
Site 122
S916
E
Q
E
E
N
R
F
S
F
R
H
S
T
S
V
Site 123
S920
N
R
F
S
F
R
H
S
T
S
V
S
S
L
A
Site 124
T921
R
F
S
F
R
H
S
T
S
V
S
S
L
A
E
Site 125
S922
F
S
F
R
H
S
T
S
V
S
S
L
A
E
R
Site 126
S924
F
R
H
S
T
S
V
S
S
L
A
E
R
L
V
Site 127
S925
R
H
S
T
S
V
S
S
L
A
E
R
L
V
V
Site 128
Y960
L
P
I
R
D
A
I
Y
H
C
R
E
Q
P
A
Site 129
S984
L
I
G
R
Q
D
L
S
K
Q
A
C
E
G
N
Site 130
S997
G
N
L
P
K
G
K
S
V
L
S
S
D
V
P
Site 131
S1000
P
K
G
K
S
V
L
S
S
D
V
P
S
G
T
Site 132
S1001
K
G
K
S
V
L
S
S
D
V
P
S
G
T
E
Site 133
S1005
V
L
S
S
D
V
P
S
G
T
E
T
E
E
E
Site 134
T1009
D
V
P
S
G
T
E
T
E
E
E
D
D
G
M
Site 135
S1029
E
V
M
S
L
I
W
S
E
D
L
R
V
Q
D
Site 136
S1043
D
V
R
R
L
L
Q
S
A
H
P
V
R
V
N
Site 137
Y1054
V
R
V
N
V
V
Q
Y
P
E
L
S
D
H
E
Site 138
S1058
V
V
Q
Y
P
E
L
S
D
H
E
F
I
E
E
Site 139
S1091
R
G
M
F
T
L
F
S
Y
H
P
V
P
T
E
Site 140
Y1092
G
M
F
T
L
F
S
Y
H
P
V
P
T
E
P
Site 141
T1108
P
I
P
K
L
N
L
T
G
R
A
P
P
R
N
Site 142
T1116
G
R
A
P
P
R
N
T
T
V
D
L
N
S
G
Site 143
T1117
R
A
P
P
R
N
T
T
V
D
L
N
S
G
N
Site 144
Y1160
I
D
S
A
W
I
V
Y
N
K
P
K
H
A
E
Site 145
Y1196
A
T
L
N
I
H
D
Y
L
T
K
G
H
E
M
Site 146
T1198
L
N
I
H
D
Y
L
T
K
G
H
E
M
T
S
Site 147
S1240
P
A
L
L
P
P
T
S
T
E
L
D
V
P
H
Site 148
T1241
A
L
L
P
P
T
S
T
E
L
D
V
P
H
N
Site 149
T1264
I
G
L
V
Y
Q
G
T
A
H
R
H
T
A
E
Site 150
T1269
Q
G
T
A
H
R
H
T
A
E
V
L
L
A
E
Site 151
Y1287
P
P
G
P
E
M
E
Y
C
T
D
R
E
S
Y
Site 152
T1289
G
P
E
M
E
Y
C
T
D
R
E
S
Y
S
L
Site 153
S1293
E
Y
C
T
D
R
E
S
Y
S
L
A
A
G
L
Site 154
Y1294
Y
C
T
D
R
E
S
Y
S
L
A
A
G
L
A
Site 155
S1317
G
S
N
L
I
G
M
S
D
L
N
V
P
E
Q
Site 156
Y1326
L
N
V
P
E
Q
L
Y
Q
Y
M
V
G
G
H
Site 157
Y1328
V
P
E
Q
L
Y
Q
Y
M
V
G
G
H
R
R
Site 158
T1338
G
G
H
R
R
F
Q
T
G
M
H
R
E
K
H
Site 159
S1347
M
H
R
E
K
H
K
S
P
S
Y
Q
I
K
E
Site 160
S1349
R
E
K
H
K
S
P
S
Y
Q
I
K
E
G
D
Site 161
Y1350
E
K
H
K
S
P
S
Y
Q
I
K
E
G
D
T
Site 162
T1378
L
A
M
I
Y
L
K
T
N
N
R
S
I
A
D
Site 163
S1428
P
N
S
K
W
V
D
S
N
V
P
Q
I
I
R
Site 164
S1438
P
Q
I
I
R
E
N
S
I
S
L
S
E
I
E
Site 165
S1442
R
E
N
S
I
S
L
S
E
I
E
L
P
C
S
Site 166
S1449
S
E
I
E
L
P
C
S
E
D
L
N
L
E
T
Site 167
T1456
S
E
D
L
N
L
E
T
L
S
Q
A
H
V
Y
Site 168
S1483
F
A
G
S
E
N
L
S
A
F
N
C
L
H
K
Site 169
T1497
K
F
A
K
D
F
M
T
Y
L
S
A
P
N
A
Site 170
S1500
K
D
F
M
T
Y
L
S
A
P
N
A
S
V
T
Site 171
Y1552
K
T
G
G
E
M
N
Y
G
F
H
L
A
H
H
Site 172
Y1572
L
F
L
G
G
G
R
Y
S
L
S
T
S
N
S
Site 173
S1573
F
L
G
G
G
R
Y
S
L
S
T
S
N
S
S
Site 174
S1575
G
G
G
R
Y
S
L
S
T
S
N
S
S
I
A
Site 175
T1576
G
G
R
Y
S
L
S
T
S
N
S
S
I
A
A
Site 176
S1577
G
R
Y
S
L
S
T
S
N
S
S
I
A
A
L
Site 177
Y1601
A
H
S
T
D
N
R
Y
H
L
Q
A
L
R
H
Site 178
Y1610
L
Q
A
L
R
H
L
Y
V
L
A
A
E
P
R
Site 179
T1628
P
V
D
V
D
T
N
T
P
C
Y
A
L
L
E
Site 180
Y1638
Y
A
L
L
E
V
T
Y
K
G
T
Q
W
Y
E
Site 181
S1681
W
E
L
L
I
D
L
S
K
G
T
Q
H
L
K
Site 182
S1689
K
G
T
Q
H
L
K
S
I
L
S
K
D
G
V
Site 183
Y1698
L
S
K
D
G
V
L
Y
V
K
L
R
A
G
Q
Site 184
S1707
K
L
R
A
G
Q
L
S
Y
K
E
D
P
M
G
Site 185
S1717
E
D
P
M
G
W
Q
S
L
L
A
Q
T
V
A
Site 186
S1728
Q
T
V
A
N
R
N
S
E
A
R
A
F
K
P
Site 187
T1737
A
R
A
F
K
P
E
T
I
S
A
F
T
S
D
Site 188
S1739
A
F
K
P
E
T
I
S
A
F
T
S
D
P
A
Site 189
T1783
Y
E
C
V
T
Q
E
T
P
E
M
L
P
A
Y
Site 190
S1806
R
L
G
R
R
E
M
S
E
T
S
E
L
W
Q
Site 191
T1808
G
R
R
E
M
S
E
T
S
E
L
W
Q
I
K
Site 192
S1823
L
V
L
E
F
F
S
S
R
S
H
Q
E
R
L
Site 193
S1825
L
E
F
F
S
S
R
S
H
Q
E
R
L
Q
N
Site 194
Y1871
G
D
M
C
V
H
A
Y
L
S
G
Q
P
L
E
Site 195
S1873
M
C
V
H
A
Y
L
S
G
Q
P
L
E
E
S
Site 196
S1880
S
G
Q
P
L
E
E
S
Q
L
S
M
L
A
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation