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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYLK2
Full Name:
Myosin light chain kinase 2, skeletal/cardiac muscle
Alias:
EC 2.7.11.18; KMLC; MLCK2; Myosin light chain kinase 2; Myosin light chain kinase 2, skeletal/cardiac muscle; Skeletal muscle myosin light chain kinase; SkMLCK
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.18;
CAMK
group; MLCK family
Mass (Da):
64554
Number AA:
595
UniProt ID:
Q9H1R3
International Prot ID:
IPI00221127
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030017
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005516
GO:0004683
PhosphoSite+
KinaseNET
Biological Process:
GO:0060048
GO:0055008
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
L
G
I
Q
N
P
S
T
D
K
A
P
K
G
P
Site 2
T49
K
K
A
P
D
P
P
T
L
K
K
D
A
K
A
Site 3
S59
K
D
A
K
A
P
A
S
E
K
G
D
G
T
L
Site 4
T65
A
S
E
K
G
D
G
T
L
A
Q
P
S
T
S
Site 5
S70
D
G
T
L
A
Q
P
S
T
S
S
Q
G
P
K
Site 6
T71
G
T
L
A
Q
P
S
T
S
S
Q
G
P
K
G
Site 7
S73
L
A
Q
P
S
T
S
S
Q
G
P
K
G
E
G
Site 8
S90
G
G
G
P
A
E
G
S
A
G
P
P
A
A
L
Site 9
T101
P
A
A
L
P
Q
Q
T
A
T
P
E
T
S
V
Site 10
T103
A
L
P
Q
Q
T
A
T
P
E
T
S
V
K
K
Site 11
S107
Q
T
A
T
P
E
T
S
V
K
K
P
K
A
E
Site 12
S118
P
K
A
E
Q
G
A
S
G
S
Q
D
P
G
K
Site 13
S120
A
E
Q
G
A
S
G
S
Q
D
P
G
K
P
R
Site 14
S143
Q
A
A
A
R
R
G
S
P
A
F
L
H
S
P
Site 15
S149
G
S
P
A
F
L
H
S
P
S
C
P
A
I
I
Site 16
S151
P
A
F
L
H
S
P
S
C
P
A
I
I
S
S
Site 17
S169
L
L
A
K
K
P
P
S
E
A
S
E
L
T
F
Site 18
T175
P
S
E
A
S
E
L
T
F
E
G
V
P
M
T
Site 19
T182
T
F
E
G
V
P
M
T
H
S
P
T
D
P
R
Site 20
S184
E
G
V
P
M
T
H
S
P
T
D
P
R
P
A
Site 21
S203
G
K
N
I
L
A
E
S
Q
K
E
V
G
E
K
Site 22
T211
Q
K
E
V
G
E
K
T
P
G
Q
A
G
Q
A
Site 23
T224
Q
A
K
M
Q
G
D
T
S
R
G
I
E
F
Q
Site 24
S225
A
K
M
Q
G
D
T
S
R
G
I
E
F
Q
A
Site 25
T276
H
R
M
V
E
L
R
T
G
N
V
S
S
E
F
Site 26
S280
E
L
R
T
G
N
V
S
S
E
F
S
M
N
S
Site 27
S281
L
R
T
G
N
V
S
S
E
F
S
M
N
S
K
Site 28
S284
G
N
V
S
S
E
F
S
M
N
S
K
E
A
L
Site 29
S287
S
S
E
F
S
M
N
S
K
E
A
L
G
G
G
Site 30
T320
A
K
V
I
K
K
Q
T
P
K
D
K
E
M
V
Site 31
Y346
H
R
N
L
I
Q
L
Y
A
A
I
E
T
P
H
Site 32
Y376
E
R
I
V
D
E
D
Y
H
L
T
E
V
D
T
Site 33
Y433
D
F
G
L
A
R
R
Y
N
P
N
E
K
L
K
Site 34
T445
K
L
K
V
N
F
G
T
P
E
F
L
S
P
E
Site 35
S450
F
G
T
P
E
F
L
S
P
E
V
V
N
Y
D
Site 36
Y456
L
S
P
E
V
V
N
Y
D
Q
I
S
D
K
T
Site 37
T488
P
F
L
G
D
D
D
T
E
T
L
N
N
V
L
Site 38
T490
L
G
D
D
D
T
E
T
L
N
N
V
L
S
G
Site 39
Y500
N
V
L
S
G
N
W
Y
F
D
E
E
T
F
E
Site 40
T505
N
W
Y
F
D
E
E
T
F
E
A
V
S
D
E
Site 41
S556
R
C
N
R
R
L
K
S
Q
I
L
L
K
K
Y
Site 42
Y563
S
Q
I
L
L
K
K
Y
L
M
K
R
R
W
K
Site 43
S577
K
K
N
F
I
A
V
S
A
A
N
R
F
K
K
Site 44
S586
A
N
R
F
K
K
I
S
S
S
G
A
L
M
A
Site 45
S588
R
F
K
K
I
S
S
S
G
A
L
M
A
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation