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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAOK3
Full Name:
Serine/threonine-protein kinase TAO3
Alias:
DPK; EC 2.7.11.1; JIK; Kinase TAO3; MAP3K18; TAO kinase 3
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
STE
group; STE20 family; TAO subfamily
Mass (Da):
105406
Number AA:
898
UniProt ID:
Q9H2K8
International Prot ID:
IPI00410485
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005739
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004860
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0046329
GO:0046330
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase TAO3 pan-specific antibody AB-NK087-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK087-2#Serine/threonine-protein kinase TAO3 (S331-S349, human) peptide - Powder PE-01BFJ90T#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFJ90T
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
P
E
I
A
D
L
F
Y
K
D
D
P
E
E
L
Site 2
Y39
H
G
S
F
G
A
V
Y
F
A
T
N
A
H
T
Site 3
S56
V
V
A
I
K
K
M
S
Y
S
G
K
Q
T
H
Site 4
Y57
V
A
I
K
K
M
S
Y
S
G
K
Q
T
H
E
Site 5
T62
M
S
Y
S
G
K
Q
T
H
E
K
W
Q
D
I
Site 6
T84
R
Q
L
K
H
P
N
T
I
E
Y
K
G
C
Y
Site 7
Y91
T
I
E
Y
K
G
C
Y
L
K
E
H
T
A
W
Site 8
Y103
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
Site 9
S109
E
Y
C
L
G
S
A
S
D
L
L
E
V
H
K
Site 10
S140
H
G
L
A
Y
L
H
S
H
A
L
I
H
R
D
Site 11
S170
L
A
D
F
G
S
A
S
M
A
S
P
A
N
S
Site 12
S173
F
G
S
A
S
M
A
S
P
A
N
S
F
V
G
Site 13
S177
S
M
A
S
P
A
N
S
F
V
G
T
P
Y
W
Site 14
T181
P
A
N
S
F
V
G
T
P
Y
W
M
A
P
E
Site 15
S238
Y
H
I
A
Q
N
D
S
P
T
L
Q
S
N
E
Site 16
T240
I
A
Q
N
D
S
P
T
L
Q
S
N
E
W
T
Site 17
T247
T
L
Q
S
N
E
W
T
D
S
F
R
R
F
V
Site 18
Y256
S
F
R
R
F
V
D
Y
C
L
Q
K
I
P
Q
Site 19
T267
K
I
P
Q
E
R
P
T
S
A
E
L
L
R
H
Site 20
S268
I
P
Q
E
R
P
T
S
A
E
L
L
R
H
D
Site 21
Y305
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
Site 22
T316
K
K
I
L
F
Q
E
T
R
N
G
P
L
N
E
Site 23
S324
R
N
G
P
L
N
E
S
Q
E
D
E
E
D
S
Site 24
S331
S
Q
E
D
E
E
D
S
E
H
G
T
S
L
N
Site 25
T335
E
E
D
S
E
H
G
T
S
L
N
R
E
M
D
Site 26
S336
E
D
S
E
H
G
T
S
L
N
R
E
M
D
S
Site 27
S343
S
L
N
R
E
M
D
S
L
G
S
N
H
S
I
Site 28
S346
R
E
M
D
S
L
G
S
N
H
S
I
P
S
M
Site 29
S349
D
S
L
G
S
N
H
S
I
P
S
M
S
V
S
Site 30
S352
G
S
N
H
S
I
P
S
M
S
V
S
T
G
S
Site 31
S354
N
H
S
I
P
S
M
S
V
S
T
G
S
Q
S
Site 32
S356
S
I
P
S
M
S
V
S
T
G
S
Q
S
S
S
Site 33
T357
I
P
S
M
S
V
S
T
G
S
Q
S
S
S
V
Site 34
S359
S
M
S
V
S
T
G
S
Q
S
S
S
V
N
S
Site 35
S361
S
V
S
T
G
S
Q
S
S
S
V
N
S
M
Q
Site 36
S362
V
S
T
G
S
Q
S
S
S
V
N
S
M
Q
E
Site 37
S363
S
T
G
S
Q
S
S
S
V
N
S
M
Q
E
V
Site 38
S366
S
Q
S
S
S
V
N
S
M
Q
E
V
M
D
E
Site 39
S375
Q
E
V
M
D
E
S
S
S
E
L
V
M
M
H
Site 40
S376
E
V
M
D
E
S
S
S
E
L
V
M
M
H
D
Site 41
S386
V
M
M
H
D
D
E
S
T
I
N
S
S
S
S
Site 42
T387
M
M
H
D
D
E
S
T
I
N
S
S
S
S
V
Site 43
S390
D
D
E
S
T
I
N
S
S
S
S
V
V
H
K
Site 44
S392
E
S
T
I
N
S
S
S
S
V
V
H
K
K
D
Site 45
S393
S
T
I
N
S
S
S
S
V
V
H
K
K
D
H
Site 46
T419
P
R
P
E
P
R
P
T
Q
S
V
Q
S
Q
A
Site 47
S421
P
E
P
R
P
T
Q
S
V
Q
S
Q
A
L
H
Site 48
Y429
V
Q
S
Q
A
L
H
Y
R
N
R
E
R
F
A
Site 49
T437
R
N
R
E
R
F
A
T
I
K
S
A
S
L
V
Site 50
S440
E
R
F
A
T
I
K
S
A
S
L
V
T
R
Q
Site 51
S442
F
A
T
I
K
S
A
S
L
V
T
R
Q
I
H
Site 52
S462
N
E
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Site 53
Y464
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Q
H
Site 54
T499
K
L
Q
K
E
V
E
T
H
A
N
N
S
S
I
Site 55
T546
A
Q
Q
K
K
D
L
T
T
F
L
E
S
Q
K
Site 56
T547
Q
Q
K
K
D
L
T
T
F
L
E
S
Q
K
K
Site 57
S551
D
L
T
T
F
L
E
S
Q
K
K
Q
Y
K
I
Site 58
S572
E
E
M
N
E
D
H
S
T
P
K
K
E
K
Q
Site 59
T573
E
M
N
E
D
H
S
T
P
K
K
E
K
Q
E
Site 60
S583
K
E
K
Q
E
R
I
S
K
H
K
E
N
L
Q
Site 61
T602
E
E
E
A
H
L
L
T
Q
Q
R
L
Y
Y
D
Site 62
Y607
L
L
T
Q
Q
R
L
Y
Y
D
K
N
C
R
F
Site 63
Y608
L
T
Q
Q
R
L
Y
Y
D
K
N
C
R
F
F
Site 64
T640
E
E
L
N
K
K
R
T
Q
K
E
M
E
H
A
Site 65
S655
M
L
I
R
H
D
E
S
T
R
E
L
E
Y
R
Site 66
T656
L
I
R
H
D
E
S
T
R
E
L
E
Y
R
Q
Site 67
T681
L
I
R
L
Q
H
Q
T
E
L
E
N
Q
L
E
Site 68
T726
I
K
K
Q
F
Q
D
T
C
K
V
Q
T
K
Q
Site 69
T745
K
N
H
Q
L
E
V
T
P
K
N
E
H
K
T
Site 70
T752
T
P
K
N
E
H
K
T
I
L
K
T
L
K
D
Site 71
T756
E
H
K
T
I
L
K
T
L
K
D
E
Q
T
R
Site 72
S775
L
A
E
Q
Y
E
Q
S
I
N
E
M
M
A
S
Site 73
S782
S
I
N
E
M
M
A
S
Q
A
L
R
L
D
E
Site 74
Y812
E
M
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
Site 75
S814
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
T
E
Site 76
S836
Q
K
L
E
Q
R
V
S
L
R
R
A
H
L
E
Site 77
S858
A
A
L
Q
K
E
R
S
E
R
I
K
N
L
L
Site 78
T874
R
Q
E
R
E
I
E
T
F
D
M
E
S
L
R
Site 79
Y897
L
D
F
P
K
E
D
Y
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation