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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIPK2
Full Name:
Homeodomain-interacting protein kinase 2
Alias:
EC 2.7.11.1; Homeodomain interacting protein kinase 2; Kinase HIPK2; NBAK1; Nuclear body associated kinase 1; Sialophorin tail associated nuclear serine,threonine kinase; Sialophorin tail associated nuclear serine/threonine kinase; STANK
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
CMGC
group; DYRK family; HIPK subfamily
Mass (Da):
130966
Number AA:
1198
UniProt ID:
Q9H2X6
International Prot ID:
IPI00289892
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0016604
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046332
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006978
GO:0060395
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Homeodomain-interacting protein-serine kinase 2 pan-specific antibody AB-NK272-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK272-1#DYRKtide KinSub - DYR peptide substrate - Powder PE-01ACQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACQ95#Homeodomain-interacting protein-serine kinase 2 (H1159-S1176, human) peptide - Powder PE-01BDD99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDD99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
S
H
V
Q
V
F
S
P
H
T
L
Q
S
S
Site 2
S22
F
S
P
H
T
L
Q
S
S
A
F
C
S
V
K
Site 3
S23
S
P
H
T
L
Q
S
S
A
F
C
S
V
K
K
Site 4
S27
L
Q
S
S
A
F
C
S
V
K
K
L
K
I
E
Site 5
S36
K
K
L
K
I
E
P
S
S
N
W
D
M
T
G
Site 6
S37
K
L
K
I
E
P
S
S
N
W
D
M
T
G
Y
Site 7
T42
P
S
S
N
W
D
M
T
G
Y
G
S
H
S
K
Site 8
Y44
S
N
W
D
M
T
G
Y
G
S
H
S
K
V
Y
Site 9
S48
M
T
G
Y
G
S
H
S
K
V
Y
S
Q
S
K
Site 10
S52
G
S
H
S
K
V
Y
S
Q
S
K
N
I
P
L
Site 11
S54
H
S
K
V
Y
S
Q
S
K
N
I
P
L
S
Q
Site 12
S60
Q
S
K
N
I
P
L
S
Q
P
A
T
T
T
V
Site 13
S70
A
T
T
T
V
S
T
S
L
P
V
P
N
P
S
Site 14
S77
S
L
P
V
P
N
P
S
L
P
Y
E
Q
T
I
Site 15
T83
P
S
L
P
Y
E
Q
T
I
V
F
P
G
S
T
Site 16
T104
S
A
S
S
T
S
V
T
G
Q
V
L
G
G
P
Site 17
S118
P
H
N
L
M
R
R
S
T
V
S
L
L
D
T
Site 18
T119
H
N
L
M
R
R
S
T
V
S
L
L
D
T
Y
Site 19
S121
L
M
R
R
S
T
V
S
L
L
D
T
Y
Q
K
Site 20
T125
S
T
V
S
L
L
D
T
Y
Q
K
C
G
L
K
Site 21
Y126
T
V
S
L
L
D
T
Y
Q
K
C
G
L
K
R
Site 22
S135
K
C
G
L
K
R
K
S
E
E
I
E
N
T
S
Site 23
T141
K
S
E
E
I
E
N
T
S
S
V
Q
I
I
E
Site 24
S143
E
E
I
E
N
T
S
S
V
Q
I
I
E
E
H
Site 25
S169
T
V
A
T
A
T
T
S
T
A
T
S
K
N
S
Site 26
S173
A
T
T
S
T
A
T
S
K
N
S
G
S
N
S
Site 27
S176
S
T
A
T
S
K
N
S
G
S
N
S
E
G
D
Site 28
S178
A
T
S
K
N
S
G
S
N
S
E
G
D
Y
Q
Site 29
S180
S
K
N
S
G
S
N
S
E
G
D
Y
Q
L
V
Site 30
Y184
G
S
N
S
E
G
D
Y
Q
L
V
Q
H
E
V
Site 31
T221
V
K
C
W
K
R
G
T
N
E
I
V
A
I
K
Site 32
S235
K
I
L
K
N
H
P
S
Y
A
R
Q
G
Q
I
Site 33
Y236
I
L
K
N
H
P
S
Y
A
R
Q
G
Q
I
E
Site 34
S251
V
S
I
L
A
R
L
S
T
E
S
A
D
D
Y
Site 35
T252
S
I
L
A
R
L
S
T
E
S
A
D
D
Y
N
Site 36
S254
L
A
R
L
S
T
E
S
A
D
D
Y
N
F
V
Site 37
Y258
S
T
E
S
A
D
D
Y
N
F
V
R
A
Y
E
Site 38
Y264
D
Y
N
F
V
R
A
Y
E
C
F
Q
H
K
N
Site 39
Y285
E
M
L
E
Q
N
L
Y
D
F
L
K
Q
N
K
Site 40
S294
F
L
K
Q
N
K
F
S
P
L
P
L
K
Y
I
Site 41
Y300
F
S
P
L
P
L
K
Y
I
R
P
V
L
Q
Q
Site 42
S336
N
I
M
L
V
D
P
S
R
Q
P
Y
R
V
K
Site 43
Y340
V
D
P
S
R
Q
P
Y
R
V
K
V
I
D
F
Site 44
S359
H
V
S
K
A
V
C
S
T
Y
L
Q
S
R
Y
Site 45
T360
V
S
K
A
V
C
S
T
Y
L
Q
S
R
Y
Y
Site 46
Y361
S
K
A
V
C
S
T
Y
L
Q
S
R
Y
Y
R
Site 47
S364
V
C
S
T
Y
L
Q
S
R
Y
Y
R
A
P
E
Site 48
Y366
S
T
Y
L
Q
S
R
Y
Y
R
A
P
E
I
I
Site 49
Y367
T
Y
L
Q
S
R
Y
Y
R
A
P
E
I
I
L
Site 50
Y401
L
F
L
G
W
P
L
Y
P
G
A
S
E
Y
D
Site 51
Y407
L
Y
P
G
A
S
E
Y
D
Q
I
R
Y
I
S
Site 52
Y412
S
E
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
Site 53
S414
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
P
A
Site 54
T416
Q
I
R
Y
I
S
Q
T
Q
G
L
P
A
E
Y
Site 55
Y423
T
Q
G
L
P
A
E
Y
L
L
S
A
G
T
K
Site 56
S426
L
P
A
E
Y
L
L
S
A
G
T
K
T
T
R
Site 57
T431
L
L
S
A
G
T
K
T
T
R
F
F
N
R
D
Site 58
T439
T
R
F
F
N
R
D
T
D
S
P
Y
P
L
W
Site 59
S441
F
F
N
R
D
T
D
S
P
Y
P
L
W
R
L
Site 60
Y443
N
R
D
T
D
S
P
Y
P
L
W
R
L
K
T
Site 61
T450
Y
P
L
W
R
L
K
T
P
D
D
H
E
A
E
Site 62
Y468
K
S
K
E
A
R
K
Y
I
F
N
C
L
D
D
Site 63
T517
I
D
A
D
K
R
I
T
P
I
E
T
L
N
H
Site 64
T539
L
L
D
F
P
H
S
T
H
V
K
S
C
F
Q
Site 65
Y558
C
K
R
R
V
N
M
Y
D
T
V
N
Q
S
K
Site 66
T560
R
R
V
N
M
Y
D
T
V
N
Q
S
K
T
P
Site 67
T566
D
T
V
N
Q
S
K
T
P
F
I
T
H
V
A
Site 68
T581
P
S
T
S
T
N
L
T
M
T
F
N
N
Q
L
Site 69
T583
T
S
T
N
L
T
M
T
F
N
N
Q
L
T
T
Site 70
S597
T
V
H
N
Q
A
P
S
S
T
S
A
T
I
S
Site 71
S598
V
H
N
Q
A
P
S
S
T
S
A
T
I
S
L
Site 72
S600
N
Q
A
P
S
S
T
S
A
T
I
S
L
A
N
Site 73
T602
A
P
S
S
T
S
A
T
I
S
L
A
N
P
E
Site 74
S604
S
S
T
S
A
T
I
S
L
A
N
P
E
V
S
Site 75
S611
S
L
A
N
P
E
V
S
I
L
N
Y
P
S
T
Site 76
Y615
P
E
V
S
I
L
N
Y
P
S
T
L
Y
Q
P
Site 77
S617
V
S
I
L
N
Y
P
S
T
L
Y
Q
P
S
A
Site 78
T618
S
I
L
N
Y
P
S
T
L
Y
Q
P
S
A
A
Site 79
Y620
L
N
Y
P
S
T
L
Y
Q
P
S
A
A
S
M
Site 80
S668
G
F
Q
G
L
Q
A
S
P
S
K
H
A
G
Y
Site 81
S670
Q
G
L
Q
A
S
P
S
K
H
A
G
Y
S
V
Site 82
S676
P
S
K
H
A
G
Y
S
V
R
M
E
N
A
V
Site 83
T687
E
N
A
V
P
I
V
T
Q
A
P
G
A
Q
P
Site 84
T736
H
T
S
V
Q
H
A
T
V
I
P
E
T
M
A
Site 85
T796
H
V
M
R
Q
Q
P
T
S
T
T
S
S
R
K
Site 86
S797
V
M
R
Q
Q
P
T
S
T
T
S
S
R
K
S
Site 87
S800
Q
Q
P
T
S
T
T
S
S
R
K
S
K
Q
H
Site 88
S801
Q
P
T
S
T
T
S
S
R
K
S
K
Q
H
Q
Site 89
S804
S
T
T
S
S
R
K
S
K
Q
H
Q
S
S
V
Site 90
S809
R
K
S
K
Q
H
Q
S
S
V
R
N
V
S
T
Site 91
S810
K
S
K
Q
H
Q
S
S
V
R
N
V
S
T
C
Site 92
S815
Q
S
S
V
R
N
V
S
T
C
E
V
S
S
S
Site 93
T816
S
S
V
R
N
V
S
T
C
E
V
S
S
S
Q
Site 94
S821
V
S
T
C
E
V
S
S
S
Q
A
I
S
S
P
Site 95
S822
S
T
C
E
V
S
S
S
Q
A
I
S
S
P
Q
Site 96
S826
V
S
S
S
Q
A
I
S
S
P
Q
R
S
K
R
Site 97
S827
S
S
S
Q
A
I
S
S
P
Q
R
S
K
R
V
Site 98
S831
A
I
S
S
P
Q
R
S
K
R
V
K
E
N
T
Site 99
T838
S
K
R
V
K
E
N
T
P
P
R
C
A
M
V
Site 100
S847
P
R
C
A
M
V
H
S
S
P
A
C
S
T
S
Site 101
S854
S
S
P
A
C
S
T
S
V
T
C
G
W
G
D
Site 102
S864
C
G
W
G
D
V
A
S
S
T
T
R
E
R
Q
Site 103
S865
G
W
G
D
V
A
S
S
T
T
R
E
R
Q
R
Site 104
T866
W
G
D
V
A
S
S
T
T
R
E
R
Q
R
Q
Site 105
T874
T
R
E
R
Q
R
Q
T
I
V
I
P
D
T
P
Site 106
S886
D
T
P
S
P
T
V
S
V
I
T
I
S
S
D
Site 107
S906
E
Q
K
H
A
P
T
S
T
V
S
K
Q
R
K
Site 108
S917
K
Q
R
K
N
V
I
S
C
V
T
V
H
D
S
Site 109
T920
K
N
V
I
S
C
V
T
V
H
D
S
P
Y
S
Site 110
S924
S
C
V
T
V
H
D
S
P
Y
S
D
S
S
S
Site 111
Y926
V
T
V
H
D
S
P
Y
S
D
S
S
S
N
T
Site 112
S927
T
V
H
D
S
P
Y
S
D
S
S
S
N
T
S
Site 113
S929
H
D
S
P
Y
S
D
S
S
S
N
T
S
P
Y
Site 114
S930
D
S
P
Y
S
D
S
S
S
N
T
S
P
Y
S
Site 115
S931
S
P
Y
S
D
S
S
S
N
T
S
P
Y
S
V
Site 116
T933
Y
S
D
S
S
S
N
T
S
P
Y
S
V
Q
Q
Site 117
S934
S
D
S
S
S
N
T
S
P
Y
S
V
Q
Q
R
Site 118
S937
S
S
N
T
S
P
Y
S
V
Q
Q
R
A
G
H
Site 119
T961
G
S
L
E
N
H
C
T
G
N
P
R
T
I
I
Site 120
T966
H
C
T
G
N
P
R
T
I
I
V
P
P
L
K
Site 121
S977
P
P
L
K
T
Q
A
S
E
V
L
V
E
C
D
Site 122
T991
D
S
L
V
P
V
N
T
S
H
H
S
S
S
Y
Site 123
S992
S
L
V
P
V
N
T
S
H
H
S
S
S
Y
K
Site 124
S995
P
V
N
T
S
H
H
S
S
S
Y
K
S
K
S
Site 125
S996
V
N
T
S
H
H
S
S
S
Y
K
S
K
S
S
Site 126
S997
N
T
S
H
H
S
S
S
Y
K
S
K
S
S
S
Site 127
Y998
T
S
H
H
S
S
S
Y
K
S
K
S
S
S
N
Site 128
S1000
H
H
S
S
S
Y
K
S
K
S
S
S
N
V
T
Site 129
S1002
S
S
S
Y
K
S
K
S
S
S
N
V
T
S
T
Site 130
S1003
S
S
Y
K
S
K
S
S
S
N
V
T
S
T
S
Site 131
S1004
S
Y
K
S
K
S
S
S
N
V
T
S
T
S
G
Site 132
T1007
S
K
S
S
S
N
V
T
S
T
S
G
H
S
S
Site 133
S1008
K
S
S
S
N
V
T
S
T
S
G
H
S
S
G
Site 134
T1009
S
S
S
N
V
T
S
T
S
G
H
S
S
G
S
Site 135
S1010
S
S
N
V
T
S
T
S
G
H
S
S
G
S
S
Site 136
S1013
V
T
S
T
S
G
H
S
S
G
S
S
S
G
A
Site 137
S1014
T
S
T
S
G
H
S
S
G
S
S
S
G
A
I
Site 138
S1016
T
S
G
H
S
S
G
S
S
S
G
A
I
T
Y
Site 139
S1017
S
G
H
S
S
G
S
S
S
G
A
I
T
Y
R
Site 140
S1018
G
H
S
S
G
S
S
S
G
A
I
T
Y
R
Q
Site 141
T1022
G
S
S
S
G
A
I
T
Y
R
Q
Q
R
P
G
Site 142
Y1023
S
S
S
G
A
I
T
Y
R
Q
Q
R
P
G
P
Site 143
S1041
Q
Q
Q
P
L
N
L
S
Q
A
Q
Q
H
I
T
Site 144
T1048
S
Q
A
Q
Q
H
I
T
T
D
R
T
G
S
H
Site 145
T1049
Q
A
Q
Q
H
I
T
T
D
R
T
G
S
H
R
Site 146
S1054
I
T
T
D
R
T
G
S
H
R
R
Q
Q
A
Y
Site 147
Y1061
S
H
R
R
Q
Q
A
Y
I
T
P
T
M
A
Q
Site 148
T1063
R
R
Q
Q
A
Y
I
T
P
T
M
A
Q
A
P
Site 149
Y1071
P
T
M
A
Q
A
P
Y
S
F
P
H
N
S
P
Site 150
S1072
T
M
A
Q
A
P
Y
S
F
P
H
N
S
P
S
Site 151
S1077
P
Y
S
F
P
H
N
S
P
S
H
G
T
V
H
Site 152
S1079
S
F
P
H
N
S
P
S
H
G
T
V
H
P
H
Site 153
T1082
H
N
S
P
S
H
G
T
V
H
P
H
L
A
A
Site 154
Y1103
L
P
T
Q
P
H
L
Y
T
Y
T
A
P
A
A
Site 155
Y1105
T
Q
P
H
L
Y
T
Y
T
A
P
A
A
L
G
Site 156
S1123
T
V
A
H
L
V
A
S
Q
G
S
A
R
H
T
Site 157
S1126
H
L
V
A
S
Q
G
S
A
R
H
T
V
Q
H
Site 158
T1130
S
Q
G
S
A
R
H
T
V
Q
H
T
A
Y
P
Site 159
T1134
A
R
H
T
V
Q
H
T
A
Y
P
A
S
I
V
Site 160
Y1136
H
T
V
Q
H
T
A
Y
P
A
S
I
V
H
Q
Site 161
S1139
Q
H
T
A
Y
P
A
S
I
V
H
Q
V
P
V
Site 162
S1155
M
G
P
R
V
L
P
S
P
T
I
H
P
S
Q
Site 163
T1157
P
R
V
L
P
S
P
T
I
H
P
S
Q
Y
P
Site 164
S1161
P
S
P
T
I
H
P
S
Q
Y
P
A
Q
F
A
Site 165
Y1163
P
T
I
H
P
S
Q
Y
P
A
Q
F
A
H
Q
Site 166
Y1172
A
Q
F
A
H
Q
T
Y
I
S
A
S
P
A
S
Site 167
S1176
H
Q
T
Y
I
S
A
S
P
A
S
T
V
Y
T
Site 168
S1179
Y
I
S
A
S
P
A
S
T
V
Y
T
G
Y
P
Site 169
T1183
S
P
A
S
T
V
Y
T
G
Y
P
L
S
P
A
Site 170
S1188
V
Y
T
G
Y
P
L
S
P
A
K
V
N
Q
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation