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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIPK3
Full Name:
Homeodomain-interacting protein kinase 3
Alias:
DJ8L15.1; EC 2.7.11.1
Type:
Protein-serine kinase, CMGC group, DYRK family, HIPK subfamily
Mass (Da):
133743
Number AA:
1215
UniProt ID:
Q9H422
International Prot ID:
IPI00099522
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0043508
Phosida
TranscriptoNet
STRING
Kinexus Products
DYRKtide KinSub - DYR peptide substrate - Powder PE-01ACQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACQ95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
A
S
Q
V
L
V
Y
P
P
Y
V
Y
Q
T
Site 2
Y11
Q
V
L
V
Y
P
P
Y
V
Y
Q
T
Q
S
S
Site 3
Y13
L
V
Y
P
P
Y
V
Y
Q
T
Q
S
S
A
F
Site 4
S17
P
Y
V
Y
Q
T
Q
S
S
A
F
C
S
V
K
Site 5
S22
T
Q
S
S
A
F
C
S
V
K
K
L
K
V
E
Site 6
S31
K
K
L
K
V
E
P
S
S
C
V
F
Q
E
R
Site 7
S32
K
L
K
V
E
P
S
S
C
V
F
Q
E
R
N
Site 8
Y40
C
V
F
Q
E
R
N
Y
P
R
T
Y
V
N
G
Site 9
T43
Q
E
R
N
Y
P
R
T
Y
V
N
G
R
N
F
Site 10
Y44
E
R
N
Y
P
R
T
Y
V
N
G
R
N
F
G
Site 11
S53
N
G
R
N
F
G
N
S
H
P
P
T
K
G
S
Site 12
T57
F
G
N
S
H
P
P
T
K
G
S
A
F
Q
T
Site 13
T64
T
K
G
S
A
F
Q
T
K
I
P
F
N
R
P
Site 14
S77
R
P
R
G
H
N
F
S
L
Q
T
S
A
V
V
Site 15
S81
H
N
F
S
L
Q
T
S
A
V
V
L
K
N
T
Site 16
S131
R
C
G
L
K
R
K
S
E
E
L
D
N
H
S
Site 17
Y182
C
T
T
G
E
G
D
Y
Q
L
V
Q
H
E
V
Site 18
T219
V
K
C
W
K
R
G
T
N
E
I
V
A
I
K
Site 19
S233
K
I
L
K
N
H
P
S
Y
A
R
Q
G
Q
I
Site 20
Y234
I
L
K
N
H
P
S
Y
A
R
Q
G
Q
I
E
Site 21
S249
V
S
I
L
A
R
L
S
T
E
N
A
D
E
Y
Site 22
T250
S
I
L
A
R
L
S
T
E
N
A
D
E
Y
N
Site 23
Y256
S
T
E
N
A
D
E
Y
N
F
V
R
A
Y
E
Site 24
Y262
E
Y
N
F
V
R
A
Y
E
C
F
Q
H
R
N
Site 25
Y283
E
M
L
E
Q
N
L
Y
D
F
L
K
Q
N
K
Site 26
Y338
V
D
P
V
R
Q
P
Y
R
V
K
V
I
D
F
Site 27
S352
F
G
S
A
S
H
V
S
K
T
V
C
S
T
Y
Site 28
T354
S
A
S
H
V
S
K
T
V
C
S
T
Y
L
Q
Site 29
S357
H
V
S
K
T
V
C
S
T
Y
L
Q
S
R
Y
Site 30
T358
V
S
K
T
V
C
S
T
Y
L
Q
S
R
Y
Y
Site 31
Y359
S
K
T
V
C
S
T
Y
L
Q
S
R
Y
Y
R
Site 32
S362
V
C
S
T
Y
L
Q
S
R
Y
Y
R
A
P
E
Site 33
Y364
S
T
Y
L
Q
S
R
Y
Y
R
A
P
E
I
I
Site 34
Y365
T
Y
L
Q
S
R
Y
Y
R
A
P
E
I
I
L
Site 35
Y405
L
Y
P
G
A
L
E
Y
D
Q
I
R
Y
I
S
Site 36
Y410
L
E
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
Site 37
S412
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
P
G
Site 38
T414
Q
I
R
Y
I
S
Q
T
Q
G
L
P
G
E
Q
Site 39
S429
L
L
N
V
G
T
K
S
T
R
F
F
C
K
E
Site 40
T448
H
S
G
W
R
L
K
T
L
E
E
H
E
A
E
Site 41
Y466
K
S
K
E
A
R
K
Y
I
F
N
S
L
D
D
Site 42
S470
A
R
K
Y
I
F
N
S
L
D
D
V
A
H
V
Site 43
T479
D
D
V
A
H
V
N
T
V
M
D
L
E
G
S
Site 44
S500
A
D
R
R
E
F
V
S
L
L
K
K
M
L
L
Site 45
T515
I
D
A
D
L
R
I
T
P
A
E
T
L
N
H
Site 46
T579
S
S
S
T
A
T
L
T
A
N
F
T
K
I
G
Site 47
S590
T
K
I
G
T
L
R
S
Q
A
L
T
T
S
A
Site 48
S596
R
S
Q
A
L
T
T
S
A
H
S
V
V
H
H
Site 49
T637
A
I
Q
G
I
P
A
T
H
G
K
P
T
S
Y
Site 50
S643
A
T
H
G
K
P
T
S
Y
S
I
R
V
D
N
Site 51
S645
H
G
K
P
T
S
Y
S
I
R
V
D
N
T
V
Site 52
S672
Q
I
R
P
G
V
L
S
Q
T
W
S
G
R
T
Site 53
T674
R
P
G
V
L
S
Q
T
W
S
G
R
T
Q
Q
Site 54
S676
G
V
L
S
Q
T
W
S
G
R
T
Q
Q
M
L
Site 55
S702
P
A
T
T
T
L
T
S
E
S
V
A
G
S
H
Site 56
S704
T
T
T
L
T
S
E
S
V
A
G
S
H
R
L
Site 57
S708
T
S
E
S
V
A
G
S
H
R
L
G
D
W
G
Site 58
Y724
M
I
S
C
S
N
H
Y
N
S
V
M
P
Q
P
Site 59
S726
S
C
S
N
H
Y
N
S
V
M
P
Q
P
L
L
Site 60
S789
R
E
E
I
N
A
F
S
W
S
N
S
L
Q
N
Site 61
S793
N
A
F
S
W
S
N
S
L
Q
N
T
N
I
P
Site 62
S802
Q
N
T
N
I
P
H
S
A
F
I
S
P
K
I
Site 63
S819
G
K
D
V
E
E
V
S
C
I
E
T
Q
D
N
Site 64
T823
E
E
V
S
C
I
E
T
Q
D
N
Q
N
S
E
Site 65
T839
E
A
R
N
C
C
E
T
S
I
R
Q
D
S
D
Site 66
S840
A
R
N
C
C
E
T
S
I
R
Q
D
S
D
S
Site 67
S845
E
T
S
I
R
Q
D
S
D
S
S
V
S
D
K
Site 68
S847
S
I
R
Q
D
S
D
S
S
V
S
D
K
Q
R
Site 69
S848
I
R
Q
D
S
D
S
S
V
S
D
K
Q
R
Q
Site 70
T856
V
S
D
K
Q
R
Q
T
I
I
I
A
D
S
P
Site 71
S868
D
S
P
S
P
A
V
S
V
I
T
I
S
S
D
Site 72
S874
V
S
V
I
T
I
S
S
D
T
D
E
E
E
T
Site 73
T876
V
I
T
I
S
S
D
T
D
E
E
E
T
S
Q
Site 74
S882
D
T
D
E
E
E
T
S
Q
R
H
S
L
R
E
Site 75
S886
E
E
T
S
Q
R
H
S
L
R
E
C
K
G
S
Site 76
S893
S
L
R
E
C
K
G
S
L
D
C
E
A
C
Q
Site 77
S910
L
N
I
D
R
M
C
S
L
S
S
P
D
S
T
Site 78
S912
I
D
R
M
C
S
L
S
S
P
D
S
T
L
S
Site 79
S913
D
R
M
C
S
L
S
S
P
D
S
T
L
S
T
Site 80
S916
C
S
L
S
S
P
D
S
T
L
S
T
S
S
S
Site 81
T917
S
L
S
S
P
D
S
T
L
S
T
S
S
S
G
Site 82
S919
S
S
P
D
S
T
L
S
T
S
S
S
G
Q
S
Site 83
T920
S
P
D
S
T
L
S
T
S
S
S
G
Q
S
S
Site 84
S921
P
D
S
T
L
S
T
S
S
S
G
Q
S
S
P
Site 85
S922
D
S
T
L
S
T
S
S
S
G
Q
S
S
P
S
Site 86
S923
S
T
L
S
T
S
S
S
G
Q
S
S
P
S
P
Site 87
S926
S
T
S
S
S
G
Q
S
S
P
S
P
C
K
R
Site 88
S927
T
S
S
S
G
Q
S
S
P
S
P
C
K
R
P
Site 89
S929
S
S
G
Q
S
S
P
S
P
C
K
R
P
N
S
Site 90
S936
S
P
C
K
R
P
N
S
M
S
D
E
E
Q
E
Site 91
S938
C
K
R
P
N
S
M
S
D
E
E
Q
E
S
S
Site 92
S944
M
S
D
E
E
Q
E
S
S
C
D
T
V
D
G
Site 93
S945
S
D
E
E
Q
E
S
S
C
D
T
V
D
G
S
Site 94
T948
E
Q
E
S
S
C
D
T
V
D
G
S
P
T
S
Site 95
S952
S
C
D
T
V
D
G
S
P
T
S
D
S
S
G
Site 96
T954
D
T
V
D
G
S
P
T
S
D
S
S
G
H
D
Site 97
S955
T
V
D
G
S
P
T
S
D
S
S
G
H
D
S
Site 98
S957
D
G
S
P
T
S
D
S
S
G
H
D
S
P
F
Site 99
S958
G
S
P
T
S
D
S
S
G
H
D
S
P
F
A
Site 100
S962
S
D
S
S
G
H
D
S
P
F
A
E
S
T
F
Site 101
T968
D
S
P
F
A
E
S
T
F
V
E
D
T
H
E
Site 102
T973
E
S
T
F
V
E
D
T
H
E
N
T
E
L
V
Site 103
T977
V
E
D
T
H
E
N
T
E
L
V
S
S
A
D
Site 104
S982
E
N
T
E
L
V
S
S
A
D
T
E
T
K
P
Site 105
T985
E
L
V
S
S
A
D
T
E
T
K
P
A
V
C
Site 106
S1026
Q
P
L
I
K
G
R
S
A
P
G
R
L
N
Q
Site 107
S1035
P
G
R
L
N
Q
P
S
A
V
G
T
R
Q
Q
Site 108
T1039
N
Q
P
S
A
V
G
T
R
Q
Q
K
L
T
S
Site 109
T1045
G
T
R
Q
Q
K
L
T
S
A
F
Q
Q
Q
H
Site 110
Y1080
G
H
R
R
Q
Q
A
Y
I
P
T
S
V
T
S
Site 111
S1084
Q
Q
A
Y
I
P
T
S
V
T
S
N
P
F
T
Site 112
S1087
Y
I
P
T
S
V
T
S
N
P
F
T
L
S
H
Site 113
T1091
S
V
T
S
N
P
F
T
L
S
H
G
S
P
N
Site 114
S1093
T
S
N
P
F
T
L
S
H
G
S
P
N
H
T
Site 115
S1096
P
F
T
L
S
H
G
S
P
N
H
T
A
V
H
Site 116
T1100
S
H
G
S
P
N
H
T
A
V
H
A
H
L
A
Site 117
T1117
T
H
L
G
G
Q
P
T
L
L
P
Y
P
S
S
Site 118
Y1121
G
Q
P
T
L
L
P
Y
P
S
S
A
T
L
S
Site 119
S1128
Y
P
S
S
A
T
L
S
S
A
A
P
V
A
H
Site 120
T1142
H
L
L
A
S
P
C
T
S
R
P
M
L
Q
H
Site 121
S1143
L
L
A
S
P
C
T
S
R
P
M
L
Q
H
P
Site 122
T1151
R
P
M
L
Q
H
P
T
Y
N
I
S
H
P
S
Site 123
Y1152
P
M
L
Q
H
P
T
Y
N
I
S
H
P
S
G
Site 124
S1175
L
N
P
R
L
L
P
S
P
T
I
H
Q
T
Q
Site 125
T1177
P
R
L
L
P
S
P
T
I
H
Q
T
Q
Y
K
Site 126
T1181
P
S
P
T
I
H
Q
T
Q
Y
K
P
I
F
P
Site 127
Y1183
P
T
I
H
Q
T
Q
Y
K
P
I
F
P
P
H
Site 128
S1191
K
P
I
F
P
P
H
S
Y
I
A
A
S
P
A
Site 129
S1196
P
H
S
Y
I
A
A
S
P
A
Y
T
G
F
P
Site 130
S1205
A
Y
T
G
F
P
L
S
P
T
K
L
S
Q
Y
Site 131
S1210
P
L
S
P
T
K
L
S
Q
Y
P
Y
M
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation