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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RBM21
Full Name:
U6 snRNA-specific terminal uridylyltransferase 1
Alias:
EC 2.7.7.52; FLJ21850; FLJ22267; FLJ22347; PAP associated domain containing 2; PAPD2; RNA-binding motif protein 21; RNA-binding protein 21; Terminal uridylyl transferase 1, U6 snRNA-specific; TUT1; TUTase; U6-TUTase
Type:
EC 2.7.7.52; Transferase
Mass (Da):
93847
Number AA:
874
UniProt ID:
Q9H6E5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0050265
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
A
V
D
S
D
V
E
S
L
P
R
Site 2
S10
A
V
D
S
D
V
E
S
L
P
R
G
G
F
R
Site 3
S30
V
T
T
A
N
R
P
S
L
D
A
H
L
G
G
Site 4
S57
R
K
A
Q
G
L
R
S
V
F
V
S
G
F
P
Site 5
S61
G
L
R
S
V
F
V
S
G
F
P
R
D
V
D
Site 6
S69
G
F
P
R
D
V
D
S
A
Q
L
S
E
Y
F
Site 7
S110
G
A
R
E
A
V
L
S
Q
S
Q
H
S
L
G
Site 8
S112
R
E
A
V
L
S
Q
S
Q
H
S
L
G
G
H
Site 9
S133
R
E
Q
K
E
F
Q
S
P
A
S
K
S
P
K
Site 10
S136
K
E
F
Q
S
P
A
S
K
S
P
K
G
A
A
Site 11
S138
F
Q
S
P
A
S
K
S
P
K
G
A
A
P
D
Site 12
S146
P
K
G
A
A
P
D
S
H
Q
L
A
K
A
L
Site 13
S173
L
V
G
L
R
E
L
S
E
A
E
R
Q
L
R
Site 14
S209
P
F
G
S
S
I
N
S
F
D
V
H
G
C
D
Site 15
S238
P
V
P
K
A
P
E
S
P
S
L
D
S
A
L
Site 16
S240
P
K
A
P
E
S
P
S
L
D
S
A
L
A
S
Site 17
S243
P
E
S
P
S
L
D
S
A
L
A
S
P
L
D
Site 18
T257
D
P
Q
A
L
A
C
T
P
A
S
P
P
D
S
Site 19
S260
A
L
A
C
T
P
A
S
P
P
D
S
Q
P
P
Site 20
S264
T
P
A
S
P
P
D
S
Q
P
P
A
S
P
Q
Site 21
S269
P
D
S
Q
P
P
A
S
P
Q
D
S
E
A
L
Site 22
S273
P
P
A
S
P
Q
D
S
E
A
L
D
F
E
T
Site 23
T280
S
E
A
L
D
F
E
T
P
S
S
S
L
A
P
Site 24
S282
A
L
D
F
E
T
P
S
S
S
L
A
P
Q
T
Site 25
S283
L
D
F
E
T
P
S
S
S
L
A
P
Q
T
P
Site 26
S284
D
F
E
T
P
S
S
S
L
A
P
Q
T
P
D
Site 27
T289
S
S
S
L
A
P
Q
T
P
D
S
A
L
A
S
Site 28
S292
L
A
P
Q
T
P
D
S
A
L
A
S
E
T
L
Site 29
S296
T
P
D
S
A
L
A
S
E
T
L
A
S
P
Q
Site 30
S301
L
A
S
E
T
L
A
S
P
Q
S
L
P
P
A
Site 31
S304
E
T
L
A
S
P
Q
S
L
P
P
A
S
P
L
Site 32
S309
P
Q
S
L
P
P
A
S
P
L
L
E
D
R
E
Site 33
T329
K
A
S
E
L
A
E
T
P
K
E
E
K
A
E
Site 34
Y356
R
G
C
V
P
G
V
Y
R
V
Q
T
V
P
S
Site 35
T360
P
G
V
Y
R
V
Q
T
V
P
S
A
R
R
P
Site 36
S363
Y
R
V
Q
T
V
P
S
A
R
R
P
V
V
K
Site 37
S376
V
K
F
C
H
R
P
S
G
L
H
G
D
V
S
Site 38
S385
L
H
G
D
V
S
L
S
N
R
L
A
L
H
N
Site 39
S393
N
R
L
A
L
H
N
S
R
F
L
S
L
C
S
Site 40
S397
L
H
N
S
R
F
L
S
L
C
S
E
L
D
G
Site 41
S400
S
R
F
L
S
L
C
S
E
L
D
G
R
V
R
Site 42
T412
R
V
R
P
L
V
Y
T
L
R
C
W
A
Q
G
Site 43
S423
W
A
Q
G
R
G
L
S
G
S
G
P
L
L
S
Site 44
S425
Q
G
R
G
L
S
G
S
G
P
L
L
S
N
Y
Site 45
T452
R
D
P
P
V
L
P
T
V
S
Q
L
T
Q
K
Site 46
S454
P
P
V
L
P
T
V
S
Q
L
T
Q
K
A
G
Site 47
S474
E
V
D
G
W
D
C
S
F
P
R
D
A
S
R
Site 48
S480
C
S
F
P
R
D
A
S
R
L
E
P
S
I
N
Site 49
S485
D
A
S
R
L
E
P
S
I
N
V
E
P
L
S
Site 50
S510
S
C
W
D
L
R
G
S
L
L
S
L
R
E
G
Site 51
S513
D
L
R
G
S
L
L
S
L
R
E
G
Q
A
L
Site 52
S528
P
V
A
G
G
L
P
S
N
L
W
E
G
L
R
Site 53
S548
L
Q
D
P
F
D
L
S
H
N
V
A
A
N
V
Site 54
Y573
C
C
R
A
A
A
N
Y
C
R
S
L
Q
Y
Q
Site 55
Y579
N
Y
C
R
S
L
Q
Y
Q
R
R
S
S
R
G
Site 56
S583
S
L
Q
Y
Q
R
R
S
S
R
G
R
D
W
G
Site 57
S584
L
Q
Y
Q
R
R
S
S
R
G
R
D
W
G
L
Site 58
T639
G
C
H
I
E
Q
A
T
K
R
T
R
S
E
G
Site 59
S644
Q
A
T
K
R
T
R
S
E
G
G
G
T
G
E
Site 60
T649
T
R
S
E
G
G
G
T
G
E
S
S
Q
G
G
Site 61
S652
E
G
G
G
T
G
E
S
S
Q
G
G
T
S
K
Site 62
S653
G
G
G
T
G
E
S
S
Q
G
G
T
S
K
R
Site 63
S658
E
S
S
Q
G
G
T
S
K
R
L
K
V
D
G
Site 64
S707
V
Q
D
W
A
M
Q
S
P
G
Q
P
G
D
L
Site 65
T717
Q
P
G
D
L
P
L
T
T
G
K
H
G
A
P
Site 66
S731
P
G
E
E
G
Q
P
S
H
A
A
L
A
E
R
Site 67
S750
H
E
A
A
Q
E
W
S
Q
G
E
A
G
K
G
Site 68
S759
G
E
A
G
K
G
A
S
L
P
S
S
A
S
W
Site 69
S762
G
K
G
A
S
L
P
S
S
A
S
W
R
C
A
Site 70
S763
K
G
A
S
L
P
S
S
A
S
W
R
C
A
L
Site 71
S765
A
S
L
P
S
S
A
S
W
R
C
A
L
W
H
Site 72
T789
R
R
R
L
Q
Q
Q
T
K
E
G
A
G
G
G
Site 73
T811
L
A
T
E
A
Q
V
T
Q
E
L
K
G
L
S
Site 74
T826
G
G
E
E
R
P
E
T
E
P
L
L
S
F
V
Site 75
T844
S
P
A
D
R
M
L
T
V
T
P
L
Q
D
P
Site 76
T846
A
D
R
M
L
T
V
T
P
L
Q
D
P
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation