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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK6
Full Name:
Serine/threonine-protein kinase Nek6
Alias:
2.7.11.1; Kinase Nek6; NIMA; NIMA (never in mitosis gene a)-related expressed kinase 6; NIMA (never in mitosis gene a)-related kinase 6; NIMA-related kinase 6; NIMA-related serine/threonine kinase; Putative serine-threonine protein kinase; SID6-1512
Type:
EC 2.7.11.1; Protein kinase, tyrosine (non-receptor); Protein kinase, Ser/Thr (non-receptor); Other group; NEK family
Mass (Da):
35714
Number AA:
313
UniProt ID:
Q9HC98
International Prot ID:
IPI00550738
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0051301
GO:0007059
Phosida
TranscriptoNet
STRING
Kinexus Products
NIMA (never-in-mitosis)-related protein-serine kinase 6 S206 phosphosite-specific antibody AB-PK734#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK734#NIMA (never-in-mitosis)-related protein-serine kinase 6 (A203-G209, human) pS206 phosphopeptide - Powder PE-04AOE99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOE99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
S
S
N
N
L
C
H
T
L
G
P
V
H
P
P
Site 2
T35
D
P
Q
R
H
P
N
T
L
S
F
R
C
S
L
Site 3
S37
Q
R
H
P
N
T
L
S
F
R
C
S
L
A
D
Site 4
S41
N
T
L
S
F
R
C
S
L
A
D
F
Q
I
E
Site 5
Y60
R
G
Q
F
S
E
V
Y
K
A
T
C
L
L
D
Site 6
T70
T
C
L
L
D
R
K
T
V
A
L
K
K
V
Q
Site 7
Y108
N
H
P
N
I
I
K
Y
L
D
S
F
I
E
D
Site 8
S111
N
I
I
K
Y
L
D
S
F
I
E
D
N
E
L
Site 9
S131
L
A
D
A
G
D
L
S
Q
M
I
K
Y
F
K
Site 10
Y136
D
L
S
Q
M
I
K
Y
F
K
K
Q
K
R
L
Site 11
Y152
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
Site 12
S158
K
Y
F
V
Q
L
C
S
A
V
E
H
M
H
S
Site 13
S165
S
A
V
E
H
M
H
S
R
R
V
M
H
R
D
Site 14
S198
L
G
L
G
R
F
F
S
S
E
T
T
A
A
H
Site 15
S199
G
L
G
R
F
F
S
S
E
T
T
A
A
H
S
Site 16
T201
G
R
F
F
S
S
E
T
T
A
A
H
S
L
V
Site 17
T202
R
F
F
S
S
E
T
T
A
A
H
S
L
V
G
Site 18
S206
S
E
T
T
A
A
H
S
L
V
G
T
P
Y
Y
NIMA (never-in-mitosis)-related protein-serine kinase 6 S206 phosphosite-specific antibody AB-PK734#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK734#NIMA (never-in-mitosis)-related protein-serine kinase 6 (A203-G209, human) pS206 phosphopeptide - Powder PE-04AOE99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOE99
Site 19
T210
A
A
H
S
L
V
G
T
P
Y
Y
M
S
P
E
Site 20
Y212
H
S
L
V
G
T
P
Y
Y
M
S
P
E
R
I
Site 21
Y213
S
L
V
G
T
P
Y
Y
M
S
P
E
R
I
H
Site 22
S215
V
G
T
P
Y
Y
M
S
P
E
R
I
H
E
N
Site 23
Y224
E
R
I
H
E
N
G
Y
N
F
K
S
D
I
W
Site 24
S245
Y
E
M
A
A
L
Q
S
P
F
Y
G
D
K
M
Site 25
Y248
A
A
L
Q
S
P
F
Y
G
D
K
M
N
L
F
Site 26
S256
G
D
K
M
N
L
F
S
L
C
Q
K
I
E
Q
Site 27
Y266
Q
K
I
E
Q
C
D
Y
P
P
L
P
G
E
H
Site 28
Y274
P
P
L
P
G
E
H
Y
S
E
K
L
R
E
L
Site 29
S275
P
L
P
G
E
H
Y
S
E
K
L
R
E
L
V
Site 30
S283
E
K
L
R
E
L
V
S
M
C
I
C
P
D
P
Site 31
Y298
H
Q
R
P
D
I
G
Y
V
H
Q
V
A
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation