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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LATS2
Full Name:
Serine/threonine-protein kinase LATS2
Alias:
EC 2.7.11.1
Type:
Protein-serine kinase, AGC group, NDR family
Mass (Da):
120194
Number AA:
1088
UniProt ID:
Q9NRM7
International Prot ID:
IPI00016690
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
GO:0000922
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0051301
GO:0009755
Phosida
TranscriptoNet
STRING
Kinexus Products
Large tumour suppressor 2 protein-serine kinase pan-specific antibody AB-NK092-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK092-1#Large tumour suppressor 2 protein-serine kinase pan-specific antibody AB-NK092-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK092-2#Large tumour suppressor 2 protein-serine kinase (S43-Q61, human) peptide - Powder PE-01BDN85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDN85#Large tumour suppressor 2 protein-serine kinase (S1064-C1083, human) peptide - Powder PE-01BDO95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDO95#LATSSubtide - LATS2 (KPM) protein kinase substrate peptide - Powder PE-01BHU90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BHU90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
R
P
K
T
F
P
A
T
T
Y
S
G
N
S
R
Site 2
T10
P
K
T
F
P
A
T
T
Y
S
G
N
S
R
Q
Site 3
Y11
K
T
F
P
A
T
T
Y
S
G
N
S
R
Q
R
Site 4
S12
T
F
P
A
T
T
Y
S
G
N
S
R
Q
R
L
Site 5
S30
R
E
G
L
K
Q
P
S
K
S
S
V
Q
G
L
Site 6
S32
G
L
K
Q
P
S
K
S
S
V
Q
G
L
P
A
Site 7
S33
L
K
Q
P
S
K
S
S
V
Q
G
L
P
A
G
Site 8
S43
G
L
P
A
G
P
N
S
D
T
S
L
D
A
K
Site 9
S46
A
G
P
N
S
D
T
S
L
D
A
K
V
L
G
Site 10
T58
V
L
G
S
K
D
A
T
R
Q
Q
Q
Q
M
R
Site 11
T67
Q
Q
Q
Q
M
R
A
T
P
K
F
G
P
Y
Q
Site 12
Y82
K
A
L
R
E
I
R
Y
S
L
L
P
F
A
N
Site 13
S83
A
L
R
E
I
R
Y
S
L
L
P
F
A
N
E
Site 14
T124
A
G
R
A
L
K
Q
T
G
S
R
S
I
E
A
Site 15
S126
R
A
L
K
Q
T
G
S
R
S
I
E
A
A
L
Site 16
S128
L
K
Q
T
G
S
R
S
I
E
A
A
L
E
Y
Site 17
Y141
E
Y
I
S
K
M
G
Y
L
D
P
R
N
E
Q
Site 18
S157
V
R
V
I
K
Q
T
S
P
G
K
G
L
M
P
Site 19
T165
P
G
K
G
L
M
P
T
P
V
T
R
R
P
S
Site 20
T168
G
L
M
P
T
P
V
T
R
R
P
S
F
E
G
Site 21
S172
T
P
V
T
R
R
P
S
F
E
G
T
G
D
S
Site 22
T176
R
R
P
S
F
E
G
T
G
D
S
F
A
S
Y
Site 23
S179
S
F
E
G
T
G
D
S
F
A
S
Y
H
Q
L
Site 24
S182
G
T
G
D
S
F
A
S
Y
H
Q
L
S
G
T
Site 25
Y183
T
G
D
S
F
A
S
Y
H
Q
L
S
G
T
P
Site 26
S187
F
A
S
Y
H
Q
L
S
G
T
P
Y
E
G
P
Site 27
T189
S
Y
H
Q
L
S
G
T
P
Y
E
G
P
S
F
Site 28
Y191
H
Q
L
S
G
T
P
Y
E
G
P
S
F
G
A
Site 29
S195
G
T
P
Y
E
G
P
S
F
G
A
D
G
P
T
Site 30
Y211
L
E
E
M
P
R
P
Y
V
D
Y
L
F
P
G
Site 31
Y214
M
P
R
P
Y
V
D
Y
L
F
P
G
V
G
P
Site 32
S238
P
P
K
G
Y
G
A
S
V
E
A
A
G
A
H
Site 33
Y253
F
P
L
Q
G
A
H
Y
G
R
P
H
L
L
V
Site 34
Y267
V
P
G
E
P
L
G
Y
G
V
Q
R
S
P
S
Site 35
S272
L
G
Y
G
V
Q
R
S
P
S
F
Q
S
K
T
Site 36
S274
Y
G
V
Q
R
S
P
S
F
Q
S
K
T
P
P
Site 37
S277
Q
R
S
P
S
F
Q
S
K
T
P
P
E
T
G
Site 38
T279
S
P
S
F
Q
S
K
T
P
P
E
T
G
G
Y
Site 39
Y286
T
P
P
E
T
G
G
Y
A
S
L
P
T
K
G
Site 40
S288
P
E
T
G
G
Y
A
S
L
P
T
K
G
Q
G
Site 41
Y312
P
P
P
A
A
G
L
Y
V
P
H
P
H
H
K
Site 42
S333
H
Q
L
H
V
L
G
S
R
S
Q
V
F
A
S
Site 43
S335
L
H
V
L
G
S
R
S
Q
V
F
A
S
D
S
Site 44
S340
S
R
S
Q
V
F
A
S
D
S
P
P
Q
S
L
Site 45
S342
S
Q
V
F
A
S
D
S
P
P
Q
S
L
L
T
Site 46
S346
A
S
D
S
P
P
Q
S
L
L
T
P
S
R
N
Site 47
T349
S
P
P
Q
S
L
L
T
P
S
R
N
S
L
N
Site 48
S354
L
L
T
P
S
R
N
S
L
N
V
D
L
Y
E
Site 49
Y360
N
S
L
N
V
D
L
Y
E
L
G
S
T
S
V
Site 50
S364
V
D
L
Y
E
L
G
S
T
S
V
Q
Q
W
P
Site 51
T365
D
L
Y
E
L
G
S
T
S
V
Q
Q
W
P
A
Site 52
S366
L
Y
E
L
G
S
T
S
V
Q
Q
W
P
A
A
Site 53
S380
A
T
L
A
R
R
D
S
L
Q
K
P
G
L
E
Site 54
S404
R
P
D
C
P
V
P
S
R
T
N
S
F
N
S
Site 55
T406
D
C
P
V
P
S
R
T
N
S
F
N
S
H
Q
Site 56
S408
P
V
P
S
R
T
N
S
F
N
S
H
Q
P
R
Site 57
S411
S
R
T
N
S
F
N
S
H
Q
P
R
P
G
P
Site 58
S425
P
P
G
K
A
E
P
S
L
P
A
P
N
T
V
Site 59
T436
P
N
T
V
T
A
V
T
A
A
H
I
L
H
P
Site 60
S446
H
I
L
H
P
V
K
S
V
R
V
L
R
P
E
Site 61
T456
V
L
R
P
E
P
Q
T
A
V
G
P
S
H
P
Site 62
Y506
A
F
P
L
D
V
E
Y
G
G
P
D
R
R
C
Site 63
Y518
R
R
C
P
P
P
P
Y
P
K
H
L
L
L
R
Site 64
S528
H
L
L
L
R
S
K
S
E
Q
Y
D
L
D
S
Site 65
Y531
L
R
S
K
S
E
Q
Y
D
L
D
S
L
C
A
Site 66
S535
S
E
Q
Y
D
L
D
S
L
C
A
G
M
E
Q
Site 67
S543
L
C
A
G
M
E
Q
S
L
R
A
G
P
N
E
Site 68
S557
E
P
E
G
G
D
K
S
R
K
S
A
K
G
D
Site 69
S560
G
G
D
K
S
R
K
S
A
K
G
D
K
G
G
Site 70
S576
D
K
K
Q
I
Q
T
S
P
V
P
V
R
K
N
Site 71
S584
P
V
P
V
R
K
N
S
R
D
E
E
K
R
E
Site 72
S592
R
D
E
E
K
R
E
S
R
I
K
S
Y
S
P
Site 73
S596
K
R
E
S
R
I
K
S
Y
S
P
Y
A
F
K
Site 74
S598
E
S
R
I
K
S
Y
S
P
Y
A
F
K
F
F
Site 75
Y600
R
I
K
S
Y
S
P
Y
A
F
K
F
F
M
E
Site 76
Y649
E
Q
M
R
K
I
L
Y
Q
K
E
S
N
Y
N
Site 77
S653
K
I
L
Y
Q
K
E
S
N
Y
N
R
L
K
R
Site 78
Y655
L
Y
Q
K
E
S
N
Y
N
R
L
K
R
A
K
Site 79
S666
K
R
A
K
M
D
K
S
M
F
V
K
I
K
T
Site 80
T690
C
L
A
C
K
V
D
T
H
A
L
Y
A
M
K
Site 81
Y694
K
V
D
T
H
A
L
Y
A
M
K
T
L
R
K
Site 82
T698
H
A
L
Y
A
M
K
T
L
R
K
K
D
V
L
Site 83
Y732
N
E
W
V
V
K
L
Y
Y
S
F
Q
D
K
D
Site 84
S734
W
V
V
K
L
Y
Y
S
F
Q
D
K
D
S
L
Site 85
Y742
F
Q
D
K
D
S
L
Y
F
V
M
D
Y
I
P
Site 86
Y824
R
W
T
H
N
S
K
Y
Y
Q
K
G
S
H
V
Site 87
Y825
W
T
H
N
S
K
Y
Y
Q
K
G
S
H
V
R
Site 88
S829
S
K
Y
Y
Q
K
G
S
H
V
R
Q
D
S
M
Site 89
S835
G
S
H
V
R
Q
D
S
M
E
P
S
D
L
W
Site 90
S839
R
Q
D
S
M
E
P
S
D
L
W
D
D
V
S
Site 91
T856
R
C
G
D
R
L
K
T
L
E
Q
R
A
R
K
Site 92
S872
H
Q
R
C
L
A
H
S
L
V
G
T
P
N
Y
Site 93
Y890
E
V
L
L
R
K
G
Y
T
Q
L
C
D
W
W
Site 94
T917
Q
P
P
F
L
A
P
T
P
T
E
T
Q
L
K
Site 95
T949
P
E
A
R
D
L
I
T
K
L
C
C
S
A
D
Site 96
S954
L
I
T
K
L
C
C
S
A
D
H
R
L
G
R
Site 97
S974
L
K
A
H
P
F
F
S
A
I
D
F
S
S
D
Site 98
S979
F
F
S
A
I
D
F
S
S
D
I
R
K
Q
P
Site 99
S980
F
S
A
I
D
F
S
S
D
I
R
K
Q
P
A
Site 100
Y989
I
R
K
Q
P
A
P
Y
V
P
T
I
S
H
P
Site 101
S994
A
P
Y
V
P
T
I
S
H
P
M
D
T
S
N
Site 102
T999
T
I
S
H
P
M
D
T
S
N
F
D
P
V
D
Site 103
S1000
I
S
H
P
M
D
T
S
N
F
D
P
V
D
E
Site 104
S1009
F
D
P
V
D
E
E
S
P
W
N
D
A
S
E
Site 105
S1015
E
S
P
W
N
D
A
S
E
G
S
T
K
A
W
Site 106
T1024
G
S
T
K
A
W
D
T
L
T
S
P
N
N
K
Site 107
T1026
T
K
A
W
D
T
L
T
S
P
N
N
K
H
P
Site 108
S1027
K
A
W
D
T
L
T
S
P
N
N
K
H
P
E
Site 109
Y1038
K
H
P
E
H
A
F
Y
E
F
T
F
R
R
F
Site 110
T1041
E
H
A
F
Y
E
F
T
F
R
R
F
F
D
D
Site 111
Y1051
R
F
F
D
D
N
G
Y
P
F
R
C
P
K
P
Site 112
S1059
P
F
R
C
P
K
P
S
G
A
E
A
S
Q
A
Site 113
S1064
K
P
S
G
A
E
A
S
Q
A
E
S
S
D
L
Site 114
S1068
A
E
A
S
Q
A
E
S
S
D
L
E
S
S
D
Site 115
S1069
E
A
S
Q
A
E
S
S
D
L
E
S
S
D
L
Site 116
S1073
A
E
S
S
D
L
E
S
S
D
L
V
D
Q
T
Site 117
S1074
E
S
S
D
L
E
S
S
D
L
V
D
Q
T
E
Site 118
T1080
S
S
D
L
V
D
Q
T
E
G
C
Q
P
V
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation