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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BCLAF1
Full Name:
Bcl-2-associated transcription factor 1
Alias:
BCL2-associated transcription factor 1; Bcl-2-associated transcription factor 1; BCLF1; Btf; BTF; KIAA0164
Type:
Transcription protein
Mass (Da):
106122
Number AA:
920
UniProt ID:
Q9NYF8
International Prot ID:
IPI00006079
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0016564
PhosphoSite+
KinaseNET
Biological Process:
GO:0006917
GO:0016481
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
R
S
N
S
R
S
H
S
S
R
S
Site 2
S8
M
G
R
S
N
S
R
S
H
S
S
R
S
K
S
Site 3
S10
R
S
N
S
R
S
H
S
S
R
S
K
S
R
S
Site 4
S11
S
N
S
R
S
H
S
S
R
S
K
S
R
S
Q
Site 5
S13
S
R
S
H
S
S
R
S
K
S
R
S
Q
S
S
Site 6
S15
S
H
S
S
R
S
K
S
R
S
Q
S
S
S
R
Site 7
S17
S
S
R
S
K
S
R
S
Q
S
S
S
R
S
R
Site 8
S19
R
S
K
S
R
S
Q
S
S
S
R
S
R
S
R
Site 9
S20
S
K
S
R
S
Q
S
S
S
R
S
R
S
R
S
Site 10
S21
K
S
R
S
Q
S
S
S
R
S
R
S
R
S
H
Site 11
S23
R
S
Q
S
S
S
R
S
R
S
R
S
H
S
R
Site 12
S25
Q
S
S
S
R
S
R
S
R
S
H
S
R
K
K
Site 13
S27
S
S
R
S
R
S
R
S
H
S
R
K
K
R
Y
Site 14
S29
R
S
R
S
R
S
H
S
R
K
K
R
Y
S
S
Site 15
Y34
S
H
S
R
K
K
R
Y
S
S
R
S
R
S
R
Site 16
S35
H
S
R
K
K
R
Y
S
S
R
S
R
S
R
T
Site 17
S36
S
R
K
K
R
Y
S
S
R
S
R
S
R
T
Y
Site 18
S38
K
K
R
Y
S
S
R
S
R
S
R
T
Y
S
R
Site 19
S40
R
Y
S
S
R
S
R
S
R
T
Y
S
R
S
R
Site 20
T42
S
S
R
S
R
S
R
T
Y
S
R
S
R
S
R
Site 21
Y43
S
R
S
R
S
R
T
Y
S
R
S
R
S
R
D
Site 22
S44
R
S
R
S
R
T
Y
S
R
S
R
S
R
D
R
Site 23
S46
R
S
R
T
Y
S
R
S
R
S
R
D
R
M
Y
Site 24
S48
R
T
Y
S
R
S
R
S
R
D
R
M
Y
S
R
Site 25
Y53
S
R
S
R
D
R
M
Y
S
R
D
Y
R
R
D
Site 26
S54
R
S
R
D
R
M
Y
S
R
D
Y
R
R
D
Y
Site 27
Y57
D
R
M
Y
S
R
D
Y
R
R
D
Y
R
N
N
Site 28
Y61
S
R
D
Y
R
R
D
Y
R
N
N
R
G
M
R
Site 29
Y71
N
R
G
M
R
R
P
Y
G
Y
R
G
R
G
R
Site 30
Y73
G
M
R
R
P
Y
G
Y
R
G
R
G
R
G
Y
Site 31
Y80
Y
R
G
R
G
R
G
Y
Y
Q
G
G
G
G
R
Site 32
Y81
R
G
R
G
R
G
Y
Y
Q
G
G
G
G
R
Y
Site 33
Y88
Y
Q
G
G
G
G
R
Y
H
R
G
G
Y
R
P
Site 34
Y93
G
R
Y
H
R
G
G
Y
R
P
V
W
N
R
R
Site 35
S102
P
V
W
N
R
R
H
S
R
S
P
R
R
G
R
Site 36
S104
W
N
R
R
H
S
R
S
P
R
R
G
R
S
R
Site 37
S110
R
S
P
R
R
G
R
S
R
S
R
S
P
K
R
Site 38
S112
P
R
R
G
R
S
R
S
R
S
P
K
R
R
S
Site 39
S114
R
G
R
S
R
S
R
S
P
K
R
R
S
V
S
Site 40
S119
S
R
S
P
K
R
R
S
V
S
S
Q
R
S
R
Site 41
S121
S
P
K
R
R
S
V
S
S
Q
R
S
R
S
R
Site 42
S122
P
K
R
R
S
V
S
S
Q
R
S
R
S
R
S
Site 43
S125
R
S
V
S
S
Q
R
S
R
S
R
S
R
R
S
Site 44
S127
V
S
S
Q
R
S
R
S
R
S
R
R
S
Y
R
Site 45
S129
S
Q
R
S
R
S
R
S
R
R
S
Y
R
S
S
Site 46
S132
S
R
S
R
S
R
R
S
Y
R
S
S
R
S
P
Site 47
Y133
R
S
R
S
R
R
S
Y
R
S
S
R
S
P
R
Site 48
S135
R
S
R
R
S
Y
R
S
S
R
S
P
R
S
S
Site 49
S136
S
R
R
S
Y
R
S
S
R
S
P
R
S
S
S
Site 50
S138
R
S
Y
R
S
S
R
S
P
R
S
S
S
S
R
Site 51
S141
R
S
S
R
S
P
R
S
S
S
S
R
S
S
S
Site 52
S142
S
S
R
S
P
R
S
S
S
S
R
S
S
S
P
Site 53
S143
S
R
S
P
R
S
S
S
S
R
S
S
S
P
Y
Site 54
S144
R
S
P
R
S
S
S
S
R
S
S
S
P
Y
S
Site 55
S146
P
R
S
S
S
S
R
S
S
S
P
Y
S
K
S
Site 56
S147
R
S
S
S
S
R
S
S
S
P
Y
S
K
S
P
Site 57
S148
S
S
S
S
R
S
S
S
P
Y
S
K
S
P
V
Site 58
Y150
S
S
R
S
S
S
P
Y
S
K
S
P
V
S
K
Site 59
S151
S
R
S
S
S
P
Y
S
K
S
P
V
S
K
R
Site 60
S153
S
S
S
P
Y
S
K
S
P
V
S
K
R
R
G
Site 61
S156
P
Y
S
K
S
P
V
S
K
R
R
G
S
Q
E
Site 62
S161
P
V
S
K
R
R
G
S
Q
E
K
Q
T
K
K
Site 63
S177
E
G
E
P
Q
E
E
S
P
L
K
S
K
S
Q
Site 64
S181
Q
E
E
S
P
L
K
S
K
S
Q
E
E
P
K
Site 65
S183
E
S
P
L
K
S
K
S
Q
E
E
P
K
D
T
Site 66
T190
S
Q
E
E
P
K
D
T
F
E
H
D
P
S
E
Site 67
S196
D
T
F
E
H
D
P
S
E
S
I
D
E
F
N
Site 68
S198
F
E
H
D
P
S
E
S
I
D
E
F
N
K
S
Site 69
S205
S
I
D
E
F
N
K
S
S
A
T
S
G
D
I
Site 70
S206
I
D
E
F
N
K
S
S
A
T
S
G
D
I
W
Site 71
T208
E
F
N
K
S
S
A
T
S
G
D
I
W
P
G
Site 72
S209
F
N
K
S
S
A
T
S
G
D
I
W
P
G
L
Site 73
S217
G
D
I
W
P
G
L
S
A
Y
D
N
S
P
R
Site 74
Y219
I
W
P
G
L
S
A
Y
D
N
S
P
R
S
P
Site 75
S222
G
L
S
A
Y
D
N
S
P
R
S
P
H
S
P
Site 76
S225
A
Y
D
N
S
P
R
S
P
H
S
P
S
P
I
Site 77
S228
N
S
P
R
S
P
H
S
P
S
P
I
A
T
P
Site 78
S230
P
R
S
P
H
S
P
S
P
I
A
T
P
P
S
Site 79
T234
H
S
P
S
P
I
A
T
P
P
S
Q
S
S
S
Site 80
S237
S
P
I
A
T
P
P
S
Q
S
S
S
C
S
D
Site 81
S239
I
A
T
P
P
S
Q
S
S
S
C
S
D
A
P
Site 82
S240
A
T
P
P
S
Q
S
S
S
C
S
D
A
P
M
Site 83
S241
T
P
P
S
Q
S
S
S
C
S
D
A
P
M
L
Site 84
S243
P
S
Q
S
S
S
C
S
D
A
P
M
L
S
T
Site 85
S249
C
S
D
A
P
M
L
S
T
V
H
S
A
K
N
Site 86
T250
S
D
A
P
M
L
S
T
V
H
S
A
K
N
T
Site 87
S253
P
M
L
S
T
V
H
S
A
K
N
T
P
S
Q
Site 88
T257
T
V
H
S
A
K
N
T
P
S
Q
H
S
H
S
Site 89
S259
H
S
A
K
N
T
P
S
Q
H
S
H
S
I
Q
Site 90
S262
K
N
T
P
S
Q
H
S
H
S
I
Q
H
S
P
Site 91
S264
T
P
S
Q
H
S
H
S
I
Q
H
S
P
E
R
Site 92
S268
H
S
H
S
I
Q
H
S
P
E
R
S
G
S
G
Site 93
S272
I
Q
H
S
P
E
R
S
G
S
G
S
V
G
N
Site 94
S274
H
S
P
E
R
S
G
S
G
S
V
G
N
G
S
Site 95
S276
P
E
R
S
G
S
G
S
V
G
N
G
S
S
R
Site 96
S281
S
G
S
V
G
N
G
S
S
R
Y
S
P
S
Q
Site 97
S282
G
S
V
G
N
G
S
S
R
Y
S
P
S
Q
N
Site 98
Y284
V
G
N
G
S
S
R
Y
S
P
S
Q
N
S
P
Site 99
S285
G
N
G
S
S
R
Y
S
P
S
Q
N
S
P
I
Site 100
S287
G
S
S
R
Y
S
P
S
Q
N
S
P
I
H
H
Site 101
S290
R
Y
S
P
S
Q
N
S
P
I
H
H
I
P
S
Site 102
S297
S
P
I
H
H
I
P
S
R
R
S
P
A
K
T
Site 103
S300
H
H
I
P
S
R
R
S
P
A
K
T
I
A
P
Site 104
T304
S
R
R
S
P
A
K
T
I
A
P
Q
N
A
P
Site 105
S315
Q
N
A
P
R
D
E
S
R
G
R
S
S
F
Y
Site 106
S319
R
D
E
S
R
G
R
S
S
F
Y
P
D
G
G
Site 107
S320
D
E
S
R
G
R
S
S
F
Y
P
D
G
G
D
Site 108
Y322
S
R
G
R
S
S
F
Y
P
D
G
G
D
Q
E
Site 109
T330
P
D
G
G
D
Q
E
T
A
K
T
G
K
F
L
Site 110
T333
G
D
Q
E
T
A
K
T
G
K
F
L
K
R
F
Site 111
T341
G
K
F
L
K
R
F
T
D
E
E
S
R
V
F
Site 112
T355
F
L
L
D
R
G
N
T
R
D
K
E
A
S
K
Site 113
S361
N
T
R
D
K
E
A
S
K
E
K
G
S
E
K
Site 114
Y383
E
D
Q
E
A
L
D
Y
F
S
D
K
E
S
G
Site 115
S385
Q
E
A
L
D
Y
F
S
D
K
E
S
G
K
Q
Site 116
S389
D
Y
F
S
D
K
E
S
G
K
Q
K
F
N
D
Site 117
S397
G
K
Q
K
F
N
D
S
E
G
D
D
T
E
E
Site 118
T402
N
D
S
E
G
D
D
T
E
E
T
E
D
Y
R
Site 119
T405
E
G
D
D
T
E
E
T
E
D
Y
R
Q
F
R
Site 120
Y408
D
T
E
E
T
E
D
Y
R
Q
F
R
K
S
V
Site 121
S414
D
Y
R
Q
F
R
K
S
V
L
A
D
Q
G
K
Site 122
S422
V
L
A
D
Q
G
K
S
F
A
T
A
S
H
R
Site 123
S427
G
K
S
F
A
T
A
S
H
R
N
T
E
E
E
Site 124
T431
A
T
A
S
H
R
N
T
E
E
E
G
L
K
Y
Site 125
Y438
T
E
E
E
G
L
K
Y
K
S
K
V
S
L
K
Site 126
S440
E
E
G
L
K
Y
K
S
K
V
S
L
K
G
N
Site 127
S443
L
K
Y
K
S
K
V
S
L
K
G
N
R
E
S
Site 128
S450
S
L
K
G
N
R
E
S
D
G
F
R
E
E
K
Site 129
Y459
G
F
R
E
E
K
N
Y
K
L
K
E
T
G
Y
Site 130
T464
K
N
Y
K
L
K
E
T
G
Y
V
V
E
R
P
Site 131
Y466
Y
K
L
K
E
T
G
Y
V
V
E
R
P
S
T
Site 132
S472
G
Y
V
V
E
R
P
S
T
T
K
D
K
H
K
Site 133
T473
Y
V
V
E
R
P
S
T
T
K
D
K
H
K
E
Site 134
T474
V
V
E
R
P
S
T
T
K
D
K
H
K
E
E
Site 135
S485
H
K
E
E
D
K
N
S
E
R
I
T
V
K
K
Site 136
T489
D
K
N
S
E
R
I
T
V
K
K
E
T
Q
S
Site 137
T494
R
I
T
V
K
K
E
T
Q
S
P
E
Q
V
K
Site 138
S496
T
V
K
K
E
T
Q
S
P
E
Q
V
K
S
E
Site 139
S502
Q
S
P
E
Q
V
K
S
E
K
L
K
D
L
F
Site 140
Y511
K
L
K
D
L
F
D
Y
S
P
P
L
H
K
N
Site 141
S512
L
K
D
L
F
D
Y
S
P
P
L
H
K
N
L
Site 142
S525
N
L
D
A
R
E
K
S
T
F
R
E
E
S
P
Site 143
T526
L
D
A
R
E
K
S
T
F
R
E
E
S
P
L
Site 144
S531
K
S
T
F
R
E
E
S
P
L
R
I
K
M
I
Site 145
S540
L
R
I
K
M
I
A
S
D
S
H
R
P
E
V
Site 146
S542
I
K
M
I
A
S
D
S
H
R
P
E
V
K
L
Site 147
S559
A
P
V
P
L
D
D
S
N
R
P
A
S
L
T
Site 148
S564
D
D
S
N
R
P
A
S
L
T
K
D
R
L
L
Site 149
T566
S
N
R
P
A
S
L
T
K
D
R
L
L
A
S
Site 150
S573
T
K
D
R
L
L
A
S
T
L
V
H
S
V
K
Site 151
T574
K
D
R
L
L
A
S
T
L
V
H
S
V
K
K
Site 152
S578
L
A
S
T
L
V
H
S
V
K
K
E
Q
E
F
Site 153
S598
H
I
K
L
P
Q
A
S
K
S
T
S
E
S
F
Site 154
S600
K
L
P
Q
A
S
K
S
T
S
E
S
F
I
Q
Site 155
S602
P
Q
A
S
K
S
T
S
E
S
F
I
Q
H
I
Site 156
S604
A
S
K
S
T
S
E
S
F
I
Q
H
I
V
S
Site 157
Y620
V
H
H
V
K
E
Q
Y
F
K
S
A
A
M
T
Site 158
S623
V
K
E
Q
Y
F
K
S
A
A
M
T
L
N
E
Site 159
T627
Y
F
K
S
A
A
M
T
L
N
E
R
F
T
S
Site 160
T633
M
T
L
N
E
R
F
T
S
Y
Q
K
A
T
E
Site 161
S634
T
L
N
E
R
F
T
S
Y
Q
K
A
T
E
E
Site 162
S643
Q
K
A
T
E
E
H
S
T
R
Q
K
S
P
E
Site 163
T644
K
A
T
E
E
H
S
T
R
Q
K
S
P
E
I
Site 164
S648
E
H
S
T
R
Q
K
S
P
E
I
H
R
R
I
Site 165
S658
I
H
R
R
I
D
I
S
P
S
T
L
R
K
H
Site 166
S660
R
R
I
D
I
S
P
S
T
L
R
K
H
T
R
Site 167
T661
R
I
D
I
S
P
S
T
L
R
K
H
T
R
L
Site 168
T666
P
S
T
L
R
K
H
T
R
L
A
G
E
E
R
Site 169
S690
D
K
K
L
R
C
D
S
A
D
L
R
H
D
I
Site 170
S705
D
R
R
R
K
E
R
S
K
E
R
G
D
S
K
Site 171
S711
R
S
K
E
R
G
D
S
K
G
S
R
E
S
S
Site 172
S714
E
R
G
D
S
K
G
S
R
E
S
S
G
S
R
Site 173
S717
D
S
K
G
S
R
E
S
S
G
S
R
K
Q
E
Site 174
S718
S
K
G
S
R
E
S
S
G
S
R
K
Q
E
K
Site 175
S720
G
S
R
E
S
S
G
S
R
K
Q
E
K
T
P
Site 176
T726
G
S
R
K
Q
E
K
T
P
K
D
Y
K
E
Y
Site 177
Y730
Q
E
K
T
P
K
D
Y
K
E
Y
K
S
Y
K
Site 178
S735
K
D
Y
K
E
Y
K
S
Y
K
D
D
S
K
H
Site 179
Y736
D
Y
K
E
Y
K
S
Y
K
D
D
S
K
H
K
Site 180
S740
Y
K
S
Y
K
D
D
S
K
H
K
R
E
Q
D
Site 181
S749
H
K
R
E
Q
D
H
S
R
S
S
S
S
S
A
Site 182
S751
R
E
Q
D
H
S
R
S
S
S
S
S
A
S
P
Site 183
S752
E
Q
D
H
S
R
S
S
S
S
S
A
S
P
S
Site 184
S753
Q
D
H
S
R
S
S
S
S
S
A
S
P
S
S
Site 185
S754
D
H
S
R
S
S
S
S
S
A
S
P
S
S
P
Site 186
S755
H
S
R
S
S
S
S
S
A
S
P
S
S
P
S
Site 187
S757
R
S
S
S
S
S
A
S
P
S
S
P
S
S
R
Site 188
S759
S
S
S
S
A
S
P
S
S
P
S
S
R
E
E
Site 189
S760
S
S
S
A
S
P
S
S
P
S
S
R
E
E
K
Site 190
S762
S
A
S
P
S
S
P
S
S
R
E
E
K
E
S
Site 191
S763
A
S
P
S
S
P
S
S
R
E
E
K
E
S
K
Site 192
S769
S
S
R
E
E
K
E
S
K
K
E
R
E
E
E
Site 193
T779
E
R
E
E
E
F
K
T
H
H
E
M
K
E
Y
Site 194
Y786
T
H
H
E
M
K
E
Y
S
G
F
A
G
V
S
Site 195
S793
Y
S
G
F
A
G
V
S
R
P
R
G
T
F
F
Site 196
T798
G
V
S
R
P
R
G
T
F
F
R
I
R
G
R
Site 197
T817
G
V
F
A
G
T
N
T
G
P
N
N
S
N
T
Site 198
S822
T
N
T
G
P
N
N
S
N
T
T
F
Q
K
R
Site 199
T824
T
G
P
N
N
S
N
T
T
F
Q
K
R
P
K
Site 200
T825
G
P
N
N
S
N
T
T
F
Q
K
R
P
K
E
Site 201
Y839
E
E
E
W
D
P
E
Y
T
P
K
S
K
K
Y
Site 202
T840
E
E
W
D
P
E
Y
T
P
K
S
K
K
Y
F
Site 203
S843
D
P
E
Y
T
P
K
S
K
K
Y
F
L
H
D
Site 204
Y846
Y
T
P
K
S
K
K
Y
F
L
H
D
D
R
D
Site 205
Y858
D
R
D
D
G
V
D
Y
W
A
K
R
G
R
G
Site 206
T868
K
R
G
R
G
R
G
T
F
Q
R
G
R
G
R
Site 207
S881
G
R
F
N
F
K
K
S
G
S
S
P
K
W
T
Site 208
S883
F
N
F
K
K
S
G
S
S
P
K
W
T
H
D
Site 209
S884
N
F
K
K
S
G
S
S
P
K
W
T
H
D
K
Site 210
T888
S
G
S
S
P
K
W
T
H
D
K
Y
Q
G
D
Site 211
Y892
P
K
W
T
H
D
K
Y
Q
G
D
G
I
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation