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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MLTK
Full Name:
Mitogen-activated protein kinase kinase kinase MLT
Alias:
AZK; EC 2.7.11.25; HCCS-4; Mixed lineage kinase-related kinase; MLK-like mitogen-activated protein triple kinase; MRK-beta; Sterile alpha motif and leucine zipper containing kinase AZK
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25;
TKL
group; MLK family; MLK subfamily
Mass (Da):
91181
Number AA:
800
UniProt ID:
Q9NYL2
International Prot ID:
IPI00329638
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0000287
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0000075
GO:0000077
GO:0000186
Phosida
TranscriptoNet
STRING
Kinexus Products
Mitogen-activated protein kinase kinase kinase MLT T161+T162 phosphosite-specific antibody AB-PK719#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK719#Mitogen-activated protein kinase kinase kinase MLT (H158-S165, human) pT161+pT162 phosphopeptide - Powder PE-04AQP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQP95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
L
G
A
S
F
V
Site 2
S3
_
_
_
_
_
M
S
S
L
G
A
S
F
V
Q
Site 3
S26
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
Site 4
Y31
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
Site 5
S37
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
Site 6
S58
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
Site 7
Y78
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
Site 8
T82
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
Site 9
Y84
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
Site 10
S89
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
Site 11
Y91
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
Site 12
Y93
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
Site 13
S96
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
Site 14
Y120
D
V
A
K
G
M
H
Y
L
H
M
E
A
P
V
Site 15
S136
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
Site 16
S155
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
Site 17
T161
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
Mitogen-activated protein kinase kinase kinase MLT T161+T162 phosphosite-specific antibody AB-PK719#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK719#Mitogen-activated protein kinase kinase kinase MLT (H158-S165, human) pT161+pT162 phosphopeptide - Powder PE-04AQP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQP95
Site 18
T162
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
Mitogen-activated protein kinase kinase kinase MLT T161+T162 phosphosite-specific antibody AB-PK719#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK719#Mitogen-activated protein kinase kinase kinase MLT (H158-S165, human) pT161+pT162 phosphopeptide - Powder PE-04AQP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQP95
Site 19
S165
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
Site 20
S184
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Site 21
T186
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
Site 22
Y192
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
Site 23
T226
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
Site 24
S229
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
Site 25
S230
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
Site 26
S234
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
Site 27
S252
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
Site 28
S258
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
Site 29
S264
I
S
I
L
E
S
M
S
N
D
T
S
L
P
D
Site 30
T267
L
E
S
M
S
N
D
T
S
L
P
D
K
C
N
Site 31
S268
E
S
M
S
N
D
T
S
L
P
D
K
C
N
S
Site 32
S275
S
L
P
D
K
C
N
S
F
L
H
N
K
A
E
Site 33
T290
W
R
C
E
I
E
A
T
L
E
R
L
K
K
L
Site 34
S302
K
K
L
E
R
D
L
S
F
K
E
Q
E
L
K
Site 35
T323
K
M
W
E
Q
K
L
T
E
Q
S
N
T
P
L
Site 36
S326
E
Q
K
L
T
E
Q
S
N
T
P
L
L
P
S
Site 37
T328
K
L
T
E
Q
S
N
T
P
L
L
P
S
F
E
Site 38
Y345
A
W
T
E
D
D
V
Y
C
W
V
Q
Q
L
V
Site 39
S357
Q
L
V
R
K
G
D
S
S
A
E
M
S
V
Y
Site 40
S358
L
V
R
K
G
D
S
S
A
E
M
S
V
Y
A
Site 41
S362
G
D
S
S
A
E
M
S
V
Y
A
S
L
F
K
Site 42
Y364
S
S
A
E
M
S
V
Y
A
S
L
F
K
E
N
Site 43
S366
A
E
M
S
V
Y
A
S
L
F
K
E
N
N
I
Site 44
Y411
I
E
K
L
T
H
D
Y
I
N
L
F
H
F
P
Site 45
S424
F
P
P
L
I
K
D
S
G
G
E
P
E
E
N
Site 46
T477
I
T
Y
I
K
D
V
T
F
N
T
N
L
P
D
Site 47
T491
D
A
E
I
L
K
M
T
K
P
P
F
V
M
E
Site 48
T513
K
S
Q
T
V
E
C
T
V
T
Y
E
S
D
V
Site 49
T515
Q
T
V
E
C
T
V
T
Y
E
S
D
V
R
T
Site 50
S518
E
C
T
V
T
Y
E
S
D
V
R
T
P
K
S
Site 51
T522
T
Y
E
S
D
V
R
T
P
K
S
T
K
H
V
Site 52
S525
S
D
V
R
T
P
K
S
T
K
H
V
H
L
I
Site 53
T526
D
V
R
T
P
K
S
T
K
H
V
H
L
I
Q
Site 54
S557
I
Q
T
L
F
T
N
S
D
G
N
P
G
S
R
Site 55
S563
N
S
D
G
N
P
G
S
R
S
D
S
S
A
D
Site 56
S565
D
G
N
P
G
S
R
S
D
S
S
A
D
C
Q
Site 57
S567
N
P
G
S
R
S
D
S
S
A
D
C
Q
W
L
Site 58
S568
P
G
S
R
S
D
S
S
A
D
C
Q
W
L
D
Site 59
T576
A
D
C
Q
W
L
D
T
L
R
M
R
Q
I
A
Site 60
S584
L
R
M
R
Q
I
A
S
N
T
S
L
Q
R
S
Site 61
T586
M
R
Q
I
A
S
N
T
S
L
Q
R
S
Q
S
Site 62
S587
R
Q
I
A
S
N
T
S
L
Q
R
S
Q
S
N
Site 63
S591
S
N
T
S
L
Q
R
S
Q
S
N
P
I
L
G
Site 64
S593
T
S
L
Q
R
S
Q
S
N
P
I
L
G
S
P
Site 65
S599
Q
S
N
P
I
L
G
S
P
F
F
S
H
F
D
Site 66
S603
I
L
G
S
P
F
F
S
H
F
D
G
Q
D
S
Site 67
S610
S
H
F
D
G
Q
D
S
Y
A
A
A
V
R
R
Site 68
Y611
H
F
D
G
Q
D
S
Y
A
A
A
V
R
R
P
Site 69
Y624
R
P
Q
V
P
I
K
Y
Q
Q
I
T
P
V
N
Site 70
T628
P
I
K
Y
Q
Q
I
T
P
V
N
Q
S
R
S
Site 71
S633
Q
I
T
P
V
N
Q
S
R
S
S
S
P
T
Q
Site 72
S635
T
P
V
N
Q
S
R
S
S
S
P
T
Q
Y
G
Site 73
S636
P
V
N
Q
S
R
S
S
S
P
T
Q
Y
G
L
Site 74
S637
V
N
Q
S
R
S
S
S
P
T
Q
Y
G
L
T
Site 75
T639
Q
S
R
S
S
S
P
T
Q
Y
G
L
T
K
N
Site 76
Y641
R
S
S
S
P
T
Q
Y
G
L
T
K
N
F
S
Site 77
T644
S
P
T
Q
Y
G
L
T
K
N
F
S
S
L
H
Site 78
S648
Y
G
L
T
K
N
F
S
S
L
H
L
N
S
R
Site 79
S649
G
L
T
K
N
F
S
S
L
H
L
N
S
R
D
Site 80
S654
F
S
S
L
H
L
N
S
R
D
S
G
F
S
S
Site 81
S657
L
H
L
N
S
R
D
S
G
F
S
S
G
N
T
Site 82
S660
N
S
R
D
S
G
F
S
S
G
N
T
D
T
S
Site 83
S661
S
R
D
S
G
F
S
S
G
N
T
D
T
S
S
Site 84
T664
S
G
F
S
S
G
N
T
D
T
S
S
E
R
G
Site 85
T666
F
S
S
G
N
T
D
T
S
S
E
R
G
R
Y
Site 86
S667
S
S
G
N
T
D
T
S
S
E
R
G
R
Y
S
Site 87
S668
S
G
N
T
D
T
S
S
E
R
G
R
Y
S
D
Site 88
Y673
T
S
S
E
R
G
R
Y
S
D
R
S
R
N
K
Site 89
S674
S
S
E
R
G
R
Y
S
D
R
S
R
N
K
Y
Site 90
S677
R
G
R
Y
S
D
R
S
R
N
K
Y
G
R
G
Site 91
Y681
S
D
R
S
R
N
K
Y
G
R
G
S
I
S
L
Site 92
S685
R
N
K
Y
G
R
G
S
I
S
L
N
S
S
P
Site 93
S687
K
Y
G
R
G
S
I
S
L
N
S
S
P
R
G
Site 94
S690
R
G
S
I
S
L
N
S
S
P
R
G
R
Y
S
Site 95
S691
G
S
I
S
L
N
S
S
P
R
G
R
Y
S
G
Site 96
Y696
N
S
S
P
R
G
R
Y
S
G
K
S
Q
H
S
Site 97
S697
S
S
P
R
G
R
Y
S
G
K
S
Q
H
S
T
Site 98
S700
R
G
R
Y
S
G
K
S
Q
H
S
T
P
S
R
Site 99
S703
Y
S
G
K
S
Q
H
S
T
P
S
R
G
R
Y
Site 100
T704
S
G
K
S
Q
H
S
T
P
S
R
G
R
Y
P
Site 101
S706
K
S
Q
H
S
T
P
S
R
G
R
Y
P
G
K
Site 102
Y710
S
T
P
S
R
G
R
Y
P
G
K
F
Y
R
V
Site 103
Y715
G
R
Y
P
G
K
F
Y
R
V
S
Q
S
A
L
Site 104
S718
P
G
K
F
Y
R
V
S
Q
S
A
L
N
P
H
Site 105
S720
K
F
Y
R
V
S
Q
S
A
L
N
P
H
Q
S
Site 106
S727
S
A
L
N
P
H
Q
S
P
D
F
K
R
S
P
Site 107
S733
Q
S
P
D
F
K
R
S
P
R
D
L
H
Q
P
Site 108
T742
R
D
L
H
Q
P
N
T
I
P
G
M
P
L
H
Site 109
T752
G
M
P
L
H
P
E
T
D
S
R
A
S
E
E
Site 110
S754
P
L
H
P
E
T
D
S
R
A
S
E
E
D
S
Site 111
S757
P
E
T
D
S
R
A
S
E
E
D
S
K
V
S
Site 112
S761
S
R
A
S
E
E
D
S
K
V
S
E
G
G
W
Site 113
S764
S
E
E
D
S
K
V
S
E
G
G
W
T
K
V
Site 114
T769
K
V
S
E
G
G
W
T
K
V
E
Y
R
K
K
Site 115
Y773
G
G
W
T
K
V
E
Y
R
K
K
P
H
R
P
Site 116
S781
R
K
K
P
H
R
P
S
P
A
K
T
N
K
E
Site 117
T785
H
R
P
S
P
A
K
T
N
K
E
R
A
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation