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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TIF-IA
Full Name:
RNA polymerase I-specific transcription initiation factor RRN3
Alias:
DKFZp566E104; RRN3; RRN3 RNA polymerase I transcription factor; Transcription initiation factor IA
Type:
Transcription regulation protein
Mass (Da):
74107
Number AA:
651
UniProt ID:
Q9NYV6
International Prot ID:
IPI00152960
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003701
GO:0030528
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
G
D
A
A
A
S
S
S
A
V
K
K
L
G
A
Site 2
S27
A
V
K
K
L
G
A
S
R
T
G
I
S
N
M
Site 3
T29
K
K
L
G
A
S
R
T
G
I
S
N
M
R
A
Site 4
S44
L
E
N
D
F
F
N
S
P
P
R
K
T
V
R
Site 5
T49
F
N
S
P
P
R
K
T
V
R
F
G
G
T
V
Site 6
Y63
V
T
E
V
L
L
K
Y
K
K
G
E
T
N
D
Site 7
S98
W
L
L
E
F
R
S
S
I
M
Y
L
T
K
D
Site 8
Y101
E
F
R
S
S
I
M
Y
L
T
K
D
F
E
Q
Site 9
S122
R
L
P
W
L
N
R
S
Q
T
V
V
E
E
Y
Site 10
T124
P
W
L
N
R
S
Q
T
V
V
E
E
Y
L
A
Site 11
S170
K
E
G
D
V
D
V
S
D
S
D
D
E
D
D
Site 12
S172
G
D
V
D
V
S
D
S
D
D
E
D
D
N
L
Site 13
S199
I
I
A
R
Y
V
P
S
T
P
W
F
L
M
P
Site 14
T200
I
A
R
Y
V
P
S
T
P
W
F
L
M
P
I
Site 15
S218
K
F
P
F
V
R
K
S
E
R
T
L
E
C
Y
Site 16
T221
F
V
R
K
S
E
R
T
L
E
C
Y
V
H
N
Site 17
Y225
S
E
R
T
L
E
C
Y
V
H
N
L
L
R
I
Site 18
S233
V
H
N
L
L
R
I
S
V
Y
F
P
T
L
R
Site 19
Y235
N
L
L
R
I
S
V
Y
F
P
T
L
R
H
E
Site 20
T271
E
D
A
E
E
T
A
T
Q
T
C
G
G
T
D
Site 21
S279
Q
T
C
G
G
T
D
S
T
E
G
L
F
N
M
Site 22
T280
T
C
G
G
T
D
S
T
E
G
L
F
N
M
D
Site 23
T292
N
M
D
E
D
E
E
T
E
H
E
T
K
A
G
Site 24
S319
E
R
L
D
I
L
M
S
L
V
L
S
Y
M
K
Site 25
Y330
S
Y
M
K
D
V
C
Y
V
D
G
K
V
D
N
Site 26
Y344
N
G
K
T
K
D
L
Y
R
D
L
I
N
I
F
Site 27
Y436
L
V
N
W
L
H
I
Y
L
N
N
Q
D
S
G
Site 28
S476
F
R
H
K
Q
L
L
S
G
N
L
K
E
G
L
Site 29
Y485
N
L
K
E
G
L
Q
Y
L
Q
S
L
N
F
E
Site 30
S488
E
G
L
Q
Y
L
Q
S
L
N
F
E
R
I
V
Site 31
S497
N
F
E
R
I
V
M
S
Q
L
N
P
L
K
I
Site 32
S548
R
S
T
A
G
G
D
S
V
Q
I
C
T
N
P
Site 33
Y578
K
K
F
I
D
P
I
Y
Q
V
W
E
D
M
S
Site 34
T618
G
E
V
P
Q
N
D
T
V
I
G
I
T
P
S
Site 35
T623
N
D
T
V
I
G
I
T
P
S
S
F
D
T
H
Site 36
S625
T
V
I
G
I
T
P
S
S
F
D
T
H
F
R
Site 37
S626
V
I
G
I
T
P
S
S
F
D
T
H
F
R
S
Site 38
T629
I
T
P
S
S
F
D
T
H
F
R
S
P
S
S
Site 39
S633
S
F
D
T
H
F
R
S
P
S
S
S
V
G
S
Site 40
S635
D
T
H
F
R
S
P
S
S
S
V
G
S
P
P
Site 41
S636
T
H
F
R
S
P
S
S
S
V
G
S
P
P
V
Site 42
S637
H
F
R
S
P
S
S
S
V
G
S
P
P
V
L
Site 43
S640
S
P
S
S
S
V
G
S
P
P
V
L
Y
M
Q
Site 44
S649
P
V
L
Y
M
Q
P
S
P
L
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation