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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IMP-1
Full Name:
Insulin-like growth factor 2 mRNA-binding protein 1
Alias:
Coding region determinant-binding protein; CRDBP; CRD-BP; IF2B1; IGF II mRNA binding protein 1; IGF-II mRNA-binding protein 1; IMP1; Insulin-like growth factor 2 mRNA binding protein 1; MRNA-binding protein CRDBP; Oncofetal protein ZBP1; VICKZ family member 1; VICKZ1; ZBP1; Zip code-binding protein 1
Type:
Translation
Mass (Da):
63456
Number AA:
577
UniProt ID:
Q9NZI8
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070937
GO:0005634
GO:0010494
Uniprot
OncoNet
Molecular Function:
GO:0048027
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0070934
GO:0017148
GO:0042035
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Y
I
G
N
L
N
E
S
V
T
P
A
D
L
E
Site 2
T14
G
N
L
N
E
S
V
T
P
A
D
L
E
K
V
Site 3
Y39
Q
F
L
V
K
S
G
Y
A
F
V
D
C
P
D
Site 4
S58
M
K
A
I
E
T
F
S
G
K
V
E
L
Q
G
Site 5
S73
K
R
L
E
I
E
H
S
V
P
K
K
Q
R
S
Site 6
T115
E
N
C
E
Q
V
N
T
E
S
E
T
A
V
V
Site 7
S127
A
V
V
N
V
T
Y
S
N
R
E
Q
T
R
Q
Site 8
T132
T
Y
S
N
R
E
Q
T
R
Q
A
I
M
K
L
Site 9
S173
G
R
R
G
G
F
G
S
R
G
Q
P
R
Q
G
Site 10
S181
R
G
Q
P
R
Q
G
S
P
V
A
A
G
A
P
Site 11
T222
G
A
T
I
R
N
I
T
K
Q
T
Q
S
K
I
Site 12
S245
G
A
A
E
K
A
I
S
V
H
S
T
P
E
G
Site 13
S248
E
K
A
I
S
V
H
S
T
P
E
G
C
S
S
Site 14
T249
K
A
I
S
V
H
S
T
P
E
G
C
S
S
A
Site 15
S255
S
T
P
E
G
C
S
S
A
C
K
M
I
L
E
Site 16
T271
M
H
K
E
A
K
D
T
K
T
A
D
E
V
P
Site 17
T273
K
E
A
K
D
T
K
T
A
D
E
V
P
L
K
Site 18
T281
A
D
E
V
P
L
K
T
L
A
H
N
N
F
V
Site 19
T308
K
V
E
Q
D
T
E
T
K
I
T
I
S
S
L
Site 20
T311
Q
D
T
E
T
K
I
T
I
S
S
L
Q
D
L
Site 21
S314
E
T
K
I
T
I
S
S
L
Q
D
L
T
L
Y
Site 22
T319
I
S
S
L
Q
D
L
T
L
Y
N
P
E
R
T
Site 23
Y321
S
L
Q
D
L
T
L
Y
N
P
E
R
T
I
T
Site 24
T326
T
L
Y
N
P
E
R
T
I
T
V
K
G
A
I
Site 25
T328
Y
N
P
E
R
T
I
T
V
K
G
A
I
E
N
Site 26
Y351
M
K
K
V
R
E
A
Y
E
N
D
V
A
A
M
Site 27
S359
E
N
D
V
A
A
M
S
L
Q
S
H
L
T
P
Site 28
S381
G
L
F
P
A
S
S
S
A
V
P
P
P
P
S
Site 29
S388
S
A
V
P
P
P
P
S
S
V
T
G
A
A
P
Site 30
S389
A
V
P
P
P
P
S
S
V
T
G
A
A
P
Y
Site 31
Y396
S
V
T
G
A
A
P
Y
S
S
F
M
Q
A
P
Site 32
S397
V
T
G
A
A
P
Y
S
S
F
M
Q
A
P
E
Site 33
S398
T
G
A
A
P
Y
S
S
F
M
Q
A
P
E
Q
Site 34
S432
G
Q
H
I
K
Q
L
S
R
F
A
S
A
S
I
Site 35
S436
K
Q
L
S
R
F
A
S
A
S
I
K
I
A
P
Site 36
S438
L
S
R
F
A
S
A
S
I
K
I
A
P
P
E
Site 37
T446
I
K
I
A
P
P
E
T
P
D
S
K
V
R
M
Site 38
S449
A
P
P
E
T
P
D
S
K
V
R
M
V
I
I
Site 39
Y471
F
K
A
Q
G
R
I
Y
G
K
L
K
E
E
N
Site 40
T509
V
I
G
K
G
G
K
T
V
N
E
L
Q
N
L
Site 41
T528
V
V
V
P
R
D
Q
T
P
D
E
N
D
Q
V
Site 42
Y544
V
K
I
I
G
H
F
Y
A
S
Q
M
A
Q
R
Site 43
S546
I
I
G
H
F
Y
A
S
Q
M
A
Q
R
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation