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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DARPP-32
Full Name:
Dopamine- and cAMP-regulated neuronal phosphoprotein 32 KDa protein
Alias:
Dopamine and cAMP regulated phosphoprotein; Dopamine- and cAMP-regulated neuronal phosphoprotein; FLJ20940; IPPD; Neuronal phosphoprotein DARPP-32; PPP1R1B; PPR1B; Protein phosphatase 1, regulatory (inhibitor) subunit 1B
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
22963
Number AA:
204
UniProt ID:
Q9UD71
International Prot ID:
IPI00003363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004864
GO:0004860
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
D
R
K
K
I
Q
F
S
V
P
A
P
P
S
Q
Site 2
S18
F
S
V
P
A
P
P
S
Q
L
D
P
R
Q
V
Site 3
T34
M
I
R
R
R
R
P
T
P
A
M
L
F
R
L
Site 4
S42
P
A
M
L
F
R
L
S
E
H
S
S
P
E
E
Site 5
S45
L
F
R
L
S
E
H
S
S
P
E
E
E
A
S
Site 6
S46
F
R
L
S
E
H
S
S
P
E
E
E
A
S
P
Site 7
S52
S
S
P
E
E
E
A
S
P
H
Q
R
A
S
G
Site 8
S58
A
S
P
H
Q
R
A
S
G
E
G
H
H
L
K
Site 9
S66
G
E
G
H
H
L
K
S
K
R
P
N
P
C
A
Site 10
Y74
K
R
P
N
P
C
A
Y
T
P
P
S
L
K
A
Site 11
T75
R
P
N
P
C
A
Y
T
P
P
S
L
K
A
V
Site 12
S78
P
C
A
Y
T
P
P
S
L
K
A
V
Q
R
I
Site 13
S88
A
V
Q
R
I
A
E
S
H
L
Q
S
I
S
N
Site 14
S92
I
A
E
S
H
L
Q
S
I
S
N
L
N
E
N
Site 15
S102
N
L
N
E
N
Q
A
S
E
E
E
D
E
L
G
Site 16
Y116
G
E
L
R
E
L
G
Y
P
R
E
E
D
E
E
Site 17
S137
E
E
E
E
E
E
D
S
Q
A
E
V
L
K
V
Site 18
S148
V
L
K
V
I
R
Q
S
A
G
Q
K
T
T
C
Site 19
T153
R
Q
S
A
G
Q
K
T
T
C
G
Q
G
L
E
Site 20
S172
R
P
P
P
L
D
E
S
E
R
D
G
G
S
E
Site 21
S188
Q
V
E
D
P
A
L
S
E
P
G
E
E
P
Q
Site 22
S198
G
E
E
P
Q
R
P
S
P
S
E
P
G
T
_
Site 23
S200
E
P
Q
R
P
S
P
S
E
P
G
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation