KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
STK39
Full Name:
STE20/SPS1-related proline-alanine-rich protein kinase
Alias:
DCHT; EC 2.7.11.1; Serine threonine kinase 39; Serine/threonine-protein kinase 39; SPAK; Ste-20 related kinase; STE20/SPS1-related proline-alanine rich protein kinase
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
STE
group; STE20 family; FRAY subfamily
Mass (Da):
59642
Number AA:
547
UniProt ID:
Q9UEW8
International Prot ID:
IPI00004363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004702
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
SLC12A2 (198-217) KinSub - SLC12A2-derived peptide substrate; CATCHtide protein kinase substrate peptide - Powder PE-01ADS95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADS95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
E
P
S
G
S
P
V
H
V
Q
L
P
Site 2
Y65
W
P
I
C
R
D
A
Y
E
L
Q
E
V
I
G
Site 3
T103
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
Site 4
S104
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
Site 5
S116
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
Site 6
Y126
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
Site 7
Y127
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
Site 8
Y154
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
Site 9
Y184
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
Site 10
T233
T
R
N
K
V
R
K
T
F
V
G
T
P
C
W
Site 11
T237
V
R
K
T
F
V
G
T
P
C
W
M
A
P
E
Site 12
Y252
V
M
E
Q
V
R
G
Y
D
F
K
A
D
M
W
Site 13
Y278
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
Site 14
T287
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
T
Site 15
T294
T
L
Q
N
D
P
P
T
L
E
T
G
V
E
D
Site 16
Y308
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
Site 17
S311
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
Site 18
S317
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
Site 19
S325
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
Site 20
T329
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
Site 21
Y347
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
T
Site 22
T354
Y
L
I
E
K
L
L
T
R
T
P
D
I
A
Q
Site 23
T356
I
E
K
L
L
T
R
T
P
D
I
A
Q
R
A
Site 24
S372
K
V
R
R
V
P
G
S
S
G
H
L
H
K
T
Site 25
S373
V
R
R
V
P
G
S
S
G
H
L
H
K
T
E
Site 26
S387
E
D
G
D
W
E
W
S
D
D
E
M
D
E
K
Site 27
S395
D
D
E
M
D
E
K
S
E
E
G
K
A
A
F
Site 28
S403
E
E
G
K
A
A
F
S
Q
E
K
S
R
R
V
Site 29
S407
A
A
F
S
Q
E
K
S
R
R
V
K
E
E
N
Site 30
S420
E
N
P
E
I
A
V
S
A
S
T
I
P
E
Q
Site 31
S430
T
I
P
E
Q
I
Q
S
L
S
V
H
D
S
Q
Site 32
S432
P
E
Q
I
Q
S
L
S
V
H
D
S
Q
G
P
Site 33
S436
Q
S
L
S
V
H
D
S
Q
G
P
P
N
A
N
Site 34
Y446
P
P
N
A
N
E
D
Y
R
E
A
S
S
C
A
Site 35
S450
N
E
D
Y
R
E
A
S
S
C
A
V
N
L
V
Site 36
S463
L
V
L
R
L
R
N
S
R
K
E
L
N
D
I
Site 37
T475
N
D
I
R
F
E
F
T
P
G
R
D
T
A
D
Site 38
T480
E
F
T
P
G
R
D
T
A
D
G
V
S
Q
E
Site 39
S485
R
D
T
A
D
G
V
S
Q
E
L
F
S
A
G
Site 40
T518
D
D
P
K
A
L
K
T
L
T
F
K
L
A
S
Site 41
S530
L
A
S
G
C
D
G
S
E
I
P
D
E
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation