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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADD3
Full Name:
ISOFORM 2 OF GAMMA-ADDUCIN.
Alias:
ADDG; ADDL; adducin 3 (gamma); adducin, gamma; adducin-like protein 70; gamma adducin; protein kinase C binding protein 35H
Type:
Cytoskeletal protein
Mass (Da):
79155
Number AA:
706
UniProt ID:
Q9UEY8
International Prot ID:
IPI00004408
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005516
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
D
A
S
Q
G
V
Site 2
S3
_
_
_
_
_
M
S
S
D
A
S
Q
G
V
I
Site 3
S6
_
_
M
S
S
D
A
S
Q
G
V
I
T
T
P
Site 4
T11
D
A
S
Q
G
V
I
T
T
P
P
P
P
S
M
Site 5
T12
A
S
Q
G
V
I
T
T
P
P
P
P
S
M
P
Site 6
S17
I
T
T
P
P
P
P
S
M
P
H
K
E
R
Y
Site 7
Y24
S
M
P
H
K
E
R
Y
F
D
R
I
N
E
N
Site 8
Y35
I
N
E
N
D
P
E
Y
I
R
E
R
N
M
S
Site 9
S42
Y
I
R
E
R
N
M
S
P
D
L
R
Q
D
F
Site 10
T59
M
E
Q
R
K
R
V
T
Q
I
L
Q
S
P
A
Site 11
S64
R
V
T
Q
I
L
Q
S
P
A
F
R
E
D
L
Site 12
S102
A
D
Y
I
M
A
N
S
F
S
G
F
S
S
P
Site 13
S107
A
N
S
F
S
G
F
S
S
P
P
L
S
L
G
Site 14
S108
N
S
F
S
G
F
S
S
P
P
L
S
L
G
M
Site 15
T127
N
D
L
P
G
A
D
T
S
S
Y
V
K
G
E
Site 16
S128
D
L
P
G
A
D
T
S
S
Y
V
K
G
E
K
Site 17
S129
L
P
G
A
D
T
S
S
Y
V
K
G
E
K
L
Site 18
Y130
P
G
A
D
T
S
S
Y
V
K
G
E
K
L
T
Site 19
Y160
W
A
H
L
A
N
T
Y
I
S
V
R
I
S
K
Site 20
S162
H
L
A
N
T
Y
I
S
V
R
I
S
K
E
Q
Site 21
S166
T
Y
I
S
V
R
I
S
K
E
Q
D
H
I
I
Site 22
S180
I
I
I
P
R
G
L
S
F
S
E
A
T
A
S
Site 23
S182
I
P
R
G
L
S
F
S
E
A
T
A
S
N
L
Site 24
S187
S
F
S
E
A
T
A
S
N
L
V
K
V
N
I
Site 25
S203
G
E
V
V
D
Q
G
S
T
N
L
K
I
D
H
Site 26
T211
T
N
L
K
I
D
H
T
G
F
S
P
H
A
A
Site 27
S214
K
I
D
H
T
G
F
S
P
H
A
A
I
Y
S
Site 28
S221
S
P
H
A
A
I
Y
S
T
R
P
D
V
K
C
Site 29
Y263
L
L
G
D
V
A
Y
Y
D
Y
Q
G
S
L
E
Site 30
Y265
G
D
V
A
Y
Y
D
Y
Q
G
S
L
E
E
Q
Site 31
S268
A
Y
Y
D
Y
Q
G
S
L
E
E
Q
E
E
R
Site 32
Y341
H
V
L
D
F
Q
K
Y
K
A
F
T
Y
T
V
Site 33
Y346
Q
K
Y
K
A
F
T
Y
T
V
A
A
S
G
G
Site 34
T347
K
Y
K
A
F
T
Y
T
V
A
A
S
G
G
G
Site 35
S360
G
G
G
V
N
M
G
S
H
Q
K
W
K
V
G
Site 36
T377
E
F
E
G
L
M
R
T
L
D
N
L
G
Y
R
Site 37
Y383
R
T
L
D
N
L
G
Y
R
T
G
Y
A
Y
R
Site 38
Y387
N
L
G
Y
R
T
G
Y
A
Y
R
H
P
L
I
Site 39
Y389
G
Y
R
T
G
Y
A
Y
R
H
P
L
I
R
E
Site 40
S402
R
E
K
P
R
H
K
S
D
V
E
I
P
A
T
Site 41
T409
S
D
V
E
I
P
A
T
V
T
A
F
S
F
E
Site 42
S414
P
A
T
V
T
A
F
S
F
E
D
D
T
V
P
Site 43
T419
A
F
S
F
E
D
D
T
V
P
L
S
P
L
K
Site 44
S423
E
D
D
T
V
P
L
S
P
L
K
Y
M
A
Q
Site 45
Y427
V
P
L
S
P
L
K
Y
M
A
Q
R
Q
Q
R
Site 46
T437
Q
R
Q
Q
R
E
K
T
R
W
L
N
S
P
N
Site 47
S442
E
K
T
R
W
L
N
S
P
N
T
Y
M
K
V
Site 48
T445
R
W
L
N
S
P
N
T
Y
M
K
V
N
V
P
Site 49
Y446
W
L
N
S
P
N
T
Y
M
K
V
N
V
P
E
Site 50
S455
K
V
N
V
P
E
E
S
R
N
G
E
T
S
P
Site 51
T460
E
E
S
R
N
G
E
T
S
P
R
T
K
I
T
Site 52
S461
E
S
R
N
G
E
T
S
P
R
T
K
I
T
W
Site 53
S474
T
W
M
K
A
E
D
S
S
K
V
S
G
G
T
Site 54
S475
W
M
K
A
E
D
S
S
K
V
S
G
G
T
P
Site 55
S478
A
E
D
S
S
K
V
S
G
G
T
P
I
K
I
Site 56
T481
S
S
K
V
S
G
G
T
P
I
K
I
E
D
P
Site 57
Y514
K
I
R
E
Q
N
R
Y
D
L
K
T
A
G
P
Site 58
T518
Q
N
R
Y
D
L
K
T
A
G
P
Q
S
Q
L
Site 59
S536
I
V
V
D
K
P
P
S
T
M
Q
F
E
D
D
Site 60
S555
P
A
P
P
N
P
F
S
H
L
T
E
G
E
L
Site 61
Y565
T
E
G
E
L
E
E
Y
K
R
T
I
E
R
K
Site 62
T568
E
L
E
E
Y
K
R
T
I
E
R
K
Q
Q
G
Site 63
S585
D
A
E
Q
E
L
L
S
D
D
A
S
S
V
S
Site 64
S589
E
L
L
S
D
D
A
S
S
V
S
Q
I
Q
S
Site 65
S590
L
L
S
D
D
A
S
S
V
S
Q
I
Q
S
Q
Site 66
S592
S
D
D
A
S
S
V
S
Q
I
Q
S
Q
T
Q
Site 67
S596
S
S
V
S
Q
I
Q
S
Q
T
Q
S
P
Q
N
Site 68
T598
V
S
Q
I
Q
S
Q
T
Q
S
P
Q
N
V
P
Site 69
S600
Q
I
Q
S
Q
T
Q
S
P
Q
N
V
P
E
K
Site 70
S618
N
H
E
L
F
S
K
S
F
I
S
M
E
V
P
Site 71
S621
L
F
S
K
S
F
I
S
M
E
V
P
V
M
V
Site 72
S647
D
E
L
A
K
R
V
S
R
L
S
T
S
T
T
Site 73
S650
A
K
R
V
S
R
L
S
T
S
T
T
I
E
N
Site 74
T651
K
R
V
S
R
L
S
T
S
T
T
I
E
N
I
Site 75
S652
R
V
S
R
L
S
T
S
T
T
I
E
N
I
E
Site 76
T654
S
R
L
S
T
S
T
T
I
E
N
I
E
I
T
Site 77
S664
N
I
E
I
T
I
K
S
P
E
K
I
E
E
V
Site 78
S673
E
K
I
E
E
V
L
S
P
E
G
S
P
S
K
Site 79
S677
E
V
L
S
P
E
G
S
P
S
K
S
P
S
K
Site 80
S679
L
S
P
E
G
S
P
S
K
S
P
S
K
K
K
Site 81
S681
P
E
G
S
P
S
K
S
P
S
K
K
K
K
K
Site 82
S683
G
S
P
S
K
S
P
S
K
K
K
K
K
F
R
Site 83
T691
K
K
K
K
K
F
R
T
P
S
F
L
K
K
N
Site 84
S693
K
K
K
F
R
T
P
S
F
L
K
K
N
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation