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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLL
Full Name:
DNA polymerase lambda
Alias:
BETA-N; DNA polymerase beta-2; DNA polymerase kappa; DPOLL; EC 2.7.7.7; EC 4.2.99.-; Pol beta2; Pol-kappa; Polymerase (DNA directed), lambda
Type:
DNA repair, Lyase, Transferase
Mass (Da):
63482
Number AA:
575
UniProt ID:
Q9UGP5
International Prot ID:
IPI00002284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003887
GO:0016829
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0006289
GO:0016446
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
E
E
A
E
E
W
L
S
S
L
R
A
H
V
V
Site 2
S43
E
A
E
E
W
L
S
S
L
R
A
H
V
V
R
Site 3
Y91
V
V
D
E
G
M
D
Y
E
R
A
L
R
L
L
Site 4
S116
L
V
K
S
A
W
L
S
L
C
L
Q
E
R
R
Site 5
S136
G
F
S
I
F
I
P
S
R
Y
L
D
H
P
Q
Site 6
Y138
S
I
F
I
P
S
R
Y
L
D
H
P
Q
P
S
Site 7
S152
S
K
A
E
Q
D
A
S
I
P
P
G
T
H
E
Site 8
S167
A
L
L
Q
T
A
L
S
P
P
P
P
P
T
R
Site 9
T173
L
S
P
P
P
P
P
T
R
P
V
S
P
P
Q
Site 10
S177
P
P
P
T
R
P
V
S
P
P
Q
K
A
K
E
Site 11
T188
K
A
K
E
A
P
N
T
Q
A
Q
P
I
S
D
Site 12
S194
N
T
Q
A
Q
P
I
S
D
D
E
A
S
D
G
Site 13
S199
P
I
S
D
D
E
A
S
D
G
E
E
T
Q
V
Site 14
S207
D
G
E
E
T
Q
V
S
A
A
D
L
E
A
L
Site 15
Y219
E
A
L
I
S
G
H
Y
P
T
S
L
E
G
D
Site 16
S222
I
S
G
H
Y
P
T
S
L
E
G
D
C
E
P
Site 17
S230
L
E
G
D
C
E
P
S
P
A
P
A
V
L
D
Site 18
S246
W
V
C
A
Q
P
S
S
Q
K
A
T
N
H
N
Site 19
T250
Q
P
S
S
Q
K
A
T
N
H
N
L
H
I
T
Site 20
S268
E
V
L
A
K
A
Y
S
V
Q
G
D
K
W
R
Site 21
S288
K
A
I
N
A
L
K
S
F
H
K
P
V
T
S
Site 22
S295
S
F
H
K
P
V
T
S
Y
Q
E
A
C
S
I
Site 23
S301
T
S
Y
Q
E
A
C
S
I
P
G
I
G
K
R
Site 24
S319
K
I
I
E
I
L
E
S
G
H
L
R
K
L
D
Site 25
S329
L
R
K
L
D
H
I
S
E
S
V
P
V
L
E
Site 26
Y353
T
K
T
A
Q
M
W
Y
Q
Q
G
F
R
S
L
Site 27
S359
W
Y
Q
Q
G
F
R
S
L
E
D
I
R
S
Q
Site 28
S365
R
S
L
E
D
I
R
S
Q
A
S
L
T
T
Q
Site 29
S368
E
D
I
R
S
Q
A
S
L
T
T
Q
Q
A
I
Site 30
Y380
Q
A
I
G
L
K
H
Y
S
D
F
L
E
R
M
Site 31
S381
A
I
G
L
K
H
Y
S
D
F
L
E
R
M
P
Site 32
T398
E
A
T
E
I
E
Q
T
V
Q
K
A
A
Q
A
Site 33
T424
S
Y
R
R
G
K
A
T
C
G
D
V
D
V
L
Site 34
S439
I
T
H
P
D
G
R
S
H
R
G
I
F
S
R
Site 35
S445
R
S
H
R
G
I
F
S
R
L
L
D
S
L
R
Site 36
T458
L
R
Q
E
G
F
L
T
D
D
L
V
S
Q
E
Site 37
S463
F
L
T
D
D
L
V
S
Q
E
E
N
G
Q
Q
Site 38
Y473
E
N
G
Q
Q
Q
K
Y
L
G
V
C
R
L
P
Site 39
S515
G
S
A
H
F
N
R
S
M
R
A
L
A
K
T
Site 40
T522
S
M
R
A
L
A
K
T
K
G
M
S
L
S
E
Site 41
S526
L
A
K
T
K
G
M
S
L
S
E
H
A
L
S
Site 42
S528
K
T
K
G
M
S
L
S
E
H
A
L
S
T
A
Site 43
S533
S
L
S
E
H
A
L
S
T
A
V
V
R
N
T
Site 44
T540
S
T
A
V
V
R
N
T
H
G
C
K
V
G
P
Site 45
T553
G
P
G
R
V
L
P
T
P
T
E
K
D
V
F
Site 46
Y567
F
R
L
L
G
L
P
Y
R
E
P
A
E
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation