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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKLN1
Full Name:
Muskelin
Alias:
Muskelin 1, intracellular mediator containing kelch motifs; TWA2
Type:
Adhesion
Mass (Da):
84749
Number AA:
735
UniProt ID:
Q9UL63
International Prot ID:
IPI00783648
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
P
E
C
R
L
L
P
Y
A
L
H
K
W
S
S
Site 2
S24
P
Y
A
L
H
K
W
S
S
F
S
S
T
Y
L
Site 3
S25
Y
A
L
H
K
W
S
S
F
S
S
T
Y
L
P
Site 4
S27
L
H
K
W
S
S
F
S
S
T
Y
L
P
E
N
Site 5
S28
H
K
W
S
S
F
S
S
T
Y
L
P
E
N
I
Site 6
T29
K
W
S
S
F
S
S
T
Y
L
P
E
N
I
L
Site 7
S44
V
D
K
P
N
D
Q
S
S
R
W
S
S
E
S
Site 8
S45
D
K
P
N
D
Q
S
S
R
W
S
S
E
S
N
Site 9
S48
N
D
Q
S
S
R
W
S
S
E
S
N
Y
P
P
Site 10
S49
D
Q
S
S
R
W
S
S
E
S
N
Y
P
P
Q
Site 11
S51
S
S
R
W
S
S
E
S
N
Y
P
P
Q
Y
L
Site 12
Y53
R
W
S
S
E
S
N
Y
P
P
Q
Y
L
I
L
Site 13
Y57
E
S
N
Y
P
P
Q
Y
L
I
L
K
L
E
R
Site 14
T72
P
A
I
V
Q
N
I
T
F
G
K
Y
E
K
T
Site 15
Y76
Q
N
I
T
F
G
K
Y
E
K
T
H
V
C
N
Site 16
T79
T
F
G
K
Y
E
K
T
H
V
C
N
L
K
K
Site 17
T99
G
M
N
E
E
N
M
T
E
L
L
S
S
G
L
Site 18
S104
N
M
T
E
L
L
S
S
G
L
K
N
D
Y
N
Site 19
Y110
S
S
G
L
K
N
D
Y
N
K
E
T
F
T
L
Site 20
S153
S
I
W
Y
V
E
L
S
G
I
D
D
P
D
I
Site 21
Y171
C
L
N
W
Y
S
K
Y
R
E
Q
E
A
I
R
Site 22
Y189
K
H
F
R
Q
H
N
Y
T
E
A
F
E
S
L
Site 23
T190
H
F
R
Q
H
N
Y
T
E
A
F
E
S
L
Q
Site 24
S195
N
Y
T
E
A
F
E
S
L
Q
K
K
T
K
I
Site 25
Y241
N
D
G
L
F
N
Q
Y
I
S
Q
Q
E
Y
K
Site 26
S243
G
L
F
N
Q
Y
I
S
Q
Q
E
Y
K
P
R
Site 27
Y247
Q
Y
I
S
Q
Q
E
Y
K
P
R
W
S
Q
I
Site 28
S252
Q
E
Y
K
P
R
W
S
Q
I
I
P
K
S
T
Site 29
S258
W
S
Q
I
I
P
K
S
T
K
G
D
G
E
D
Site 30
Y286
D
V
Q
T
E
T
V
Y
L
F
G
G
W
D
G
Site 31
T311
S
V
K
E
N
Q
W
T
C
I
S
R
D
T
E
Site 32
T317
W
T
C
I
S
R
D
T
E
K
E
N
G
P
S
Site 33
S324
T
E
K
E
N
G
P
S
A
R
S
C
H
K
M
Site 34
Y341
D
I
Q
R
R
Q
I
Y
T
L
G
R
Y
L
D
Site 35
T342
I
Q
R
R
Q
I
Y
T
L
G
R
Y
L
D
S
Site 36
Y346
Q
I
Y
T
L
G
R
Y
L
D
S
S
V
R
N
Site 37
S349
T
L
G
R
Y
L
D
S
S
V
R
N
S
K
S
Site 38
S350
L
G
R
Y
L
D
S
S
V
R
N
S
K
S
L
Site 39
S354
L
D
S
S
V
R
N
S
K
S
L
K
S
D
F
Site 40
S356
S
S
V
R
N
S
K
S
L
K
S
D
F
Y
R
Site 41
S359
R
N
S
K
S
L
K
S
D
F
Y
R
Y
D
I
Site 42
Y362
K
S
L
K
S
D
F
Y
R
Y
D
I
D
T
N
Site 43
Y364
L
K
S
D
F
Y
R
Y
D
I
D
T
N
T
W
Site 44
T370
R
Y
D
I
D
T
N
T
W
M
L
L
S
E
D
Site 45
T378
W
M
L
L
S
E
D
T
A
A
D
G
G
P
K
Site 46
Y402
D
S
E
K
H
M
I
Y
T
F
G
G
R
I
L
Site 47
T403
S
E
K
H
M
I
Y
T
F
G
G
R
I
L
T
Site 48
T410
T
F
G
G
R
I
L
T
C
N
G
S
V
D
D
Site 49
S414
R
I
L
T
C
N
G
S
V
D
D
S
R
A
S
Site 50
S418
C
N
G
S
V
D
D
S
R
A
S
E
P
Q
F
Site 51
S421
S
V
D
D
S
R
A
S
E
P
Q
F
S
G
L
Site 52
S426
R
A
S
E
P
Q
F
S
G
L
F
A
F
N
C
Site 53
S445
W
K
L
L
R
E
D
S
C
N
A
G
P
E
D
Site 54
Y471
H
S
K
N
R
C
L
Y
V
F
G
G
Q
R
S
Site 55
T480
F
G
G
Q
R
S
K
T
Y
L
N
D
F
F
S
Site 56
Y481
G
G
Q
R
S
K
T
Y
L
N
D
F
F
S
Y
Site 57
Y488
Y
L
N
D
F
F
S
Y
D
V
D
S
D
H
V
Site 58
S492
F
F
S
Y
D
V
D
S
D
H
V
D
I
I
S
Site 59
S499
S
D
H
V
D
I
I
S
D
G
T
K
K
D
S
Site 60
T502
V
D
I
I
S
D
G
T
K
K
D
S
G
M
V
Site 61
S506
S
D
G
T
K
K
D
S
G
M
V
P
M
T
G
Site 62
T515
M
V
P
M
T
G
F
T
Q
R
A
T
I
D
P
Site 63
T519
T
G
F
T
Q
R
A
T
I
D
P
E
L
N
E
Site 64
S531
L
N
E
I
H
V
L
S
G
L
S
K
D
K
E
Site 65
Y551
V
R
N
S
F
W
I
Y
D
I
V
R
N
S
W
Site 66
S575
A
K
D
N
P
T
K
S
L
Q
E
E
E
P
C
Site 67
Y591
R
F
A
H
Q
L
V
Y
D
E
L
H
K
V
H
Site 68
Y599
D
E
L
H
K
V
H
Y
L
F
G
G
N
P
G
Site 69
S608
F
G
G
N
P
G
K
S
C
S
P
K
M
R
L
Site 70
S610
G
N
P
G
K
S
C
S
P
K
M
R
L
D
D
Site 71
S620
M
R
L
D
D
F
W
S
L
K
L
C
R
P
S
Site 72
S627
S
L
K
L
C
R
P
S
K
D
Y
L
L
R
H
Site 73
Y630
L
C
R
P
S
K
D
Y
L
L
R
H
C
K
Y
Site 74
Y637
Y
L
L
R
H
C
K
Y
L
I
R
K
H
R
F
Site 75
S654
K
A
Q
V
D
P
L
S
A
L
K
Y
L
Q
N
Site 76
Y658
D
P
L
S
A
L
K
Y
L
Q
N
D
L
Y
I
Site 77
Y664
K
Y
L
Q
N
D
L
Y
I
T
V
D
H
S
D
Site 78
T666
L
Q
N
D
L
Y
I
T
V
D
H
S
D
P
E
Site 79
S670
L
Y
I
T
V
D
H
S
D
P
E
E
T
K
E
Site 80
S698
D
F
T
A
L
G
F
S
D
V
D
H
T
Y
A
Site 81
T703
G
F
S
D
V
D
H
T
Y
A
Q
R
T
Q
L
Site 82
Y704
F
S
D
V
D
H
T
Y
A
Q
R
T
Q
L
F
Site 83
T713
Q
R
T
Q
L
F
D
T
L
V
N
F
F
P
D
Site 84
S721
L
V
N
F
F
P
D
S
M
T
P
P
K
G
N
Site 85
T723
N
F
F
P
D
S
M
T
P
P
K
G
N
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation