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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DAPP1
Full Name:
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Alias:
3' phosphoinositide-interacting SH2 domain containing protein; B lymphocyte adapter protein Bam32; B lymphocyte adapter protein BAM32; Bam32; B-cell adapter molecule of 32 kDa; Dual adapter for phosphotyrosine and 3-phosphoinositides; Dual adaptor for phosphotyrosine and 3-phosphoinositides 1; Dual adaptor of phosphotyrosine and 3-phosphoinositides; PHISH
Type:
Adapter/scaffold protein
Mass (Da):
32194
Number AA:
280
UniProt ID:
Q9UN19
International Prot ID:
IPI00004301
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005543
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
L
L
E
G
K
M
S
T
Q
D
P
S
D
L
Site 2
T13
L
L
E
G
K
M
S
T
Q
D
P
S
D
L
W
Site 3
S17
K
M
S
T
Q
D
P
S
D
L
W
S
R
S
D
Site 4
S21
Q
D
P
S
D
L
W
S
R
S
D
G
E
A
E
Site 5
S23
P
S
D
L
W
S
R
S
D
G
E
A
E
L
L
Site 6
S57
L
S
N
G
C
D
G
S
Y
L
L
R
D
S
N
Site 7
Y58
S
N
G
C
D
G
S
Y
L
L
R
D
S
N
E
Site 8
S63
G
S
Y
L
L
R
D
S
N
E
T
T
G
L
Y
Site 9
T67
L
R
D
S
N
E
T
T
G
L
Y
S
L
S
V
Site 10
S71
N
E
T
T
G
L
Y
S
L
S
V
R
A
K
D
Site 11
S73
T
T
G
L
Y
S
L
S
V
R
A
K
D
S
V
Site 12
S79
L
S
V
R
A
K
D
S
V
K
H
F
H
V
E
Site 13
Y87
V
K
H
F
H
V
E
Y
T
G
Y
S
F
K
F
Site 14
Y90
F
H
V
E
Y
T
G
Y
S
F
K
F
G
F
N
Site 15
S100
K
F
G
F
N
E
F
S
S
L
K
D
F
V
K
Site 16
S101
F
G
F
N
E
F
S
S
L
K
D
F
V
K
H
Site 17
Y129
L
M
V
L
K
H
P
Y
P
R
K
V
E
E
P
Site 18
S137
P
R
K
V
E
E
P
S
I
Y
E
S
V
R
V
Site 19
Y139
K
V
E
E
P
S
I
Y
E
S
V
R
V
H
T
Site 20
S141
E
E
P
S
I
Y
E
S
V
R
V
H
T
A
M
Site 21
T146
Y
E
S
V
R
V
H
T
A
M
Q
T
G
R
T
Site 22
Y170
S
L
G
T
K
E
G
Y
L
T
K
Q
G
G
L
Site 23
T172
G
T
K
E
G
Y
L
T
K
Q
G
G
L
V
K
Site 24
Y195
L
H
R
N
E
L
K
Y
F
K
D
Q
M
S
P
Site 25
S201
K
Y
F
K
D
Q
M
S
P
E
P
I
R
I
L
Site 26
Y220
C
S
A
V
Q
F
D
Y
S
Q
E
R
V
N
C
Site 27
S259
K
I
L
R
W
K
L
S
Q
I
R
K
Q
L
N
Site 28
T271
Q
L
N
Q
G
E
G
T
I
R
S
R
S
F
I
Site 29
S274
Q
G
E
G
T
I
R
S
R
S
F
I
F
K
_
Site 30
S276
E
G
T
I
R
S
R
S
F
I
F
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation