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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCG2
Full Name:
ATP-binding cassette sub-family G member 2
Alias:
Abcp; ATP-binding cassette, sub-family G (WHITE) member 2; Bcrp; Bcrp1; Breast cancer resistance protein; CD338; CDw338; EST157481; Mitoxantrone resistance-associated protein; Mxr; Placenta-specific ATP-binding cassette transporter
Type:
Transporter; Membrane protein, integral
Mass (Da):
72314
Number AA:
655
UniProt ID:
Q9UNQ0
International Prot ID:
IPI00298214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
GO:0016020
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0042221
GO:0042493
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
S
N
V
E
V
F
Site 2
Y44
L
S
F
H
N
I
C
Y
R
V
K
L
K
S
G
Site 3
S50
C
Y
R
V
K
L
K
S
G
F
L
P
C
R
K
Site 4
S65
P
V
E
K
E
I
L
S
N
I
N
G
I
M
K
Site 5
S100
L
A
A
R
K
D
P
S
G
L
S
G
D
V
L
Site 6
S103
R
K
D
P
S
G
L
S
G
D
V
L
I
N
G
Site 7
Y123
N
F
K
C
N
S
G
Y
V
V
Q
D
D
V
V
Site 8
T150
S
A
A
L
R
L
A
T
T
M
T
N
H
E
K
Site 9
S176
G
L
D
K
V
A
D
S
K
V
G
T
Q
F
I
Site 10
S187
T
Q
F
I
R
G
V
S
G
G
E
R
K
R
T
Site 11
T194
S
G
G
E
R
K
R
T
S
I
G
M
E
L
I
Site 12
S195
G
G
E
R
K
R
T
S
I
G
M
E
L
I
T
Site 13
T214
L
F
L
D
E
P
T
T
G
L
D
S
S
T
A
Site 14
S218
E
P
T
T
G
L
D
S
S
T
A
N
A
V
L
Site 15
S241
Q
G
R
T
I
I
F
S
I
H
Q
P
R
Y
S
Site 16
Y247
F
S
I
H
Q
P
R
Y
S
I
F
K
L
F
D
Site 17
S248
S
I
H
Q
P
R
Y
S
I
F
K
L
F
D
S
Site 18
Y276
P
A
Q
E
A
L
G
Y
F
E
S
A
G
Y
H
Site 19
S279
E
A
L
G
Y
F
E
S
A
G
Y
H
C
E
A
Site 20
Y282
G
Y
F
E
S
A
G
Y
H
C
E
A
Y
N
N
Site 21
Y287
A
G
Y
H
C
E
A
Y
N
N
P
A
D
F
F
Site 22
S322
A
T
E
I
I
E
P
S
K
Q
D
K
P
L
I
Site 23
Y336
I
E
K
L
A
E
I
Y
V
N
S
S
F
Y
K
Site 24
S340
A
E
I
Y
V
N
S
S
F
Y
K
E
T
K
A
Site 25
T362
G
E
K
K
K
K
I
T
V
F
K
E
I
S
Y
Site 26
Y369
T
V
F
K
E
I
S
Y
T
T
S
F
C
H
Q
Site 27
S384
L
R
W
V
S
K
R
S
F
K
N
L
L
G
N
Site 28
S420
Y
F
G
L
K
N
D
S
T
G
I
Q
N
R
A
Site 29
T421
F
G
L
K
N
D
S
T
G
I
Q
N
R
A
G
Site 30
Y459
K
K
L
F
I
H
E
Y
I
S
G
Y
Y
R
V
Site 31
Y463
I
H
E
Y
I
S
G
Y
Y
R
V
S
S
Y
F
Site 32
S468
S
G
Y
Y
R
V
S
S
Y
F
L
G
K
L
L
Site 33
Y469
G
Y
Y
R
V
S
S
Y
F
L
G
K
L
L
S
Site 34
Y570
S
W
L
S
W
L
Q
Y
F
S
I
P
R
Y
G
Site 35
Y576
Q
Y
F
S
I
P
R
Y
G
F
T
A
L
Q
H
Site 36
Y605
T
G
N
N
P
C
N
Y
A
T
C
T
G
E
E
Site 37
Y613
A
T
C
T
G
E
E
Y
L
V
K
Q
G
I
D
Site 38
S622
V
K
Q
G
I
D
L
S
P
W
G
L
W
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation