KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SRRM2
Full Name:
Serine,arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
Alias:
AT-rich element binding factor; CWF21; KIAA0324; RNA binding protein; Ser/Arg-related nuclear matrix protein; Serine/arginine repetitive matrix 2; Serine/arginine repetitive matrix protein 2; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa; Splicing coactivator SRm300; SRL300; SRm300; SR-related nuclear matrix protein of 300 kDa
Type:
RNA binding protein
Mass (Da):
299615
Number AA:
2752
UniProt ID:
Q9UQ35
International Prot ID:
IPI00782992
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0016604
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
Y
N
G
I
G
L
P
T
P
R
G
S
G
T
N
Site 2
S13
G
L
P
T
P
R
G
S
G
T
N
G
Y
V
Q
Site 3
T15
P
T
P
R
G
S
G
T
N
G
Y
V
Q
R
N
Site 4
Y18
R
G
S
G
T
N
G
Y
V
Q
R
N
L
S
L
Site 5
S24
G
Y
V
Q
R
N
L
S
L
V
R
G
R
R
G
Site 6
Y36
R
R
G
E
R
P
D
Y
K
G
E
E
E
L
R
Site 7
Y82
E
M
M
E
E
Q
G
Y
E
E
Q
Q
I
Q
E
Site 8
T111
N
P
G
G
K
E
E
T
P
G
Q
R
P
A
V
Site 9
T121
Q
R
P
A
V
T
E
T
H
Q
L
A
E
L
N
Site 10
S142
L
R
A
A
F
G
I
S
D
S
Y
V
D
G
S
Site 11
S144
A
A
F
G
I
S
D
S
Y
V
D
G
S
S
F
Site 12
Y145
A
F
G
I
S
D
S
Y
V
D
G
S
S
F
D
Site 13
S150
D
S
Y
V
D
G
S
S
F
D
P
Q
R
R
A
Site 14
S172
P
E
P
P
K
P
Y
S
L
V
R
E
S
S
S
Site 15
S177
P
Y
S
L
V
R
E
S
S
S
S
R
S
P
T
Site 16
S178
Y
S
L
V
R
E
S
S
S
S
R
S
P
T
P
Site 17
S179
S
L
V
R
E
S
S
S
S
R
S
P
T
P
K
Site 18
S180
L
V
R
E
S
S
S
S
R
S
P
T
P
K
Q
Site 19
S182
R
E
S
S
S
S
R
S
P
T
P
K
Q
K
K
Site 20
T184
S
S
S
S
R
S
P
T
P
K
Q
K
K
K
K
Site 21
S200
K
K
D
R
G
R
R
S
E
S
S
S
P
R
R
Site 22
S202
D
R
G
R
R
S
E
S
S
S
P
R
R
E
R
Site 23
S203
R
G
R
R
S
E
S
S
S
P
R
R
E
R
K
Site 24
S204
G
R
R
S
E
S
S
S
P
R
R
E
R
K
K
Site 25
S212
P
R
R
E
R
K
K
S
S
K
K
K
K
H
R
Site 26
S213
R
R
E
R
K
K
S
S
K
K
K
K
H
R
S
Site 27
S220
S
K
K
K
K
H
R
S
E
S
E
S
K
K
R
Site 28
S222
K
K
K
H
R
S
E
S
E
S
K
K
R
K
H
Site 29
S224
K
H
R
S
E
S
E
S
K
K
R
K
H
R
S
Site 30
S231
S
K
K
R
K
H
R
S
P
T
P
K
S
K
R
Site 31
T233
K
R
K
H
R
S
P
T
P
K
S
K
R
K
S
Site 32
S236
H
R
S
P
T
P
K
S
K
R
K
S
K
D
K
Site 33
S240
T
P
K
S
K
R
K
S
K
D
K
K
R
K
R
Site 34
S248
K
D
K
K
R
K
R
S
R
S
T
T
P
A
P
Site 35
S250
K
K
R
K
R
S
R
S
T
T
P
A
P
K
S
Site 36
T251
K
R
K
R
S
R
S
T
T
P
A
P
K
S
R
Site 37
T252
R
K
R
S
R
S
T
T
P
A
P
K
S
R
R
Site 38
S257
S
T
T
P
A
P
K
S
R
R
A
H
R
S
T
Site 39
S263
K
S
R
R
A
H
R
S
T
S
A
D
S
A
S
Site 40
T264
S
R
R
A
H
R
S
T
S
A
D
S
A
S
S
Site 41
S265
R
R
A
H
R
S
T
S
A
D
S
A
S
S
S
Site 42
S268
H
R
S
T
S
A
D
S
A
S
S
S
D
T
S
Site 43
S270
S
T
S
A
D
S
A
S
S
S
D
T
S
R
S
Site 44
S271
T
S
A
D
S
A
S
S
S
D
T
S
R
S
R
Site 45
S272
S
A
D
S
A
S
S
S
D
T
S
R
S
R
S
Site 46
T274
D
S
A
S
S
S
D
T
S
R
S
R
S
R
S
Site 47
S275
S
A
S
S
S
D
T
S
R
S
R
S
R
S
A
Site 48
S277
S
S
S
D
T
S
R
S
R
S
R
S
A
A
A
Site 49
S279
S
D
T
S
R
S
R
S
R
S
A
A
A
K
T
Site 50
S281
T
S
R
S
R
S
R
S
A
A
A
K
T
H
T
Site 51
T286
S
R
S
A
A
A
K
T
H
T
T
A
L
A
G
Site 52
T288
S
A
A
A
K
T
H
T
T
A
L
A
G
R
S
Site 53
T289
A
A
A
K
T
H
T
T
A
L
A
G
R
S
P
Site 54
S295
T
T
A
L
A
G
R
S
P
S
P
A
S
G
R
Site 55
S297
A
L
A
G
R
S
P
S
P
A
S
G
R
R
G
Site 56
S300
G
R
S
P
S
P
A
S
G
R
R
G
E
G
D
Site 57
S311
G
E
G
D
A
P
F
S
E
P
G
T
T
S
T
Site 58
T315
A
P
F
S
E
P
G
T
T
S
T
Q
R
P
S
Site 59
T316
P
F
S
E
P
G
T
T
S
T
Q
R
P
S
S
Site 60
S317
F
S
E
P
G
T
T
S
T
Q
R
P
S
S
P
Site 61
T318
S
E
P
G
T
T
S
T
Q
R
P
S
S
P
E
Site 62
S322
T
T
S
T
Q
R
P
S
S
P
E
T
A
T
K
Site 63
S323
T
S
T
Q
R
P
S
S
P
E
T
A
T
K
Q
Site 64
T326
Q
R
P
S
S
P
E
T
A
T
K
Q
P
S
S
Site 65
T328
P
S
S
P
E
T
A
T
K
Q
P
S
S
P
Y
Site 66
S332
E
T
A
T
K
Q
P
S
S
P
Y
E
D
K
D
Site 67
S333
T
A
T
K
Q
P
S
S
P
Y
E
D
K
D
K
Site 68
Y335
T
K
Q
P
S
S
P
Y
E
D
K
D
K
D
K
Site 69
S346
D
K
D
K
K
E
K
S
A
T
R
P
S
P
S
Site 70
T348
D
K
K
E
K
S
A
T
R
P
S
P
S
P
E
Site 71
S351
E
K
S
A
T
R
P
S
P
S
P
E
R
S
S
Site 72
S353
S
A
T
R
P
S
P
S
P
E
R
S
S
T
G
Site 73
S357
P
S
P
S
P
E
R
S
S
T
G
P
E
P
P
Site 74
S358
S
P
S
P
E
R
S
S
T
G
P
E
P
P
A
Site 75
T359
P
S
P
E
R
S
S
T
G
P
E
P
P
A
P
Site 76
T367
G
P
E
P
P
A
P
T
P
L
L
A
E
R
H
Site 77
S377
L
A
E
R
H
G
G
S
P
Q
P
L
A
T
T
Site 78
T383
G
S
P
Q
P
L
A
T
T
P
L
S
Q
E
P
Site 79
T384
S
P
Q
P
L
A
T
T
P
L
S
Q
E
P
V
Site 80
S387
P
L
A
T
T
P
L
S
Q
E
P
V
N
P
P
Site 81
S395
Q
E
P
V
N
P
P
S
E
A
S
P
T
R
D
Site 82
S398
V
N
P
P
S
E
A
S
P
T
R
D
R
S
P
Site 83
T400
P
P
S
E
A
S
P
T
R
D
R
S
P
P
K
Site 84
S404
A
S
P
T
R
D
R
S
P
P
K
S
P
E
K
Site 85
S408
R
D
R
S
P
P
K
S
P
E
K
L
P
Q
S
Site 86
S415
S
P
E
K
L
P
Q
S
S
S
S
E
S
S
P
Site 87
S416
P
E
K
L
P
Q
S
S
S
S
E
S
S
P
P
Site 88
S417
E
K
L
P
Q
S
S
S
S
E
S
S
P
P
S
Site 89
S418
K
L
P
Q
S
S
S
S
E
S
S
P
P
S
P
Site 90
S420
P
Q
S
S
S
S
E
S
S
P
P
S
P
Q
P
Site 91
S421
Q
S
S
S
S
E
S
S
P
P
S
P
Q
P
T
Site 92
S424
S
S
E
S
S
P
P
S
P
Q
P
T
K
V
S
Site 93
T428
S
P
P
S
P
Q
P
T
K
V
S
R
H
A
S
Site 94
S431
S
P
Q
P
T
K
V
S
R
H
A
S
S
S
P
Site 95
S435
T
K
V
S
R
H
A
S
S
S
P
E
S
P
K
Site 96
S436
K
V
S
R
H
A
S
S
S
P
E
S
P
K
P
Site 97
S437
V
S
R
H
A
S
S
S
P
E
S
P
K
P
A
Site 98
S440
H
A
S
S
S
P
E
S
P
K
P
A
P
A
P
Site 99
S449
K
P
A
P
A
P
G
S
H
R
E
I
S
S
S
Site 100
S454
P
G
S
H
R
E
I
S
S
S
P
T
S
K
N
Site 101
S455
G
S
H
R
E
I
S
S
S
P
T
S
K
N
R
Site 102
S456
S
H
R
E
I
S
S
S
P
T
S
K
N
R
S
Site 103
T458
R
E
I
S
S
S
P
T
S
K
N
R
S
H
G
Site 104
S459
E
I
S
S
S
P
T
S
K
N
R
S
H
G
R
Site 105
S463
S
P
T
S
K
N
R
S
H
G
R
A
K
R
D
Site 106
S472
G
R
A
K
R
D
K
S
H
S
H
T
P
S
R
Site 107
S474
A
K
R
D
K
S
H
S
H
T
P
S
R
R
M
Site 108
T476
R
D
K
S
H
S
H
T
P
S
R
R
M
G
R
Site 109
S478
K
S
H
S
H
T
P
S
R
R
M
G
R
S
R
Site 110
S484
P
S
R
R
M
G
R
S
R
S
P
A
T
A
K
Site 111
S486
R
R
M
G
R
S
R
S
P
A
T
A
K
R
G
Site 112
T489
G
R
S
R
S
P
A
T
A
K
R
G
R
S
R
Site 113
S495
A
T
A
K
R
G
R
S
R
S
R
T
P
T
K
Site 114
S497
A
K
R
G
R
S
R
S
R
T
P
T
K
R
G
Site 115
T499
R
G
R
S
R
S
R
T
P
T
K
R
G
H
S
Site 116
T501
R
S
R
S
R
T
P
T
K
R
G
H
S
R
S
Site 117
S506
T
P
T
K
R
G
H
S
R
S
R
S
P
Q
W
Site 118
S508
T
K
R
G
H
S
R
S
R
S
P
Q
W
R
R
Site 119
S510
R
G
H
S
R
S
R
S
P
Q
W
R
R
S
R
Site 120
S516
R
S
P
Q
W
R
R
S
R
S
A
Q
R
W
G
Site 121
S518
P
Q
W
R
R
S
R
S
A
Q
R
W
G
R
S
Site 122
S525
S
A
Q
R
W
G
R
S
R
S
P
Q
R
R
G
Site 123
S527
Q
R
W
G
R
S
R
S
P
Q
R
R
G
R
S
Site 124
S534
S
P
Q
R
R
G
R
S
R
S
P
Q
R
P
G
Site 125
S536
Q
R
R
G
R
S
R
S
P
Q
R
P
G
W
S
Site 126
S543
S
P
Q
R
P
G
W
S
R
S
R
N
T
Q
R
Site 127
S545
Q
R
P
G
W
S
R
S
R
N
T
Q
R
R
G
Site 128
T548
G
W
S
R
S
R
N
T
Q
R
R
G
R
S
R
Site 129
S554
N
T
Q
R
R
G
R
S
R
S
A
R
R
G
R
Site 130
S556
Q
R
R
G
R
S
R
S
A
R
R
G
R
S
H
Site 131
S562
R
S
A
R
R
G
R
S
H
S
R
S
P
A
T
Site 132
S564
A
R
R
G
R
S
H
S
R
S
P
A
T
R
G
Site 133
S566
R
G
R
S
H
S
R
S
P
A
T
R
G
R
S
Site 134
T569
S
H
S
R
S
P
A
T
R
G
R
S
R
S
R
Site 135
S573
S
P
A
T
R
G
R
S
R
S
R
T
P
A
R
Site 136
S575
A
T
R
G
R
S
R
S
R
T
P
A
R
R
G
Site 137
T577
R
G
R
S
R
S
R
T
P
A
R
R
G
R
S
Site 138
S584
T
P
A
R
R
G
R
S
R
S
R
T
P
A
R
Site 139
S586
A
R
R
G
R
S
R
S
R
T
P
A
R
R
R
Site 140
T588
R
G
R
S
R
S
R
T
P
A
R
R
R
S
R
Site 141
S594
R
T
P
A
R
R
R
S
R
S
R
T
P
T
R
Site 142
S596
P
A
R
R
R
S
R
S
R
T
P
T
R
R
R
Site 143
T598
R
R
R
S
R
S
R
T
P
T
R
R
R
S
R
Site 144
T600
R
S
R
S
R
T
P
T
R
R
R
S
R
S
R
Site 145
S604
R
T
P
T
R
R
R
S
R
S
R
T
P
A
R
Site 146
S606
P
T
R
R
R
S
R
S
R
T
P
A
R
R
G
Site 147
T608
R
R
R
S
R
S
R
T
P
A
R
R
G
R
S
Site 148
S625
R
T
P
A
R
R
R
S
R
T
R
S
P
V
R
Site 149
T627
P
A
R
R
R
S
R
T
R
S
P
V
R
R
R
Site 150
S629
R
R
R
S
R
T
R
S
P
V
R
R
R
S
R
Site 151
S635
R
S
P
V
R
R
R
S
R
S
R
S
P
A
R
Site 152
S637
P
V
R
R
R
S
R
S
R
S
P
A
R
R
S
Site 153
S639
R
R
R
S
R
S
R
S
P
A
R
R
S
G
R
Site 154
S644
S
R
S
P
A
R
R
S
G
R
S
R
S
R
T
Site 155
S647
P
A
R
R
S
G
R
S
R
S
R
T
P
A
R
Site 156
S649
R
R
S
G
R
S
R
S
R
T
P
A
R
R
G
Site 157
T651
S
G
R
S
R
S
R
T
P
A
R
R
G
R
S
Site 158
S660
A
R
R
G
R
S
R
S
R
T
P
A
R
R
G
Site 159
S671
A
R
R
G
R
S
R
S
R
T
P
A
R
R
S
Site 160
T673
R
G
R
S
R
S
R
T
P
A
R
R
S
G
R
Site 161
S678
S
R
T
P
A
R
R
S
G
R
S
R
S
R
T
Site 162
S692
T
P
A
R
R
G
R
S
R
S
R
T
P
R
R
Site 163
S694
A
R
R
G
R
S
R
S
R
T
P
R
R
G
R
Site 164
T696
R
G
R
S
R
S
R
T
P
R
R
G
R
S
R
Site 165
S702
R
T
P
R
R
G
R
S
R
S
R
S
L
V
R
Site 166
S704
P
R
R
G
R
S
R
S
R
S
L
V
R
R
G
Site 167
S706
R
G
R
S
R
S
R
S
L
V
R
R
G
R
S
Site 168
S713
S
L
V
R
R
G
R
S
H
S
R
T
P
Q
R
Site 169
S715
V
R
R
G
R
S
H
S
R
T
P
Q
R
R
G
Site 170
T717
R
G
R
S
H
S
R
T
P
Q
R
R
G
R
S
Site 171
S724
T
P
Q
R
R
G
R
S
G
S
S
S
E
R
K
Site 172
S726
Q
R
R
G
R
S
G
S
S
S
E
R
K
N
K
Site 173
S727
R
R
G
R
S
G
S
S
S
E
R
K
N
K
S
Site 174
S728
R
G
R
S
G
S
S
S
E
R
K
N
K
S
R
Site 175
S734
S
S
E
R
K
N
K
S
R
T
S
Q
R
R
S
Site 176
T736
E
R
K
N
K
S
R
T
S
Q
R
R
S
R
S
Site 177
S737
R
K
N
K
S
R
T
S
Q
R
R
S
R
S
N
Site 178
S741
S
R
T
S
Q
R
R
S
R
S
N
S
S
P
E
Site 179
S743
T
S
Q
R
R
S
R
S
N
S
S
P
E
M
K
Site 180
S745
Q
R
R
S
R
S
N
S
S
P
E
M
K
K
S
Site 181
S746
R
R
S
R
S
N
S
S
P
E
M
K
K
S
R
Site 182
S752
S
S
P
E
M
K
K
S
R
I
S
S
R
R
S
Site 183
S755
E
M
K
K
S
R
I
S
S
R
R
S
R
S
L
Site 184
S756
M
K
K
S
R
I
S
S
R
R
S
R
S
L
S
Site 185
S759
S
R
I
S
S
R
R
S
R
S
L
S
S
P
R
Site 186
S761
I
S
S
R
R
S
R
S
L
S
S
P
R
S
K
Site 187
S763
S
R
R
S
R
S
L
S
S
P
R
S
K
A
K
Site 188
S764
R
R
S
R
S
L
S
S
P
R
S
K
A
K
S
Site 189
S767
R
S
L
S
S
P
R
S
K
A
K
S
R
L
S
Site 190
S771
S
P
R
S
K
A
K
S
R
L
S
L
R
R
S
Site 191
S774
S
K
A
K
S
R
L
S
L
R
R
S
L
S
G
Site 192
S778
S
R
L
S
L
R
R
S
L
S
G
S
S
P
C
Site 193
S780
L
S
L
R
R
S
L
S
G
S
S
P
C
P
K
Site 194
S782
L
R
R
S
L
S
G
S
S
P
C
P
K
Q
K
Site 195
S783
R
R
S
L
S
G
S
S
P
C
P
K
Q
K
S
Site 196
S790
S
P
C
P
K
Q
K
S
Q
T
P
P
R
R
S
Site 197
T792
C
P
K
Q
K
S
Q
T
P
P
R
R
S
R
S
Site 198
S797
S
Q
T
P
P
R
R
S
R
S
G
S
S
Q
P
Site 199
S799
T
P
P
R
R
S
R
S
G
S
S
Q
P
K
A
Site 200
S801
P
R
R
S
R
S
G
S
S
Q
P
K
A
K
S
Site 201
S802
R
R
S
R
S
G
S
S
Q
P
K
A
K
S
R
Site 202
S808
S
S
Q
P
K
A
K
S
R
T
P
P
R
R
S
Site 203
T810
Q
P
K
A
K
S
R
T
P
P
R
R
S
R
S
Site 204
S815
S
R
T
P
P
R
R
S
R
S
S
S
S
P
P
Site 205
S817
T
P
P
R
R
S
R
S
S
S
S
P
P
P
K
Site 206
S818
P
P
R
R
S
R
S
S
S
S
P
P
P
K
Q
Site 207
S819
P
R
R
S
R
S
S
S
S
P
P
P
K
Q
K
Site 208
S820
R
R
S
R
S
S
S
S
P
P
P
K
Q
K
S
Site 209
S827
S
P
P
P
K
Q
K
S
K
T
P
S
R
Q
S
Site 210
T829
P
P
K
Q
K
S
K
T
P
S
R
Q
S
H
S
Site 211
S831
K
Q
K
S
K
T
P
S
R
Q
S
H
S
S
S
Site 212
S834
S
K
T
P
S
R
Q
S
H
S
S
S
S
P
H
Site 213
S836
T
P
S
R
Q
S
H
S
S
S
S
P
H
P
K
Site 214
S837
P
S
R
Q
S
H
S
S
S
S
P
H
P
K
V
Site 215
S838
S
R
Q
S
H
S
S
S
S
P
H
P
K
V
K
Site 216
S839
R
Q
S
H
S
S
S
S
P
H
P
K
V
K
S
Site 217
S846
S
P
H
P
K
V
K
S
G
T
P
P
R
Q
G
Site 218
T848
H
P
K
V
K
S
G
T
P
P
R
Q
G
S
I
Site 219
S854
G
T
P
P
R
Q
G
S
I
T
S
P
Q
A
N
Site 220
T856
P
P
R
Q
G
S
I
T
S
P
Q
A
N
E
Q
Site 221
S857
P
R
Q
G
S
I
T
S
P
Q
A
N
E
Q
S
Site 222
S864
S
P
Q
A
N
E
Q
S
V
T
P
Q
R
R
S
Site 223
T866
Q
A
N
E
Q
S
V
T
P
Q
R
R
S
C
F
Site 224
S871
S
V
T
P
Q
R
R
S
C
F
E
S
S
P
D
Site 225
S875
Q
R
R
S
C
F
E
S
S
P
D
P
E
L
K
Site 226
S876
R
R
S
C
F
E
S
S
P
D
P
E
L
K
S
Site 227
S883
S
P
D
P
E
L
K
S
R
T
P
S
R
H
S
Site 228
T885
D
P
E
L
K
S
R
T
P
S
R
H
S
C
S
Site 229
S887
E
L
K
S
R
T
P
S
R
H
S
C
S
G
S
Site 230
S890
S
R
T
P
S
R
H
S
C
S
G
S
S
P
P
Site 231
S892
T
P
S
R
H
S
C
S
G
S
S
P
P
R
V
Site 232
S894
S
R
H
S
C
S
G
S
S
P
P
R
V
K
S
Site 233
S895
R
H
S
C
S
G
S
S
P
P
R
V
K
S
S
Site 234
S901
S
S
P
P
R
V
K
S
S
T
P
P
R
Q
S
Site 235
S902
S
P
P
R
V
K
S
S
T
P
P
R
Q
S
P
Site 236
T903
P
P
R
V
K
S
S
T
P
P
R
Q
S
P
S
Site 237
S908
S
S
T
P
P
R
Q
S
P
S
R
S
S
S
P
Site 238
S910
T
P
P
R
Q
S
P
S
R
S
S
S
P
Q
P
Site 239
S912
P
R
Q
S
P
S
R
S
S
S
P
Q
P
K
V
Site 240
S913
R
Q
S
P
S
R
S
S
S
P
Q
P
K
V
K
Site 241
S914
Q
S
P
S
R
S
S
S
P
Q
P
K
V
K
A
Site 242
S924
P
K
V
K
A
I
I
S
P
R
Q
R
S
H
S
Site 243
S929
I
I
S
P
R
Q
R
S
H
S
G
S
S
S
P
Site 244
S931
S
P
R
Q
R
S
H
S
G
S
S
S
P
S
P
Site 245
S933
R
Q
R
S
H
S
G
S
S
S
P
S
P
S
R
Site 246
S934
Q
R
S
H
S
G
S
S
S
P
S
P
S
R
V
Site 247
S935
R
S
H
S
G
S
S
S
P
S
P
S
R
V
T
Site 248
S937
H
S
G
S
S
S
P
S
P
S
R
V
T
S
R
Site 249
S939
G
S
S
S
P
S
P
S
R
V
T
S
R
T
T
Site 250
T942
S
P
S
P
S
R
V
T
S
R
T
T
P
R
R
Site 251
S943
P
S
P
S
R
V
T
S
R
T
T
P
R
R
S
Site 252
T945
P
S
R
V
T
S
R
T
T
P
R
R
S
R
S
Site 253
T946
S
R
V
T
S
R
T
T
P
R
R
S
R
S
V
Site 254
S950
S
R
T
T
P
R
R
S
R
S
V
S
P
C
S
Site 255
S952
T
T
P
R
R
S
R
S
V
S
P
C
S
N
V
Site 256
S954
P
R
R
S
R
S
V
S
P
C
S
N
V
E
S
Site 257
S957
S
R
S
V
S
P
C
S
N
V
E
S
R
L
L
Site 258
S961
S
P
C
S
N
V
E
S
R
L
L
P
R
Y
S
Site 259
Y967
E
S
R
L
L
P
R
Y
S
H
S
G
S
S
S
Site 260
S968
S
R
L
L
P
R
Y
S
H
S
G
S
S
S
P
Site 261
S970
L
L
P
R
Y
S
H
S
G
S
S
S
P
D
T
Site 262
S972
P
R
Y
S
H
S
G
S
S
S
P
D
T
K
V
Site 263
S973
R
Y
S
H
S
G
S
S
S
P
D
T
K
V
K
Site 264
S974
Y
S
H
S
G
S
S
S
P
D
T
K
V
K
P
Site 265
T977
S
G
S
S
S
P
D
T
K
V
K
P
E
T
P
Site 266
T983
D
T
K
V
K
P
E
T
P
P
R
Q
S
H
S
Site 267
S988
P
E
T
P
P
R
Q
S
H
S
G
S
I
S
P
Site 268
S990
T
P
P
R
Q
S
H
S
G
S
I
S
P
Y
P
Site 269
S992
P
R
Q
S
H
S
G
S
I
S
P
Y
P
K
V
Site 270
S994
Q
S
H
S
G
S
I
S
P
Y
P
K
V
K
A
Site 271
Y996
H
S
G
S
I
S
P
Y
P
K
V
K
A
Q
T
Site 272
T1003
Y
P
K
V
K
A
Q
T
P
P
G
P
S
L
S
Site 273
S1008
A
Q
T
P
P
G
P
S
L
S
G
S
K
S
P
Site 274
S1010
T
P
P
G
P
S
L
S
G
S
K
S
P
C
P
Site 275
S1012
P
G
P
S
L
S
G
S
K
S
P
C
P
Q
E
Site 276
S1014
P
S
L
S
G
S
K
S
P
C
P
Q
E
K
S
Site 277
S1021
S
P
C
P
Q
E
K
S
K
D
S
L
V
Q
S
Site 278
S1024
P
Q
E
K
S
K
D
S
L
V
Q
S
C
P
G
Site 279
S1028
S
K
D
S
L
V
Q
S
C
P
G
S
L
S
L
Site 280
S1032
L
V
Q
S
C
P
G
S
L
S
L
C
A
G
V
Site 281
S1034
Q
S
C
P
G
S
L
S
L
C
A
G
V
K
S
Site 282
S1041
S
L
C
A
G
V
K
S
S
T
P
P
G
E
S
Site 283
S1042
L
C
A
G
V
K
S
S
T
P
P
G
E
S
Y
Site 284
T1043
C
A
G
V
K
S
S
T
P
P
G
E
S
Y
F
Site 285
S1048
S
S
T
P
P
G
E
S
Y
F
G
V
S
S
L
Site 286
Y1049
S
T
P
P
G
E
S
Y
F
G
V
S
S
L
Q
Site 287
S1054
E
S
Y
F
G
V
S
S
L
Q
L
K
G
Q
S
Site 288
S1061
S
L
Q
L
K
G
Q
S
Q
T
S
P
D
H
R
Site 289
T1063
Q
L
K
G
Q
S
Q
T
S
P
D
H
R
S
D
Site 290
S1064
L
K
G
Q
S
Q
T
S
P
D
H
R
S
D
T
Site 291
S1069
Q
T
S
P
D
H
R
S
D
T
S
S
P
E
V
Site 292
T1071
S
P
D
H
R
S
D
T
S
S
P
E
V
R
Q
Site 293
S1072
P
D
H
R
S
D
T
S
S
P
E
V
R
Q
S
Site 294
S1073
D
H
R
S
D
T
S
S
P
E
V
R
Q
S
H
Site 295
S1079
S
S
P
E
V
R
Q
S
H
S
E
S
P
S
L
Site 296
S1081
P
E
V
R
Q
S
H
S
E
S
P
S
L
Q
S
Site 297
S1083
V
R
Q
S
H
S
E
S
P
S
L
Q
S
K
S
Site 298
S1085
Q
S
H
S
E
S
P
S
L
Q
S
K
S
Q
T
Site 299
S1088
S
E
S
P
S
L
Q
S
K
S
Q
T
S
P
K
Site 300
S1090
S
P
S
L
Q
S
K
S
Q
T
S
P
K
G
G
Site 301
T1092
S
L
Q
S
K
S
Q
T
S
P
K
G
G
R
S
Site 302
S1093
L
Q
S
K
S
Q
T
S
P
K
G
G
R
S
R
Site 303
S1099
T
S
P
K
G
G
R
S
R
S
S
S
P
V
T
Site 304
S1101
P
K
G
G
R
S
R
S
S
S
P
V
T
E
L
Site 305
S1102
K
G
G
R
S
R
S
S
S
P
V
T
E
L
A
Site 306
S1103
G
G
R
S
R
S
S
S
P
V
T
E
L
A
S
Site 307
T1106
S
R
S
S
S
P
V
T
E
L
A
S
R
S
P
Site 308
S1110
S
P
V
T
E
L
A
S
R
S
P
I
R
Q
D
Site 309
S1112
V
T
E
L
A
S
R
S
P
I
R
Q
D
R
G
Site 310
S1122
R
Q
D
R
G
E
F
S
A
S
P
M
L
K
S
Site 311
S1124
D
R
G
E
F
S
A
S
P
M
L
K
S
G
M
Site 312
S1129
S
A
S
P
M
L
K
S
G
M
S
P
E
Q
S
Site 313
S1132
P
M
L
K
S
G
M
S
P
E
Q
S
R
F
Q
Site 314
S1136
S
G
M
S
P
E
Q
S
R
F
Q
S
D
S
S
Site 315
S1140
P
E
Q
S
R
F
Q
S
D
S
S
S
Y
P
T
Site 316
S1142
Q
S
R
F
Q
S
D
S
S
S
Y
P
T
V
D
Site 317
S1143
S
R
F
Q
S
D
S
S
S
Y
P
T
V
D
S
Site 318
S1144
R
F
Q
S
D
S
S
S
Y
P
T
V
D
S
N
Site 319
Y1145
F
Q
S
D
S
S
S
Y
P
T
V
D
S
N
S
Site 320
T1147
S
D
S
S
S
Y
P
T
V
D
S
N
S
L
L
Site 321
S1150
S
S
Y
P
T
V
D
S
N
S
L
L
G
Q
S
Site 322
S1152
Y
P
T
V
D
S
N
S
L
L
G
Q
S
R
L
Site 323
S1157
S
N
S
L
L
G
Q
S
R
L
E
T
A
E
S
Site 324
T1161
L
G
Q
S
R
L
E
T
A
E
S
K
E
K
M
Site 325
S1164
S
R
L
E
T
A
E
S
K
E
K
M
A
L
P
Site 326
T1177
L
P
P
Q
E
D
A
T
A
S
P
P
R
Q
K
Site 327
S1179
P
Q
E
D
A
T
A
S
P
P
R
Q
K
D
K
Site 328
S1188
P
R
Q
K
D
K
F
S
P
F
P
V
Q
D
R
Site 329
S1198
P
V
Q
D
R
P
E
S
S
L
V
F
K
D
T
Site 330
S1199
V
Q
D
R
P
E
S
S
L
V
F
K
D
T
L
Site 331
T1205
S
S
L
V
F
K
D
T
L
R
T
P
P
R
E
Site 332
T1208
V
F
K
D
T
L
R
T
P
P
R
E
R
S
G
Site 333
S1214
R
T
P
P
R
E
R
S
G
A
G
S
S
P
E
Site 334
S1218
R
E
R
S
G
A
G
S
S
P
E
T
K
E
Q
Site 335
S1219
E
R
S
G
A
G
S
S
P
E
T
K
E
Q
N
Site 336
T1222
G
A
G
S
S
P
E
T
K
E
Q
N
S
A
L
Site 337
S1227
P
E
T
K
E
Q
N
S
A
L
P
T
S
S
Q
Site 338
T1231
E
Q
N
S
A
L
P
T
S
S
Q
D
E
E
L
Site 339
S1232
Q
N
S
A
L
P
T
S
S
Q
D
E
E
L
M
Site 340
S1233
N
S
A
L
P
T
S
S
Q
D
E
E
L
M
E
Site 341
S1245
L
M
E
V
V
E
K
S
E
E
P
A
G
Q
I
Site 342
S1254
E
P
A
G
Q
I
L
S
H
L
S
S
E
L
K
Site 343
S1257
G
Q
I
L
S
H
L
S
S
E
L
K
E
M
S
Site 344
S1258
Q
I
L
S
H
L
S
S
E
L
K
E
M
S
T
Site 345
S1264
S
S
E
L
K
E
M
S
T
S
N
F
E
S
S
Site 346
T1265
S
E
L
K
E
M
S
T
S
N
F
E
S
S
P
Site 347
S1266
E
L
K
E
M
S
T
S
N
F
E
S
S
P
E
Site 348
S1270
M
S
T
S
N
F
E
S
S
P
E
V
E
E
R
Site 349
S1271
S
T
S
N
F
E
S
S
P
E
V
E
E
R
P
Site 350
T1283
E
R
P
A
V
S
L
T
L
D
Q
S
Q
S
Q
Site 351
S1287
V
S
L
T
L
D
Q
S
Q
S
Q
A
S
L
E
Site 352
S1289
L
T
L
D
Q
S
Q
S
Q
A
S
L
E
A
V
Site 353
S1292
D
Q
S
Q
S
Q
A
S
L
E
A
V
E
V
P
Site 354
S1304
E
V
P
S
M
A
S
S
W
G
G
P
H
F
S
Site 355
S1311
S
W
G
G
P
H
F
S
P
E
H
K
E
L
S
Site 356
S1318
S
P
E
H
K
E
L
S
N
S
P
L
R
E
N
Site 357
S1320
E
H
K
E
L
S
N
S
P
L
R
E
N
S
F
Site 358
S1326
N
S
P
L
R
E
N
S
F
G
S
P
L
E
F
Site 359
S1329
L
R
E
N
S
F
G
S
P
L
E
F
R
N
S
Site 360
S1336
S
P
L
E
F
R
N
S
G
P
L
G
T
E
M
Site 361
T1341
R
N
S
G
P
L
G
T
E
M
N
T
G
F
S
Site 362
T1345
P
L
G
T
E
M
N
T
G
F
S
S
E
V
K
Site 363
S1348
T
E
M
N
T
G
F
S
S
E
V
K
E
D
L
Site 364
S1349
E
M
N
T
G
F
S
S
E
V
K
E
D
L
N
Site 365
T1365
P
F
L
N
Q
L
E
T
D
P
S
L
D
M
K
Site 366
S1368
N
Q
L
E
T
D
P
S
L
D
M
K
E
Q
S
Site 367
S1375
S
L
D
M
K
E
Q
S
T
R
S
S
G
H
S
Site 368
T1376
L
D
M
K
E
Q
S
T
R
S
S
G
H
S
S
Site 369
S1378
M
K
E
Q
S
T
R
S
S
G
H
S
S
S
E
Site 370
S1379
K
E
Q
S
T
R
S
S
G
H
S
S
S
E
L
Site 371
S1382
S
T
R
S
S
G
H
S
S
S
E
L
S
P
D
Site 372
S1383
T
R
S
S
G
H
S
S
S
E
L
S
P
D
A
Site 373
S1384
R
S
S
G
H
S
S
S
E
L
S
P
D
A
V
Site 374
S1387
G
H
S
S
S
E
L
S
P
D
A
V
E
K
A
Site 375
S1397
A
V
E
K
A
G
M
S
S
N
Q
S
I
S
S
Site 376
S1398
V
E
K
A
G
M
S
S
N
Q
S
I
S
S
P
Site 377
S1401
A
G
M
S
S
N
Q
S
I
S
S
P
V
L
D
Site 378
S1403
M
S
S
N
Q
S
I
S
S
P
V
L
D
A
V
Site 379
S1404
S
S
N
Q
S
I
S
S
P
V
L
D
A
V
P
Site 380
T1413
V
L
D
A
V
P
R
T
P
S
R
E
R
S
S
Site 381
S1415
D
A
V
P
R
T
P
S
R
E
R
S
S
S
A
Site 382
S1419
R
T
P
S
R
E
R
S
S
S
A
S
S
P
E
Site 383
S1420
T
P
S
R
E
R
S
S
S
A
S
S
P
E
M
Site 384
S1421
P
S
R
E
R
S
S
S
A
S
S
P
E
M
K
Site 385
S1423
R
E
R
S
S
S
A
S
S
P
E
M
K
D
G
Site 386
S1424
E
R
S
S
S
A
S
S
P
E
M
K
D
G
L
Site 387
T1434
M
K
D
G
L
P
R
T
P
S
R
R
S
R
S
Site 388
S1436
D
G
L
P
R
T
P
S
R
R
S
R
S
G
S
Site 389
S1439
P
R
T
P
S
R
R
S
R
S
G
S
S
P
G
Site 390
S1441
T
P
S
R
R
S
R
S
G
S
S
P
G
L
R
Site 391
S1443
S
R
R
S
R
S
G
S
S
P
G
L
R
D
G
Site 392
S1444
R
R
S
R
S
G
S
S
P
G
L
R
D
G
S
Site 393
S1451
S
P
G
L
R
D
G
S
G
T
P
S
R
H
S
Site 394
T1453
G
L
R
D
G
S
G
T
P
S
R
H
S
L
S
Site 395
S1455
R
D
G
S
G
T
P
S
R
H
S
L
S
G
S
Site 396
S1458
S
G
T
P
S
R
H
S
L
S
G
S
S
P
G
Site 397
S1460
T
P
S
R
H
S
L
S
G
S
S
P
G
M
K
Site 398
S1462
S
R
H
S
L
S
G
S
S
P
G
M
K
D
I
Site 399
S1463
R
H
S
L
S
G
S
S
P
G
M
K
D
I
P
Site 400
T1472
G
M
K
D
I
P
R
T
P
S
R
G
R
S
E
Site 401
S1474
K
D
I
P
R
T
P
S
R
G
R
S
E
C
D
Site 402
S1478
R
T
P
S
R
G
R
S
E
C
D
S
S
P
E
Site 403
S1482
R
G
R
S
E
C
D
S
S
P
E
P
K
A
L
Site 404
S1483
G
R
S
E
C
D
S
S
P
E
P
K
A
L
P
Site 405
T1492
E
P
K
A
L
P
Q
T
P
R
P
R
S
R
S
Site 406
S1497
P
Q
T
P
R
P
R
S
R
S
P
S
S
P
E
Site 407
S1499
T
P
R
P
R
S
R
S
P
S
S
P
E
L
N
Site 408
S1501
R
P
R
S
R
S
P
S
S
P
E
L
N
N
K
Site 409
S1502
P
R
S
R
S
P
S
S
P
E
L
N
N
K
C
Site 410
T1511
E
L
N
N
K
C
L
T
P
Q
R
E
R
S
G
Site 411
S1517
L
T
P
Q
R
E
R
S
G
S
E
S
S
V
D
Site 412
S1519
P
Q
R
E
R
S
G
S
E
S
S
V
D
Q
K
Site 413
S1521
R
E
R
S
G
S
E
S
S
V
D
Q
K
T
V
Site 414
S1522
E
R
S
G
S
E
S
S
V
D
Q
K
T
V
A
Site 415
T1527
E
S
S
V
D
Q
K
T
V
A
R
T
P
L
G
Site 416
T1531
D
Q
K
T
V
A
R
T
P
L
G
Q
R
S
R
Site 417
S1537
R
T
P
L
G
Q
R
S
R
S
G
S
S
Q
E
Site 418
S1539
P
L
G
Q
R
S
R
S
G
S
S
Q
E
L
D
Site 419
S1541
G
Q
R
S
R
S
G
S
S
Q
E
L
D
V
K
Site 420
S1542
Q
R
S
R
S
G
S
S
Q
E
L
D
V
K
P
Site 421
S1550
Q
E
L
D
V
K
P
S
A
S
P
Q
E
R
S
Site 422
S1552
L
D
V
K
P
S
A
S
P
Q
E
R
S
E
S
Site 423
S1557
S
A
S
P
Q
E
R
S
E
S
D
S
S
P
D
Site 424
S1559
S
P
Q
E
R
S
E
S
D
S
S
P
D
S
K
Site 425
S1561
Q
E
R
S
E
S
D
S
S
P
D
S
K
A
K
Site 426
S1562
E
R
S
E
S
D
S
S
P
D
S
K
A
K
T
Site 427
S1565
E
S
D
S
S
P
D
S
K
A
K
T
R
T
P
Site 428
T1569
S
P
D
S
K
A
K
T
R
T
P
L
R
Q
R
Site 429
T1571
D
S
K
A
K
T
R
T
P
L
R
Q
R
S
R
Site 430
S1577
R
T
P
L
R
Q
R
S
R
S
G
S
S
P
E
Site 431
S1579
P
L
R
Q
R
S
R
S
G
S
S
P
E
V
D
Site 432
S1581
R
Q
R
S
R
S
G
S
S
P
E
V
D
S
K
Site 433
S1582
Q
R
S
R
S
G
S
S
P
E
V
D
S
K
S
Site 434
S1587
G
S
S
P
E
V
D
S
K
S
R
L
S
P
R
Site 435
S1589
S
P
E
V
D
S
K
S
R
L
S
P
R
R
S
Site 436
S1592
V
D
S
K
S
R
L
S
P
R
R
S
R
S
G
Site 437
S1596
S
R
L
S
P
R
R
S
R
S
G
S
S
P
E
Site 438
S1598
L
S
P
R
R
S
R
S
G
S
S
P
E
V
K
Site 439
S1600
P
R
R
S
R
S
G
S
S
P
E
V
K
D
K
Site 440
S1601
R
R
S
R
S
G
S
S
P
E
V
K
D
K
P
Site 441
S1616
R
A
A
P
R
A
Q
S
G
S
D
S
S
P
E
Site 442
S1618
A
P
R
A
Q
S
G
S
D
S
S
P
E
P
K
Site 443
S1620
R
A
Q
S
G
S
D
S
S
P
E
P
K
A
P
Site 444
S1621
A
Q
S
G
S
D
S
S
P
E
P
K
A
P
A
Site 445
S1636
P
R
A
L
P
R
R
S
R
S
G
S
S
S
K
Site 446
S1638
A
L
P
R
R
S
R
S
G
S
S
S
K
G
R
Site 447
S1640
P
R
R
S
R
S
G
S
S
S
K
G
R
G
P
Site 448
S1641
R
R
S
R
S
G
S
S
S
K
G
R
G
P
S
Site 449
S1642
R
S
R
S
G
S
S
S
K
G
R
G
P
S
P
Site 450
S1648
S
S
K
G
R
G
P
S
P
E
G
S
S
S
T
Site 451
S1652
R
G
P
S
P
E
G
S
S
S
T
E
S
S
P
Site 452
S1653
G
P
S
P
E
G
S
S
S
T
E
S
S
P
E
Site 453
S1654
P
S
P
E
G
S
S
S
T
E
S
S
P
E
H
Site 454
T1655
S
P
E
G
S
S
S
T
E
S
S
P
E
H
P
Site 455
S1657
E
G
S
S
S
T
E
S
S
P
E
H
P
P
K
Site 456
S1658
G
S
S
S
T
E
S
S
P
E
H
P
P
K
S
Site 457
S1665
S
P
E
H
P
P
K
S
R
T
A
R
R
G
S
Site 458
T1667
E
H
P
P
K
S
R
T
A
R
R
G
S
R
S
Site 459
S1672
S
R
T
A
R
R
G
S
R
S
S
P
E
P
K
Site 460
S1674
T
A
R
R
G
S
R
S
S
P
E
P
K
T
K
Site 461
S1675
A
R
R
G
S
R
S
S
P
E
P
K
T
K
S
Site 462
T1680
R
S
S
P
E
P
K
T
K
S
R
T
P
P
R
Site 463
S1682
S
P
E
P
K
T
K
S
R
T
P
P
R
R
R
Site 464
T1684
E
P
K
T
K
S
R
T
P
P
R
R
R
S
S
Site 465
S1690
R
T
P
P
R
R
R
S
S
R
S
S
P
E
L
Site 466
S1691
T
P
P
R
R
R
S
S
R
S
S
P
E
L
T
Site 467
S1693
P
R
R
R
S
S
R
S
S
P
E
L
T
R
K
Site 468
S1694
R
R
R
S
S
R
S
S
P
E
L
T
R
K
A
Site 469
T1698
S
R
S
S
P
E
L
T
R
K
A
R
L
S
R
Site 470
S1704
L
T
R
K
A
R
L
S
R
R
S
R
S
A
S
Site 471
S1707
K
A
R
L
S
R
R
S
R
S
A
S
S
S
P
Site 472
S1709
R
L
S
R
R
S
R
S
A
S
S
S
P
E
T
Site 473
S1711
S
R
R
S
R
S
A
S
S
S
P
E
T
R
S
Site 474
S1712
R
R
S
R
S
A
S
S
S
P
E
T
R
S
R
Site 475
S1713
R
S
R
S
A
S
S
S
P
E
T
R
S
R
T
Site 476
T1716
S
A
S
S
S
P
E
T
R
S
R
T
P
P
R
Site 477
S1718
S
S
S
P
E
T
R
S
R
T
P
P
R
H
R
Site 478
T1720
S
P
E
T
R
S
R
T
P
P
R
H
R
R
S
Site 479
S1727
T
P
P
R
H
R
R
S
P
S
V
S
S
P
E
Site 480
S1729
P
R
H
R
R
S
P
S
V
S
S
P
E
P
A
Site 481
S1731
H
R
R
S
P
S
V
S
S
P
E
P
A
E
K
Site 482
S1732
R
R
S
P
S
V
S
S
P
E
P
A
E
K
S
Site 483
S1739
S
P
E
P
A
E
K
S
R
S
S
R
R
R
R
Site 484
S1741
E
P
A
E
K
S
R
S
S
R
R
R
R
S
A
Site 485
S1742
P
A
E
K
S
R
S
S
R
R
R
R
S
A
S
Site 486
S1747
R
S
S
R
R
R
R
S
A
S
S
P
R
T
K
Site 487
S1749
S
R
R
R
R
S
A
S
S
P
R
T
K
T
T
Site 488
S1750
R
R
R
R
S
A
S
S
P
R
T
K
T
T
S
Site 489
T1753
R
S
A
S
S
P
R
T
K
T
T
S
R
R
G
Site 490
T1755
A
S
S
P
R
T
K
T
T
S
R
R
G
R
S
Site 491
T1756
S
S
P
R
T
K
T
T
S
R
R
G
R
S
P
Site 492
S1757
S
P
R
T
K
T
T
S
R
R
G
R
S
P
S
Site 493
S1762
T
T
S
R
R
G
R
S
P
S
P
K
P
R
G
Site 494
S1764
S
R
R
G
R
S
P
S
P
K
P
R
G
L
Q
Site 495
S1773
K
P
R
G
L
Q
R
S
R
S
R
S
R
R
E
Site 496
S1775
R
G
L
Q
R
S
R
S
R
S
R
R
E
K
T
Site 497
S1777
L
Q
R
S
R
S
R
S
R
R
E
K
T
R
T
Site 498
T1782
S
R
S
R
R
E
K
T
R
T
T
R
R
R
D
Site 499
T1784
S
R
R
E
K
T
R
T
T
R
R
R
D
R
S
Site 500
T1785
R
R
E
K
T
R
T
T
R
R
R
D
R
S
G
Site 501
S1791
T
T
R
R
R
D
R
S
G
S
S
Q
S
T
S
Site 502
S1793
R
R
R
D
R
S
G
S
S
Q
S
T
S
R
R
Site 503
S1794
R
R
D
R
S
G
S
S
Q
S
T
S
R
R
R
Site 504
S1796
D
R
S
G
S
S
Q
S
T
S
R
R
R
Q
R
Site 505
T1797
R
S
G
S
S
Q
S
T
S
R
R
R
Q
R
S
Site 506
S1798
S
G
S
S
Q
S
T
S
R
R
R
Q
R
S
R
Site 507
S1804
T
S
R
R
R
Q
R
S
R
S
R
S
R
V
T
Site 508
S1806
R
R
R
Q
R
S
R
S
R
S
R
V
T
R
R
Site 509
S1808
R
Q
R
S
R
S
R
S
R
V
T
R
R
R
R
Site 510
T1811
S
R
S
R
S
R
V
T
R
R
R
R
G
G
S
Site 511
S1818
T
R
R
R
R
G
G
S
G
Y
H
S
R
S
P
Site 512
Y1820
R
R
R
G
G
S
G
Y
H
S
R
S
P
A
R
Site 513
S1822
R
G
G
S
G
Y
H
S
R
S
P
A
R
Q
E
Site 514
S1824
G
S
G
Y
H
S
R
S
P
A
R
Q
E
S
S
Site 515
S1830
R
S
P
A
R
Q
E
S
S
R
T
S
S
R
R
Site 516
S1831
S
P
A
R
Q
E
S
S
R
T
S
S
R
R
R
Site 517
T1833
A
R
Q
E
S
S
R
T
S
S
R
R
R
R
G
Site 518
S1834
R
Q
E
S
S
R
T
S
S
R
R
R
R
G
R
Site 519
S1835
Q
E
S
S
R
T
S
S
R
R
R
R
G
R
S
Site 520
S1842
S
R
R
R
R
G
R
S
R
T
P
P
T
S
R
Site 521
T1844
R
R
R
G
R
S
R
T
P
P
T
S
R
K
R
Site 522
T1847
G
R
S
R
T
P
P
T
S
R
K
R
S
R
S
Site 523
S1848
R
S
R
T
P
P
T
S
R
K
R
S
R
S
R
Site 524
S1852
P
P
T
S
R
K
R
S
R
S
R
T
S
P
A
Site 525
S1854
T
S
R
K
R
S
R
S
R
T
S
P
A
P
W
Site 526
T1856
R
K
R
S
R
S
R
T
S
P
A
P
W
K
R
Site 527
S1857
K
R
S
R
S
R
T
S
P
A
P
W
K
R
S
Site 528
S1864
S
P
A
P
W
K
R
S
R
S
R
A
S
P
A
Site 529
S1866
A
P
W
K
R
S
R
S
R
A
S
P
A
T
H
Site 530
S1869
K
R
S
R
S
R
A
S
P
A
T
H
R
R
S
Site 531
T1872
R
S
R
A
S
P
A
T
H
R
R
S
R
S
R
Site 532
S1876
S
P
A
T
H
R
R
S
R
S
R
T
P
L
I
Site 533
S1878
A
T
H
R
R
S
R
S
R
T
P
L
I
S
R
Site 534
T1880
H
R
R
S
R
S
R
T
P
L
I
S
R
R
R
Site 535
S1884
R
S
R
T
P
L
I
S
R
R
R
S
R
S
R
Site 536
S1888
P
L
I
S
R
R
R
S
R
S
R
T
S
P
V
Site 537
S1890
I
S
R
R
R
S
R
S
R
T
S
P
V
S
R
Site 538
T1892
R
R
R
S
R
S
R
T
S
P
V
S
R
R
R
Site 539
S1893
R
R
S
R
S
R
T
S
P
V
S
R
R
R
S
Site 540
S1896
R
S
R
T
S
P
V
S
R
R
R
S
R
S
R
Site 541
S1900
S
P
V
S
R
R
R
S
R
S
R
T
S
V
T
Site 542
S1902
V
S
R
R
R
S
R
S
R
T
S
V
T
R
R
Site 543
T1904
R
R
R
S
R
S
R
T
S
V
T
R
R
R
S
Site 544
S1905
R
R
S
R
S
R
T
S
V
T
R
R
R
S
R
Site 545
T1907
S
R
S
R
T
S
V
T
R
R
R
S
R
S
R
Site 546
S1911
T
S
V
T
R
R
R
S
R
S
R
A
S
P
V
Site 547
S1913
V
T
R
R
R
S
R
S
R
A
S
P
V
S
R
Site 548
S1916
R
R
S
R
S
R
A
S
P
V
S
R
R
R
S
Site 549
S1919
R
S
R
A
S
P
V
S
R
R
R
S
R
S
R
Site 550
S1923
S
P
V
S
R
R
R
S
R
S
R
T
P
P
V
Site 551
S1925
V
S
R
R
R
S
R
S
R
T
P
P
V
T
R
Site 552
T1927
R
R
R
S
R
S
R
T
P
P
V
T
R
R
R
Site 553
T1931
R
S
R
T
P
P
V
T
R
R
R
S
R
S
R
Site 554
S1935
P
P
V
T
R
R
R
S
R
S
R
T
P
T
T
Site 555
S1937
V
T
R
R
R
S
R
S
R
T
P
T
T
R
R
Site 556
T1939
R
R
R
S
R
S
R
T
P
T
T
R
R
R
S
Site 557
T1941
R
S
R
S
R
T
P
T
T
R
R
R
S
R
S
Site 558
T1942
S
R
S
R
T
P
T
T
R
R
R
S
R
S
R
Site 559
S1946
T
P
T
T
R
R
R
S
R
S
R
T
P
P
V
Site 560
S1948
T
T
R
R
R
S
R
S
R
T
P
P
V
T
R
Site 561
S1958
P
P
V
T
R
R
R
S
R
S
R
T
P
P
V
Site 562
S1960
V
T
R
R
R
S
R
S
R
T
P
P
V
T
R
Site 563
S1970
P
P
V
T
R
R
R
S
R
S
R
T
S
P
I
Site 564
S1972
V
T
R
R
R
S
R
S
R
T
S
P
I
T
R
Site 565
T1974
R
R
R
S
R
S
R
T
S
P
I
T
R
R
R
Site 566
S1975
R
R
S
R
S
R
T
S
P
I
T
R
R
R
S
Site 567
T1978
R
S
R
T
S
P
I
T
R
R
R
S
R
S
R
Site 568
S1982
S
P
I
T
R
R
R
S
R
S
R
T
S
P
V
Site 569
S1984
I
T
R
R
R
S
R
S
R
T
S
P
V
T
R
Site 570
T1986
R
R
R
S
R
S
R
T
S
P
V
T
R
R
R
Site 571
S1987
R
R
S
R
S
R
T
S
P
V
T
R
R
R
S
Site 572
T1990
R
S
R
T
S
P
V
T
R
R
R
S
R
S
R
Site 573
S1994
S
P
V
T
R
R
R
S
R
S
R
T
S
P
V
Site 574
S1996
V
T
R
R
R
S
R
S
R
T
S
P
V
T
R
Site 575
S2018
S
P
V
T
R
R
R
S
R
S
R
T
P
P
A
Site 576
S2020
V
T
R
R
R
S
R
S
R
T
P
P
A
I
R
Site 577
T2022
R
R
R
S
R
S
R
T
P
P
A
I
R
R
R
Site 578
S2030
P
P
A
I
R
R
R
S
R
S
R
T
P
L
L
Site 579
S2032
A
I
R
R
R
S
R
S
R
T
P
L
L
P
R
Site 580
T2034
R
R
R
S
R
S
R
T
P
L
L
P
R
K
R
Site 581
S2042
P
L
L
P
R
K
R
S
R
S
R
S
P
L
A
Site 582
S2044
L
P
R
K
R
S
R
S
R
S
P
L
A
I
R
Site 583
S2046
R
K
R
S
R
S
R
S
P
L
A
I
R
R
R
Site 584
S2054
P
L
A
I
R
R
R
S
R
S
R
T
P
R
T
Site 585
S2056
A
I
R
R
R
S
R
S
R
T
P
R
T
A
R
Site 586
T2058
R
R
R
S
R
S
R
T
P
R
T
A
R
G
K
Site 587
T2061
S
R
S
R
T
P
R
T
A
R
G
K
R
S
L
Site 588
S2067
R
T
A
R
G
K
R
S
L
T
R
S
P
P
A
Site 589
T2069
A
R
G
K
R
S
L
T
R
S
P
P
A
I
R
Site 590
S2071
G
K
R
S
L
T
R
S
P
P
A
I
R
R
R
Site 591
S2079
P
P
A
I
R
R
R
S
A
S
G
S
S
S
D
Site 592
S2081
A
I
R
R
R
S
A
S
G
S
S
S
D
R
S
Site 593
S2083
R
R
R
S
A
S
G
S
S
S
D
R
S
R
S
Site 594
S2084
R
R
S
A
S
G
S
S
S
D
R
S
R
S
A
Site 595
S2085
R
S
A
S
G
S
S
S
D
R
S
R
S
A
T
Site 596
S2088
S
G
S
S
S
D
R
S
R
S
A
T
P
P
A
Site 597
S2090
S
S
S
D
R
S
R
S
A
T
P
P
A
T
R
Site 598
T2092
S
D
R
S
R
S
A
T
P
P
A
T
R
N
H
Site 599
T2096
R
S
A
T
P
P
A
T
R
N
H
S
G
S
R
Site 600
S2100
P
P
A
T
R
N
H
S
G
S
R
T
P
P
V
Site 601
S2102
A
T
R
N
H
S
G
S
R
T
P
P
V
A
L
Site 602
T2104
R
N
H
S
G
S
R
T
P
P
V
A
L
N
S
Site 603
S2111
T
P
P
V
A
L
N
S
S
R
M
S
C
F
S
Site 604
S2112
P
P
V
A
L
N
S
S
R
M
S
C
F
S
R
Site 605
S2115
A
L
N
S
S
R
M
S
C
F
S
R
P
S
M
Site 606
S2118
S
S
R
M
S
C
F
S
R
P
S
M
S
P
T
Site 607
S2121
M
S
C
F
S
R
P
S
M
S
P
T
P
L
D
Site 608
S2123
C
F
S
R
P
S
M
S
P
T
P
L
D
R
C
Site 609
T2125
S
R
P
S
M
S
P
T
P
L
D
R
C
R
S
Site 610
S2132
T
P
L
D
R
C
R
S
P
G
M
L
E
P
L
Site 611
S2141
G
M
L
E
P
L
G
S
S
R
T
P
M
S
V
Site 612
T2144
E
P
L
G
S
S
R
T
P
M
S
V
L
Q
Q
Site 613
S2147
G
S
S
R
T
P
M
S
V
L
Q
Q
A
G
G
Site 614
S2155
V
L
Q
Q
A
G
G
S
M
M
D
G
P
G
P
Site 615
T2170
R
I
P
D
H
Q
R
T
S
V
P
E
N
H
A
Site 616
S2171
I
P
D
H
Q
R
T
S
V
P
E
N
H
A
Q
Site 617
S2198
G
T
A
R
P
P
P
S
M
S
A
A
G
L
A
Site 618
S2200
A
R
P
P
P
S
M
S
A
A
G
L
A
A
R
Site 619
S2209
A
G
L
A
A
R
M
S
Q
V
P
A
P
V
P
Site 620
S2236
A
S
R
I
P
A
A
S
A
A
A
M
N
L
A
Site 621
T2247
M
N
L
A
S
A
R
T
P
A
I
P
T
A
V
Site 622
T2252
A
R
T
P
A
I
P
T
A
V
N
L
A
D
S
Site 623
S2259
T
A
V
N
L
A
D
S
R
T
P
A
A
A
A
Site 624
T2261
V
N
L
A
D
S
R
T
P
A
A
A
A
A
M
Site 625
S2272
A
A
A
M
N
L
A
S
P
R
T
A
V
A
P
Site 626
T2289
V
N
L
A
D
P
R
T
P
T
A
P
A
V
N
Site 627
T2291
L
A
D
P
R
T
P
T
A
P
A
V
N
L
A
Site 628
T2302
V
N
L
A
G
A
R
T
P
A
A
L
A
A
L
Site 629
S2310
P
A
A
L
A
A
L
S
L
T
G
S
G
T
P
Site 630
T2312
A
L
A
A
L
S
L
T
G
S
G
T
P
P
T
Site 631
S2314
A
A
L
S
L
T
G
S
G
T
P
P
T
A
A
Site 632
T2316
L
S
L
T
G
S
G
T
P
P
T
A
A
N
Y
Site 633
T2319
T
G
S
G
T
P
P
T
A
A
N
Y
P
S
S
Site 634
Y2323
T
P
P
T
A
A
N
Y
P
S
S
S
R
T
P
Site 635
S2325
P
T
A
A
N
Y
P
S
S
S
R
T
P
Q
A
Site 636
S2326
T
A
A
N
Y
P
S
S
S
R
T
P
Q
A
P
Site 637
S2327
A
A
N
Y
P
S
S
S
R
T
P
Q
A
P
A
Site 638
T2329
N
Y
P
S
S
S
R
T
P
Q
A
P
A
S
A
Site 639
S2335
R
T
P
Q
A
P
A
S
A
N
L
V
G
P
R
Site 640
S2343
A
N
L
V
G
P
R
S
A
H
A
T
A
P
V
Site 641
T2347
G
P
R
S
A
H
A
T
A
P
V
N
I
A
G
Site 642
S2355
A
P
V
N
I
A
G
S
R
T
A
A
A
L
A
Site 643
T2357
V
N
I
A
G
S
R
T
A
A
A
L
A
P
A
Site 644
S2365
A
A
A
L
A
P
A
S
L
T
S
A
R
M
A
Site 645
S2376
A
R
M
A
P
A
L
S
G
A
N
L
T
S
P
Site 646
T2381
A
L
S
G
A
N
L
T
S
P
R
V
P
L
S
Site 647
S2382
L
S
G
A
N
L
T
S
P
R
V
P
L
S
A
Site 648
S2388
T
S
P
R
V
P
L
S
A
Y
E
R
V
S
G
Site 649
Y2390
P
R
V
P
L
S
A
Y
E
R
V
S
G
R
T
Site 650
S2394
L
S
A
Y
E
R
V
S
G
R
T
S
P
P
L
Site 651
T2397
Y
E
R
V
S
G
R
T
S
P
P
L
L
D
R
Site 652
S2398
E
R
V
S
G
R
T
S
P
P
L
L
D
R
A
Site 653
S2407
P
L
L
D
R
A
R
S
R
T
P
P
S
A
P
Site 654
T2409
L
D
R
A
R
S
R
T
P
P
S
A
P
S
Q
Site 655
S2412
A
R
S
R
T
P
P
S
A
P
S
Q
S
R
M
Site 656
S2415
R
T
P
P
S
A
P
S
Q
S
R
M
T
S
E
Site 657
S2417
P
P
S
A
P
S
Q
S
R
M
T
S
E
R
A
Site 658
T2420
A
P
S
Q
S
R
M
T
S
E
R
A
P
S
P
Site 659
S2421
P
S
Q
S
R
M
T
S
E
R
A
P
S
P
S
Site 660
S2426
M
T
S
E
R
A
P
S
P
S
S
R
M
G
Q
Site 661
S2428
S
E
R
A
P
S
P
S
S
R
M
G
Q
A
P
Site 662
S2429
E
R
A
P
S
P
S
S
R
M
G
Q
A
P
S
Site 663
S2436
S
R
M
G
Q
A
P
S
Q
S
L
L
P
P
A
Site 664
S2438
M
G
Q
A
P
S
Q
S
L
L
P
P
A
Q
D
Site 665
S2449
P
A
Q
D
Q
P
R
S
P
V
P
S
A
F
S
Site 666
S2453
Q
P
R
S
P
V
P
S
A
F
S
D
Q
S
R
Site 667
S2456
S
P
V
P
S
A
F
S
D
Q
S
R
C
L
I
Site 668
S2459
P
S
A
F
S
D
Q
S
R
C
L
I
A
Q
T
Site 669
T2467
R
C
L
I
A
Q
T
T
P
V
A
G
S
Q
S
Site 670
S2472
Q
T
T
P
V
A
G
S
Q
S
L
S
S
G
A
Site 671
T2484
S
G
A
V
A
T
T
T
S
S
A
G
D
H
N
Site 672
S2495
G
D
H
N
G
M
L
S
V
P
A
P
G
V
P
Site 673
S2504
P
A
P
G
V
P
H
S
D
V
G
E
P
P
A
Site 674
S2512
D
V
G
E
P
P
A
S
T
G
A
Q
Q
P
S
Site 675
S2532
Q
P
A
K
E
R
R
S
S
S
S
S
S
S
S
Site 676
S2533
P
A
K
E
R
R
S
S
S
S
S
S
S
S
S
Site 677
S2534
A
K
E
R
R
S
S
S
S
S
S
S
S
S
S
Site 678
S2535
K
E
R
R
S
S
S
S
S
S
S
S
S
S
S
Site 679
S2536
E
R
R
S
S
S
S
S
S
S
S
S
S
S
S
Site 680
S2537
R
R
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 681
S2538
R
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 682
S2539
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 683
S2550
S
S
S
S
S
S
S
S
S
S
S
S
S
S
G
Site 684
S2551
S
S
S
S
S
S
S
S
S
S
S
S
S
G
S
Site 685
S2552
S
S
S
S
S
S
S
S
S
S
S
S
G
S
S
Site 686
S2553
S
S
S
S
S
S
S
S
S
S
S
G
S
S
S
Site 687
S2554
S
S
S
S
S
S
S
S
S
S
G
S
S
S
S
Site 688
S2555
S
S
S
S
S
S
S
S
S
G
S
S
S
S
D
Site 689
S2556
S
S
S
S
S
S
S
S
G
S
S
S
S
D
S
Site 690
S2558
S
S
S
S
S
S
G
S
S
S
S
D
S
E
G
Site 691
S2559
S
S
S
S
S
G
S
S
S
S
D
S
E
G
S
Site 692
S2560
S
S
S
S
G
S
S
S
S
D
S
E
G
S
S
Site 693
S2561
S
S
S
G
S
S
S
S
D
S
E
G
S
S
L
Site 694
S2563
S
G
S
S
S
S
D
S
E
G
S
S
L
P
V
Site 695
S2566
S
S
S
D
S
E
G
S
S
L
P
V
Q
P
E
Site 696
S2567
S
S
D
S
E
G
S
S
L
P
V
Q
P
E
V
Site 697
S2581
V
A
L
K
R
V
P
S
P
T
P
A
P
K
E
Site 698
T2583
L
K
R
V
P
S
P
T
P
A
P
K
E
A
V
Site 699
T2599
E
G
R
P
P
E
P
T
P
A
K
R
K
R
R
Site 700
S2607
P
A
K
R
K
R
R
S
S
S
S
S
S
S
S
Site 701
S2608
A
K
R
K
R
R
S
S
S
S
S
S
S
S
S
Site 702
S2609
K
R
K
R
R
S
S
S
S
S
S
S
S
S
S
Site 703
S2610
R
K
R
R
S
S
S
S
S
S
S
S
S
S
S
Site 704
S2611
K
R
R
S
S
S
S
S
S
S
S
S
S
S
S
Site 705
S2642
S
S
S
S
S
S
S
S
S
S
S
S
S
S
P
Site 706
S2643
S
S
S
S
S
S
S
S
S
S
S
S
S
P
S
Site 707
S2644
S
S
S
S
S
S
S
S
S
S
S
S
P
S
P
Site 708
S2645
S
S
S
S
S
S
S
S
S
S
S
P
S
P
A
Site 709
S2646
S
S
S
S
S
S
S
S
S
S
P
S
P
A
K
Site 710
S2647
S
S
S
S
S
S
S
S
S
P
S
P
A
K
P
Site 711
S2648
S
S
S
S
S
S
S
S
P
S
P
A
K
P
G
Site 712
S2650
S
S
S
S
S
S
P
S
P
A
K
P
G
P
Q
Site 713
S2664
Q
A
L
P
K
P
A
S
P
K
K
P
P
P
G
Site 714
S2675
P
P
P
G
E
R
R
S
R
S
P
R
K
P
I
Site 715
S2677
P
G
E
R
R
S
R
S
P
R
K
P
I
D
S
Site 716
S2684
S
P
R
K
P
I
D
S
L
R
D
S
R
S
L
Site 717
S2688
P
I
D
S
L
R
D
S
R
S
L
S
Y
S
P
Site 718
S2690
D
S
L
R
D
S
R
S
L
S
Y
S
P
V
E
Site 719
S2692
L
R
D
S
R
S
L
S
Y
S
P
V
E
R
R
Site 720
Y2693
R
D
S
R
S
L
S
Y
S
P
V
E
R
R
R
Site 721
S2694
D
S
R
S
L
S
Y
S
P
V
E
R
R
R
P
Site 722
S2702
P
V
E
R
R
R
P
S
P
Q
P
S
P
R
D
Site 723
S2706
R
R
P
S
P
Q
P
S
P
R
D
Q
Q
S
S
Site 724
S2712
P
S
P
R
D
Q
Q
S
S
S
S
E
R
G
S
Site 725
S2713
S
P
R
D
Q
Q
S
S
S
S
E
R
G
S
R
Site 726
S2714
P
R
D
Q
Q
S
S
S
S
E
R
G
S
R
R
Site 727
S2715
R
D
Q
Q
S
S
S
S
E
R
G
S
R
R
G
Site 728
S2719
S
S
S
S
E
R
G
S
R
R
G
Q
R
G
D
Site 729
S2727
R
R
G
Q
R
G
D
S
R
S
P
S
H
K
R
Site 730
S2729
G
Q
R
G
D
S
R
S
P
S
H
K
R
R
R
Site 731
S2731
R
G
D
S
R
S
P
S
H
K
R
R
R
E
T
Site 732
T2738
S
H
K
R
R
R
E
T
P
S
P
R
P
M
R
Site 733
S2740
K
R
R
R
E
T
P
S
P
R
P
M
R
H
R
Site 734
S2748
P
R
P
M
R
H
R
S
S
R
S
P
_
_
_
Site 735
S2749
R
P
M
R
H
R
S
S
R
S
P
_
_
_
_
Site 736
S2751
M
R
H
R
S
S
R
S
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation