KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DYRK1B
Full Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Alias:
Dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B; Dual-specificity tyrosine-phosphorylation regulated kinase 1B; DYR1B; EC 2.7.12.1; Kinase DYRK1B; Minibrain-related kinase; MIRK; Mirk protein kinase
Type:
Protein kinase, dual-specificity; EC 2.7.12.1;
CMGC
group; DYRK family; Dyrk1 subfamily
Mass (Da):
69198
Number AA:
629
UniProt ID:
Q9Y463
International Prot ID:
IPI00000352
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
GO:0045893
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
P
G
H
G
P
F
S
G
F
P
G
P
Q
E
Site 2
T41
P
L
A
F
R
D
A
T
S
A
P
L
R
K
L
Site 3
S49
S
A
P
L
R
K
L
S
V
D
L
I
K
T
Y
Site 4
Y56
S
V
D
L
I
K
T
Y
K
H
I
N
E
V
Y
Site 5
Y63
Y
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
Site 6
Y64
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
A
Site 7
S80
Q
A
P
P
Q
D
S
S
N
K
K
E
K
K
V
Site 8
Y92
K
K
V
L
N
H
G
Y
D
D
D
N
H
D
Y
Site 9
Y99
Y
D
D
D
N
H
D
Y
I
V
R
S
G
E
R
Site 10
Y111
G
E
R
W
L
E
R
Y
E
I
D
S
L
I
G
Site 11
S115
L
E
R
Y
E
I
D
S
L
I
G
K
G
S
F
Site 12
Y129
F
G
Q
V
V
K
A
Y
D
H
Q
T
Q
E
L
Site 13
T133
V
K
A
Y
D
H
Q
T
Q
E
L
V
A
I
K
Site 14
Y171
Q
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
Site 15
Y172
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Site 16
Y198
E
L
L
S
Y
N
L
Y
D
L
L
R
N
T
H
Site 17
T204
L
Y
D
L
L
R
N
T
H
F
R
G
V
S
L
Site 18
S210
N
T
H
F
R
G
V
S
L
N
L
T
R
K
L
Site 19
T214
R
G
V
S
L
N
L
T
R
K
L
A
Q
Q
L
Site 20
S262
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
Site 21
Y271
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Site 22
Y273
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
Site 23
S276
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
Site 24
Y279
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
Site 25
S281
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
T
Site 26
S314
H
T
G
E
P
L
F
S
G
S
N
E
V
D
Q
Site 27
S316
G
E
P
L
F
S
G
S
N
E
V
D
Q
M
N
Site 28
Y346
Q
A
P
K
A
R
K
Y
F
E
R
L
P
G
G
Site 29
T356
R
L
P
G
G
G
W
T
L
R
R
T
K
E
L
Site 30
T360
G
G
W
T
L
R
R
T
K
E
L
R
K
D
Y
Site 31
Y367
T
K
E
L
R
K
D
Y
Q
G
P
G
T
R
R
Site 32
T372
K
D
Y
Q
G
P
G
T
R
R
L
Q
E
V
L
Site 33
T383
Q
E
V
L
G
V
Q
T
G
G
P
G
G
R
R
Site 34
S397
R
A
G
E
P
G
H
S
P
A
D
Y
L
R
F
Site 35
Y401
P
G
H
S
P
A
D
Y
L
R
F
Q
D
L
V
Site 36
Y414
L
V
L
R
M
L
E
Y
E
P
A
A
R
I
S
Site 37
S421
Y
E
P
A
A
R
I
S
P
L
G
A
L
Q
H
Site 38
T434
Q
H
G
F
F
R
R
T
A
D
E
A
T
N
T
Site 39
T441
T
A
D
E
A
T
N
T
G
P
A
G
S
S
A
Site 40
S446
T
N
T
G
P
A
G
S
S
A
S
T
S
P
A
Site 41
S447
N
T
G
P
A
G
S
S
A
S
T
S
P
A
P
Site 42
S449
G
P
A
G
S
S
A
S
T
S
P
A
P
L
D
Site 43
T450
P
A
G
S
S
A
S
T
S
P
A
P
L
D
T
Site 44
S451
A
G
S
S
A
S
T
S
P
A
P
L
D
T
C
Site 45
T457
T
S
P
A
P
L
D
T
C
P
S
S
S
T
A
Site 46
S460
A
P
L
D
T
C
P
S
S
S
T
A
S
S
I
Site 47
S461
P
L
D
T
C
P
S
S
S
T
A
S
S
I
S
Site 48
S462
L
D
T
C
P
S
S
S
T
A
S
S
I
S
S
Site 49
T463
D
T
C
P
S
S
S
T
A
S
S
I
S
S
S
Site 50
S465
C
P
S
S
S
T
A
S
S
I
S
S
S
G
G
Site 51
S466
P
S
S
S
T
A
S
S
I
S
S
S
G
G
S
Site 52
S468
S
S
T
A
S
S
I
S
S
S
G
G
S
S
G
Site 53
S469
S
T
A
S
S
I
S
S
S
G
G
S
S
G
S
Site 54
S470
T
A
S
S
I
S
S
S
G
G
S
S
G
S
S
Site 55
S473
S
I
S
S
S
G
G
S
S
G
S
S
S
D
N
Site 56
S474
I
S
S
S
G
G
S
S
G
S
S
S
D
N
R
Site 57
S476
S
S
G
G
S
S
G
S
S
S
D
N
R
T
Y
Site 58
S477
S
G
G
S
S
G
S
S
S
D
N
R
T
Y
R
Site 59
S478
G
G
S
S
G
S
S
S
D
N
R
T
Y
R
Y
Site 60
T482
G
S
S
S
D
N
R
T
Y
R
Y
S
N
R
Y
Site 61
Y483
S
S
S
D
N
R
T
Y
R
Y
S
N
R
Y
C
Site 62
Y485
S
D
N
R
T
Y
R
Y
S
N
R
Y
C
G
G
Site 63
S486
D
N
R
T
Y
R
Y
S
N
R
Y
C
G
G
P
Site 64
Y489
T
Y
R
Y
S
N
R
Y
C
G
G
P
G
P
P
Site 65
T498
G
G
P
G
P
P
I
T
D
C
E
M
N
S
P
Site 66
S504
I
T
D
C
E
M
N
S
P
Q
V
P
P
S
Q
Site 67
S510
N
S
P
Q
V
P
P
S
Q
P
L
R
P
W
A
Site 68
T525
G
G
D
V
P
H
K
T
H
Q
A
P
A
S
A
Site 69
S531
K
T
H
Q
A
P
A
S
A
S
S
L
P
G
T
Site 70
S533
H
Q
A
P
A
S
A
S
S
L
P
G
T
G
A
Site 71
S534
Q
A
P
A
S
A
S
S
L
P
G
T
G
A
Q
Site 72
T538
S
A
S
S
L
P
G
T
G
A
Q
L
P
P
Q
Site 73
Y548
Q
L
P
P
Q
P
R
Y
L
G
R
P
P
S
P
Site 74
S554
R
Y
L
G
R
P
P
S
P
T
S
P
P
P
P
Site 75
T556
L
G
R
P
P
S
P
T
S
P
P
P
P
E
L
Site 76
S557
G
R
P
P
S
P
T
S
P
P
P
P
E
L
M
Site 77
S576
V
G
G
P
A
D
C
S
P
P
H
P
A
P
A
Site 78
T594
P
A
A
S
A
L
R
T
R
M
T
G
G
R
P
Site 79
T597
S
A
L
R
T
R
M
T
G
G
R
P
P
L
P
Site 80
T611
P
P
P
D
D
P
A
T
L
G
P
H
L
G
L
Site 81
S624
G
L
R
G
V
P
Q
S
T
A
A
S
S
_
_
Site 82
T625
L
R
G
V
P
Q
S
T
A
A
S
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation