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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRRAP
Full Name:
Transformation/transcription domain-associated protein
Alias:
350,400 kDa PCAF-associated factor; 350/400 kDa PCAF-associated factor; PAF350,400; PAF350/400; PAF400; STAF40; Tra1; Transformation/transcription domain-associated; TRAP; TR-AP
Type:
Transcription, coactivator/corepressor; Protein kinase, Ser/Thr (non-receptor); Nuclear receptor co-regulator;
ATYPICAL
group; PIKK family; TRRAP subfamily
Mass (Da):
437600
Number AA:
3859
UniProt ID:
Q9Y4A5
International Prot ID:
IPI00069084
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000123
GO:0000125
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003712
GO:0003713
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0000075
GO:0006139
GO:0006325
Phosida
TranscriptoNet
STRING
Kinexus Products
Transformation/transcription domain-associated protein pan-specific antibody AB-NK232#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK232#Transformation/transcription domain-associated protein pan-specific antibody AB-NK232-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK232-1#Transformation/transcription domain-associated protein pan-specific antibody AB-NK232-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK232-3#Transformation/transcription domain-associated protein (A3513-P3527, human) peptide - Powder PE-01ATL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ATL99#Transformation/transcription domain-associated protein (A3513-P3527, human) peptide - Powder PE-01ATL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ATL99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
A
T
V
V
D
Q
T
T
L
M
K
K
Y
L
Q
Site 2
T33
A
A
L
T
D
V
N
T
P
D
E
T
K
L
K
Site 3
T53
S
E
N
F
E
N
V
T
S
S
P
Q
Y
S
T
Site 4
S55
N
F
E
N
V
T
S
S
P
Q
Y
S
T
F
L
Site 5
Y58
N
V
T
S
S
P
Q
Y
S
T
F
L
E
H
I
Site 6
S59
V
T
S
S
P
Q
Y
S
T
F
L
E
H
I
I
Site 7
T60
T
S
S
P
Q
Y
S
T
F
L
E
H
I
I
P
Site 8
T102
E
I
I
H
R
I
P
T
N
E
H
L
R
P
H
Site 9
T110
N
E
H
L
R
P
H
T
K
N
V
L
S
V
M
Site 10
T148
K
Q
F
R
P
P
I
T
Q
E
I
H
H
F
L
Site 11
Y172
L
P
K
V
V
N
R
Y
F
E
N
P
Q
V
I
Site 12
T183
P
Q
V
I
P
E
N
T
V
P
P
P
E
M
V
Site 13
S207
V
N
P
E
R
E
D
S
E
T
R
T
H
S
I
Site 14
T209
P
E
R
E
D
S
E
T
R
T
H
S
I
I
P
Site 15
T211
R
E
D
S
E
T
R
T
H
S
I
I
P
R
G
Site 16
S213
D
S
E
T
R
T
H
S
I
I
P
R
G
S
L
Site 17
Y272
Q
A
R
Q
H
K
L
Y
N
K
E
L
Y
A
D
Site 18
Y277
K
L
Y
N
K
E
L
Y
A
D
F
I
A
A
Q
Site 19
S306
Q
E
L
V
T
K
Y
S
Q
Q
M
V
K
G
M
Site 20
Y365
S
I
L
I
G
S
G
Y
T
A
R
E
T
L
R
Site 21
T370
S
G
Y
T
A
R
E
T
L
R
P
L
A
Y
S
Site 22
S410
A
K
N
I
D
D
E
S
L
P
S
S
I
Q
T
Site 23
S413
I
D
D
E
S
L
P
S
S
I
Q
T
M
S
C
Site 24
S414
D
D
E
S
L
P
S
S
I
Q
T
M
S
C
K
Site 25
S434
V
D
C
I
R
S
K
S
E
Q
E
S
G
N
G
Site 26
S438
R
S
K
S
E
Q
E
S
G
N
G
R
D
V
L
Site 27
S475
F
K
K
C
K
P
Q
S
E
L
G
A
V
E
A
Site 28
S499
A
A
P
G
P
A
P
S
P
A
P
V
P
A
P
Site 29
T517
P
P
P
P
P
P
A
T
P
V
T
P
A
P
V
Site 30
T540
K
D
K
E
D
K
Q
T
F
Q
V
T
D
C
R
Site 31
T544
D
K
Q
T
F
Q
V
T
D
C
R
S
L
V
K
Site 32
Y589
Q
P
K
E
T
Q
I
Y
I
K
L
V
K
Y
A
Site 33
Y614
I
A
G
N
G
Q
T
Y
I
R
V
A
N
C
Q
Site 34
T622
I
R
V
A
N
C
Q
T
V
R
M
K
E
E
K
Site 35
Y666
V
E
R
I
S
K
N
Y
A
L
Q
I
V
A
N
Site 36
S702
D
R
L
P
E
M
G
S
N
V
E
L
S
N
L
Site 37
T749
S
S
M
E
L
A
Q
T
A
K
E
P
Y
N
Y
Site 38
S766
L
L
R
A
L
F
R
S
I
G
G
G
S
H
D
Site 39
S818
L
T
V
P
V
R
L
S
S
L
L
P
Y
L
P
Site 40
T840
S
A
L
N
G
S
Q
T
L
V
S
Q
G
L
R
Site 41
S843
N
G
S
Q
T
L
V
S
Q
G
L
R
T
L
E
Site 42
Y862
N
L
Q
P
D
F
L
Y
D
H
I
Q
P
V
R
Site 43
S886
T
L
R
N
P
A
D
S
I
S
H
V
A
Y
R
Site 44
S888
R
N
P
A
D
S
I
S
H
V
A
Y
R
V
L
Site 45
S901
V
L
G
K
F
G
G
S
N
R
K
M
L
K
E
Site 46
Y914
K
E
S
Q
K
L
H
Y
V
V
T
E
V
Q
G
Site 47
T917
Q
K
L
H
Y
V
V
T
E
V
Q
G
P
S
I
Site 48
T925
E
V
Q
G
P
S
I
T
V
E
F
S
D
C
K
Site 49
S929
P
S
I
T
V
E
F
S
D
C
K
A
S
L
Q
Site 50
S952
T
A
L
D
C
L
K
S
A
N
T
E
P
Y
Y
Site 51
Y958
K
S
A
N
T
E
P
Y
Y
R
R
Q
A
W
E
Site 52
Y959
S
A
N
T
E
P
Y
Y
R
R
Q
A
W
E
V
Site 53
Y985
E
D
N
K
H
A
L
Y
Q
L
L
A
H
P
N
Site 54
Y1007
N
V
I
I
S
H
R
Y
K
A
Q
D
T
P
A
Site 55
T1012
H
R
Y
K
A
Q
D
T
P
A
R
K
T
F
E
Site 56
T1017
Q
D
T
P
A
R
K
T
F
E
Q
A
L
T
G
Site 57
S1044
S
A
L
P
F
V
A
S
L
I
R
H
Y
T
M
Site 58
Y1066
G
P
F
L
L
P
C
Y
Q
V
G
S
Q
P
S
Site 59
S1073
Y
Q
V
G
S
Q
P
S
T
A
M
F
H
S
E
Site 60
T1074
Q
V
G
S
Q
P
S
T
A
M
F
H
S
E
E
Site 61
S1079
P
S
T
A
M
F
H
S
E
E
N
G
S
K
G
Site 62
T1174
L
M
E
R
L
P
L
T
W
V
L
Q
N
Q
Q
Site 63
T1219
Q
L
L
M
R
C
A
T
P
L
K
D
E
E
R
Site 64
T1250
H
D
L
V
R
E
V
T
S
P
N
S
T
V
R
Site 65
S1251
D
L
V
R
E
V
T
S
P
N
S
T
V
R
K
Site 66
S1254
R
E
V
T
S
P
N
S
T
V
R
K
Q
A
M
Site 67
T1255
E
V
T
S
P
N
S
T
V
R
K
Q
A
M
H
Site 68
T1276
Q
V
T
G
K
S
V
T
V
I
M
E
P
H
K
Site 69
T1317
E
G
N
T
F
C
T
T
L
Q
P
R
L
F
T
Site 70
S1348
N
L
C
E
A
E
D
S
A
L
T
K
L
P
C
Site 71
Y1378
N
A
L
A
A
C
N
Y
L
P
Q
S
R
E
K
Site 72
S1382
A
C
N
Y
L
P
Q
S
R
E
K
I
I
A
A
Site 73
S1396
A
L
F
K
A
L
N
S
T
N
S
E
L
Q
E
Site 74
Y1437
L
L
M
M
L
G
D
Y
R
S
L
T
L
N
V
Site 75
T1441
L
G
D
Y
R
S
L
T
L
N
V
V
N
R
L
Site 76
S1450
N
V
V
N
R
L
T
S
V
T
R
L
F
P
N
Site 77
T1452
V
N
R
L
T
S
V
T
R
L
F
P
N
S
F
Site 78
S1488
T
H
K
G
G
Q
R
S
D
G
N
E
S
I
S
Site 79
S1495
S
D
G
N
E
S
I
S
E
C
G
R
C
P
L
Site 80
S1503
E
C
G
R
C
P
L
S
P
F
C
Q
F
E
E
Site 81
S1552
A
M
L
I
E
A
G
S
P
F
R
E
P
L
I
Site 82
T1563
E
P
L
I
K
F
L
T
R
H
P
S
Q
T
V
Site 83
S1567
K
F
L
T
R
H
P
S
Q
T
V
E
L
F
M
Site 84
T1569
L
T
R
H
P
S
Q
T
V
E
L
F
M
M
E
Site 85
S1628
Q
T
A
V
R
P
G
S
P
S
T
S
T
M
R
Site 86
S1630
A
V
R
P
G
S
P
S
T
S
T
M
R
L
D
Site 87
S1632
R
P
G
S
P
S
T
S
T
M
R
L
D
L
Q
Site 88
T1633
P
G
S
P
S
T
S
T
M
R
L
D
L
Q
F
Site 89
S1655
I
I
V
K
N
D
D
S
W
L
A
S
Q
H
S
Site 90
S1659
N
D
D
S
W
L
A
S
Q
H
S
L
V
S
Q
Site 91
S1662
S
W
L
A
S
Q
H
S
L
V
S
Q
L
R
R
Site 92
S1665
A
S
Q
H
S
L
V
S
Q
L
R
R
V
W
V
Site 93
Y1703
L
A
Y
C
L
L
N
Y
C
K
R
N
Y
G
D
Site 94
Y1708
L
N
Y
C
K
R
N
Y
G
D
I
E
L
L
F
Site 95
T1730
G
R
F
L
C
N
M
T
F
L
K
E
Y
M
E
Site 96
Y1735
N
M
T
F
L
K
E
Y
M
E
E
E
I
P
K
Site 97
Y1783
I
L
N
P
A
F
L
Y
S
F
E
K
G
E
G
Site 98
S1784
L
N
P
A
F
L
Y
S
F
E
K
G
E
G
E
Site 99
S1806
P
E
G
D
N
P
E
S
I
T
S
V
F
I
T
Site 100
S1827
K
Q
A
D
M
L
D
S
L
R
I
Y
L
L
Q
Site 101
S1856
D
N
N
K
N
R
N
S
K
L
R
R
L
M
T
Site 102
Y1974
I
V
Q
H
F
K
V
Y
Y
P
V
R
H
H
L
Site 103
Y1975
V
Q
H
F
K
V
Y
Y
P
V
R
H
H
L
V
Site 104
T1995
A
M
Q
R
L
G
F
T
P
S
V
T
I
E
Q
Site 105
S1997
Q
R
L
G
F
T
P
S
V
T
I
E
Q
R
R
Site 106
T1999
L
G
F
T
P
S
V
T
I
E
Q
R
R
L
A
Site 107
S2028
I
K
D
Q
Q
P
D
S
D
M
D
P
N
S
S
Site 108
S2034
D
S
D
M
D
P
N
S
S
G
E
G
V
N
S
Site 109
S2035
S
D
M
D
P
N
S
S
G
E
G
V
N
S
V
Site 110
S2041
S
S
G
E
G
V
N
S
V
S
S
S
I
K
R
Site 111
S2043
G
E
G
V
N
S
V
S
S
S
I
K
R
G
L
Site 112
S2044
E
G
V
N
S
V
S
S
S
I
K
R
G
L
S
Site 113
S2045
G
V
N
S
V
S
S
S
I
K
R
G
L
S
V
Site 114
S2051
S
S
I
K
R
G
L
S
V
D
S
A
Q
E
V
Site 115
T2063
Q
E
V
K
R
F
R
T
A
T
G
A
I
S
A
Site 116
S2069
R
T
A
T
G
A
I
S
A
V
F
G
R
S
Q
Site 117
S2075
I
S
A
V
F
G
R
S
Q
S
L
P
G
A
D
Site 118
S2077
A
V
F
G
R
S
Q
S
L
P
G
A
D
S
L
Site 119
S2083
Q
S
L
P
G
A
D
S
L
L
A
K
P
I
D
Site 120
T2096
I
D
K
Q
H
T
D
T
V
V
N
F
L
I
R
Site 121
T2112
A
C
Q
V
N
D
N
T
N
T
A
G
S
P
G
Site 122
S2117
D
N
T
N
T
A
G
S
P
G
E
V
L
S
R
Site 123
T2132
R
C
V
N
L
L
K
T
A
L
R
P
D
M
W
Site 124
T2155
W
F
D
K
L
L
M
T
V
E
Q
P
N
Q
V
Site 125
Y2164
E
Q
P
N
Q
V
N
Y
G
N
I
C
T
G
L
Site 126
S2188
L
Q
S
P
A
I
L
S
S
F
K
P
L
Q
R
Site 127
S2189
Q
S
P
A
I
L
S
S
F
K
P
L
Q
R
G
Site 128
T2225
R
L
M
S
I
F
P
T
E
P
S
T
S
S
V
Site 129
S2228
S
I
F
P
T
E
P
S
T
S
S
V
A
S
K
Site 130
T2229
I
F
P
T
E
P
S
T
S
S
V
A
S
K
Y
Site 131
S2230
F
P
T
E
P
S
T
S
S
V
A
S
K
Y
E
Site 132
S2231
P
T
E
P
S
T
S
S
V
A
S
K
Y
E
E
Site 133
S2234
P
S
T
S
S
V
A
S
K
Y
E
E
L
E
C
Site 134
Y2236
T
S
S
V
A
S
K
Y
E
E
L
E
C
L
Y
Site 135
Y2257
I
Y
E
G
L
T
N
Y
E
K
A
T
N
A
N
Site 136
S2266
K
A
T
N
A
N
P
S
Q
L
F
G
T
L
M
Site 137
S2277
G
T
L
M
I
L
K
S
A
C
S
N
N
P
S
Site 138
S2280
M
I
L
K
S
A
C
S
N
N
P
S
Y
I
D
Site 139
S2284
S
A
C
S
N
N
P
S
Y
I
D
R
L
I
S
Site 140
Y2285
A
C
S
N
N
P
S
Y
I
D
R
L
I
S
V
Site 141
S2313
N
P
Q
A
A
S
G
S
T
E
A
T
S
G
T
Site 142
T2317
A
S
G
S
T
E
A
T
S
G
T
S
E
L
V
Site 143
S2318
S
G
S
T
E
A
T
S
G
T
S
E
L
V
M
Site 144
T2333
L
S
L
E
L
V
K
T
R
L
A
V
M
S
M
Site 145
S2339
K
T
R
L
A
V
M
S
M
E
M
R
K
N
F
Site 146
S2358
L
T
S
L
I
E
K
S
P
D
A
K
I
L
R
Site 147
S2379
E
E
W
V
K
N
N
S
P
M
A
A
N
Q
T
Site 148
T2386
S
P
M
A
A
N
Q
T
P
T
L
R
E
K
S
Site 149
T2388
M
A
A
N
Q
T
P
T
L
R
E
K
S
I
L
Site 150
T2401
I
L
L
V
K
M
M
T
Y
I
E
K
R
F
P
Site 151
Y2423
Q
F
L
D
L
V
N
Y
V
Y
R
D
E
T
L
Site 152
Y2425
L
D
L
V
N
Y
V
Y
R
D
E
T
L
S
G
Site 153
T2429
N
Y
V
Y
R
D
E
T
L
S
G
S
E
L
T
Site 154
S2431
V
Y
R
D
E
T
L
S
G
S
E
L
T
A
K
Site 155
Y2471
N
S
M
K
R
R
V
Y
E
R
L
L
Y
V
T
Site 156
Y2476
R
V
Y
E
R
L
L
Y
V
T
C
S
Q
N
W
Site 157
S2552
E
P
R
E
R
E
N
S
E
S
K
E
E
D
V
Site 158
S2554
R
E
R
E
N
S
E
S
K
E
E
D
V
E
I
Site 159
T2571
E
L
A
P
G
D
Q
T
S
T
P
K
T
K
E
Site 160
S2572
L
A
P
G
D
Q
T
S
T
P
K
T
K
E
L
Site 161
T2573
A
P
G
D
Q
T
S
T
P
K
T
K
E
L
S
Site 162
T2576
D
Q
T
S
T
P
K
T
K
E
L
S
E
K
D
Site 163
S2580
T
P
K
T
K
E
L
S
E
K
D
I
G
N
Q
Site 164
T2601
R
H
D
K
F
L
D
T
L
R
E
V
K
T
G
Site 165
S2641
P
R
L
W
K
I
L
S
D
R
Q
Q
H
A
L
Site 166
S2658
E
I
S
P
F
L
C
S
G
S
H
Q
V
Q
R
Site 167
S2660
S
P
F
L
C
S
G
S
H
Q
V
Q
R
D
C
Site 168
Y2695
I
R
P
C
V
L
K
Y
L
G
K
T
H
N
L
Site 169
S2720
Q
A
F
E
K
G
L
S
L
Q
I
K
P
K
Q
Site 170
Y2732
P
K
Q
T
T
E
F
Y
E
Q
E
S
I
T
P
Site 171
T2738
F
Y
E
Q
E
S
I
T
P
P
Q
Q
E
I
L
Site 172
S2747
P
Q
Q
E
I
L
D
S
L
A
E
L
Y
S
L
Site 173
S2753
D
S
L
A
E
L
Y
S
L
L
Q
E
E
D
M
Site 174
Y2771
L
W
Q
K
R
C
K
Y
S
E
T
A
T
A
I
Site 175
Y2780
E
T
A
T
A
I
A
Y
E
Q
H
G
F
F
E
Site 176
S2807
A
K
K
E
H
E
R
S
N
A
S
P
A
I
F
Site 177
S2810
E
H
E
R
S
N
A
S
P
A
I
F
P
E
Y
Site 178
Y2817
S
P
A
I
F
P
E
Y
Q
L
W
E
D
H
W
Site 179
T2838
L
N
Q
W
E
A
L
T
E
Y
G
Q
S
K
G
Site 180
Y2840
Q
W
E
A
L
T
E
Y
G
Q
S
K
G
H
I
Site 181
T2863
A
W
R
V
S
N
W
T
A
M
K
E
A
L
V
Site 182
Y2890
K
V
N
M
Y
R
G
Y
L
A
I
C
H
P
E
Site 183
S2902
H
P
E
E
Q
Q
L
S
F
I
E
R
L
V
E
Site 184
S2912
E
R
L
V
E
M
A
S
S
L
A
I
R
E
W
Site 185
S2913
R
L
V
E
M
A
S
S
L
A
I
R
E
W
R
Site 186
S2927
R
R
L
P
H
V
V
S
H
V
H
T
P
L
L
Site 187
S2963
T
N
L
G
R
N
N
S
L
H
D
M
K
T
V
Site 188
T2969
N
S
L
H
D
M
K
T
V
V
K
T
W
R
N
Site 189
T2973
D
M
K
T
V
V
K
T
W
R
N
R
L
P
I
Site 190
S2982
R
N
R
L
P
I
V
S
D
D
L
S
H
W
S
Site 191
S3006
Y
Q
G
K
P
T
W
S
G
M
H
S
S
S
I
Site 192
S3010
P
T
W
S
G
M
H
S
S
S
I
V
T
A
Y
Site 193
S3011
T
W
S
G
M
H
S
S
S
I
V
T
A
Y
E
Site 194
S3012
W
S
G
M
H
S
S
S
I
V
T
A
Y
E
N
Site 195
T3015
M
H
S
S
S
I
V
T
A
Y
E
N
S
S
Q
Site 196
Y3017
S
S
S
I
V
T
A
Y
E
N
S
S
Q
H
D
Site 197
S3021
V
T
A
Y
E
N
S
S
Q
H
D
P
S
S
N
Site 198
S3026
N
S
S
Q
H
D
P
S
S
N
N
A
M
L
G
Site 199
S3027
S
S
Q
H
D
P
S
S
N
N
A
M
L
G
V
Site 200
S3107
Q
G
L
E
V
I
E
S
T
N
L
K
Y
F
T
Site 201
Y3112
I
E
S
T
N
L
K
Y
F
T
K
E
M
T
A
Site 202
Y3122
K
E
M
T
A
E
F
Y
A
L
K
G
M
F
L
Site 203
S3135
F
L
A
Q
I
N
K
S
E
E
A
N
K
A
F
Site 204
Y3183
G
V
S
A
I
T
C
Y
L
H
A
C
R
H
Q
Site 205
S3193
A
C
R
H
Q
N
E
S
K
S
R
K
Y
L
A
Site 206
S3195
R
H
Q
N
E
S
K
S
R
K
Y
L
A
K
V
Site 207
Y3198
N
E
S
K
S
R
K
Y
L
A
K
V
L
W
L
Site 208
S3207
A
K
V
L
W
L
L
S
F
D
D
D
K
N
T
Site 209
T3214
S
F
D
D
D
K
N
T
L
A
D
A
V
D
K
Site 210
S3255
K
L
L
L
N
L
I
S
Q
V
G
R
V
Y
P
Site 211
T3275
P
I
R
T
L
Y
L
T
L
K
I
E
Q
R
E
Site 212
Y3284
K
I
E
Q
R
E
R
Y
K
S
D
P
G
P
I
Site 213
S3286
E
Q
R
E
R
Y
K
S
D
P
G
P
I
R
A
Site 214
T3294
D
P
G
P
I
R
A
T
A
P
M
W
R
C
S
Site 215
T3313
M
Q
R
E
L
H
P
T
L
L
S
S
L
E
G
Site 216
S3349
Q
G
L
A
K
C
Y
S
V
A
F
E
K
S
G
Site 217
S3355
Y
S
V
A
F
E
K
S
G
A
V
S
D
A
K
Site 218
S3359
F
E
K
S
G
A
V
S
D
A
K
I
T
P
H
Site 219
T3390
E
N
V
S
N
V
S
T
M
F
S
S
A
A
S
Site 220
S3393
S
N
V
S
T
M
F
S
S
A
A
S
E
S
L
Site 221
S3397
T
M
F
S
S
A
A
S
E
S
L
A
R
R
A
Site 222
S3399
F
S
S
A
A
S
E
S
L
A
R
R
A
Q
A
Site 223
T3407
L
A
R
R
A
Q
A
T
A
Q
D
P
V
F
Q
Site 224
S3469
E
E
K
C
R
F
L
S
N
F
S
A
Q
T
A
Site 225
Y3492
L
M
P
K
P
T
H
Y
Y
I
K
I
A
R
F
Site 226
T3511
E
I
V
Q
K
H
N
T
A
A
R
R
L
Y
I
Site 227
Y3517
N
T
A
A
R
R
L
Y
I
R
G
H
N
G
K
Site 228
Y3526
R
G
H
N
G
K
I
Y
P
Y
L
V
M
N
D
Site 229
Y3528
H
N
G
K
I
Y
P
Y
L
V
M
N
D
A
C
Site 230
T3537
V
M
N
D
A
C
L
T
E
S
R
R
E
E
R
Site 231
S3539
N
D
A
C
L
T
E
S
R
R
E
E
R
V
L
Site 232
T3562
C
L
E
K
R
K
E
T
T
K
R
H
L
F
F
Site 233
S3589
R
L
V
E
D
N
P
S
S
L
S
L
V
E
I
Site 234
S3592
E
D
N
P
S
S
L
S
L
V
E
I
Y
K
Q
Site 235
S3613
I
E
H
D
N
P
I
S
R
Y
Y
D
R
L
A
Site 236
Y3616
D
N
P
I
S
R
Y
Y
D
R
L
A
T
V
Q
Site 237
T3621
R
Y
Y
D
R
L
A
T
V
Q
A
R
G
T
Q
Site 238
T3627
A
T
V
Q
A
R
G
T
Q
A
S
H
Q
V
L
Site 239
S3630
Q
A
R
G
T
Q
A
S
H
Q
V
L
R
D
I
Site 240
S3643
D
I
L
K
E
V
Q
S
N
M
V
P
R
S
M
Site 241
S3649
Q
S
N
M
V
P
R
S
M
L
K
E
W
A
L
Site 242
T3658
L
K
E
W
A
L
H
T
F
P
N
A
T
D
Y
Site 243
Y3709
T
G
K
L
N
V
A
Y
F
R
F
D
I
N
D
Site 244
T3718
R
F
D
I
N
D
A
T
G
D
L
D
A
N
R
Site 245
T3732
R
P
V
P
F
R
L
T
P
N
I
S
E
F
L
Site 246
T3785
I
I
A
W
H
K
K
T
Q
E
D
T
S
S
P
Site 247
T3789
H
K
K
T
Q
E
D
T
S
S
P
L
S
A
A
Site 248
S3790
K
K
T
Q
E
D
T
S
S
P
L
S
A
A
G
Site 249
S3791
K
T
Q
E
D
T
S
S
P
L
S
A
A
G
Q
Site 250
S3794
E
D
T
S
S
P
L
S
A
A
G
Q
P
E
N
Site 251
S3804
G
Q
P
E
N
M
D
S
Q
Q
L
V
S
L
V
Site 252
T3837
G
G
E
S
K
V
N
T
L
V
A
A
A
N
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation