KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IRS2
Full Name:
Insulin receptor substrate 2
Alias:
IRS-2
Type:
Adapter/scaffold protein
Mass (Da):
137334
Number AA:
1338
UniProt ID:
Q9Y4H2
International Prot ID:
IPI00464978
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
GO:0016020
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0004871
GO:0005102
GO:0005158
PhosphoSite+
KinaseNET
Biological Process:
GO:0006006
GO:0008286
GO:0055088
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
P
P
R
H
G
P
P
Site 2
S14
H
G
P
P
G
P
A
S
G
D
G
P
N
L
N
Site 3
Y36
H
S
V
R
K
C
G
Y
L
R
K
Q
K
H
G
Site 4
T61
G
A
G
G
D
E
A
T
A
G
G
G
S
A
P
Site 5
Y75
P
Q
P
P
R
L
E
Y
Y
E
S
E
K
K
W
Site 6
Y76
Q
P
P
R
L
E
Y
Y
E
S
E
K
K
W
R
Site 7
S78
P
R
L
E
Y
Y
E
S
E
K
K
W
R
S
K
Site 8
S84
E
S
E
K
K
W
R
S
K
A
G
A
P
K
R
Site 9
Y111
R
A
D
A
K
H
K
Y
L
I
A
L
Y
T
K
Site 10
Y116
H
K
Y
L
I
A
L
Y
T
K
D
E
Y
F
A
Site 11
Y121
A
L
Y
T
K
D
E
Y
F
A
V
A
A
E
N
Site 12
T140
E
G
W
Y
R
A
L
T
D
L
V
S
E
G
R
Site 13
S144
R
A
L
T
D
L
V
S
E
G
R
A
A
A
G
Site 14
Y184
A
A
G
A
E
D
S
Y
G
L
V
A
P
A
T
Site 15
S210
K
P
K
G
L
G
Q
S
K
N
L
T
G
V
Y
Site 16
S253
R
R
C
G
H
S
D
S
F
F
F
I
E
V
G
Site 17
S304
L
F
E
F
R
P
R
S
K
S
Q
S
S
G
S
Site 18
S306
E
F
R
P
R
S
K
S
Q
S
S
G
S
S
A
Site 19
S308
R
P
R
S
K
S
Q
S
S
G
S
S
A
T
H
Site 20
S309
P
R
S
K
S
Q
S
S
G
S
S
A
T
H
P
Site 21
S311
S
K
S
Q
S
S
G
S
S
A
T
H
P
I
S
Site 22
S312
K
S
Q
S
S
G
S
S
A
T
H
P
I
S
V
Site 23
T314
Q
S
S
G
S
S
A
T
H
P
I
S
V
P
G
Site 24
S318
S
S
A
T
H
P
I
S
V
P
G
A
R
R
H
Site 25
S334
H
L
V
N
L
P
P
S
Q
T
G
L
V
R
R
Site 26
S342
Q
T
G
L
V
R
R
S
R
T
D
S
L
A
A
Site 27
T344
G
L
V
R
R
S
R
T
D
S
L
A
A
T
P
Site 28
S346
V
R
R
S
R
T
D
S
L
A
A
T
P
P
A
Site 29
T350
R
T
D
S
L
A
A
T
P
P
A
A
K
C
S
Site 30
S357
T
P
P
A
A
K
C
S
S
C
R
V
R
T
A
Site 31
S358
P
P
A
A
K
C
S
S
C
R
V
R
T
A
S
Site 32
T363
C
S
S
C
R
V
R
T
A
S
E
G
D
G
G
Site 33
S365
S
C
R
V
R
T
A
S
E
G
D
G
G
A
A
Site 34
S384
A
A
G
A
R
P
V
S
V
A
G
S
P
L
S
Site 35
S388
R
P
V
S
V
A
G
S
P
L
S
P
G
P
V
Site 36
S391
S
V
A
G
S
P
L
S
P
G
P
V
R
A
P
Site 37
S400
G
P
V
R
A
P
L
S
R
S
H
T
L
S
G
Site 38
S402
V
R
A
P
L
S
R
S
H
T
L
S
G
G
C
Site 39
T404
A
P
L
S
R
S
H
T
L
S
G
G
C
G
G
Site 40
S406
L
S
R
S
H
T
L
S
G
G
C
G
G
R
G
Site 41
S428
A
G
G
A
L
Q
H
S
R
S
M
S
M
P
V
Site 42
S430
G
A
L
Q
H
S
R
S
M
S
M
P
V
A
H
Site 43
S432
L
Q
H
S
R
S
M
S
M
P
V
A
H
S
P
Site 44
S438
M
S
M
P
V
A
H
S
P
P
A
A
T
S
P
Site 45
T443
A
H
S
P
P
A
A
T
S
P
G
S
L
S
S
Site 46
S444
H
S
P
P
A
A
T
S
P
G
S
L
S
S
S
Site 47
S447
P
A
A
T
S
P
G
S
L
S
S
S
S
G
H
Site 48
S449
A
T
S
P
G
S
L
S
S
S
S
G
H
G
S
Site 49
S450
T
S
P
G
S
L
S
S
S
S
G
H
G
S
G
Site 50
S451
S
P
G
S
L
S
S
S
S
G
H
G
S
G
S
Site 51
S452
P
G
S
L
S
S
S
S
G
H
G
S
G
S
Y
Site 52
S456
S
S
S
S
G
H
G
S
G
S
Y
P
P
P
P
Site 53
S458
S
S
G
H
G
S
G
S
Y
P
P
P
P
G
P
Site 54
Y459
S
G
H
G
S
G
S
Y
P
P
P
P
G
P
H
Site 55
S482
H
G
P
G
Q
R
P
S
S
G
S
A
S
A
S
Site 56
S483
G
P
G
Q
R
P
S
S
G
S
A
S
A
S
G
Site 57
S485
G
Q
R
P
S
S
G
S
A
S
A
S
G
S
P
Site 58
S487
R
P
S
S
G
S
A
S
A
S
G
S
P
S
D
Site 59
S489
S
S
G
S
A
S
A
S
G
S
P
S
D
P
G
Site 60
S491
G
S
A
S
A
S
G
S
P
S
D
P
G
F
M
Site 61
S493
A
S
A
S
G
S
P
S
D
P
G
F
M
S
L
Site 62
S499
P
S
D
P
G
F
M
S
L
D
E
Y
G
S
S
Site 63
Y503
G
F
M
S
L
D
E
Y
G
S
S
P
G
D
L
Site 64
S505
M
S
L
D
E
Y
G
S
S
P
G
D
L
R
A
Site 65
S506
S
L
D
E
Y
G
S
S
P
G
D
L
R
A
F
Site 66
S515
G
D
L
R
A
F
C
S
H
R
S
N
T
P
E
Site 67
S518
R
A
F
C
S
H
R
S
N
T
P
E
S
I
A
Site 68
T520
F
C
S
H
R
S
N
T
P
E
S
I
A
E
T
Site 69
S523
H
R
S
N
T
P
E
S
I
A
E
T
P
P
A
Site 70
T527
T
P
E
S
I
A
E
T
P
P
A
R
D
G
G
Site 71
Y540
G
G
G
G
G
E
F
Y
G
Y
M
T
M
D
R
Site 72
Y542
G
G
G
E
F
Y
G
Y
M
T
M
D
R
P
L
Site 73
T544
G
E
F
Y
G
Y
M
T
M
D
R
P
L
S
H
Site 74
S550
M
T
M
D
R
P
L
S
H
C
G
R
S
Y
R
Site 75
S555
P
L
S
H
C
G
R
S
Y
R
R
V
S
G
D
Site 76
Y556
L
S
H
C
G
R
S
Y
R
R
V
S
G
D
A
Site 77
S560
G
R
S
Y
R
R
V
S
G
D
A
A
Q
D
L
Site 78
T575
D
R
G
L
R
K
R
T
Y
S
L
T
T
P
A
Site 79
Y576
R
G
L
R
K
R
T
Y
S
L
T
T
P
A
R
Site 80
S577
G
L
R
K
R
T
Y
S
L
T
T
P
A
R
Q
Site 81
T579
R
K
R
T
Y
S
L
T
T
P
A
R
Q
R
P
Site 82
T580
K
R
T
Y
S
L
T
T
P
A
R
Q
R
P
V
Site 83
S591
Q
R
P
V
P
Q
P
S
S
A
S
L
D
E
Y
Site 84
S592
R
P
V
P
Q
P
S
S
A
S
L
D
E
Y
T
Site 85
S594
V
P
Q
P
S
S
A
S
L
D
E
Y
T
L
M
Site 86
Y598
S
S
A
S
L
D
E
Y
T
L
M
R
A
T
F
Site 87
T599
S
A
S
L
D
E
Y
T
L
M
R
A
T
F
S
Site 88
T604
E
Y
T
L
M
R
A
T
F
S
G
S
A
G
R
Site 89
S606
T
L
M
R
A
T
F
S
G
S
A
G
R
L
C
Site 90
S608
M
R
A
T
F
S
G
S
A
G
R
L
C
P
S
Site 91
S615
S
A
G
R
L
C
P
S
C
P
A
S
S
P
K
Site 92
S619
L
C
P
S
C
P
A
S
S
P
K
V
A
Y
H
Site 93
S620
C
P
S
C
P
A
S
S
P
K
V
A
Y
H
P
Site 94
Y628
P
K
V
A
Y
H
P
Y
P
E
D
Y
G
D
I
Site 95
Y632
Y
H
P
Y
P
E
D
Y
G
D
I
E
I
G
S
Site 96
S639
Y
G
D
I
E
I
G
S
H
R
S
S
S
S
N
Site 97
S642
I
E
I
G
S
H
R
S
S
S
S
N
L
G
A
Site 98
S643
E
I
G
S
H
R
S
S
S
S
N
L
G
A
D
Site 99
S644
I
G
S
H
R
S
S
S
S
N
L
G
A
D
D
Site 100
S645
G
S
H
R
S
S
S
S
N
L
G
A
D
D
G
Site 101
Y653
N
L
G
A
D
D
G
Y
M
P
M
T
P
G
A
Site 102
T657
D
D
G
Y
M
P
M
T
P
G
A
A
L
A
G
Site 103
S665
P
G
A
A
L
A
G
S
G
S
G
S
C
R
S
Site 104
S667
A
A
L
A
G
S
G
S
G
S
C
R
S
D
D
Site 105
S669
L
A
G
S
G
S
G
S
C
R
S
D
D
Y
M
Site 106
S672
S
G
S
G
S
C
R
S
D
D
Y
M
P
M
S
Site 107
Y675
G
S
C
R
S
D
D
Y
M
P
M
S
P
A
S
Site 108
S679
S
D
D
Y
M
P
M
S
P
A
S
V
S
A
P
Site 109
S682
Y
M
P
M
S
P
A
S
V
S
A
P
K
Q
I
Site 110
S684
P
M
S
P
A
S
V
S
A
P
K
Q
I
L
Q
Site 111
T713
G
P
A
G
P
A
P
T
S
A
A
G
R
T
F
Site 112
S714
P
A
G
P
A
P
T
S
A
A
G
R
T
F
P
Site 113
T719
P
T
S
A
A
G
R
T
F
P
A
S
G
G
G
Site 114
S723
A
G
R
T
F
P
A
S
G
G
G
Y
K
A
S
Site 115
Y727
F
P
A
S
G
G
G
Y
K
A
S
S
P
A
E
Site 116
S730
S
G
G
G
Y
K
A
S
S
P
A
E
S
S
P
Site 117
S731
G
G
G
Y
K
A
S
S
P
A
E
S
S
P
E
Site 118
S735
K
A
S
S
P
A
E
S
S
P
E
D
S
G
Y
Site 119
S736
A
S
S
P
A
E
S
S
P
E
D
S
G
Y
M
Site 120
S740
A
E
S
S
P
E
D
S
G
Y
M
R
M
W
C
Site 121
Y742
S
S
P
E
D
S
G
Y
M
R
M
W
C
G
S
Site 122
Y766
K
L
L
P
N
G
D
Y
L
N
V
S
P
S
D
Site 123
S770
N
G
D
Y
L
N
V
S
P
S
D
A
V
T
T
Site 124
S772
D
Y
L
N
V
S
P
S
D
A
V
T
T
G
T
Site 125
T776
V
S
P
S
D
A
V
T
T
G
T
P
P
D
F
Site 126
T777
S
P
S
D
A
V
T
T
G
T
P
P
D
F
F
Site 127
T779
S
D
A
V
T
T
G
T
P
P
D
F
F
S
A
Site 128
S785
G
T
P
P
D
F
F
S
A
A
L
H
P
G
G
Site 129
Y803
R
G
V
P
G
C
C
Y
S
S
L
P
R
S
Y
Site 130
S804
G
V
P
G
C
C
Y
S
S
L
P
R
S
Y
K
Site 131
S805
V
P
G
C
C
Y
S
S
L
P
R
S
Y
K
A
Site 132
S809
C
Y
S
S
L
P
R
S
Y
K
A
P
Y
T
C
Site 133
Y810
Y
S
S
L
P
R
S
Y
K
A
P
Y
T
C
G
Site 134
Y814
P
R
S
Y
K
A
P
Y
T
C
G
G
D
S
D
Site 135
T815
R
S
Y
K
A
P
Y
T
C
G
G
D
S
D
Q
Site 136
S820
P
Y
T
C
G
G
D
S
D
Q
Y
V
L
M
S
Site 137
Y823
C
G
G
D
S
D
Q
Y
V
L
M
S
S
P
V
Site 138
S828
D
Q
Y
V
L
M
S
S
P
V
G
R
I
L
E
Site 139
T844
E
R
L
E
P
Q
A
T
P
G
P
S
Q
A
A
Site 140
S848
P
Q
A
T
P
G
P
S
Q
A
A
S
A
F
G
Site 141
S852
P
G
P
S
Q
A
A
S
A
F
G
A
G
P
T
Site 142
T859
S
A
F
G
A
G
P
T
Q
P
P
H
P
V
V
Site 143
S868
P
P
H
P
V
V
P
S
P
V
R
P
S
G
G
Site 144
S873
V
P
S
P
V
R
P
S
G
G
R
P
E
G
F
Site 145
T891
R
G
R
A
V
R
P
T
R
L
S
L
E
G
L
Site 146
S894
A
V
R
P
T
R
L
S
L
E
G
L
P
S
L
Site 147
S900
L
S
L
E
G
L
P
S
L
P
S
M
H
E
Y
Site 148
S903
E
G
L
P
S
L
P
S
M
H
E
Y
P
L
P
Site 149
Y907
S
L
P
S
M
H
E
Y
P
L
P
P
E
P
K
Site 150
S915
P
L
P
P
E
P
K
S
P
G
E
Y
I
N
I
Site 151
Y919
E
P
K
S
P
G
E
Y
I
N
I
D
F
G
E
Site 152
S932
G
E
P
G
A
R
L
S
P
P
A
P
P
L
L
Site 153
S947
A
S
A
A
S
S
S
S
L
L
S
A
S
S
P
Site 154
S950
A
S
S
S
S
L
L
S
A
S
S
P
A
S
S
Site 155
S952
S
S
S
L
L
S
A
S
S
P
A
S
S
L
G
Site 156
S953
S
S
L
L
S
A
S
S
P
A
S
S
L
G
S
Site 157
S956
L
S
A
S
S
P
A
S
S
L
G
S
G
T
P
Site 158
S957
S
A
S
S
P
A
S
S
L
G
S
G
T
P
G
Site 159
S960
S
P
A
S
S
L
G
S
G
T
P
G
T
S
S
Site 160
T962
A
S
S
L
G
S
G
T
P
G
T
S
S
D
S
Site 161
T965
L
G
S
G
T
P
G
T
S
S
D
S
R
Q
R
Site 162
S966
G
S
G
T
P
G
T
S
S
D
S
R
Q
R
S
Site 163
S967
S
G
T
P
G
T
S
S
D
S
R
Q
R
S
P
Site 164
S969
T
P
G
T
S
S
D
S
R
Q
R
S
P
L
S
Site 165
S973
S
S
D
S
R
Q
R
S
P
L
S
D
Y
M
N
Site 166
S976
S
R
Q
R
S
P
L
S
D
Y
M
N
L
D
F
Site 167
Y978
Q
R
S
P
L
S
D
Y
M
N
L
D
F
S
S
Site 168
S984
D
Y
M
N
L
D
F
S
S
P
K
S
P
K
P
Site 169
S985
Y
M
N
L
D
F
S
S
P
K
S
P
K
P
G
Site 170
S988
L
D
F
S
S
P
K
S
P
K
P
G
A
P
S
Site 171
S995
S
P
K
P
G
A
P
S
G
H
P
V
G
S
L
Site 172
S1001
P
S
G
H
P
V
G
S
L
D
G
L
L
S
P
Site 173
S1007
G
S
L
D
G
L
L
S
P
E
A
S
S
P
Y
Site 174
S1011
G
L
L
S
P
E
A
S
S
P
Y
P
P
L
P
Site 175
S1012
L
L
S
P
E
A
S
S
P
Y
P
P
L
P
P
Site 176
Y1014
S
P
E
A
S
S
P
Y
P
P
L
P
P
R
P
Site 177
S1022
P
P
L
P
P
R
P
S
A
S
P
S
S
S
L
Site 178
S1024
L
P
P
R
P
S
A
S
P
S
S
S
L
Q
P
Site 179
S1026
P
R
P
S
A
S
P
S
S
S
L
Q
P
P
P
Site 180
S1027
R
P
S
A
S
P
S
S
S
L
Q
P
P
P
P
Site 181
S1028
P
S
A
S
P
S
S
S
L
Q
P
P
P
P
P
Site 182
Y1042
P
P
A
P
G
E
L
Y
R
L
P
P
A
S
A
Site 183
S1060
A
Q
G
P
G
A
A
S
S
L
S
S
D
T
G
Site 184
S1061
Q
G
P
G
A
A
S
S
L
S
S
D
T
G
D
Site 185
S1063
P
G
A
A
S
S
L
S
S
D
T
G
D
N
G
Site 186
S1064
G
A
A
S
S
L
S
S
D
T
G
D
N
G
D
Site 187
Y1072
D
T
G
D
N
G
D
Y
T
E
M
A
F
G
V
Site 188
T1073
T
G
D
N
G
D
Y
T
E
M
A
F
G
V
A
Site 189
S1100
P
E
A
A
R
V
A
S
P
T
S
G
V
K
R
Site 190
T1102
A
A
R
V
A
S
P
T
S
G
V
K
R
L
S
Site 191
S1103
A
R
V
A
S
P
T
S
G
V
K
R
L
S
L
Site 192
S1109
T
S
G
V
K
R
L
S
L
M
E
Q
V
S
G
Site 193
S1124
V
E
A
F
L
Q
A
S
Q
P
P
D
P
H
R
Site 194
S1148
Q
G
G
R
R
R
H
S
S
E
T
F
S
S
T
Site 195
S1149
G
G
R
R
R
H
S
S
E
T
F
S
S
T
T
Site 196
T1151
R
R
R
H
S
S
E
T
F
S
S
T
T
T
V
Site 197
S1153
R
H
S
S
E
T
F
S
S
T
T
T
V
T
P
Site 198
S1154
H
S
S
E
T
F
S
S
T
T
T
V
T
P
V
Site 199
T1155
S
S
E
T
F
S
S
T
T
T
V
T
P
V
S
Site 200
T1156
S
E
T
F
S
S
T
T
T
V
T
P
V
S
P
Site 201
T1157
E
T
F
S
S
T
T
T
V
T
P
V
S
P
S
Site 202
T1159
F
S
S
T
T
T
V
T
P
V
S
P
S
F
A
Site 203
S1162
T
T
T
V
T
P
V
S
P
S
F
A
H
N
P
Site 204
S1164
T
V
T
P
V
S
P
S
F
A
H
N
P
K
R
Site 205
S1174
H
N
P
K
R
H
N
S
A
S
V
E
N
V
S
Site 206
S1176
P
K
R
H
N
S
A
S
V
E
N
V
S
L
R
Site 207
S1181
S
A
S
V
E
N
V
S
L
R
K
S
S
E
G
Site 208
S1185
E
N
V
S
L
R
K
S
S
E
G
G
V
G
V
Site 209
S1186
N
V
S
L
R
K
S
S
E
G
G
V
G
V
G
Site 210
T1202
G
G
G
D
E
P
P
T
S
P
R
Q
L
Q
P
Site 211
S1203
G
G
D
E
P
P
T
S
P
R
Q
L
Q
P
A
Site 212
T1221
A
P
Q
G
R
P
W
T
P
G
Q
P
G
G
L
Site 213
S1234
G
L
V
G
C
P
G
S
G
G
S
P
M
R
R
Site 214
S1237
G
C
P
G
S
G
G
S
P
M
R
R
E
T
S
Site 215
T1243
G
S
P
M
R
R
E
T
S
A
G
F
Q
N
G
Site 216
S1244
S
P
M
R
R
E
T
S
A
G
F
Q
N
G
L
Site 217
Y1253
G
F
Q
N
G
L
N
Y
I
A
I
D
V
R
E
Site 218
S1282
L
P
Q
P
G
D
K
S
S
W
G
R
T
R
S
Site 219
S1283
P
Q
P
G
D
K
S
S
W
G
R
T
R
S
L
Site 220
T1287
D
K
S
S
W
G
R
T
R
S
L
G
G
L
I
Site 221
S1289
S
S
W
G
R
T
R
S
L
G
G
L
I
S
A
Site 222
S1322
P
P
A
N
T
Y
A
S
I
D
F
L
S
H
H
Site 223
S1327
Y
A
S
I
D
F
L
S
H
H
L
K
E
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation