PhosphoNET

           
Protein Info 
   
Short Name:  KHS1
Full Name:  Mitogen-activated protein kinase kinase kinase kinase 5
Alias:  EC 2.7.11.1; GCKR; Germinal center kinase-related; Germinal center kinase-related enzyme; KHS; Kinase KHS1; M4K5; MAP4K5
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; KHS subfamily
Mass (Da):  95040
Number AA:  846
UniProt ID:  Q9Y4K4
International Prot ID:  IPI00294842
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0007257  GO:0006468  GO:0006950 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y20RRNPQQDYELVQRVG
Site 2S28ELVQRVGSGTYGDVY
Site 3T30VQRVGSGTYGDVYKA
Site 4Y31QRVGSGTYGDVYKAR
Site 5Y35SGTYGDVYKARNVHT
Site 6S60LEPGDDFSLIQQEIF
Site 7Y80KHCNIVAYFGSYLSR
Site 8Y106GGSLQDIYHVTGPLS
Site 9Y130ETLQGLAYLHTKGKM
Site 10T133QGLAYLHTKGKMHRD
Site 11T149KGANILLTDHGDVKL
Site 12T168VAAKITATIAKRKSF
Site 13S174ATIAKRKSFIGTPYW
Site 14T178KRKSFIGTPYWMAPE
Site 15S233ALFLMSKSNFQPPKL
Site 16T244PPKLKDKTKWSSTFH
Site 17T267KNPKKRPTAERLLTH
Site 18T273PTAERLLTHTFVAQP
Site 19Y303NPDNHAHYTEADDDD
Site 20T304PDNHAHYTEADDDDF
Site 21T320PHAIIRHTIRSTNRN
Site 22S323IIRHTIRSTNRNARA
Site 23T324IRHTIRSTNRNARAE
Site 24T333RNARAERTASEINFD
Site 25S335ARAERTASEINFDKL
Site 26T352EPPLRKETEARDEMG
Site 27S361ARDEMGLSSDPNFML
Site 28S362RDEMGLSSDPNFMLQ
Site 29S382DGANTGKSTSKRAIP
Site 30S384ANTGKSTSKRAIPPP
Site 31S399LPPKPRISSYPEDNF
Site 32S400PPKPRISSYPEDNFP
Site 33Y401PKPRISSYPEDNFPD
Site 34S413FPDEEKASTIKHCPD
Site 35T414PDEEKASTIKHCPDS
Site 36S421TIKHCPDSESRAPQI
Site 37S423KHCPDSESRAPQILR
Site 38S433PQILRRQSSPSCGPV
Site 39S434QILRRQSSPSCGPVA
Site 40S436LRRQSSPSCGPVAET
Site 41S444CGPVAETSSIGNGDG
Site 42S445GPVAETSSIGNGDGI
Site 43S453IGNGDGISKLMSENT
Site 44S457DGISKLMSENTEGSA
Site 45Y524HPDTKDQYIIFGTED
Site 46Y534FGTEDGIYTLNLNEL
Site 47Y558PRKCTWLYVINNTLM
Site 48S566VINNTLMSLSEGKTF
Site 49S568NNTLMSLSEGKTFQL
Site 50T572MSLSEGKTFQLYSHN
Site 51Y576EGKTFQLYSHNLIAL
Site 52T613LPRKFALTTKIPDTK
Site 53T619LTTKIPDTKGCHKCC
Site 54Y637NPYTGHKYLCGALQS
Site 55S693PMVCVAISKGTESNQ
Site 56S698AISKGTESNQVVQFE
Site 57S711FETINLNSASSWFTE
Site 58S713TINLNSASSWFTEIG
Site 59T717NSASSWFTEIGAGSQ
Site 60S723FTEIGAGSQQLDSIH
Site 61S728AGSQQLDSIHVTQLE
Site 62T732QLDSIHVTQLERDTV
Site 63S758NLQGKLKSSKKLASE
Site 64S759LQGKLKSSKKLASEL
Site 65S764KSSKKLASELSFDFR
Site 66S767KKLASELSFDFRIES
Site 67S794KHGMQGKSFKSDEVT
Site 68S797MQGKSFKSDEVTQEI
Site 69T801SFKSDEVTQEISDET
Site 70T827VVLESRPTENPTAHS
Site 71T831SRPTENPTAHSNLYI
Site 72Y837PTAHSNLYILAGHEN
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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