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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC42BPB
Full Name:
Serine/threonine-protein kinase MRCK beta
Alias:
CDC42 binding protein kinase beta; CDC42-binding protein kinase beta; DMPK-like; DMPK-like beta; EC 2.7.11.1; KIAA1124; MRCK beta; MRCKB; Myotonic dystrophy protein kinase-like beta
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
AGC
group; DMPK family; GEK subfamily
Mass (Da):
194315
Number AA:
1711
UniProt ID:
Q9Y5S2
International Prot ID:
IPI00477763
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031252
GO:0005911
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0031532
GO:0007163
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Myotonic dystrophy kinase-related CDC42-binding kinase beta (C408-D427, human) peptide - Powder PE-01BEE65#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEE65
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
D
G
P
W
R
N
E
S
A
L
S
V
E
T
L
Site 2
S26
W
R
N
E
S
A
L
S
V
E
T
L
L
D
V
Site 3
S42
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
Site 4
S44
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
Site 5
Y51
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
Site 6
Y102
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
Site 7
T118
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
Site 8
Y150
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
Site 9
S166
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
Site 10
Y196
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
Site 11
S221
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
Site 12
T230
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
Site 13
S234
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Site 14
T239
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
Site 15
T279
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
Site 16
Y282
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Site 17
S285
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
Site 18
T289
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
Site 19
S304
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
Site 20
T307
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
Site 21
S310
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Site 22
S323
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
Site 23
S362
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
Site 24
S363
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
Site 25
S365
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
Site 26
T367
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
Site 27
S368
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
Site 28
T380
D
D
D
V
L
R
N
T
E
I
L
P
P
G
S
Site 29
S387
T
E
I
L
P
P
G
S
H
T
G
F
S
G
L
Site 30
S407
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
Site 31
S410
F
T
T
E
S
C
F
S
D
R
G
S
L
K
S
Site 32
S414
S
C
F
S
D
R
G
S
L
K
S
I
M
Q
S
Site 33
S417
S
D
R
G
S
L
K
S
I
M
Q
S
N
T
L
Site 34
S421
S
L
K
S
I
M
Q
S
N
T
L
T
K
D
E
Site 35
T423
K
S
I
M
Q
S
N
T
L
T
K
D
E
D
V
Site 36
T425
I
M
Q
S
N
T
L
T
K
D
E
D
V
Q
R
Site 37
S437
V
Q
R
D
L
E
H
S
L
Q
M
E
A
Y
E
Site 38
Y443
H
S
L
Q
M
E
A
Y
E
R
R
I
R
R
L
Site 39
S464
L
S
R
K
L
Q
E
S
T
Q
T
V
Q
S
L
Site 40
T465
S
R
K
L
Q
E
S
T
Q
T
V
Q
S
L
H
Site 41
T467
K
L
Q
E
S
T
Q
T
V
Q
S
L
H
G
S
Site 42
S470
E
S
T
Q
T
V
Q
S
L
H
G
S
S
R
A
Site 43
S474
T
V
Q
S
L
H
G
S
S
R
A
L
S
N
S
Site 44
S475
V
Q
S
L
H
G
S
S
R
A
L
S
N
S
N
Site 45
S479
H
G
S
S
R
A
L
S
N
S
N
R
D
K
E
Site 46
S481
S
S
R
A
L
S
N
S
N
R
D
K
E
I
K
Site 47
S504
L
K
N
K
I
A
D
S
N
R
L
E
R
Q
L
Site 48
T514
L
E
R
Q
L
E
D
T
V
A
L
R
Q
E
R
Site 49
S524
L
R
Q
E
R
E
D
S
T
Q
R
L
R
G
L
Site 50
T525
R
Q
E
R
E
D
S
T
Q
R
L
R
G
L
E
Site 51
S553
H
K
Q
L
V
E
A
S
E
R
L
K
S
Q
A
Site 52
S558
E
A
S
E
R
L
K
S
Q
A
K
E
L
K
D
Site 53
S641
D
D
A
V
A
E
A
S
K
E
R
K
L
R
E
Site 54
S650
E
R
K
L
R
E
H
S
E
N
F
C
K
Q
M
Site 55
S659
N
F
C
K
Q
M
E
S
E
L
E
A
L
K
V
Site 56
T676
G
G
R
G
A
G
A
T
L
E
H
Q
Q
E
I
Site 57
S688
Q
E
I
S
K
I
K
S
E
L
E
K
K
V
L
Site 58
S707
E
L
V
R
R
E
A
S
H
V
L
E
V
K
N
Site 59
S722
V
K
K
E
V
H
D
S
E
S
H
Q
L
A
L
Site 60
S724
K
E
V
H
D
S
E
S
H
Q
L
A
L
Q
K
Site 61
S743
L
K
D
K
L
E
K
S
K
R
E
R
H
N
E
Site 62
T757
E
M
E
E
A
V
G
T
I
K
D
K
Y
E
R
Site 63
Y762
V
G
T
I
K
D
K
Y
E
R
E
R
A
M
L
Site 64
S785
A
E
N
E
K
L
C
S
F
V
D
K
L
T
A
Site 65
S810
D
L
A
A
K
K
E
S
V
A
H
W
E
A
Q
Site 66
S826
A
E
I
I
Q
W
V
S
D
E
K
D
A
R
G
Site 67
Y834
D
E
K
D
A
R
G
Y
L
Q
A
L
A
S
K
Site 68
S840
G
Y
L
Q
A
L
A
S
K
M
T
E
E
L
E
Site 69
T843
Q
A
L
A
S
K
M
T
E
E
L
E
A
L
R
Site 70
S851
E
E
L
E
A
L
R
S
S
S
L
G
S
R
T
Site 71
S852
E
L
E
A
L
R
S
S
S
L
G
S
R
T
L
Site 72
S853
L
E
A
L
R
S
S
S
L
G
S
R
T
L
D
Site 73
S856
L
R
S
S
S
L
G
S
R
T
L
D
P
L
W
Site 74
T858
S
S
S
L
G
S
R
T
L
D
P
L
W
K
V
Site 75
S868
P
L
W
K
V
R
R
S
Q
K
L
D
M
S
A
Site 76
S874
R
S
Q
K
L
D
M
S
A
R
L
E
L
Q
S
Site 77
S881
S
A
R
L
E
L
Q
S
A
L
E
A
E
I
R
Site 78
T906
K
V
K
D
A
N
L
T
L
E
S
K
L
K
D
Site 79
S914
L
E
S
K
L
K
D
S
E
A
K
N
R
E
L
Site 80
T940
E
E
K
F
R
A
D
T
G
L
K
L
P
D
F
Site 81
Y954
F
Q
D
S
I
F
E
Y
F
N
T
A
P
L
A
Site 82
T965
A
P
L
A
H
D
L
T
F
R
T
S
S
A
S
Site 83
S969
H
D
L
T
F
R
T
S
S
A
S
E
Q
E
T
Site 84
S970
D
L
T
F
R
T
S
S
A
S
E
Q
E
T
Q
Site 85
S972
T
F
R
T
S
S
A
S
E
Q
E
T
Q
A
P
Site 86
T976
S
S
A
S
E
Q
E
T
Q
A
P
K
P
E
A
Site 87
S984
Q
A
P
K
P
E
A
S
P
S
M
S
V
A
A
Site 88
S986
P
K
P
E
A
S
P
S
M
S
V
A
A
S
E
Site 89
S988
P
E
A
S
P
S
M
S
V
A
A
S
E
Q
Q
Site 90
S992
P
S
M
S
V
A
A
S
E
Q
Q
E
D
M
A
Site 91
S1006
A
R
P
P
Q
R
P
S
A
V
P
L
P
T
T
Site 92
S1029
K
P
K
A
H
Q
F
S
I
K
S
F
S
S
P
Site 93
S1032
A
H
Q
F
S
I
K
S
F
S
S
P
T
Q
C
Site 94
S1034
Q
F
S
I
K
S
F
S
S
P
T
Q
C
S
H
Site 95
S1035
F
S
I
K
S
F
S
S
P
T
Q
C
S
H
C
Site 96
S1082
C
P
I
P
P
E
Q
S
K
R
P
L
G
V
D
Site 97
Y1118
K
K
G
W
Q
R
A
Y
A
V
V
C
D
C
K
Site 98
Y1129
C
D
C
K
L
F
L
Y
D
L
P
E
G
K
S
Site 99
S1136
Y
D
L
P
E
G
K
S
T
Q
P
G
V
I
A
Site 100
T1137
D
L
P
E
G
K
S
T
Q
P
G
V
I
A
S
Site 101
S1144
T
Q
P
G
V
I
A
S
Q
V
L
D
L
R
D
Site 102
S1155
D
L
R
D
D
E
F
S
V
S
S
V
L
A
S
Site 103
S1157
R
D
D
E
F
S
V
S
S
V
L
A
S
D
V
Site 104
S1190
L
G
A
P
S
K
T
S
S
L
L
I
L
T
E
Site 105
S1191
G
A
P
S
K
T
S
S
L
L
I
L
T
E
N
Site 106
T1196
T
S
S
L
L
I
L
T
E
N
E
N
E
K
R
Site 107
S1214
G
I
L
E
G
L
Q
S
I
L
H
K
N
R
L
Site 108
Y1233
V
H
V
P
L
E
A
Y
D
S
S
L
P
L
I
Site 109
Y1306
R
N
H
H
V
H
L
Y
P
W
S
S
L
D
G
Site 110
S1309
H
V
H
L
Y
P
W
S
S
L
D
G
A
E
G
Site 111
S1310
V
H
L
Y
P
W
S
S
L
D
G
A
E
G
S
Site 112
S1317
S
L
D
G
A
E
G
S
F
D
I
K
L
P
E
Site 113
T1335
C
Q
L
M
A
T
A
T
L
K
R
N
S
G
T
Site 114
Y1355
V
K
R
L
I
L
C
Y
E
I
Q
R
T
K
P
Site 115
S1398
P
S
G
F
C
L
L
S
I
Q
G
D
G
Q
P
Site 116
S1415
L
V
N
P
N
D
P
S
L
A
F
L
S
Q
Q
Site 117
S1420
D
P
S
L
A
F
L
S
Q
Q
S
F
D
A
L
Site 118
Y1447
C
F
S
H
M
G
L
Y
V
D
P
Q
G
R
R
Site 119
T1477
S
C
S
P
T
H
V
T
V
Y
S
E
Y
G
V
Site 120
Y1479
S
P
T
H
V
T
V
Y
S
E
Y
G
V
D
V
Site 121
T1497
R
T
M
E
W
V
Q
T
I
G
L
R
R
I
R
Site 122
S1508
R
R
I
R
P
L
N
S
E
G
T
L
N
L
L
Site 123
Y1524
C
E
P
P
R
L
I
Y
F
K
S
K
F
S
G
Site 124
T1539
A
V
L
N
V
P
D
T
S
D
N
S
K
K
Q
Site 125
S1540
V
L
N
V
P
D
T
S
D
N
S
K
K
Q
M
Site 126
S1543
V
P
D
T
S
D
N
S
K
K
Q
M
L
R
T
Site 127
S1552
K
Q
M
L
R
T
R
S
K
R
R
F
V
F
K
Site 128
S1580
L
R
D
P
E
L
R
S
K
M
I
S
N
P
T
Site 129
S1584
E
L
R
S
K
M
I
S
N
P
T
N
F
N
H
Site 130
S1615
P
L
S
A
V
P
P
S
Q
E
E
R
P
G
P
Site 131
S1633
N
L
A
R
Q
P
P
S
R
N
K
P
Y
I
S
Site 132
Y1638
P
P
S
R
N
K
P
Y
I
S
W
P
S
S
G
Site 133
S1640
S
R
N
K
P
Y
I
S
W
P
S
S
G
G
S
Site 134
S1643
K
P
Y
I
S
W
P
S
S
G
G
S
E
P
S
Site 135
S1644
P
Y
I
S
W
P
S
S
G
G
S
E
P
S
V
Site 136
S1647
S
W
P
S
S
G
G
S
E
P
S
V
T
V
P
Site 137
S1650
S
S
G
G
S
E
P
S
V
T
V
P
L
R
S
Site 138
T1652
G
G
S
E
P
S
V
T
V
P
L
R
S
M
S
Site 139
S1657
S
V
T
V
P
L
R
S
M
S
D
P
D
Q
D
Site 140
S1659
T
V
P
L
R
S
M
S
D
P
D
Q
D
F
D
Site 141
S1671
D
F
D
K
E
P
D
S
D
S
T
K
H
S
T
Site 142
S1673
D
K
E
P
D
S
D
S
T
K
H
S
T
P
S
Site 143
T1674
K
E
P
D
S
D
S
T
K
H
S
T
P
S
N
Site 144
S1677
D
S
D
S
T
K
H
S
T
P
S
N
S
S
N
Site 145
T1678
S
D
S
T
K
H
S
T
P
S
N
S
S
N
P
Site 146
S1680
S
T
K
H
S
T
P
S
N
S
S
N
P
S
G
Site 147
S1682
K
H
S
T
P
S
N
S
S
N
P
S
G
P
P
Site 148
S1683
H
S
T
P
S
N
S
S
N
P
S
G
P
P
S
Site 149
S1686
P
S
N
S
S
N
P
S
G
P
P
S
P
N
S
Site 150
S1690
S
N
P
S
G
P
P
S
P
N
S
P
H
R
S
Site 151
S1693
S
G
P
P
S
P
N
S
P
H
R
S
Q
L
P
Site 152
S1697
S
P
N
S
P
H
R
S
Q
L
P
L
E
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation