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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRAK3
Full Name:
Interleukin-1 receptor-associated kinase 3
Alias:
EC 2.7.11.1; IRAK-M
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
TKL
group; IRAK family
Mass (Da):
67753
Number AA:
596
UniProt ID:
Q9Y616
International Prot ID:
IPI00026984
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0002755
GO:0070498
GO:0043407
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
R
G
L
A
E
R
L
S
S
S
W
L
D
V
R
Site 2
S50
G
L
A
E
R
L
S
S
S
W
L
D
V
R
H
Site 3
S51
L
A
E
R
L
S
S
S
W
L
D
V
R
H
I
Site 4
Y61
D
V
R
H
I
E
K
Y
V
D
Q
G
K
S
G
Site 5
S67
K
Y
V
D
Q
G
K
S
G
T
R
E
L
L
W
Site 6
S75
G
T
R
E
L
L
W
S
W
A
Q
K
N
K
T
Site 7
T82
S
W
A
Q
K
N
K
T
I
G
D
L
L
Q
V
Site 8
S110
T
N
Y
G
A
V
L
S
P
S
E
K
S
Y
Q
Site 9
S112
Y
G
A
V
L
S
P
S
E
K
S
Y
Q
E
G
Site 10
S115
V
L
S
P
S
E
K
S
Y
Q
E
G
G
F
P
Site 11
Y116
L
S
P
S
E
K
S
Y
Q
E
G
G
F
P
N
Site 12
S151
E
K
G
V
L
L
K
S
S
I
S
F
Q
N
I
Site 13
S154
V
L
L
K
S
S
I
S
F
Q
N
I
I
E
G
Site 14
T162
F
Q
N
I
I
E
G
T
R
N
F
H
K
D
F
Site 15
Y180
E
G
E
I
F
E
V
Y
R
V
E
I
Q
N
L
Site 16
T188
R
V
E
I
Q
N
L
T
Y
A
V
K
L
F
K
Site 17
Y189
V
E
I
Q
N
L
T
Y
A
V
K
L
F
K
Q
Site 18
Y241
T
E
K
F
C
L
I
Y
P
Y
M
R
N
G
T
Site 19
T248
Y
P
Y
M
R
N
G
T
L
F
D
R
L
Q
C
Site 20
Y280
G
I
S
K
A
I
H
Y
L
H
N
V
Q
P
C
Site 21
T331
Q
S
C
T
I
N
M
T
S
S
S
S
K
H
L
Site 22
S332
S
C
T
I
N
M
T
S
S
S
S
K
H
L
W
Site 23
Y340
S
S
S
K
H
L
W
Y
M
P
E
E
Y
I
R
Site 24
Y345
L
W
Y
M
P
E
E
Y
I
R
Q
G
K
L
S
Site 25
S352
Y
I
R
Q
G
K
L
S
I
K
T
D
V
Y
S
Site 26
T355
Q
G
K
L
S
I
K
T
D
V
Y
S
F
G
I
Site 27
S398
M
E
K
R
G
L
D
S
C
L
S
F
L
D
K
Site 28
S401
R
G
L
D
S
C
L
S
F
L
D
K
K
V
P
Site 29
S415
P
P
C
P
R
N
F
S
A
K
L
F
C
L
A
Site 30
S435
T
R
A
K
L
R
P
S
M
D
E
V
L
N
T
Site 31
T442
S
M
D
E
V
L
N
T
L
E
S
T
Q
A
S
Site 32
S445
E
V
L
N
T
L
E
S
T
Q
A
S
L
Y
F
Site 33
S449
T
L
E
S
T
Q
A
S
L
Y
F
A
E
D
P
Site 34
Y451
E
S
T
Q
A
S
L
Y
F
A
E
D
P
P
T
Site 35
T458
Y
F
A
E
D
P
P
T
S
L
K
S
F
R
C
Site 36
S459
F
A
E
D
P
P
T
S
L
K
S
F
R
C
P
Site 37
S462
D
P
P
T
S
L
K
S
F
R
C
P
S
P
L
Site 38
S467
L
K
S
F
R
C
P
S
P
L
F
L
E
N
V
Site 39
S476
L
F
L
E
N
V
P
S
I
P
V
E
D
D
E
Site 40
S484
I
P
V
E
D
D
E
S
Q
N
N
N
L
L
P
Site 41
S492
Q
N
N
N
L
L
P
S
D
E
G
L
R
I
D
Site 42
T502
G
L
R
I
D
R
M
T
Q
K
T
P
F
E
C
Site 43
T505
I
D
R
M
T
Q
K
T
P
F
E
C
S
Q
S
Site 44
S510
Q
K
T
P
F
E
C
S
Q
S
E
V
M
F
L
Site 45
S512
T
P
F
E
C
S
Q
S
E
V
M
F
L
S
L
Site 46
S518
Q
S
E
V
M
F
L
S
L
D
K
K
P
E
S
Site 47
S525
S
L
D
K
K
P
E
S
K
R
N
E
E
A
C
Site 48
S536
E
E
A
C
N
M
P
S
S
S
C
E
E
S
W
Site 49
S537
E
A
C
N
M
P
S
S
S
C
E
E
S
W
F
Site 50
S538
A
C
N
M
P
S
S
S
C
E
E
S
W
F
P
Site 51
S542
P
S
S
S
C
E
E
S
W
F
P
K
Y
I
V
Site 52
Y547
E
E
S
W
F
P
K
Y
I
V
P
S
Q
D
L
Site 53
S551
F
P
K
Y
I
V
P
S
Q
D
L
R
P
Y
K
Site 54
Y557
P
S
Q
D
L
R
P
Y
K
V
N
I
D
P
S
Site 55
S564
Y
K
V
N
I
D
P
S
S
E
A
P
G
H
S
Site 56
S565
K
V
N
I
D
P
S
S
E
A
P
G
H
S
C
Site 57
S571
S
S
E
A
P
G
H
S
C
R
S
R
P
V
E
Site 58
S574
A
P
G
H
S
C
R
S
R
P
V
E
S
S
C
Site 59
S579
C
R
S
R
P
V
E
S
S
C
S
S
K
F
S
Site 60
S580
R
S
R
P
V
E
S
S
C
S
S
K
F
S
W
Site 61
S582
R
P
V
E
S
S
C
S
S
K
F
S
W
D
E
Site 62
S583
P
V
E
S
S
C
S
S
K
F
S
W
D
E
Y
Site 63
S586
S
S
C
S
S
K
F
S
W
D
E
Y
E
Q
Y
Site 64
Y590
S
K
F
S
W
D
E
Y
E
Q
Y
K
K
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation