KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ARFGEF1
Full Name:
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Alias:
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); ARFGEP1; BIG1; Brefeldin A-inhibited GEP 1; DKFZP434L057; P200; P200 ARF guanine nucleotide exchange factor; P200 ARF-GEP1
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
208767
Number AA:
1849
UniProt ID:
Q9Y6D6
International Prot ID:
IPI00002188
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005086
GO:0017022
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
E
V
K
K
A
H
H
S
Q
L
R
K
A
C
E
Site 2
T48
L
E
E
I
K
A
E
T
E
K
Q
S
P
P
H
Site 3
S52
K
A
E
T
E
K
Q
S
P
P
H
G
E
A
K
Site 4
S63
G
E
A
K
A
G
S
S
T
L
P
P
V
K
S
Site 5
T64
E
A
K
A
G
S
S
T
L
P
P
V
K
S
K
Site 6
S70
S
T
L
P
P
V
K
S
K
T
N
F
I
E
A
Site 7
S90
P
F
E
L
A
C
Q
S
K
C
P
R
I
V
S
Site 8
S97
S
K
C
P
R
I
V
S
T
S
L
D
C
L
Q
Site 9
Y109
C
L
Q
K
L
I
A
Y
G
H
L
T
G
N
A
Site 10
S119
L
T
G
N
A
P
D
S
T
T
P
G
K
K
L
Site 11
T120
T
G
N
A
P
D
S
T
T
P
G
K
K
L
I
Site 12
T121
G
N
A
P
D
S
T
T
P
G
K
K
L
I
D
Site 13
T143
G
C
F
Q
G
P
Q
T
D
E
G
V
Q
L
Q
Site 14
S234
Q
H
H
H
L
L
Q
S
P
V
S
H
H
E
P
Site 15
S237
H
L
L
Q
S
P
V
S
H
H
E
P
E
S
P
Site 16
S243
V
S
H
H
E
P
E
S
P
Q
L
R
Y
L
P
Site 17
Y248
P
E
S
P
Q
L
R
Y
L
P
P
Q
T
V
D
Site 18
T253
L
R
Y
L
P
P
Q
T
V
D
H
I
S
Q
E
Site 19
S258
P
Q
T
V
D
H
I
S
Q
E
H
E
G
D
L
Site 20
T269
E
G
D
L
D
L
H
T
N
D
V
D
K
S
L
Site 21
S275
H
T
N
D
V
D
K
S
L
Q
D
D
T
E
P
Site 22
T280
D
K
S
L
Q
D
D
T
E
P
E
N
G
S
D
Site 23
S286
D
T
E
P
E
N
G
S
D
I
S
S
A
E
N
Site 24
S289
P
E
N
G
S
D
I
S
S
A
E
N
E
Q
T
Site 25
S290
E
N
G
S
D
I
S
S
A
E
N
E
Q
T
E
Site 26
T296
S
S
A
E
N
E
Q
T
E
A
D
Q
A
T
A
Site 27
S308
A
T
A
A
E
T
L
S
K
N
E
V
L
Y
D
Site 28
Y314
L
S
K
N
E
V
L
Y
D
G
E
N
H
D
C
Site 29
T348
V
G
D
M
G
E
G
T
T
I
N
A
S
A
D
Site 30
S353
E
G
T
T
I
N
A
S
A
D
G
N
I
G
T
Site 31
T360
S
A
D
G
N
I
G
T
I
E
D
G
S
D
S
Site 32
S365
I
G
T
I
E
D
G
S
D
S
E
N
I
Q
A
Site 33
S367
T
I
E
D
G
S
D
S
E
N
I
Q
A
N
G
Site 34
T385
T
P
I
S
V
A
Y
T
P
S
L
P
D
D
R
Site 35
S387
I
S
V
A
Y
T
P
S
L
P
D
D
R
L
S
Site 36
S394
S
L
P
D
D
R
L
S
V
S
S
N
D
T
Q
Site 37
S396
P
D
D
R
L
S
V
S
S
N
D
T
Q
E
S
Site 38
S397
D
D
R
L
S
V
S
S
N
D
T
Q
E
S
G
Site 39
T400
L
S
V
S
S
N
D
T
Q
E
S
G
N
S
S
Site 40
S403
S
S
N
D
T
Q
E
S
G
N
S
S
G
P
S
Site 41
S406
D
T
Q
E
S
G
N
S
S
G
P
S
P
G
A
Site 42
S407
T
Q
E
S
G
N
S
S
G
P
S
P
G
A
K
Site 43
S410
S
G
N
S
S
G
P
S
P
G
A
K
F
S
H
Site 44
S416
P
S
P
G
A
K
F
S
H
I
L
Q
K
D
A
Site 45
S434
F
R
S
L
C
K
L
S
M
K
P
L
S
D
G
Site 46
S439
K
L
S
M
K
P
L
S
D
G
P
P
D
P
K
Site 47
S447
D
G
P
P
D
P
K
S
H
E
L
R
S
K
I
Site 48
S452
P
K
S
H
E
L
R
S
K
I
L
S
L
Q
L
Site 49
T517
T
L
L
S
N
F
K
T
H
L
K
M
Q
I
E
Site 50
S538
F
L
Y
I
L
E
T
S
T
S
S
F
D
H
K
Site 51
S541
I
L
E
T
S
T
S
S
F
D
H
K
W
M
V
Site 52
S587
E
R
L
V
N
D
L
S
K
I
A
Q
G
R
G
Site 53
S595
K
I
A
Q
G
R
G
S
Q
E
L
G
M
S
N
Site 54
S601
G
S
Q
E
L
G
M
S
N
V
Q
E
L
S
L
Site 55
S607
M
S
N
V
Q
E
L
S
L
R
K
K
G
L
E
Site 56
S618
K
G
L
E
C
L
V
S
I
L
K
C
M
V
E
Site 57
Y631
V
E
W
S
K
D
Q
Y
V
N
P
N
S
Q
T
Site 58
S636
D
Q
Y
V
N
P
N
S
Q
T
T
L
G
Q
E
Site 59
S651
K
P
S
E
Q
E
M
S
E
I
K
H
P
E
T
Site 60
T658
S
E
I
K
H
P
E
T
I
N
R
Y
G
S
L
Site 61
Y662
H
P
E
T
I
N
R
Y
G
S
L
N
S
L
E
Site 62
S664
E
T
I
N
R
Y
G
S
L
N
S
L
E
S
T
Site 63
S667
N
R
Y
G
S
L
N
S
L
E
S
T
S
S
S
Site 64
S670
G
S
L
N
S
L
E
S
T
S
S
S
G
I
G
Site 65
T671
S
L
N
S
L
E
S
T
S
S
S
G
I
G
S
Site 66
S672
L
N
S
L
E
S
T
S
S
S
G
I
G
S
Y
Site 67
S673
N
S
L
E
S
T
S
S
S
G
I
G
S
Y
S
Site 68
S674
S
L
E
S
T
S
S
S
G
I
G
S
Y
S
T
Site 69
S678
T
S
S
S
G
I
G
S
Y
S
T
Q
M
S
G
Site 70
S680
S
S
G
I
G
S
Y
S
T
Q
M
S
G
T
D
Site 71
T681
S
G
I
G
S
Y
S
T
Q
M
S
G
T
D
N
Site 72
S684
G
S
Y
S
T
Q
M
S
G
T
D
N
P
E
Q
Site 73
T686
Y
S
T
Q
M
S
G
T
D
N
P
E
Q
F
E
Site 74
Y719
K
P
K
R
G
I
Q
Y
L
Q
E
Q
G
M
L
Site 75
T729
E
Q
G
M
L
G
T
T
P
E
D
I
A
Q
F
Site 76
S745
H
Q
E
E
R
L
D
S
T
Q
V
G
E
F
L
Site 77
T746
Q
E
E
R
L
D
S
T
Q
V
G
E
F
L
G
Site 78
Y764
K
F
N
K
E
V
M
Y
A
Y
V
D
Q
H
D
Site 79
Y766
N
K
E
V
M
Y
A
Y
V
D
Q
H
D
F
S
Site 80
S773
Y
V
D
Q
H
D
F
S
G
K
D
F
V
S
A
Site 81
Y808
M
E
K
F
A
A
R
Y
L
E
C
N
Q
G
Q
Site 82
S840
M
L
T
T
D
L
H
S
P
Q
V
K
N
K
M
Site 83
Y852
N
K
M
T
K
E
Q
Y
I
K
M
N
R
G
I
Site 84
S862
M
N
R
G
I
N
D
S
K
D
L
P
E
E
Y
Site 85
Y869
S
K
D
L
P
E
E
Y
L
S
A
I
Y
N
E
Site 86
S871
D
L
P
E
E
Y
L
S
A
I
Y
N
E
I
A
Site 87
Y874
E
E
Y
L
S
A
I
Y
N
E
I
A
G
K
K
Site 88
S883
E
I
A
G
K
K
I
S
M
K
E
T
K
E
L
Site 89
T887
K
K
I
S
M
K
E
T
K
E
L
T
I
P
T
Site 90
T891
M
K
E
T
K
E
L
T
I
P
T
K
S
S
K
Site 91
T894
T
K
E
L
T
I
P
T
K
S
S
K
Q
N
V
Site 92
S896
E
L
T
I
P
T
K
S
S
K
Q
N
V
A
S
Site 93
Y911
E
K
Q
R
R
L
L
Y
N
L
E
M
E
Q
M
Site 94
T937
S
H
V
Q
A
P
F
T
S
A
T
H
L
E
H
Site 95
Y999
I
Q
L
E
R
D
A
Y
V
Q
A
L
A
R
F
Site 96
T1031
D
T
I
K
T
L
I
T
V
A
H
T
D
G
N
Site 97
Y1039
V
A
H
T
D
G
N
Y
L
G
N
S
W
H
E
Site 98
T1062
E
L
A
Q
L
I
G
T
G
V
K
P
R
Y
I
Site 99
Y1068
G
T
G
V
K
P
R
Y
I
S
G
T
V
R
G
Site 100
S1070
G
V
K
P
R
Y
I
S
G
T
V
R
G
R
E
Site 101
T1072
K
P
R
Y
I
S
G
T
V
R
G
R
E
G
S
Site 102
S1079
T
V
R
G
R
E
G
S
L
T
G
T
K
D
Q
Site 103
T1081
R
G
R
E
G
S
L
T
G
T
K
D
Q
A
P
Site 104
T1083
R
E
G
S
L
T
G
T
K
D
Q
A
P
D
E
Site 105
S1108
V
D
W
K
Q
I
A
S
I
Q
E
S
I
G
E
Site 106
S1112
Q
I
A
S
I
Q
E
S
I
G
E
T
S
S
Q
Site 107
T1116
I
Q
E
S
I
G
E
T
S
S
Q
S
V
V
V
Site 108
S1132
V
D
R
I
F
T
G
S
T
R
L
D
G
N
A
Site 109
S1157
V
S
M
D
E
L
L
S
T
T
H
P
R
M
F
Site 110
T1158
S
M
D
E
L
L
S
T
T
H
P
R
M
F
S
Site 111
S1165
T
T
H
P
R
M
F
S
L
Q
K
I
V
E
I
Site 112
Y1174
Q
K
I
V
E
I
S
Y
Y
N
M
G
R
I
R
Site 113
Y1175
K
I
V
E
I
S
Y
Y
N
M
G
R
I
R
L
Site 114
S1218
V
D
S
L
R
Q
L
S
M
K
F
L
E
K
G
Site 115
S1249
H
I
M
K
R
N
R
S
P
T
I
R
D
M
V
Site 116
T1251
M
K
R
N
R
S
P
T
I
R
D
M
V
V
R
Site 117
S1292
A
A
S
D
Q
D
E
S
I
V
E
L
A
F
Q
Site 118
Y1353
L
I
R
H
C
A
K
Y
V
S
D
R
P
Q
A
Site 119
S1355
R
H
C
A
K
Y
V
S
D
R
P
Q
A
F
K
Site 120
Y1486
D
D
I
F
A
Q
L
Y
W
C
V
Q
Q
D
N
Site 121
T1501
E
Q
L
A
R
S
G
T
N
C
L
E
N
V
V
Site 122
T1541
T
I
P
H
A
L
L
T
W
R
P
N
S
G
E
Site 123
S1546
L
L
T
W
R
P
N
S
G
E
T
A
P
P
P
Site 124
T1549
W
R
P
N
S
G
E
T
A
P
P
P
P
S
P
Site 125
S1555
E
T
A
P
P
P
P
S
P
V
S
E
K
P
L
Site 126
S1558
P
P
P
P
S
P
V
S
E
K
P
L
D
T
I
Site 127
T1564
V
S
E
K
P
L
D
T
I
S
Q
K
S
V
D
Site 128
S1566
E
K
P
L
D
T
I
S
Q
K
S
V
D
I
H
Site 129
S1569
L
D
T
I
S
Q
K
S
V
D
I
H
D
S
I
Site 130
S1575
K
S
V
D
I
H
D
S
I
Q
P
R
S
V
D
Site 131
S1580
H
D
S
I
Q
P
R
S
V
D
N
R
P
Q
A
Site 132
S1591
R
P
Q
A
P
L
V
S
A
S
A
V
N
E
E
Site 133
S1600
S
A
V
N
E
E
V
S
K
I
K
S
T
A
K
Site 134
S1604
E
E
V
S
K
I
K
S
T
A
K
F
P
E
Q
Site 135
T1665
D
F
D
V
R
V
D
T
Q
D
Q
G
M
Y
R
Site 136
T1675
Q
G
M
Y
R
F
L
T
S
Q
Q
L
F
K
L
Site 137
S1698
R
F
A
K
A
F
N
S
N
N
E
Q
R
T
A
Site 138
T1704
N
S
N
N
E
Q
R
T
A
L
W
K
A
G
F
Site 139
S1715
K
A
G
F
K
G
K
S
K
P
N
L
L
K
Q
Site 140
S1725
N
L
L
K
Q
E
T
S
S
L
A
C
G
L
R
Site 141
Y1738
L
R
I
L
F
R
M
Y
M
D
E
S
R
V
S
Site 142
S1745
Y
M
D
E
S
R
V
S
A
W
E
E
V
Q
Q
Site 143
T1767
E
A
L
S
Y
F
L
T
L
T
S
E
S
H
R
Site 144
T1769
L
S
Y
F
L
T
L
T
S
E
S
H
R
E
A
Site 145
S1770
S
Y
F
L
T
L
T
S
E
S
H
R
E
A
W
Site 146
S1772
F
L
T
L
T
S
E
S
H
R
E
A
W
T
N
Site 147
S1792
L
T
K
V
L
K
I
S
D
N
R
F
K
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation