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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SNCAIP
Full Name:
Synphilin-1
Alias:
Alpha-synuclein-interacting protein; SNCAP; Synphilin; Synuclein, alpha interacting protein; SYPH1
Type:
Vesicle protein
Mass (Da):
100409
Number AA:
919
UniProt ID:
Q9Y6H5
International Prot ID:
IPI00002293
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043025
GO:0005737
GO:0042734
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0042417
GO:0046928
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y6
_
_
M
E
A
P
E
Y
L
D
L
D
E
I
D
Site 2
S15
D
L
D
E
I
D
F
S
D
D
I
S
Y
S
V
Site 3
S19
I
D
F
S
D
D
I
S
Y
S
V
T
S
L
K
Site 4
Y20
D
F
S
D
D
I
S
Y
S
V
T
S
L
K
T
Site 5
S21
F
S
D
D
I
S
Y
S
V
T
S
L
K
T
I
Site 6
T23
D
D
I
S
Y
S
V
T
S
L
K
T
I
P
E
Site 7
T37
E
L
C
R
R
C
D
T
Q
N
E
D
R
S
V
Site 8
S43
D
T
Q
N
E
D
R
S
V
S
S
S
S
W
N
Site 9
S45
Q
N
E
D
R
S
V
S
S
S
S
W
N
C
G
Site 10
S47
E
D
R
S
V
S
S
S
S
W
N
C
G
I
S
Site 11
S48
D
R
S
V
S
S
S
S
W
N
C
G
I
S
T
Site 12
T55
S
W
N
C
G
I
S
T
L
I
T
N
T
Q
K
Site 13
T58
C
G
I
S
T
L
I
T
N
T
Q
K
P
T
G
Site 14
Y70
P
T
G
I
A
D
V
Y
S
K
F
R
P
V
K
Site 15
S71
T
G
I
A
D
V
Y
S
K
F
R
P
V
K
R
Site 16
S80
F
R
P
V
K
R
V
S
P
L
K
H
Q
P
E
Site 17
T88
P
L
K
H
Q
P
E
T
L
E
N
N
E
S
D
Site 18
S94
E
T
L
E
N
N
E
S
D
D
Q
K
N
Q
K
Site 19
Y105
K
N
Q
K
V
V
E
Y
Q
K
G
G
E
S
D
Site 20
S133
V
G
G
P
P
G
K
S
S
E
P
S
T
S
L
Site 21
S134
G
G
P
P
G
K
S
S
E
P
S
T
S
L
G
Site 22
S137
P
G
K
S
S
E
P
S
T
S
L
G
E
L
E
Site 23
T138
G
K
S
S
E
P
S
T
S
L
G
E
L
E
H
Site 24
S139
K
S
S
E
P
S
T
S
L
G
E
L
E
H
Y
Site 25
Y146
S
L
G
E
L
E
H
Y
D
L
D
M
D
E
I
Site 26
Y158
D
E
I
L
D
V
P
Y
I
K
S
S
Q
Q
L
Site 27
S161
L
D
V
P
Y
I
K
S
S
Q
Q
L
A
S
F
Site 28
S162
D
V
P
Y
I
K
S
S
Q
Q
L
A
S
F
T
Site 29
S167
K
S
S
Q
Q
L
A
S
F
T
K
V
T
S
E
Site 30
T169
S
Q
Q
L
A
S
F
T
K
V
T
S
E
K
R
Site 31
S173
A
S
F
T
K
V
T
S
E
K
R
I
L
G
L
Site 32
S193
G
L
S
G
K
A
C
S
T
G
S
S
E
S
S
Site 33
T194
L
S
G
K
A
C
S
T
G
S
S
E
S
S
S
Site 34
S196
G
K
A
C
S
T
G
S
S
E
S
S
S
S
N
Site 35
S197
K
A
C
S
T
G
S
S
E
S
S
S
S
N
M
Site 36
S200
S
T
G
S
S
E
S
S
S
S
N
M
A
P
F
Site 37
S201
T
G
S
S
E
S
S
S
S
N
M
A
P
F
C
Site 38
S202
G
S
S
E
S
S
S
S
N
M
A
P
F
C
V
Site 39
S211
M
A
P
F
C
V
L
S
P
V
K
S
P
H
L
Site 40
S215
C
V
L
S
P
V
K
S
P
H
L
R
K
A
S
Site 41
S222
S
P
H
L
R
K
A
S
A
V
I
H
D
Q
H
Site 42
S232
I
H
D
Q
H
K
L
S
T
E
E
T
E
I
S
Site 43
T236
H
K
L
S
T
E
E
T
E
I
S
P
P
L
V
Site 44
S239
S
T
E
E
T
E
I
S
P
P
L
V
K
C
G
Site 45
S247
P
P
L
V
K
C
G
S
A
Y
E
P
E
N
Q
Site 46
T262
S
K
D
F
L
N
K
T
F
S
D
P
H
G
R
Site 47
S264
D
F
L
N
K
T
F
S
D
P
H
G
R
K
V
Site 48
T274
H
G
R
K
V
E
K
T
T
P
D
C
Q
L
R
Site 49
T275
G
R
K
V
E
K
T
T
P
D
C
Q
L
R
A
Site 50
S287
L
R
A
F
H
L
Q
S
S
A
A
E
S
K
P
Site 51
S288
R
A
F
H
L
Q
S
S
A
A
E
S
K
P
E
Site 52
S292
L
Q
S
S
A
A
E
S
K
P
E
E
Q
V
S
Site 53
S299
S
K
P
E
E
Q
V
S
G
L
N
R
T
S
S
Site 54
T304
Q
V
S
G
L
N
R
T
S
S
Q
G
P
E
E
Site 55
S305
V
S
G
L
N
R
T
S
S
Q
G
P
E
E
R
Site 56
S306
S
G
L
N
R
T
S
S
Q
G
P
E
E
R
S
Site 57
Y315
G
P
E
E
R
S
E
Y
L
K
K
V
K
S
I
Site 58
S321
E
Y
L
K
K
V
K
S
I
L
N
I
V
K
E
Site 59
T383
D
C
L
N
E
R
N
T
E
K
L
T
P
A
G
Site 60
T387
E
R
N
T
E
K
L
T
P
A
G
L
A
I
K
Site 61
S406
E
C
V
R
W
M
V
S
E
T
E
A
I
A
E
Site 62
S415
T
E
A
I
A
E
L
S
C
S
K
D
F
P
S
Site 63
Y426
D
F
P
S
L
I
H
Y
A
G
C
Y
G
Q
E
Site 64
S449
F
M
Q
E
Q
G
I
S
L
D
E
V
D
Q
D
Site 65
S465
N
S
A
V
H
V
A
S
Q
H
G
Y
L
G
C
Site 66
S496
A
G
E
K
P
S
Q
S
A
E
R
Q
G
H
T
Site 67
T533
T
K
Q
L
K
E
Q
T
V
E
R
V
T
L
Q
Site 68
T538
E
Q
T
V
E
R
V
T
L
Q
N
Q
L
Q
Q
Site 69
S552
Q
F
L
E
A
Q
K
S
E
G
K
S
L
P
S
Site 70
S556
A
Q
K
S
E
G
K
S
L
P
S
S
P
S
S
Site 71
S559
S
E
G
K
S
L
P
S
S
P
S
S
P
S
S
Site 72
S560
E
G
K
S
L
P
S
S
P
S
S
P
S
S
P
Site 73
S562
K
S
L
P
S
S
P
S
S
P
S
S
P
A
S
Site 74
S563
S
L
P
S
S
P
S
S
P
S
S
P
A
S
R
Site 75
S565
P
S
S
P
S
S
P
S
S
P
A
S
R
K
S
Site 76
S566
S
S
P
S
S
P
S
S
P
A
S
R
K
S
Q
Site 77
S569
S
S
P
S
S
P
A
S
R
K
S
Q
W
K
S
Site 78
S572
S
S
P
A
S
R
K
S
Q
W
K
S
P
D
A
Site 79
S576
S
R
K
S
Q
W
K
S
P
D
A
D
D
D
S
Site 80
S583
S
P
D
A
D
D
D
S
V
A
K
S
K
P
G
Site 81
S587
D
D
D
S
V
A
K
S
K
P
G
V
Q
E
G
Site 82
S602
I
Q
V
L
G
S
L
S
A
S
S
R
A
R
P
Site 83
S604
V
L
G
S
L
S
A
S
S
R
A
R
P
K
A
Site 84
S605
L
G
S
L
S
A
S
S
R
A
R
P
K
A
K
Site 85
S616
P
K
A
K
D
E
D
S
D
K
I
L
R
Q
L
Site 86
S629
Q
L
L
G
K
E
I
S
E
N
V
C
T
Q
E
Site 87
T634
E
I
S
E
N
V
C
T
Q
E
K
L
S
L
E
Site 88
S648
E
F
Q
D
A
Q
A
S
S
R
N
S
K
K
I
Site 89
S652
A
Q
A
S
S
R
N
S
K
K
I
P
L
E
K
Site 90
S674
L
R
Q
L
M
Q
R
S
L
S
E
S
D
T
D
Site 91
S676
Q
L
M
Q
R
S
L
S
E
S
D
T
D
S
N
Site 92
S678
M
Q
R
S
L
S
E
S
D
T
D
S
N
N
S
Site 93
T680
R
S
L
S
E
S
D
T
D
S
N
N
S
E
D
Site 94
S682
L
S
E
S
D
T
D
S
N
N
S
E
D
P
K
Site 95
T690
N
N
S
E
D
P
K
T
T
P
V
R
K
A
D
Site 96
T691
N
S
E
D
P
K
T
T
P
V
R
K
A
D
R
Site 97
S707
R
P
Q
P
I
V
E
S
V
E
S
M
D
S
A
Site 98
S710
P
I
V
E
S
V
E
S
M
D
S
A
E
S
L
Site 99
S713
E
S
V
E
S
M
D
S
A
E
S
L
H
L
M
Site 100
S716
E
S
M
D
S
A
E
S
L
H
L
M
I
K
K
Site 101
S728
I
K
K
H
T
L
A
S
G
G
R
R
F
P
F
Site 102
S736
G
G
R
R
F
P
F
S
I
K
A
S
K
S
L
Site 103
S740
F
P
F
S
I
K
A
S
K
S
L
D
G
H
S
Site 104
S742
F
S
I
K
A
S
K
S
L
D
G
H
S
P
S
Site 105
S747
S
K
S
L
D
G
H
S
P
S
P
T
S
E
S
Site 106
S749
S
L
D
G
H
S
P
S
P
T
S
E
S
S
E
Site 107
T751
D
G
H
S
P
S
P
T
S
E
S
S
E
P
D
Site 108
S752
G
H
S
P
S
P
T
S
E
S
S
E
P
D
L
Site 109
S754
S
P
S
P
T
S
E
S
S
E
P
D
L
E
S
Site 110
S755
P
S
P
T
S
E
S
S
E
P
D
L
E
S
Q
Site 111
S761
S
S
E
P
D
L
E
S
Q
Y
P
G
S
G
S
Site 112
Y763
E
P
D
L
E
S
Q
Y
P
G
S
G
S
I
P
Site 113
S766
L
E
S
Q
Y
P
G
S
G
S
I
P
P
N
Q
Site 114
S768
S
Q
Y
P
G
S
G
S
I
P
P
N
Q
P
S
Site 115
S775
S
I
P
P
N
Q
P
S
G
D
P
Q
Q
P
S
Site 116
S782
S
G
D
P
Q
Q
P
S
P
D
S
T
A
A
Q
Site 117
S785
P
Q
Q
P
S
P
D
S
T
A
A
Q
K
V
A
Site 118
T786
Q
Q
P
S
P
D
S
T
A
A
Q
K
V
A
T
Site 119
S794
A
A
Q
K
V
A
T
S
P
K
S
A
L
K
S
Site 120
S797
K
V
A
T
S
P
K
S
A
L
K
S
P
S
S
Site 121
S801
S
P
K
S
A
L
K
S
P
S
S
K
R
R
T
Site 122
S803
K
S
A
L
K
S
P
S
S
K
R
R
T
S
Q
Site 123
S804
S
A
L
K
S
P
S
S
K
R
R
T
S
Q
N
Site 124
T808
S
P
S
S
K
R
R
T
S
Q
N
L
K
L
R
Site 125
S809
P
S
S
K
R
R
T
S
Q
N
L
K
L
R
V
Site 126
T817
Q
N
L
K
L
R
V
T
F
E
E
P
V
V
Q
Site 127
T843
K
D
K
D
K
G
R
T
L
Q
R
T
S
T
S
Site 128
T847
K
G
R
T
L
Q
R
T
S
T
S
N
E
S
G
Site 129
S848
G
R
T
L
Q
R
T
S
T
S
N
E
S
G
D
Site 130
T849
R
T
L
Q
R
T
S
T
S
N
E
S
G
D
Q
Site 131
S850
T
L
Q
R
T
S
T
S
N
E
S
G
D
Q
L
Site 132
S866
R
P
F
G
A
F
R
S
I
M
E
T
L
S
G
Site 133
T870
A
F
R
S
I
M
E
T
L
S
G
N
Q
N
N
Site 134
S872
R
S
I
M
E
T
L
S
G
N
Q
N
N
N
N
Site 135
T891
A
N
Q
L
K
T
S
T
L
P
L
T
S
L
G
Site 136
T895
K
T
S
T
L
P
L
T
S
L
G
R
K
T
D
Site 137
S896
T
S
T
L
P
L
T
S
L
G
R
K
T
D
A
Site 138
T901
L
T
S
L
G
R
K
T
D
A
K
G
N
P
A
Site 139
S909
D
A
K
G
N
P
A
S
S
A
S
K
G
K
N
Site 140
S910
A
K
G
N
P
A
S
S
A
S
K
G
K
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation