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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC4A4
Full Name:
Electrogenic sodium bicarbonate cotransporter 1
Alias:
HCO3; HNBC1; KNBC1; Na(+)/HCO3(-) cotransporter; NBC1; NBC2; PNBC; S4A4; SLC4A5; Solute carrier family 4 member 4; Solute carrier family 4, sodium bicarbonate cotransporter, member 4
Type:
Transporter
Mass (Da):
121461
Number AA:
1079
UniProt ID:
Q9Y6R1
International Prot ID:
IPI00016949
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005452
GO:0031402
GO:0008510
PhosphoSite+
KinaseNET
Biological Process:
GO:0006820
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
V
L
D
R
G
A
S
F
L
K
H
V
C
D
Site 2
T28
E
E
V
E
G
H
H
T
I
Y
I
G
V
H
V
Site 3
Y30
V
E
G
H
H
T
I
Y
I
G
V
H
V
P
K
Site 4
S38
I
G
V
H
V
P
K
S
Y
R
R
R
R
R
H
Site 5
Y39
G
V
H
V
P
K
S
Y
R
R
R
R
R
H
K
Site 6
T49
R
R
R
H
K
R
K
T
G
H
K
E
K
K
E
Site 7
S61
K
K
E
K
E
R
I
S
E
N
Y
S
D
K
S
Site 8
Y64
K
E
R
I
S
E
N
Y
S
D
K
S
D
I
E
Site 9
S65
E
R
I
S
E
N
Y
S
D
K
S
D
I
E
N
Site 10
S68
S
E
N
Y
S
D
K
S
D
I
E
N
A
D
E
Site 11
S76
D
I
E
N
A
D
E
S
S
S
S
I
L
K
P
Site 12
S79
N
A
D
E
S
S
S
S
I
L
K
P
L
I
S
Site 13
S102
I
L
G
E
E
D
D
S
P
A
P
P
Q
L
F
Site 14
S146
E
Q
G
G
E
R
W
S
K
P
H
V
A
T
L
Site 15
S177
I
M
L
D
R
E
A
S
S
L
P
Q
L
V
E
Site 16
S178
M
L
D
R
E
A
S
S
L
P
Q
L
V
E
M
Site 17
T205
P
E
L
K
D
K
V
T
Y
T
L
L
R
K
H
Site 18
Y206
E
L
K
D
K
V
T
Y
T
L
L
R
K
H
R
Site 19
T207
L
K
D
K
V
T
Y
T
L
L
R
K
H
R
H
Site 20
T216
L
R
K
H
R
H
Q
T
K
K
S
N
L
R
S
Site 21
S219
H
R
H
Q
T
K
K
S
N
L
R
S
L
A
D
Site 22
S223
T
K
K
S
N
L
R
S
L
A
D
I
G
K
T
Site 23
T230
S
L
A
D
I
G
K
T
V
S
S
A
S
R
M
Site 24
S232
A
D
I
G
K
T
V
S
S
A
S
R
M
F
T
Site 25
S233
D
I
G
K
T
V
S
S
A
S
R
M
F
T
N
Site 26
T239
S
S
A
S
R
M
F
T
N
P
D
N
G
S
P
Site 27
S245
F
T
N
P
D
N
G
S
P
A
M
T
H
R
N
Site 28
T249
D
N
G
S
P
A
M
T
H
R
N
L
T
S
S
Site 29
T254
A
M
T
H
R
N
L
T
S
S
S
L
N
D
I
Site 30
S255
M
T
H
R
N
L
T
S
S
S
L
N
D
I
S
Site 31
S256
T
H
R
N
L
T
S
S
S
L
N
D
I
S
D
Site 32
S257
H
R
N
L
T
S
S
S
L
N
D
I
S
D
K
Site 33
S262
S
S
S
L
N
D
I
S
D
K
P
E
K
D
Q
Site 34
S336
G
P
K
G
K
A
K
S
Y
H
E
I
G
R
A
Site 35
Y337
P
K
G
K
A
K
S
Y
H
E
I
G
R
A
I
Site 36
Y358
E
V
F
H
D
I
A
Y
K
A
K
D
R
H
D
Site 37
S396
I
R
I
E
P
P
K
S
L
P
S
S
D
K
R
Site 38
S400
P
P
K
S
L
P
S
S
D
K
R
K
N
M
Y
Site 39
Y407
S
D
K
R
K
N
M
Y
S
G
G
E
N
V
Q
Site 40
S408
D
K
R
K
N
M
Y
S
G
G
E
N
V
Q
M
Site 41
T419
N
V
Q
M
N
G
D
T
P
H
D
G
G
H
G
Site 42
T439
D
C
E
E
L
Q
R
T
G
R
F
C
G
G
L
Site 43
Y550
S
K
D
N
N
F
D
Y
L
E
F
R
L
W
I
Site 44
Y579
D
A
S
F
L
V
Q
Y
F
T
R
F
T
E
E
Site 45
T584
V
Q
Y
F
T
R
F
T
E
E
G
F
S
S
L
Site 46
Y610
K
M
I
K
L
A
D
Y
Y
P
I
N
S
N
F
Site 47
Y611
M
I
K
L
A
D
Y
Y
P
I
N
S
N
F
K
Site 48
Y621
N
S
N
F
K
V
G
Y
N
T
L
F
S
C
T
Site 49
S638
P
P
D
P
A
N
I
S
I
S
N
D
T
T
L
Site 50
T644
I
S
I
S
N
D
T
T
L
A
P
E
Y
L
P
Site 51
Y649
D
T
T
L
A
P
E
Y
L
P
T
M
S
S
T
Site 52
T652
L
A
P
E
Y
L
P
T
M
S
S
T
D
M
Y
Site 53
Y677
S
K
K
E
C
S
K
Y
G
G
N
L
V
G
N
Site 54
S707
F
L
G
T
Y
T
S
S
M
A
L
K
K
F
K
Site 55
T715
M
A
L
K
K
F
K
T
S
P
Y
F
P
T
T
Site 56
S716
A
L
K
K
F
K
T
S
P
Y
F
P
T
T
A
Site 57
Y718
K
K
F
K
T
S
P
Y
F
P
T
T
A
R
K
Site 58
T721
K
T
S
P
Y
F
P
T
T
A
R
K
L
I
S
Site 59
T722
T
S
P
Y
F
P
T
T
A
R
K
L
I
S
D
Site 60
S757
T
P
K
L
I
V
P
S
E
F
K
P
T
S
P
Site 61
T762
V
P
S
E
F
K
P
T
S
P
N
R
G
W
F
Site 62
S763
P
S
E
F
K
P
T
S
P
N
R
G
W
F
V
Site 63
S854
I
S
I
A
H
I
D
S
L
K
M
E
T
E
T
Site 64
T861
S
L
K
M
E
T
E
T
S
A
P
G
E
Q
P
Site 65
S862
L
K
M
E
T
E
T
S
A
P
G
E
Q
P
K
Site 66
Y941
K
H
Q
P
D
F
I
Y
L
R
H
V
P
L
R
Site 67
Y992
A
V
R
K
G
M
D
Y
L
F
S
Q
H
D
L
Site 68
S995
K
G
M
D
Y
L
F
S
Q
H
D
L
S
F
L
Site 69
S1026
K
K
K
K
K
K
G
S
L
D
S
D
N
D
D
Site 70
S1029
K
K
K
G
S
L
D
S
D
N
D
D
S
D
C
Site 71
S1034
L
D
S
D
N
D
D
S
D
C
P
Y
S
E
K
Site 72
Y1038
N
D
D
S
D
C
P
Y
S
E
K
V
P
S
I
Site 73
S1039
D
D
S
D
C
P
Y
S
E
K
V
P
S
I
K
Site 74
S1044
P
Y
S
E
K
V
P
S
I
K
I
P
M
D
I
Site 75
S1059
M
E
Q
Q
P
F
L
S
D
S
K
P
S
D
R
Site 76
S1061
Q
Q
P
F
L
S
D
S
K
P
S
D
R
E
R
Site 77
S1064
F
L
S
D
S
K
P
S
D
R
E
R
S
P
T
Site 78
S1069
K
P
S
D
R
E
R
S
P
T
F
L
E
R
H
Site 79
T1071
S
D
R
E
R
S
P
T
F
L
E
R
H
T
S
Site 80
T1077
P
T
F
L
E
R
H
T
S
C
_
_
_
_
_
Site 81
S1078
T
F
L
E
R
H
T
S
C
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation