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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEKK4
Full Name:
Mitogen-activated protein kinase kinase kinase 4
Alias:
EC 2.7.11.25; KIAA0213; Kinase MEKK4; M3K4; MAP three kinase 1; MAP3K4; MAPK/ERK kinase kinase 4; MAPKKK4; MEK kinase 4; MEKK 4; MTK1
Type:
EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE11 family
Mass (Da):
181552
Number AA:
1607
UniProt ID:
Q9Y6R4
International Prot ID:
IPI00186536
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004709
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0000186
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T40
P
P
P
P
E
P
E
T
E
S
E
P
E
C
C
Site 2
T55
L
A
A
R
Q
E
G
T
L
G
D
S
A
C
K
Site 3
S59
Q
E
G
T
L
G
D
S
A
C
K
S
P
E
S
Site 4
S63
L
G
D
S
A
C
K
S
P
E
S
D
L
E
D
Site 5
S66
S
A
C
K
S
P
E
S
D
L
E
D
F
S
D
Site 6
S72
E
S
D
L
E
D
F
S
D
E
T
N
T
E
N
Site 7
T75
L
E
D
F
S
D
E
T
N
T
E
N
L
Y
G
Site 8
Y81
E
T
N
T
E
N
L
Y
G
T
S
P
P
S
T
Site 9
T83
N
T
E
N
L
Y
G
T
S
P
P
S
T
P
R
Site 10
S84
T
E
N
L
Y
G
T
S
P
P
S
T
P
R
Q
Site 11
S87
L
Y
G
T
S
P
P
S
T
P
R
Q
M
K
R
Site 12
T88
Y
G
T
S
P
P
S
T
P
R
Q
M
K
R
M
Site 13
S96
P
R
Q
M
K
R
M
S
T
K
H
Q
R
N
N
Site 14
T97
R
Q
M
K
R
M
S
T
K
H
Q
R
N
N
V
Site 15
S109
N
N
V
G
R
P
A
S
R
S
N
L
K
E
K
Site 16
S111
V
G
R
P
A
S
R
S
N
L
K
E
K
M
N
Site 17
T131
P
H
K
D
T
G
K
T
V
E
N
V
E
E
Y
Site 18
Y138
T
V
E
N
V
E
E
Y
S
Y
K
Q
E
K
K
Site 19
Y140
E
N
V
E
E
Y
S
Y
K
Q
E
K
K
I
R
Site 20
T152
K
I
R
A
A
L
R
T
T
E
R
D
H
K
K
Site 21
T153
I
R
A
A
L
R
T
T
E
R
D
H
K
K
N
Site 22
S173
M
L
D
S
V
G
G
S
L
P
K
K
S
I
P
Site 23
S178
G
G
S
L
P
K
K
S
I
P
D
V
D
L
N
Site 24
Y188
D
V
D
L
N
K
P
Y
L
S
L
G
C
S
N
Site 25
S190
D
L
N
K
P
Y
L
S
L
G
C
S
N
A
K
Site 26
T213
I
A
R
P
A
R
Q
T
S
R
T
D
C
P
A
Site 27
S214
A
R
P
A
R
Q
T
S
R
T
D
C
P
A
D
Site 28
T216
P
A
R
Q
T
S
R
T
D
C
P
A
D
R
L
Site 29
T236
L
R
L
L
L
K
L
T
S
V
S
K
K
K
D
Site 30
S237
R
L
L
L
K
L
T
S
V
S
K
K
K
D
R
Site 31
S239
L
L
K
L
T
S
V
S
K
K
K
D
R
E
Q
Site 32
T252
E
Q
R
G
Q
E
N
T
S
G
F
W
L
N
R
Site 33
S253
Q
R
G
Q
E
N
T
S
G
F
W
L
N
R
S
Site 34
Y285
N
D
Q
D
F
F
L
Y
T
A
R
Q
A
I
P
Site 35
T286
D
Q
D
F
F
L
Y
T
A
R
Q
A
I
P
D
Site 36
S307
T
F
K
V
D
Y
G
S
F
A
F
V
R
D
R
Site 37
T329
V
E
G
Q
C
K
A
T
P
G
T
K
I
V
G
Site 38
Y337
P
G
T
K
I
V
G
Y
S
T
H
H
E
H
L
Site 39
S350
H
L
Q
R
Q
R
V
S
F
E
Q
V
K
R
I
Site 40
Y378
L
Q
A
L
Q
K
D
Y
E
K
Y
A
A
K
D
Site 41
S431
W
P
V
F
E
I
P
S
P
R
P
S
K
G
N
Site 42
S435
E
I
P
S
P
R
P
S
K
G
N
E
P
E
Y
Site 43
Y442
S
K
G
N
E
P
E
Y
E
G
D
D
T
E
G
Site 44
T447
P
E
Y
E
G
D
D
T
E
G
E
L
K
E
L
Site 45
S456
G
E
L
K
E
L
E
S
S
T
D
E
S
E
E
Site 46
S457
E
L
K
E
L
E
S
S
T
D
E
S
E
E
E
Site 47
T458
L
K
E
L
E
S
S
T
D
E
S
E
E
E
Q
Site 48
S461
L
E
S
S
T
D
E
S
E
E
E
Q
I
S
D
Site 49
S467
E
S
E
E
E
Q
I
S
D
P
R
V
P
E
I
Site 50
S481
I
R
Q
P
I
D
N
S
F
D
I
Q
S
R
D
Site 51
S486
D
N
S
F
D
I
Q
S
R
D
C
I
S
K
K
Site 52
S499
K
K
L
E
R
L
E
S
E
D
D
S
L
G
W
Site 53
S503
R
L
E
S
E
D
D
S
L
G
W
G
A
P
D
Site 54
S512
G
W
G
A
P
D
W
S
T
E
A
G
F
S
R
Site 55
S518
W
S
T
E
A
G
F
S
R
H
C
L
T
S
I
Site 56
S553
L
H
K
L
M
D
G
S
L
Q
R
A
R
I
A
Site 57
S580
F
P
D
P
M
W
G
S
D
Y
V
Q
L
S
R
Site 58
Y582
D
P
M
W
G
S
D
Y
V
Q
L
S
R
T
P
Site 59
S586
G
S
D
Y
V
Q
L
S
R
T
P
P
S
S
E
Site 60
T588
D
Y
V
Q
L
S
R
T
P
P
S
S
E
E
K
Site 61
S591
Q
L
S
R
T
P
P
S
S
E
E
K
C
S
A
Site 62
S592
L
S
R
T
P
P
S
S
E
E
K
C
S
A
V
Site 63
S597
P
S
S
E
E
K
C
S
A
V
S
W
E
E
L
Site 64
S644
Q
R
P
A
G
E
P
S
L
L
S
I
K
Q
L
Site 65
S647
A
G
E
P
S
L
L
S
I
K
Q
L
V
R
E
Site 66
Y668
G
G
L
L
M
K
Q
Y
Y
Q
F
M
L
Q
E
Site 67
S721
Q
L
P
Q
A
S
H
S
L
K
N
L
L
E
E
Site 68
Y739
F
T
K
E
I
T
H
Y
I
R
G
G
E
A
Q
Site 69
S773
L
E
F
G
L
Q
E
S
C
A
E
F
W
T
S
Site 70
S780
S
C
A
E
F
W
T
S
A
D
D
S
S
A
S
Site 71
S784
F
W
T
S
A
D
D
S
S
A
S
D
E
I
I
Site 72
S785
W
T
S
A
D
D
S
S
A
S
D
E
I
I
R
Site 73
S787
S
A
D
D
S
S
A
S
D
E
I
I
R
S
V
Site 74
S813
H
E
A
R
E
R
A
S
K
A
L
G
F
A
K
Site 75
S835
I
A
A
E
F
R
L
S
A
P
V
R
D
L
L
Site 76
S847
D
L
L
D
V
L
K
S
K
Q
Y
V
K
V
Q
Site 77
Y850
D
V
L
K
S
K
Q
Y
V
K
V
Q
I
P
G
Site 78
S892
G
K
D
C
S
K
D
S
D
D
V
L
I
D
A
Site 79
S913
H
G
D
R
A
R
D
S
E
D
S
W
G
T
W
Site 80
S916
R
A
R
D
S
E
D
S
W
G
T
W
E
A
Q
Site 81
T936
P
Q
V
E
T
V
D
T
L
R
S
M
Q
V
D
Site 82
T956
V
M
Q
S
A
H
L
T
I
Q
R
K
A
F
Q
Site 83
T971
Q
S
I
E
G
L
M
T
L
C
Q
E
Q
T
S
Site 84
S979
L
C
Q
E
Q
T
S
S
Q
P
V
I
A
K
A
Site 85
S1002
L
E
L
C
N
R
I
S
N
A
I
D
R
V
D
Site 86
S1014
R
V
D
H
M
F
T
S
E
F
D
A
E
V
D
Site 87
S1023
F
D
A
E
V
D
E
S
E
S
V
T
L
Q
Q
Site 88
S1025
A
E
V
D
E
S
E
S
V
T
L
Q
Q
Y
Y
Site 89
T1027
V
D
E
S
E
S
V
T
L
Q
Q
Y
Y
R
E
Site 90
Y1031
E
S
V
T
L
Q
Q
Y
Y
R
E
A
M
I
Q
Site 91
Y1040
R
E
A
M
I
Q
G
Y
N
F
G
F
E
Y
H
Site 92
S1055
K
E
V
V
R
L
M
S
G
E
F
R
Q
K
I
Site 93
Y1066
R
Q
K
I
G
D
K
Y
I
S
F
A
R
K
W
Site 94
Y1076
F
A
R
K
W
M
N
Y
V
L
T
K
C
E
S
Site 95
S1083
Y
V
L
T
K
C
E
S
G
R
G
T
R
P
R
Site 96
T1087
K
C
E
S
G
R
G
T
R
P
R
W
A
T
Q
Site 97
T1093
G
T
R
P
R
W
A
T
Q
G
F
D
F
L
Q
Site 98
S1117
L
P
E
D
D
F
L
S
L
Q
A
L
M
N
E
Site 99
S1135
H
V
I
G
K
P
H
S
P
V
T
G
L
Y
L
Site 100
Y1141
H
S
P
V
T
G
L
Y
L
A
I
H
R
N
S
Site 101
S1148
Y
L
A
I
H
R
N
S
P
R
P
M
K
V
P
Site 102
S1159
M
K
V
P
R
C
H
S
D
P
P
N
P
H
L
Site 103
T1170
N
P
H
L
I
I
P
T
P
E
G
F
S
T
R
Site 104
S1175
I
P
T
P
E
G
F
S
T
R
S
M
P
S
D
Site 105
T1176
P
T
P
E
G
F
S
T
R
S
M
P
S
D
A
Site 106
S1178
P
E
G
F
S
T
R
S
M
P
S
D
A
R
S
Site 107
S1181
F
S
T
R
S
M
P
S
D
A
R
S
H
G
S
Site 108
S1185
S
M
P
S
D
A
R
S
H
G
S
P
A
A
A
Site 109
S1188
S
D
A
R
S
H
G
S
P
A
A
A
A
A
A
Site 110
S1227
A
H
D
T
R
G
S
S
V
P
E
N
D
R
L
Site 111
S1251
R
S
L
S
R
H
S
S
P
T
E
E
R
D
E
Site 112
S1267
A
Y
P
R
G
D
S
S
G
S
T
R
R
S
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation