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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC12A8 All Species: 10
Human Site: S430 Identified Species: 22
UniProt: A0AV02 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A0AV02 NP_078904.3 714 78223 S430 G A E G L H C S E H L L L E K
Chimpanzee Pan troglodytes XP_516709 941 101578 S657 G P E G L H C S E H L L L E K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545139 840 90619 S556 G T G A L H C S E H L L L E K
Cat Felis silvestris
Mouse Mus musculus Q8VI23 705 77001 Q421 S P E P V P R Q G P D T L H C
Rat Rattus norvegicus Q8CJI3 707 77054 Q422 S P E P M P R Q G P D A L H C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6A4L1 721 79387 S437 K K N G R P N S R V M S S T Q
Zebra Danio Brachydanio rerio A2BFP5 899 98457 S505 L H Y R S P T S S W G Y I S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_397130 677 75119 V388 Q S I A S Q N V L P G I S C L
Nematode Worm Caenorhab. elegans Q09573 1020 112280 H616 K V E D K D P H P K N W R P Q
Sea Urchin Strong. purpuratus XP_796834 688 74559 E405 I L Q C I A N E N V I P I I K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38329 1120 123980 D547 P Q I L L F V D N P R T S W N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 72.4 N.A. 73.8 N.A. 79.5 77.8 N.A. N.A. N.A. 64.2 22.7 N.A. N.A. 41.7 21.8 43.7
Protein Similarity: 100 73.9 N.A. 78.4 N.A. 87.1 84.8 N.A. N.A. N.A. 76.4 41.1 N.A. N.A. 60.6 37.9 59.1
P-Site Identity: 100 93.3 N.A. 80 N.A. 13.3 13.3 N.A. N.A. N.A. 13.3 6.6 N.A. N.A. 0 6.6 6.6
P-Site Similarity: 100 93.3 N.A. 80 N.A. 20 20 N.A. N.A. N.A. 26.6 20 N.A. N.A. 13.3 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 19 0 10 0 0 0 0 0 10 0 0 0 % A
% Cys: 0 0 0 10 0 0 28 0 0 0 0 0 0 10 19 % C
% Asp: 0 0 0 10 0 10 0 10 0 0 19 0 0 0 0 % D
% Glu: 0 0 46 0 0 0 0 10 28 0 0 0 0 28 0 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 28 0 10 28 0 0 0 0 19 0 19 0 0 0 0 % G
% His: 0 10 0 0 0 28 0 10 0 28 0 0 0 19 0 % H
% Ile: 10 0 19 0 10 0 0 0 0 0 10 10 19 10 0 % I
% Lys: 19 10 0 0 10 0 0 0 0 10 0 0 0 0 37 % K
% Leu: 10 10 0 10 37 0 0 0 10 0 28 28 46 0 10 % L
% Met: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 28 0 19 0 10 0 0 0 10 % N
% Pro: 10 28 0 19 0 37 10 0 10 37 0 10 0 10 0 % P
% Gln: 10 10 10 0 0 10 0 19 0 0 0 0 0 0 28 % Q
% Arg: 0 0 0 10 10 0 19 0 10 0 10 0 10 0 0 % R
% Ser: 19 10 0 0 19 0 0 46 10 0 0 10 28 10 0 % S
% Thr: 0 10 0 0 0 0 10 0 0 0 0 19 0 10 0 % T
% Val: 0 10 0 0 10 0 10 10 0 19 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 10 0 10 0 10 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _