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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC12A8 All Species: 10
Human Site: S514 Identified Species: 22
UniProt: A0AV02 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A0AV02 NP_078904.3 714 78223 S514 L D L K S P P S F P V E I S D
Chimpanzee Pan troglodytes XP_516709 941 101578 S741 L D L K S P P S F P V E I S D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545139 840 90619 S640 L D L K S P A S F P P E G S D
Cat Felis silvestris
Mouse Mus musculus Q8VI23 705 77001 L505 T L Q D S F L L D P G S P L S
Rat Rattus norvegicus Q8CJI3 707 77054 L506 T L Q D S F L L D A E S P L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6A4L1 721 79387 L521 H Q G P E H G L E S R L L V T
Zebra Danio Brachydanio rerio A2BFP5 899 98457 N589 D P V Q P Q Y N F W L S L V D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_397130 677 75119 D472 R T Q S P T F D R D Y G S A S
Nematode Worm Caenorhab. elegans Q09573 1020 112280 M700 L R G F A K T M F Y N N H Q I
Sea Urchin Strong. purpuratus XP_796834 688 74559 S489 K E K D S L L S H V I D K N R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38329 1120 123980 K631 G S G L G G M K P N I T V V G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 72.4 N.A. 73.8 N.A. 79.5 77.8 N.A. N.A. N.A. 64.2 22.7 N.A. N.A. 41.7 21.8 43.7
Protein Similarity: 100 73.9 N.A. 78.4 N.A. 87.1 84.8 N.A. N.A. N.A. 76.4 41.1 N.A. N.A. 60.6 37.9 59.1
P-Site Identity: 100 100 N.A. 80 N.A. 13.3 6.6 N.A. N.A. N.A. 0 13.3 N.A. N.A. 0 13.3 13.3
P-Site Similarity: 100 100 N.A. 80 N.A. 13.3 6.6 N.A. N.A. N.A. 6.6 46.6 N.A. N.A. 6.6 20 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 10 0 0 10 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 28 0 28 0 0 0 10 19 10 0 10 0 0 37 % D
% Glu: 0 10 0 0 10 0 0 0 10 0 10 28 0 0 0 % E
% Phe: 0 0 0 10 0 19 10 0 46 0 0 0 0 0 0 % F
% Gly: 10 0 28 0 10 10 10 0 0 0 10 10 10 0 10 % G
% His: 10 0 0 0 0 10 0 0 10 0 0 0 10 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 19 0 19 0 10 % I
% Lys: 10 0 10 28 0 10 0 10 0 0 0 0 10 0 0 % K
% Leu: 37 19 28 10 0 10 28 28 0 0 10 10 19 19 0 % L
% Met: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 10 10 10 0 10 0 % N
% Pro: 0 10 0 10 19 28 19 0 10 37 10 0 19 0 0 % P
% Gln: 0 10 28 10 0 10 0 0 0 0 0 0 0 10 0 % Q
% Arg: 10 10 0 0 0 0 0 0 10 0 10 0 0 0 10 % R
% Ser: 0 10 0 10 55 0 0 37 0 10 0 28 10 28 28 % S
% Thr: 19 10 0 0 0 10 10 0 0 0 0 10 0 0 10 % T
% Val: 0 0 10 0 0 0 0 0 0 10 19 0 10 28 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 10 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _