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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED19
All Species:
36.06
Human Site:
S125
Identified Species:
61.03
UniProt:
A0JLT2
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A0JLT2
NP_703151.1
244
26273
S125
L
P
G
S
H
D
N
S
S
L
R
S
L
I
E
Chimpanzee
Pan troglodytes
XP_508439
244
26239
S125
L
P
G
S
H
D
N
S
S
L
R
S
L
I
E
Rhesus Macaque
Macaca mulatta
XP_001101030
244
26295
S125
L
P
G
S
H
D
N
S
S
L
R
S
L
I
E
Dog
Lupus familis
XP_852656
244
26173
S125
L
P
G
S
H
D
N
S
S
L
R
S
L
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8C1S0
244
26244
S125
L
P
G
S
H
D
N
S
S
L
R
S
L
I
E
Rat
Rattus norvegicus
NP_001101211
244
26303
S125
L
P
G
S
H
D
N
S
S
L
R
S
L
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513917
197
22078
G105
T
G
F
R
L
H
A
G
P
L
P
E
Q
C
R
Chicken
Gallus gallus
XP_426411
237
25493
S118
L
P
G
S
H
D
N
S
S
L
R
S
L
I
E
Frog
Xenopus laevis
Q5EAY2
240
26246
S125
T
P
G
T
P
D
N
S
S
L
R
S
L
I
E
Zebra Danio
Brachydanio rerio
Q6DRL8
240
26987
S122
S
P
G
I
Q
D
N
S
S
L
R
S
L
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVL6
337
35372
I124
S
V
I
E
K
P
P
I
G
G
K
E
L
L
P
Honey Bee
Apis mellifera
XP_395809
241
26966
L143
V
Q
L
A
G
F
R
L
H
P
G
P
L
P
E
Nematode Worm
Caenorhab. elegans
Q9N4F2
199
22779
M107
S
N
L
T
S
S
S
M
Q
G
F
K
L
S
A
Sea Urchin
Strong. purpuratus
XP_793184
239
26596
T131
K
E
I
T
T
F
T
T
G
M
L
Q
G
F
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
99.1
95
N.A.
94.2
94.6
N.A.
69.6
82.3
63.5
69.6
N.A.
31.7
47.9
25.4
42.6
Protein Similarity:
100
99.5
99.5
97.1
N.A.
95.9
96.3
N.A.
71.3
85.6
75
77.4
N.A.
42.1
62.7
40.9
59
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
80
80
N.A.
6.6
13.3
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
86.6
80
N.A.
20
26.6
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
65
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
8
0
0
0
0
0
0
0
15
0
0
72
% E
% Phe:
0
0
8
0
0
15
0
0
0
0
8
0
0
8
0
% F
% Gly:
0
8
65
0
8
0
0
8
15
15
8
0
8
0
0
% G
% His:
0
0
0
0
50
8
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
15
8
0
0
0
8
0
0
0
0
0
65
0
% I
% Lys:
8
0
0
0
8
0
0
0
0
0
8
8
0
0
8
% K
% Leu:
50
0
15
0
8
0
0
8
0
72
8
0
86
8
0
% L
% Met:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
65
0
0
0
0
0
0
0
0
% N
% Pro:
0
65
0
0
8
8
8
0
8
8
8
8
0
8
8
% P
% Gln:
0
8
0
0
8
0
0
0
8
0
0
8
8
0
0
% Q
% Arg:
0
0
0
8
0
0
8
0
0
0
65
0
0
0
8
% R
% Ser:
22
0
0
50
8
8
8
65
65
0
0
65
0
8
0
% S
% Thr:
15
0
0
22
8
0
8
8
0
0
0
0
0
0
0
% T
% Val:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _