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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHRS12 All Species: 5.45
Human Site: T172 Identified Species: 10.91
UniProt: A0PJE2 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A0PJE2 NP_001026889.1 317 35146 T172 E H D P R V I T V S S G G M L
Chimpanzee Pan troglodytes XP_001159419 317 35374 T172 E H D P R V I T V S S G G M L
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8BYK4 316 35274 N172 S A P A R V V N L S S I A H L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5F389 414 46711 R264 V V S S E S H R F T E I K D S
Frog Xenopus laevis Q5XG41 318 34975 T174 I M S V C Q M T R L V L P G M
Zebra Danio Brachydanio rerio Q803A8 412 46303 L265 E S H R F T D L L D S C G N L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610310 330 36563 V176 S A P S R I V V V S S L A H A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17703 314 34587 N161 I A N V T I I N T L P A T L L
Sea Urchin Strong. purpuratus XP_001187701 321 35618 V174 E N S R V I T V S S G G M Y T
Poplar Tree Populus trichocarpa XP_002307520 322 35360 I176 A A P D A R V I T V S S G G M
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_192713 322 35141 I176 A T P D A K V I T V A S G G M
Baker's Yeast Sacchar. cerevisiae Q05016 267 29140 A130 V F D T N V T A L I N I T Q A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.5 N.A. N.A. N.A. 33.4 N.A. N.A. N.A. 22.4 22.6 23.5 N.A. 36.6 N.A. 20.5 57.6
Protein Similarity: 100 97.4 N.A. N.A. N.A. 50.7 N.A. N.A. N.A. 37.6 41.8 36.8 N.A. 50.9 N.A. 38.7 73.2
P-Site Identity: 100 100 N.A. N.A. N.A. 33.3 N.A. N.A. N.A. 0 6.6 26.6 N.A. 26.6 N.A. 13.3 20
P-Site Similarity: 100 100 N.A. N.A. N.A. 46.6 N.A. N.A. N.A. 6.6 20 33.3 N.A. 40 N.A. 33.3 33.3
Percent
Protein Identity: 40.9 N.A. N.A. 43.1 20.1 N.A.
Protein Similarity: 56.8 N.A. N.A. 59.6 38.4 N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 34 0 9 17 0 0 9 0 0 9 9 17 0 17 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 25 17 0 0 9 0 0 9 0 0 0 9 0 % D
% Glu: 34 0 0 0 9 0 0 0 0 0 9 0 0 0 0 % E
% Phe: 0 9 0 0 9 0 0 0 9 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 9 25 42 25 0 % G
% His: 0 17 9 0 0 0 9 0 0 0 0 0 0 17 0 % H
% Ile: 17 0 0 0 0 25 25 17 0 9 0 25 0 0 0 % I
% Lys: 0 0 0 0 0 9 0 0 0 0 0 0 9 0 0 % K
% Leu: 0 0 0 0 0 0 0 9 25 17 0 17 0 9 42 % L
% Met: 0 9 0 0 0 0 9 0 0 0 0 0 9 17 25 % M
% Asn: 0 9 9 0 9 0 0 17 0 0 9 0 0 9 0 % N
% Pro: 0 0 34 17 0 0 0 0 0 0 9 0 9 0 0 % P
% Gln: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % Q
% Arg: 0 0 0 17 34 9 0 9 9 0 0 0 0 0 0 % R
% Ser: 17 9 25 17 0 9 0 0 9 42 50 17 0 0 9 % S
% Thr: 0 9 0 9 9 9 17 25 25 9 0 0 17 0 9 % T
% Val: 17 9 0 17 9 34 34 17 25 17 9 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _