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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRMD3
All Species:
10.3
Human Site:
Y424
Identified Species:
18.89
UniProt:
A2A2Y4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A2A2Y4
NP_777598.3
597
68772
Y424
P
V
K
A
A
R
E
Y
E
D
P
P
S
E
E
Chimpanzee
Pan troglodytes
XP_520094
581
66659
Y408
P
V
K
A
A
R
E
Y
E
D
P
P
S
E
E
Rhesus Macaque
Macaca mulatta
XP_001102733
838
94037
G679
Q
E
E
E
L
P
L
G
E
G
V
P
L
P
K
Dog
Lupus familis
XP_541268
582
66957
Y409
P
V
K
E
A
R
E
Y
E
S
P
P
S
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BHD4
595
68429
C422
S
P
V
K
G
A
Q
C
A
D
P
P
D
E
E
Rat
Rattus norvegicus
Q5FVG2
731
81700
I525
L
P
S
L
R
P
A
I
D
I
N
V
N
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510887
421
48616
V270
P
L
T
I
S
E
L
V
Y
N
P
S
A
S
L
Chicken
Gallus gallus
XP_413944
395
45595
N244
R
V
H
F
I
K
W
N
E
V
T
K
M
K
F
Frog
Xenopus laevis
P11434
801
89411
D595
D
V
K
A
T
Q
Q
D
S
P
S
P
T
V
N
Zebra Danio
Brachydanio rerio
O57457
619
70690
S421
P
Q
S
G
L
Y
N
S
A
S
E
R
N
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609384
572
64686
S405
A
N
G
G
I
Q
I
S
S
L
E
P
V
C
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
V753
D
S
L
N
S
G
K
V
V
D
H
F
E
M
L
Sea Urchin
Strong. purpuratus
XP_784053
556
63534
P403
V
D
G
H
A
R
D
P
L
P
D
V
V
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.9
65.5
94.1
N.A.
91.2
29.1
N.A.
50.5
42.5
23.3
28.7
N.A.
30.1
N.A.
20.2
30.4
Protein Similarity:
100
95.8
66.3
96.3
N.A.
95.9
45.5
N.A.
59.2
53.2
38.5
46
N.A.
47.9
N.A.
34.5
49
P-Site Identity:
100
100
13.3
86.6
N.A.
33.3
0
N.A.
13.3
13.3
26.6
6.6
N.A.
13.3
N.A.
6.6
26.6
P-Site Similarity:
100
100
26.6
86.6
N.A.
40
20
N.A.
40
26.6
46.6
20
N.A.
20
N.A.
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
24
31
8
8
0
16
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% C
% Asp:
16
8
0
0
0
0
8
8
8
31
8
0
8
0
0
% D
% Glu:
0
8
8
16
0
8
24
0
39
0
16
0
8
39
47
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
8
% F
% Gly:
0
0
16
16
8
8
0
8
0
8
0
0
0
0
0
% G
% His:
0
0
8
8
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
8
16
0
8
8
0
8
0
0
0
0
0
% I
% Lys:
0
0
31
8
0
8
8
0
0
0
0
8
0
16
8
% K
% Leu:
8
8
8
8
16
0
16
0
8
8
0
0
8
0
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
8
0
8
0
0
8
8
0
8
8
0
16
0
8
% N
% Pro:
39
16
0
0
0
16
0
8
0
16
39
54
0
8
0
% P
% Gln:
8
8
0
0
0
16
16
0
0
0
0
0
0
0
8
% Q
% Arg:
8
0
0
0
8
31
0
0
0
0
0
8
0
0
0
% R
% Ser:
8
8
16
0
16
0
0
16
16
16
8
8
24
16
8
% S
% Thr:
0
0
8
0
8
0
0
0
0
0
8
0
8
0
0
% T
% Val:
8
39
8
0
0
0
0
16
8
8
8
16
16
8
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
24
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _