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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR3E
All Species:
3.94
Human Site:
S221
Identified Species:
9.63
UniProt:
A5X5Y0
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A5X5Y0
NP_872395.2
456
51438
S221
E
W
E
L
L
G
L
S
K
A
T
A
K
L
S
Chimpanzee
Pan troglodytes
Q5IS76
494
56903
Y214
E
I
I
D
A
S
G
Y
K
H
D
I
K
Y
N
Rhesus Macaque
Macaca mulatta
Q866A2
502
56411
T267
E
K
I
S
L
G
I
T
V
L
L
S
L
T
V
Dog
Lupus familis
XP_545226
476
54223
N241
E
W
E
L
L
G
I
N
K
A
T
P
K
M
S
Cat
Felis silvestris
Mouse
Mus musculus
P23979
487
56038
P220
W
E
L
L
E
V
F
P
Q
F
K
E
F
S
I
Rat
Rattus norvegicus
P35563
483
55410
T221
W
E
L
L
G
V
F
T
K
F
Q
E
F
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519474
387
44401
R153
F
Y
V
V
I
R
R
R
P
L
F
Y
T
V
S
Chicken
Gallus gallus
Q9I8C7
452
50034
V215
G
M
P
A
T
R
N
V
V
T
Y
G
C
C
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_700338
466
53299
R227
M
K
F
H
V
V
I
R
R
R
P
L
F
Y
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P17644
576
65488
E235
D
I
L
G
V
P
A
E
R
H
E
K
Y
Y
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
26.7
27.4
73.9
N.A.
35.9
36
N.A.
33.5
26.7
N.A.
34.7
N.A.
23
N.A.
N.A.
N.A.
Protein Similarity:
100
45.7
45.2
82.1
N.A.
55.2
56.1
N.A.
49.1
46.7
N.A.
55.1
N.A.
41.3
N.A.
N.A.
N.A.
P-Site Identity:
100
20
20
73.3
N.A.
6.6
13.3
N.A.
6.6
6.6
N.A.
0
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
40
93.3
N.A.
13.3
20
N.A.
33.3
6.6
N.A.
26.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
10
0
10
0
0
20
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% C
% Asp:
10
0
0
10
0
0
0
0
0
0
10
0
0
0
0
% D
% Glu:
40
20
20
0
10
0
0
10
0
0
10
20
0
0
0
% E
% Phe:
10
0
10
0
0
0
20
0
0
20
10
0
30
0
0
% F
% Gly:
10
0
0
10
10
30
10
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
10
0
0
0
0
0
20
0
0
0
0
0
% H
% Ile:
0
20
20
0
10
0
30
0
0
0
0
10
0
0
20
% I
% Lys:
0
20
0
0
0
0
0
0
40
0
10
10
30
0
0
% K
% Leu:
0
0
30
40
30
0
10
0
0
20
10
10
10
10
0
% L
% Met:
10
10
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
10
% N
% Pro:
0
0
10
0
0
10
0
10
10
0
10
10
0
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
20
10
20
20
10
0
0
0
0
0
% R
% Ser:
0
0
0
10
0
10
0
10
0
0
0
10
0
20
40
% S
% Thr:
0
0
0
0
10
0
0
20
0
10
20
0
10
10
10
% T
% Val:
0
0
10
10
20
30
0
10
20
0
0
0
0
10
10
% V
% Trp:
20
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
10
0
0
10
10
10
30
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _