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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-6
All Species:
1.82
Human Site:
S235
Identified Species:
4
UniProt:
A6NCS4
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A6NCS4
NP_001129743
301
32121
S235
P
A
F
P
S
P
Y
S
A
A
V
S
P
Y
S
Chimpanzee
Pan troglodytes
XP_519662
366
38728
G300
P
A
F
P
S
P
Y
G
A
A
V
S
P
Y
S
Rhesus Macaque
Macaca mulatta
XP_001108914
368
39047
G302
P
A
F
P
S
P
Y
G
A
T
V
S
P
Y
S
Dog
Lupus familis
XP_543239
342
36276
G276
P
A
F
P
G
P
Y
G
A
P
A
A
P
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
P43688
289
31578
Y223
V
A
A
F
L
G
P
Y
K
A
T
S
P
Y
S
Rat
Rattus norvegicus
O35767
318
34318
A234
L
G
D
S
A
A
Y
A
P
A
Y
G
L
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
N218
S
P
Y
S
S
P
Y
N
V
S
I
N
P
Y
S
Frog
Xenopus laevis
P42583
299
34079
N223
S
P
Y
N
S
P
Y
N
V
S
I
N
P
Y
S
Zebra Danio
Brachydanio rerio
Q90481
269
30288
V204
P
R
R
V
A
V
P
V
L
V
R
D
G
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
D234
P
P
D
N
D
D
D
D
D
K
Y
S
I
E
M
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
P279
S
A
R
R
V
A
V
P
V
L
V
R
D
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.1
76.6
56.7
N.A.
59.1
43
N.A.
N.A.
42.1
41.2
35.5
N.A.
N.A.
N.A.
30.2
30.8
Protein Similarity:
100
81.4
77.9
64
N.A.
66.4
52.5
N.A.
N.A.
53.4
53.1
45.8
N.A.
N.A.
N.A.
41.5
43
P-Site Identity:
100
93.3
86.6
66.6
N.A.
40
13.3
N.A.
N.A.
40
40
6.6
N.A.
N.A.
N.A.
13.3
13.3
P-Site Similarity:
100
93.3
86.6
73.3
N.A.
40
26.6
N.A.
N.A.
73.3
73.3
13.3
N.A.
N.A.
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
55
10
0
19
19
0
10
37
37
10
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
19
0
10
10
10
10
10
0
0
10
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% E
% Phe:
0
0
37
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
10
10
0
28
0
0
0
10
10
19
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
19
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
10
0
0
0
10
10
% K
% Leu:
10
0
0
0
10
0
0
0
10
10
0
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
19
0
0
0
19
0
0
0
19
0
0
0
% N
% Pro:
55
28
0
37
0
55
19
10
10
10
0
0
64
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
19
10
0
0
0
0
0
0
10
10
0
0
0
% R
% Ser:
28
0
0
19
46
0
0
10
0
19
0
46
0
0
64
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
0
% T
% Val:
10
0
0
10
10
10
10
10
28
10
37
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
19
0
0
0
64
10
0
0
19
0
0
64
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _